ライフサイエンスコーパス: stage-specific

1 t, stable, disease specific, or even disease stage specific.

2 sis but these metabolic functions may not be stage specific.

3 ects flowering time and floret number and is stage specific.

4 d -independent functions that are tissue and stage specific.

5 afficking architectures that are tissue- and stage-specific.

6 c, and cicatricial) identified no pattern as stage-specific.

7 ortional hazards models were used to compare stage-specific 5-year survival among NHBs, NHWs, and His

8 earum that was recently shown to have sexual stage-specific A-to-I RNA editing.

9 i away from the nuclear periphery determines stage-specific accessibility of Ig loci.

10 irst, local EcR-mediated signaling induces a stage-specific accumulation of lipids in stage-10 oocyte

11 rotein reporter transgenic mice that display stage-specific activation of transgenes during odontobla

12 (GFP) reporter transgenic mice that display stage-specific activation of transgenes during odontobla

13 urther upregulated in pDCs, correlating with stage-specific activity of multiple enhancer elements.

14 ng in diverse endocytic pathways and measure stage-specific activity of processing factors in endosom

15 y having features of cell- and developmental stage-specific activity.

16 ross development is vital to predict whether stage-specific adaptation will occur in nature.

17 These results illustrate the potential for stage-specific adaptation within a complex life cycle an

18 , this is controlled by modifications of the stage-specific adhesin lipophosphoglycan (LPG).

19 We find differential, progression stage-specific alterations in phenotypic heterogeneity a

20 We found several miRNAs with 'stage specific' alterations while others display a clear

21 Stage-specific analyses led to the identification of 3 p

22 monstrates the utility of niche- rather than stage-specific analysis of parasite transcriptomes to id

23 erentiated to hematopoietic precursor cells, stage-specific analysis of T cell maturation confirmed e

24 n of progenitor cells into odontoblasts were stage specific and dependent on the stage of cell maturi

25 lncRNA expression patterns that were highly stage specific and were more lineage specific than those

26 We observed a dynamic, stage-specific and density dependent change in Aedes aeg

27 of FGF2 on cells in odontoblast lineage were stage-specific and depended on the stage of cell maturit

28 te myeloid leukemia (AML), where we observed stage-specific and diametrically opposite functions for

29 The stage-specific and differentially expressed unigenes (DE

30 Our results demonstrated differentiation stage-specific and dose-dependent roles of EED in normal

31 asites during TMP-SMX administration induces stage-specific and long-lived pre-erythrocytic protectiv

32 ates, identifying thousands of developmental-stage-specific and shared QTL.

33 The datasets on stage-specific and SHB1-induced gene expression and gene

34 stages, and that ALBA4 associates with both stage-specific and stage-independent partners to produce

35 These data establish stage-specific and stromal-dependent roles for Notch in

36 that microbiota ecology appears to be cancer stage-specific and strongly associated with histological

37 istry and a validated antibody selection for stage-specific and type-specific markers in autopsy tiss

38 of these iCGIs is tissue- and developmental stage-specific and, for the first time, we demonstrate t

39 ivity is known to depend on factors that are stage specific, and we describe a novel approximately 70

40 y morphological criteria and the analysis of stage-specific antigens (i.e., IGFBP1, PRL).

41 The cells displayed enhanced expression of stage-specific antigens that extravillous CTBs normally

42 Appropriate differentiation-stage-specific application of Gsk3 inhibitor, Wnt inhibi

43 tem that takes into account the demonstrated stage-specific architecture of the pair-rule gene networ

44 Also, we found that differentiation-stage-specific ARIH2 transcription was regulated by the

45 tissues, giving insight into cell-type- and stage-specific AS mechanisms in plants.

46 These QTLs were developmental stage specific, as different QTLs were detected before a

47 (MMB) additionally triggered strong sex- and stage-specific attraction in several Caenorhabditis spec

48 understanding local interaction between life stage-specific biological thresholds and finer scale oce

49 sistance development and advocate the use of stage-specific biomarkers.

50 d cellularity of thymus and bone marrow, and stage-specific blockage of B cell development.

51 t pathway using 2-week-wait age-specific and stage-specific breakdowns.

