ライフサイエンスコーパス: stalling

1 tion fork restart following replication fork stalling.

2 QC) pathways monitor and respond to ribosome stalling.

3 in yeast, GTP depletion may lead to Pol III stalling.

4 ch of polybasic residues that cause ribosome stalling.

5 ost, indicated that the uORF causes ribosome stalling.

6 caused G1 cell cycle arrest and S phase fork stalling.

7 hances its translation by relieving ribosome stalling.

8 ss, and secondary DNA damage related to fork stalling.

9 ent to sites of ICL-induced replication fork stalling.

10 ted a reduction of DNA replication and G0/G1 stalling.

11 utes to R-loop generation and RNA polymerase stalling.

12 sites of DNA-damage-induced replication fork stalling.

13 in the Switch 1 region contribute to pol II stalling.

14 on even in the presence of irreversible fork stalling.

15 NA Damage Tolerance (DDT) response upon fork stalling.

16 s by resolving polyproline-induced ribosomal stalling.

17 RNA degradome data in the study of ribosome stalling.

18 synthesis (TLS) that alleviates replication stalling.

19 ents of ribosome initiation, elongation, and stalling.

20 of transcripts that cause transient ribosome stalling.

21 e SUMOylated in response to replication fork stalling.

22 cultured cells is stimulated by translation stalling.

23 human replisome dynamics in response to fork stalling.

24 multiply ubiquitinated upon replication fork stalling.

25 k progression and increased replication fork stalling.

26 e suhB mutant, indicating increased ribosome stalling.

27 the nascent chain can weaken or even abolish stalling.

28 hich positions spanned by the ribosome cause stalling.

29 ion of Hel2 observed at a lower frequency of stalling.

30 ission across Africa since 2000, progress is stalling.

31 t, but can be stabilized by replication fork stalling.

32 ted genome instability, and replication fork stalling.

33 ficial mutations contributed to evolutionary stalling.

34 The mechanosensing fibers strengthened upon stalling.

35 on downstream of endogenous and exogenous RF-stalling.

36 mations of the protein to enable sliding and stalling.

37 e persistent foci are not caused by physical stalling.

38 ociated with a reduction in replication fork stalling, a known trigger for HR and loss of MRN from te

39 lasticity, reducing fitness, and potentially stalling adaptation and migration.

40 t full-length protein can still be made when stalling after the first N terminal helix has inserted i

41 However, stalling after the first three helices have exited the r

42 n DNA damage sensitivity and pronounced fork stalling after UV-C treatment.

43 Pausing, stalling and backtracking of transcribing RNA polymerase

44 nt in zelda mutants both reduces replication stalling and bypasses the requirement for a functional c

45 . pylori, is accompanied by replication fork stalling and can be observed also in primary cells deriv

46 the APP/PS1 genotype and a Hfd on capillary stalling and CBF.

47 plication stress or DNA damage triggers fork stalling and checkpoint signaling to activate repair pat

48 ased amounts of spontaneous replication fork stalling and chromosomal aberrations, as well as fewer c

49 ecifically sensitive to the replication fork stalling and collapse caused by methyl methanesulfonate

50 The S phase delay appears to be due to the stalling and collapse of replication forks.

51 -transformed cells leads to replication fork stalling and collapse with disruption of interaction bet

52 implying that they are poised to respond to stalling and collapse.

53 during translation of mRNAs lead to ribosome stalling and collisions that trigger a series of quality

54 ated and then saturated in plagioclase after stalling and cooling in shallow-level chambers.

55 ve high levels of RNA polymerase II (RNAPII) stalling and DNA accessibility and show specific enrichm

56 phase progression and induces DNA-polymerase stalling and DNA damage.

57 to replicative stress due to RNA polymerase stalling and DNA damage.

58 ms for replication, resulting in replication stalling and double-strand breaks, which are suspected t

59 ns as an HR regulator after replication fork stalling and during double-strand break repair.