52 Recent findings highlighted that upstream of stage-specific Ca(2+) effectors is a conserved interplay

53 We developed a microsimulation model of stage-specific cancer survival in 200 countries and terr

54 onitoring human cardiac disease according to stage-specific cardiogenesis, this study demonstrates RB

55 Quantitative information on endosomal stage-specific cargo processing is a critical parameter

56 iagnosis), and subsequent (ie, metachronous) stage-specific CBC occurrences in women who were diagnos

57 cal malaria and parasitemia, and fewer blood-stage specific CD4(+) T cells coproducing interleukin-10

58 o receive DP had higher frequencies of blood-stage specific CD4(+) T cells coproducing interleukin-2

59 nal cell types and enabled identification of stage-specific cellular and biological processes, and tr

60 afish embryogenesis identified developmental stage-specific ceramide changes based on long chain base

61 odel of global cancer survival, we estimated stage-specific cervical cancer 5-year net survival in 20

62 ic thymocytes are subject to a developmental stage-specific change in negative selection, which precl

63 We identified developmental-stage-specific changes in chromatin compartments and enh

64 We report stage-specific changes in INM due to a significant alter

65 reservation, and exhibit ductal- and disease-stage-specific characteristics.

66 MOF is therefore a developmental-stage-specific chromatin regulator found to be essential

67 that may be relevant in the establishment of stage-specific clinical management.

68 Together, we identify stage-specific co-regulators Kaiso and Sox10 that sequen

69 indings greatly enhance our understanding of stage-specific community assembly patterns in the fish g

70 enerated different tissue- and developmental stage-specific conditional knockout mice carrying Smarcb

71 Loss of developmental stage-specific constraint in macrometastases triggered b

72 Specifically, new fetal stage-specific contacts were uncovered between a region

73 s of additional regulators in a lineage- and stage-specific context.

74 ally, we uncovered cell-type- and cell-cycle-stage-specific control of the mechanosensation of myosin

75 Using stage-specific Cre alleles, we uncovered distinct roles

76 im1 cKO, highlighting the need for cell- and stage-specific Cre lines for an accurate phenotype-genot

77 uish CFLD from CFnoLD and determine fibrosis stage-specific cut-off values.

78 zyme that breaks down L-2HG, is required for stage-specific degradation of the L-2HG pool.

79 Stage-specific, "delayed time to" FAP-related events are

80 Stage-specific depletion experiments further demonstrate

81 erythrocyte attachment and invasion in vivo, stage-specific depletion uncovered roles in gamete devel

82 Transient, stage-specific, depletion of RB1 during hPSC differentia

83 Here we show a developmental stage-specific differential expression pattern of Nfatc1

84 t regulatory mechanisms that orchestrate the stage-specific differentiation process, we developed a c

85 maps, we identify thousands of developmental stage-specific DMRs (dsDMRs) across zebrafish developmen

86 Therefore, bypassing stage-specific DNA demethylation has significant consequ

87 to quantitatively and simultaneously measure stage-specific drug effects on parasites at different de

88 Our findings classify developmental stage-specific early, middle and late meiotic transcript

89 major life stage and incorporate these into stage-specific ecological models to reveal the life stag

90 The stage-specific editing is largely regulated by different

91 FR) ligand amphiregulin acts as an important stage-specific effector of estrogen signaling.

92 aureus sepsis, we demonstrate marked disease stage-specific effects of the anticoagulant and cell sig

93 -1, and the TGF-beta peptide DAF-7 each have stage-specific effects on behavioral trajectories, imply

94 nipostin A indicates that it exhibits growth stage-specific effects that differ from compounds that i

95 In contrast to these stage-specific effects, loss of the histone methyltransf

96 ivity, as well as the cell and developmental stage-specific effects, will need to be carefully consid

97 ion through infection, which may explain the stage-specific efficacy of different anthelmintic drugs.

98 ell-known human pluripotent stem cell marker stage-specific embryonic antigen 3 (SSEA3) and SSEA4 in

99 The effects of SSEA-1(+) (stage-specific embryonic antigen-1) PSCs was studied in

100 Stage-specific embryonic antigen-4 (SSEA-4) is one such

101 neurons is controlled by a dynamic relay of stage-specific enhancers.