60 t studies indicate polyA runs cause ribosome stalling and frameshifting, triggering mRNA surveillance

61 e-site occupancy concentrations, whereas the stalling and free rotation experiments have multiple-sit

62 reventing the accumulation of excessive fork stalling and genetic mutations.

63 p explain the emerging link between ribosome stalling and ISR activation.

64 e of ER-associated mRNAs results in ribosome stalling and mRNA degradation.

65 prone bypass, whereas Gh or Sp causes strong stalling and only allows slow error-prone incorporation

66 m of autism in humans, and understanding the stalling and reactivation mechanism could reveal new app

67 Uch37 protein levels with hallmarks of G0/G1 stalling and recovery to their steady-state protein leve

68 ts within the translated mRNA cause ribosome stalling and reduce protein output.

69 n vulnerabilities that cause persistent fork stalling and replication catastrophe.

70 Timely stalling and resumption of RNA polymerases at damaged ch

71 pression of stg is sufficient to suppress G2-stalling and reveals roles for stalling in survival, pro

72 d how they are implicated in transcriptional stalling and TC-NER in the cell remain unknown.

73 HR), non-homologous end joining (NHEJ), fork stalling and template switching (FoSTeS), and microhomol

74 nsidering the DNA replication model of 'fork stalling and template switching' for CNV formation, we h

75 timately leads to increased replication fork stalling and the attenuation of cellular DNA replication

76 te both torque-induced Escherichia coli RNAP stalling and the torque generation capacity of RNAP.

77 AL4-VVD movements, such as binding, sliding, stalling, and dissociation, was observed.

78 incomplete polypeptides produced by ribosome stalling, and Ltn1 mutation leads to neurodegeneration i

79 HRR, inability to overcome replication fork stalling, and replication stress.

80 rest by polybasic sequences induces ribosome stalling, and the arrest product is degraded by the ribo

81 ction of the dNTP pool, DNA replication fork stalling, and the suppression of tumor cell growth in vi

82 ting rate constants and free energies to the stalling angle.

83 vercoming cisplatin-induced replication fork stalling, as replication-restart was impaired in both SM

84 rapid dissociation of pol delta from PCNA on stalling at a DNA lesion.

85 e mutagenic consequences of replication fork stalling at a single, site-specific replication barrier

86 In vivo, the AtaT2 activity induces ribosome stalling at all four glycyl codons but does not evoke a

87 bmillisecond interrogation with preferential stalling at cognate sites may be common to various DNA-b

88 Leading-strand polymerase stalling at DNA damage impairs replication fork progress

89 herefore suggest that whereas DNA polymerase stalling at DNA lesions activates ATR to protect cell vi

90 Stalling at DNA replication forks generates stretches of

91 We demonstrate that DNA polymerase stalling at DNA structures induces error-prone DNA synth

92 on and that their protein knockdown leads to stalling at G0/G1 Moreover, serum-starved cells display

93 hat can unwind G4s in vitro and prevent fork stalling at G4 forming sequences in vivo.

94 Ethanol-stressed cells exhibited ribosomal stalling at internal AUG codons, which may be ameliorate

95 l elongation defect, with abundant ribosomes stalling at many sequences, not limited to proline stret

96 lethal options such as herding, fencing, and stalling at night but more details about such successful

97 ally, loss of CSA or CSB leads to polymerase stalling at non-B DNA in a neuroblastoma cell line, in p

98 t not SPRTN, protects replication forks from stalling at poly(ADP-ribose) polymerase 1 (PARP1)-DNA co

99 Stalling at poly-Pro motifs is alleviated by the elongat

100 ), traditionally known to alleviate ribosome stalling at polyproline motifs, can efficiently rescue t

101 the replication machinery showed substantial stalling at sites of damage, and these problems were fur

102 kinetics at stall sites, we induced ribosome stalling at specific codons by starving the bacterium Es

103 oportional to the degree of in vivo ribosome stalling at synonymous codons.

104 ed pool of certain mt-tRNAs and mitoribosome stalling at the corresponding codons.

105 ides of the lesion, implying that polymerase stalling at the DPC activates SPRTN on both leading and

106 s indicate abnormal organelle morphology and stalling at the G2/M checkpoint in Mrp null cells.

107 Furthermore, we observed frequent fork stalling at the junction of the common deletion, suggest

108 oded by defective messenger RNAs and undergo stalling at the ribosome during translation.

109 tryptophan codons, along with their expected stalling at the tryptophan codon.

110 We demonstrate that transient stalling at this barrier induces a distinct pattern of g

111 n heat stress, m(5) C loss leads to ribosome stalling at UUG triplets, the only codon translated by a

112 reduction of Pol II progression (pausing or stalling) at the Igh-V, additional steps such as prematu

113 s a barrier to RNAP elongation, causing RNAP stalling, backtracking, and transcriptional arrest.

114 at recombination induced by replication fork stalling but only a minor role in constraining recombina

115 One of the major polymerisation effects was stalling, but each of the individual proteins could inse

116 N(7) -CH(3) 2'-F dG adduct, albeit with some stalling, but hpol kappa is strongly blocked at this les

117 r these conditions does not result from fork stalling, but rather occurs at gaps formed by PrimPol re

118 homology-directed DNA repair and replication stalling, but until recently were undetectable in living

119 Reducing capillary stalling by blocking neutrophil adhesion improved CBF an

120 No stalling by Rev1-Pol zeta directly past the ICL was obse

121 e loss by replisome binding, and replication stalling by transcription factors.

122 e alone and that the force needed to release stalling can be generated in vivo by a nascent chain fol

123 Pol II stalling can be overcome by irradiation involving the ep

124 Replication fork stalling can promote genomic instability, predisposing t

125 and reduces global chromatin accessibility, stalling cells on their trajectory toward mature pluripo

126 Acute treatment with replication-stalling chemotherapeutics causes reversal of replicatio

127 genome instability, causing replication fork stalling, chromosome fragility, and impaired repair.

128 with replication and repair, provoking fork stalling, chromosome fragility, and recombination.

129 significant differences in replication fork stalling, collapse, and DNA damage were detected between

130 DNA replication, leading to replication fork stalling, collapse, HR and subsequent recombination-medi

131 sponse signalling following replication fork stalling/collapse.

132 suggest that FANCM prevents replisomes from stalling/collapsing at ALT telomeres by disrupting TERRA

133 rent knowledge of how these different Pol II stalling contexts are distinguished by the cell, how the

134 partum care in SSA is critical to addressing stalling declines in maternal mortality and morbidity.

135 These findings uncover a translational stalling-dependent protein aggregation mechanism, and pr

136 imulate the frameshifting, without involving stalling detectable by toe-printing.

137 ates but are heavily constrained by the mean stalling distance of replication forks, and that, for ge

138 mechanism that removes RNA polymerase (RNAP)-stalling DNA damage from the transcribed strand (TS) of

139 Upon aberrant fork stalling, DNA damage signaling and concomitant H2AX phos

140 , POLE suppression leads to replication fork stalling, DNA damage, and a senescence-like state or cel

141 tructures are implicated in replication fork stalling, DNA double strand breaks (DSBs) and human dise

142 th synergistic increases in replication fork stalling, double-strand breaks, and apoptosis.

143 These findings indicate replication stalling due to the presence of unprocessed RNA/DNA hete

144 hich can lead to "parasite-induced migratory stalling" due to a positive feedback between increasing

145 tDNA deletions initiated by replication fork stalling during strand displacement mtDNA synthesis.

146 Ribosome stalling during translation can potentially be harmful,

147 We show that observed stalling during translation correlates with slowed pepti

148 Ribosome stalling during translation has recently been shown to c

149 Stalling during translation triggers ribosome quality co

150 60S) ribosomal subunits-products of ribosome stalling during translation.

151 matic and mechanical cycles of the motor and stalling dynein on the microtubule track.

152 identify mutations that further increase the stalling efficiency.

153 pulling force and ranking them according to stalling efficiency.