102 Here we identify two stage-specific enhancers: the proximal enhancer mediates

103 , at DGET a researcher can analyze tissue or stage-specific enrichment for an inputted list of genes

104 re could be employed to identify how similar stage-specific environmental sensitivity determines dist

105 ent phenotypes in different life stages, but stage-specific evolutionary responses will depend on gen

106 thologs and other pseudogenes also displayed stage-specific expression and editing in Neurospora cras

107 cs, CNS cell type-specific and developmental stage-specific expression libraries are rapidly enhancin

108 Our data reveal that tissue and stage-specific expression of ankyrin isoforms relies on

109 Furthermore, promyelocyte stage-specific expression of genes coding for paucimanno

110 rypanosomes and that steric constraints, not stage-specific expression of glycosyltransferases, regul

111 r function by enforcing proper developmental stage-specific expression of multiple genes through chro

112 Developmental stage-specific expression of the beta-type globin genes

113 34, a primate-specific miRNA that displays a stage-specific expression pattern during progenitor expa

114 Stage-specific expression patterns of chemotaxis-associa

115 ross species, show tissue- and developmental stage-specific expression patterns, and may be associate

116 To identify novel surface markers with stage-specific expression patterns, we explored the reac

117 me miRNAs exhibited tissue- or developmental stage-specific expression patterns.

118 Markers with stage-specific expression were identified using a transg

119 role for the ENO1 3'-untranslated region in stage-specific expression.

120 an intimately linked complex of lineage- and stage-specific factors converges on specific and highly

121 hting how identification and manipulation of stage-specific factors that specify HSC developmental st

122 hey are mediated by combinations of core and stage-specific factors.

123 79860CC also have greater stage-constant and stage-specific fibrosis progression rates (P<0.0001 for

124 n Pet-1 targets uncovers a distinct neonatal stage-specific function for Pet-1, during which it promo

125 echanism of type I IFN signaling in pDCs and stage-specific function of immune cells in generating po

126 ccurs during mammary gland development and a stage-specific function of mCripto-1 signaling during ma

127 This stage-specific functionality arises from profound shifts

128 have been extensively studied, their precise stage-specific functions have been identified in only a

129 ated genes represent current and consecutive stage-specific functions, and downregulated genes repres

130 proteins are essential and to identify their stage-specific functions.

131 Stage-specific gene deletion in trophoblasts reveals tha

132 ation of the molecular players that regulate stage-specific gene expression and Pol II pausing will c

133 Stage-specific gene expression of some of these expanded

134 cteristic development cycle correlating with stage-specific gene expression profiles.

135 domain-containing protein, thereby mediating stage-specific gene expression programs and post-meiotic

136 ibute to this tightly controlled tissue- and stage-specific gene expression.

137 this is accompanied by the establishment of stage-specific gene expression.

138 dence for a role of TcUBP1 in trypomastigote stage-specific gene regulation important for T. cruzi vi

139 ion factor, BFD1 binds the promoters of many stage-specific genes and represents a counterpoint to th

140 the regulation of lineage- and developmental stage-specific genes but also the coordinated adaptation

141 loying two new statistical tools to identify stage-specific genes over time (SCPattern) and to recons

142 CDX2 responds to its environment, targeting stage-specific genes to contribute to either intestinal

143 pment that included 9669 core genes and 7302 stage-specific genes.

144 Furthermore, a stage-specific glycomic analysis revealed that the diffe

145 The model also describes the stage specific growth of maturing oocytes within the ova

146 elomerase and subjected them to an in vitro, stage-specific hepatocyte differentiation protocol that

147 This stage-specific HIF suppression is required for normal B

148 ork to RUNX1-ETO expression is developmental stage specific, highlighting the molecular mechanisms de

149 We used our stage-specific hPSC differentiation method to obtain and

150 capture the change in seroprevalence of non-stage-specific IgG and anti-TgERP IgG antibodies with hu

151 vide unique insights into stable and dynamic stage-specific immune states and define novel immune phe

152 of skeletal muscle regeneration by providing stage-specific immunomodulation and trophic and mechanic

153 A stage-specific increase in the synthesis of AMG+4 was fu

154 Mov10l1(-/-) germ-cell fractions indicated a stage-specific increase of retrotransposition in the ear

155 hemical genetics approach by screening for a stage-specific inhibitor of morphological development fr

156 We propose that stage-specific interactions between ApiAP2 proteins on p

157 es lineage specification and also identifies stage-specific interactions, like Pax5/Ebf1 vs. Pax5/Prd

158 ometric analysis, we report that mDia1 has a stage-specific interactome, including Prohibitin2, MyoD,

159 shed light on strategies for cell type- and stage-specific intervention in cardiac diseases.