154 iate RNA transcripts during transcription by stalling elongation complexes at catalytically dead EcoR

155 tification of enhancers, lncRNAs, and RNAPII stalling/elongation dynamics.

156 nzyme progress is interrupted by pausing and stalling events that can slow degradation in a sequence-

157 The molecular mechanisms that drive these stalling events, however, are still unknown.

158 rection, termination sites, and fork pausing/stalling events.

159 Stalling experiments are considered in which rates of in

160 Reasonable agreement is found with stalling experiments for ATP and GTP binding.

161 sults of controlled rotation experiments and stalling experiments, for the range of angles where the

162 ce; it vanishes at a load equal to the motor stalling force and changes to a left-hand bias above tha

163 the cargo is in the vicinity of the mutant's stalling force or a multiple of its stalling force.

164 es of opposite polarity generates a backward stalling force that prevents entry into dendrites and th

165 mutant's stalling force or a multiple of its stalling force.

166 ine residues indicating lowered single motor stalling forces.

167 corporate cytosine across from a replication-stalling G-quadruplex.

168 Recently, stalling has also been linked to the activation of integ

169 Replication stalling has been associated with the formation of patho

170 However, such evolutionary stalling has not been empirically demonstrated, and it i

171 M-FANCD2 complex following APH-mediated fork stalling in a manner dependent on MRE11 and FANCD2, foll

172 t TRF2 overexpression results in replication stalling in duplex telomeric repeat tracts and the subse

173 vel mRNA-induced mechanisms of translational stalling in eukaryotic ribosomes.

174 Because fork stalling in FAN1-deficient cells causes chromosomal inst

175 Thus, transient cell cycle stalling in G2 has key roles in wound healing but become

176 sence of functional DHX33, consistent with a stalling in initiation, and DHX33 more preferentially pr

177 Rare codons resulted in ribosome stalling in manners both dependent and independent of pr

178 We show here that replication stalling in mitochondria leads to replication fork regre

179 cation foci and counteracts replication fork stalling in RNAPI- and RNAPII-transcribed genes, suggest

180 o suppress G2-stalling and reveals roles for stalling in survival, proliferation and paracrine signal

181 lococcus aureus ErmCL leader peptide induces stalling in the presence of clinically important macroli

182 lism, the primary causes of replication fork stalling include secondary DNA structures, highly transc

183 decay and identified changes in the ribosome stalling index during stress and recovery.

184 d mammalian systems reveal the importance of stalling-induced ribosomal protein ubiquitination by Hel

185 ZNF598-mediated stalling initiated the ribosome-associated quality contr

186 G2-stalling is mediated by downregulation of the G2/M-speci

187 pared to controls, suggesting that capillary stalling is not a mechanistic link between a Hfd and inc

188 Whether this modification responds to RNAPII stalling is not yet known.

189 NC stalling is recognized by the Rqc2/Tae2 RQC subunit, whi

190 One way to prevent replication fork stalling is through the recruitment of specialized trans

191 g, which suggests that the origin of pausing/stalling is to be found in the physics of the budding pr

192 that viral latency products may repress via stalling key mediators that in turn modulate glycolysis.

193 sequences induce DNA polymerase slippage and stalling, leading to length and sequence variation.

194 Ribosome stalling leads to cleavage of the mRNA and induction of

195 Ribosome stalling leads to recruitment of the ribosome quality co

196 replication restart downstream of replicase stalling lesions and structures.

197 d DNA polymerases to bypass replication fork stalling lesions.

198 , most genome-destabilizing replication fork stalling likely occurs because of proteins bound to the

199 s by stalling ribosomes and through ribosome stalling may also modulate the level of their mRNAs.

200 Stalling may also occur at a third stage of translocatio

201 monstrated, and it is unclear to what extent stalling may limit the power of natural selection to imp

202 ns that result in irreversible transcription stalling might be important for TC-NER.

203 st of the nascent chains is achieved using a stalling motif, and isotopically labeled RNCs are produc

204 lide does not preferentially induce ribosome stalling near the 5' end of mRNAs, but rather acts at sp

205 spermidine(3+) did not produce the premature stalling observed in experiments.

206 Here, we propose that the pausing/stalling observed in the simulations can be understood a

207 Fork slowing and stalling occur at structurally distinct lesions, are alw

208 the DNA track that it is moving along, with 'stalling' occuring at subpiconewton tensions.

209 losis lysine tRNA, tRNA(Lys19-CUU), ribosome stalling occurs at in-frame cognate AAA Lys codons.

210 tide-bond formation, such that translational stalling occurs when three or more consecutive prolines

211 The stalling of an abundant outer membrane lipoprotein, Lpp,

212 has remained controversial, resulting in the stalling of any therapeutic perspective.

213 uch as starvation and antibiotics, can cause stalling of bacterial ribosomes, which may alter gene ex

214 This recruitment drives slowing or stalling of DNA replication at transcriptionally engaged

215 w, we will discuss the stresses that lead to stalling of each of the polymerases and how the cell rec

216 retained within the Golgi, likely because of stalling of insulin-granule budding.

217 that has the potential to cause significant stalling of mtDNA replication.

218 ted with each other and imbalances result in stalling of neurite outgrowth.

219 The stalling of Pol eta directly past the ICL is attributed

220 t negative form of Chd1 results in increased stalling of PolII past the entry site of the promoter pr

221 le secondary structures that can lead to the stalling of replication forks and cause genomic instabil

222 Stalling of ribosome at the PA5471 leader peptide (PA547

223 y of nucleotide excision repair triggered by stalling of RNA polymerase at DNA lesions.

224 o-2'-deoxyadenosine (CydA) induces prolonged stalling of RNA polymerase II (Pol II) followed by trans

225 repression of several Hox genes in part via stalling of RNA polymerase II (RNA Pol II).

226 C-NER in part by positioning and stabilizing stalling of RNA polymerase II (RNAPII) at DNA lesions.

227 Stalling of RNA Polymerase II (RNAPII) on chromatin duri

228 grator complex(3), concordant with increased stalling of RNA polymerase II (RNAPII).

229 Exposure to chronic morphine increased stalling of RNA polymerase II at these Bdnf promoters in

230 Convergent transcription causes stalling of RNA polymerase II during transcription, whic

231 ct cell viability and prevent apoptosis, the stalling of RNA polymerases instead activates ATR to ind

232 Efficient stalling of RNAP II is essential for efficient TCR.

233 understanding the underlying mechanisms and stalling of the dedifferentiation process would be highl

234 sfRNA results from stalling of the host 5'-3' exoribonuclease XRN1/Pacman o

235 It is thought that stalling of the mitochondrial replication machinery duri

236 l stress within the DNA template may lead to stalling of the replication fork.

237 NA polymerases at replication forks to avoid stalling of the replication machinery and consequent gen

238 Single-molecule methods revealed stalling of translation at the entrance of the peptide e

239 e report that FUS is necessary for efficient stalling of translation because deficient cells are refr

240 codon usage regulates ribosome movement and stalling on mRNA during translation.

241 Ribosome stalling on mRNAs can decrease protein expression.

242 played to apurinic/apyrimidinic 1 (APE1) and stalling on the fold to recruit activating factors, or O

243 These data suggest that ribosome stalling on Trp codons causes a negative polar effect on

244 Ser deprivation resulted in ribosomal stalling on two of the six Ser codons, TCC and TCT, and

245 ge and tumors, resulting in either transient stalling or a prolonged but reversible cell cycle arrest

246 gh numerous different obstacles cause Pol II stalling or arrest, the cell somehow distinguishes betwe

247 and take a limited number of steps prior to stalling or dissociation.

248 f new agents for rare cancers are at risk of stalling owing to the ever-increasing complexity and cos

249 zones, as well as the poleward movement and stalling patterns of jet streams.

250 the average rate, concurrent with increased stalling, pausing, arrest, and/or backtracking (transcri

251 complex, but only one is bound productively, stalling Pchlide reduction in both active sites.