160 cens as a model organism, we identify here a stage-specific iron-regulatory machinery comprising a tw

161 on and environmental plasticity (GxE) may be stage-specific, leading to a three-way interaction betwe

162 The secondary end point was stage-specific likelihood of receiving postoperative sys

163 les in lymphocyte lineage- and developmental stage-specific locus compaction as well as broad usage o

164 types are typically tissue and developmental stage specific, making relevant phenotypes difficult to

165 ctors regulate distinct genomic targets in a stage-specific manner and highlight how paralogy can ser

166 oci are regulated in a locus-, lineage-, and stage-specific manner during B lymphopoiesis, serving ei

167 x 2 (Otx2), is regulated in a cell type- and stage-specific manner during development in the mouse re

168 t variants with distinct 5' UTRs occurs in a stage-specific manner during T-cell development and is d

169 The LTRs function in a stage-specific manner during the oocyte-to-embryo transi

170 s acting between somatic and germ cells in a stage-specific manner during the perinatal period.

171 nitor cell (HSPC) numbers are also seen in a stage-specific manner in human MDS samples as well as in

172 odulate stem-cell competence in a neurogenic-stage-specific manner to shift neuron production between

173 ute to tumor progression in a sequential and stage-specific manner within the tumor microenvironment.

174 Only TP53 and SMAD4 mutations occurred in a stage-specific manner, confined to HGD and EAC, respecti

175 for Bcl11b expression, these inputs act in a stage-specific manner, providing a multitiered mechanism

176 to selected transcripts in a differentiation stage-specific manner, supporting the hypothesis that al

177 helial cells, in a tissue- and developmental stage-specific manner.

178 g structure is persistent in Plasmodium in a stage-specific manner.

179 larval crawling behavior in a developmental stage-specific manner.

180 lase (ENO1 and ENO2) that are expressed in a stage-specific manner.

181 specify PRC1 function in both a context- and stage-specific manner.

182 murine embryonic kidneys in a developmental stage-specific manner.

183 zymes, which was mediated by granulysin in a stage-specific manner.

184 A/eIF3f/HuR super-complex in a developmental stage-specific manner.

185 act in a locus, cell-type, and developmental stage-specific manner.

186 in situ and real-time expression analyses of stage-specific markers highlighted defects of primitive

187 This approach correctly identified known stage-specific markers of cardiomyocyte differentiation,

188 Among the stage-specific markers were the cell adhesion proteins C

189 This approach affirmed the utility of known stage-specific markers, as well as identifying additiona

190 mined by expression of microRNA clusters and stage-specific markers.

191 the identification of many new cell type-and stage-specific markers.

192 andidate risk genes, highlighting shared and stage-specific mechanisms in schizophrenia (SCZ).

193 pports B lineage cells through developmental stage-specific mechanisms.

194 The identity of stage-specific metabolic programs and their impact on ad

195 Our findings suggest that stage-specific methylation and demethylation events in C

196 ould also be reported, most of which capture stage-specific milestones, as well as data on graft fail

197 n-affinity miRNA pull-down approaches reveal stage-specific miR-219 targets in oligodendrocytes and f

198 nd distinct organ-specific and developmental stage-specific miRNA expression clusters, with an overal

199 Furthermore, we found that 24 PCD stage-specific miRNAs are aberrantly overexpressed in mu

200 temporally altered, revealing estrous cycle stage-specific modifications to the hypothalamic-pituita

201 short period of time is regulated by precise stage-specific molecular mechanisms.