252 These stalling points, which occur after the addition of three

253 replication origin usage combined with fork stalling promotes repeat instability during early embryo

254 G2-stalling protects cells from JNK-induced apoptosis, but

255 ess, possibly by increasing replication fork stalling, providing a molecular mechanism for the deform

256 In the absence of stalling, read-through of poly(A) produces a poly-lysine

257 ion stress, as shown by the presence of fork stalling, reduction of fork speed, and premature senesce

258 Wide stalling regions were characterized by high DNAse hypers

259 as once thought, with DNA damage frequently stalling replication forks.

260 during replication, thereby preventing fork stalling, replication stress, and secondary DNA damage r

261 Finally, using stalling reporters we show that Plasmodium cells evolved

262 DNA replication can lead to replication fork stalling, resulting in DNA damage and apoptotic death, i

263 cause translational infidelity and ribosome stalling, resulting in neurodegeneration.

264 Pol II stalling results from impaired loading of the template b

265 Ribosome stalling results in the production of truncated proteins

266 o modulate the translation of their mRNAs by stalling ribosomes and through ribosome stalling may als

267 blocks superinfection by coliphage lambda by stalling RNA polymerase (RNAP) translocation specificall

268 onitor RNA G4-mediated reverse transcriptase stalling (RTS) events.

269 force to release a stall induced by the SecM stalling sequence and that readthrough of SecM directly

270 F5A strongly promotes the translation of the stalling sequences identified by profiling and increases

271 5' end of mRNAs, but rather acts at specific stalling sites that are scattered throughout the entire

272 the largest ribosome density at established stalling sites.

273 ation risk is causally unrelated to promoter stalling (Spt5), transcriptional activity, or off-target

274 ated enzyme and unravel a mode of RNA Pol II stalling that is due to alkylation of DNA in the minor g

275 termed subgenomic flavivirus RNA (sfRNA), by stalling the cellular 5'-3'-exoribonuclease 1 (XRN1) via

276 ing strand template arrests the replisome by stalling the CMG helicase.

277 During stalling the free energy profile of the enzymatic steps

278 nce T-cell activation has occurred, however, stalling the rejection process becomes increasingly diff

279 n response to DNA damage or replication fork stalling, the basal activity of Mec1(ATR) is stimulated

280 we could show that (i) at the time point of stalling, the beta-barrel appears folded; (ii) the stall

281 This stalling time increases linearly with viomycin concentra

282 olymerase, Ctf18-RFC can rapidly signal fork stalling to activate the S phase checkpoint.

283 h FoSTeS and/or MMBIR and serial replication stalling to be the predominant mechanisms leading to NF1

284 toxin that enlists highly selective ribosome stalling to recalibrate the transcriptome and remodel th

285 hibit the synthesis of specific proteins, by stalling translation elongation.

286 Ribosome stalling triggers no-go decay (NGD) and ribosome-associa

287 In eukaryotes, ribosome stalling triggers release of 60S subunits with attached

288 ight into common principles causing ribosome stalling under physiological conditions.

289 es, namely convergent transcription and Pol2 stalling, were detected at breakpoints.

290 ribosome is slow, resulting in translational stalling when several Pro have to be incorporated into t

291 es of polypeptides that induce translational stalling when synthesized on a ribosome.

292 te the existence of a force regime far below stalling where the mechanical power transduced by the ra

293 rant or problematic mRNAs can cause ribosome stalling which leads to the production of truncated or d

294 e collisions that occur during translational stalling, which can alter frameshifting in both the stal

295 light the influence of drug-induced ribosome stalling, which causes bias at translation start sites.

296 del system reproduced protracted pausing and stalling, which suggests that the origin of pausing/stal

297 NA and cope with replication fork blocks and stalling, while simultaneously promoting sister chromati

298 t couples rG4-mediated reverse transcriptase stalling with next-generation sequencing.

299 ed in circumstances associated with ribosome stalling with no global increase in uncharged tRNAs.

300 a similar set of agents that cause ribosome stalling, with maximal activation of Hel2 observed at a