202 By using highly sensitive stage-specific molecular methods to detect P. falciparum

203 of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have

204 l approach for the discovery of subtype- and stage-specific molecular substrates of circuit wiring, m

205 dult NAFLD cohort studies reporting fibrosis stage-specific mortality (0-4).

206 stage 0 as a reference population, fibrosis stage-specific mortality rate ratios (MRRs) with 95% con

207 conserved RBPs, some of which are potential stage-specific mRNA interactors that likely reflect the

208 Here, we propose the first developmental stage-specific network approach by integrating two cruci

209 This organization implies that tissue or stage specific networks can be best identified from inte

210 ndrocyte development and uncover a cohort of stage-specific oligodendrocyte-restricted lncRNAs, inclu

211 ion of adequately adapted parasite forms and stage-specific organelles.

212 iants that specify tissue- and developmental stage-specific organization of TFIID or SAGA complexes,

213 Stage, and stage-specific outcome (7th edition), on the test set re

214 Loss of Par complex function resulted in stage-specific overactivation of the Jun-kinase (JNK) pa

215 am characterized by sequential activation of stage-specific pathways, regulated by a temporally chang

216 logy, permitting the pair-rule genes to play stage-specific patterning roles.

217 ponse elements (PREs) to maintain tissue and stage-specific patterns of gene expression.

218 Expression was driven by either stage-specific peg4 and csp promoters or the constitutiv

219 ions to 44,396 spatial observations and life-stage-specific phenology (timing) for 26 ecotypes (i.e.,

220 ites (LCSs) in the hbl-1 3'UTR, and involves stage-specific post-translational regulation of HBL-1 nu

221 vestigation of possible correlations between stage-specific preferential trans-splicing or polyadenyl

222 iterature regarding cancer therapies, cancer stage specific prognosis, the kinetics of cancer recurre

223 ic signatures that could be used to identify stage-specific prognostic subgroups of AML.

224 -CAP and profilin, in combination with three stage-specific promoters and mapped the phenotypes affor

225 Using developmental stage-specific promoters to express FCU-GFP enables the

226 early and late odontoblast marker genes and stage-specific proteases involved in dentin maturation.

227 two distinct developmental phases, each with stage-specific rate and morphologic parameters.

228 umber of genes, with a strong preference for stage-specific rather than lineage-specific genes.

229 and in vivo approaches, we report here that stage-specific reciprocal dorso-ventral inductive intera

230 specialized mechanisms enforce lineage- and stage-specific recombination.

231 These findings reveal that stage-specific redox responses distinguish human GC B ce

232 a given gene and provide tissue-specific and stage-specific regulation of gene expression.

233 Thus, the lineage- and developmental stage-specific regulation of PRC2 subunit composition le

234 ative promoter switch-mediated developmental stage-specific regulation of SATB1 in thymocytes.

235 stem enables us to visualize the dynamic and stage-specific regulation of transposable elements durin

236 eq) and immunohistology identified cell- and stage-specific regulation, and revealed that pig and hum

237 cus is a paradigm of cell- and developmental stage-specific regulation.

238 anisms of Ca(2+) homeostasis in a network of stage-specific regulator and effector pathways now repre

239 The primary end point was stage-specific relative survival, an objective measure o

240 istinct prognostic subgroups, especially for stage-specific reporting of survival in prospective clin

241 togenesis, function to direct cell type- and stage-specific repression of translation of the core G2/

242 differentiating stimuli and were detected in stage-specific repressive protein complexes containing t

243 These results indicate a stage-specific requirement for Sp2 in neural stem and pr

244 e of early lethality of CXCR4(-/-) mice, and stage-specific requirements for CXCR4 in thymus colonisa

245 These data reveal stage-specific requirements for LUBAC in coordinating th

246 These findings highlight the stage-specific requirements for the presumed "general" c

247 ased approach can be used to uncover disease-stage-specific responses to drugs.

248 at interactive scaling alters population and stage-specific responses to rising temperatures, such th

249 We aimed to quantify the fibrosis stage-specific risk of all-cause and liver-related morta

250 otivated by our genome-wide data uncovered a stage-specific role for TEAD/YAP factors in mammalian he

251 ontext of several transcription factors, the stage-specific role of GATA3 in NK cell development has

252 ults form a basis for understanding the cell stage-specific roles for CHD7-mediated chromatin remodel

253 recent work has now begun to define nuanced, stage-specific roles for Ikaros family members in the di

254 nogenesis and into the adult uncovered novel stage-specific roles for Mnx1 in endocrine lineage alloc

255 e-protecting DNA repair, RNR has complex and stage-specific roles in carcinogenesis.

256 Here, we report the stage-specific roles of PRC2 epigenetic regulators in em

257 Therefore, miR160 dictates developmental stage-specific sensitivities to auxin and cytokinin to d

258 results of transcriptomic analysis revealed stage-specific shifts in bioenergetic systems of biology

259 reased phosphorylation, indicating a role in stage-specific signal transduction.

260 ages with microbiota signatures that include stage-specific species.

261 P628 as a novel transcriptional regulator of stage-specific spermiogenesis.

262 Most developmental stage-specific splicing changes affected by drought were

263 transcription factor (TF) modules that drive stage-specific steps of human T cell development.

264 inadequacy and excess in each sex- and life stage-specific subgroup by both the UIC cutoff method an

265 odine inadequacy and excess in sex- and life stage-specific subgroups of the US population: one that

266 f iodine inadequacy across all sex- and life stage-specific subgroups with the iodine intake cutoff m

267 seq data to identify cell- and developmental-stage-specific super-enhancers (SEs).

268 We identified developmental-stage-specific super-enhancers and showed that most epig

269 This work identifies a set of novel stage-specific surface markers that can be used as a com

270 itated by the identification of lineage- and stage-specific surface markers, the continued identifica

271 dance probability estimate (CPE) of 0.57 for stage-specific survival.

272 lectively, these studies demonstrate a novel stage-specific susceptibility of A. fumigatus to zinc an

273 oping NK cells undergo unique, developmental stage-specific sustained and transient interactions with

274 Collectively, our findings suggest a stage-specific switch in CSC regulation during disease p

275 , conditional targeting revealed a postnatal stage-specific switch in Pet-1 targets from 5-HT synthes

276 We developed a stage-specific T cell differentiation protocol to valida

277 Stage-specific targeting demonstrates that Lmx1b is requ

278 wledge that is relevant for the discovery of stage-specific targets and for the design of possible an

279 owever, Cdx genes and multiple Hox genes are stage-specific targets of Sp1 and are downregulated at a

280 Here we define a stage-specific Tcf7l2-regulated transcriptional circuitr

281 ollaborative interactions among OSK and with stage-specific TFs direct both somatic-enhancer inactiva

282 asite metabolism to the activation of sexual-stage-specific transcription and gametocyte formation.

283 g of their function, we mapped OSKM-binding, stage-specific transcription factors (TFs), and chromati

284 are governed by cell type- and developmental stage-specific transcription factors.

285 and preimplantation development, we defined stage-specific transcription, which highlighted the clea

286 odulated pervasively and direct lineage- and stage-specific transcription.

287 Gene expression profiling reveals dynamic stage-specific transcriptional patterns that may link de

288 ation poise C/EBPbeta to execute diverse and stage-specific transcriptional programs by exploiting an

289 iate expression of lineage and developmental stage-specific transcriptional programs.

290 We constructed developmental stage-specific transcriptional regulatory networks by li

291 , operate repeatedly to regulate tissue- and stage-specific transcriptional responses during developm

292 Stage-specific transcriptome profiling identified differ

293 to generate a compendium of root-tissue- and stage-specific transcriptomes from two contrasting inbre

294 bridization, real-time quantitative PCR, and stage-specific transcriptomic analyses show that brachio

295 iparum clones depends on both high levels of stage-specific transcripts and high genetic diversity of

296 Identification of photoperiod and stage-specific transcripts gives insights into the regul

297 tantial association between histone PTMs and stage-specific transition provides insights into the int

298 the genetic regulatory mechanisms underlying stage-specific transitions between self-renewing and pro

299 e the mitochondrial proteome has tissue- and stage-specific variability, plus differences among exper

300 agement with OP9 stromal cells and were also stage-specific, with NOTCH1 and NOTCH2 receptors regulat