ライフサイエンスコーパス: startle

1 kin conductance response or fear potentiated startle.

2 comotor activity, and prepulse inhibition of startle.

3 ression underlying short-term habituation of startle.

4 -irradiation for activity, coordination, and startle.

5 cluding marked attenuation of light-enhanced startle.

6 s assessed by the prepulse inhibition of the startle.

7 -induced prepulse inhibition of the acoustic startle.

8 ct on the speed at which fish responded to a startle.

9 ssessed under extinction by fear-potentiated startle.

10 on available on the aged olfactory system is startling.

11 ffect on activity and prepulse inhibition of startle 1-week post-irradiation that dissipated each wee

12 hreat memory, measured with fear-potentiated startle 7 days after acquisition, is attenuated by 60% i

13 -cells abolishes short-latency tail-elicited startles [8, 9], we hypothesized that M-cell activity wa

14 Startling acoustic stimuli (SAS) can accelerate reaction

15 om two different paradigms (fear-potentiated startle, affect-modulated startle) in two independent st

16 We found an increase in startle amplitude and plasma corticosterone levels 30 mi

17 in the elevated plus maze or basal acoustic startle amplitude.

18 are represented in such natural sounds, with startle and burrowing behaviors.

19 Stressed females showed increased acoustic startle and decreased sleep maintenance, indicative of h

20 , which has been associated with exaggerated startle and deficient sensorimotor gating.

21 Abnormal information processing of acoustic startle and depressive-like behaviors are also observed.

22 d auditory processing, with reduced acoustic startle and distorted auditory brainstem responses.

23 including a loss of light-enhanced acoustic startle and less stress-induced hypophagia.

24 search in the past decades on habituation of startle and other escape responses, the underlying neura

25 ensitization of BLA manifested as heightened startle and PPI deficits in response to subsequent subth

26 stive association (p < 10(-6)) with baseline startle and PPI in the discovery cohort.

27 and environmental contributions to baseline startle and PPI showed a substantial single nucleotide p

28 a Spectrum project was assessed for baseline startle and PPI.

29 ygenic score for schizophrenia with baseline startle and PPI.

30 on genetic variants associated with baseline startle and PPI; 2) estimate the single nucleotide polym

31 exposure) on amygdala systems that modulate startle and prepulse inhibition (PPI), an operational me

32 e that could underlie certain core deficits (startle and prepulse inhibition) that are observed in po

33 ated with HDAC4 expression, fear-potentiated startle and resting-state functional connectivity of the

34 ted, low doses of ethanol induced an initial startle and slow ramping of group activity, whereas high

35 lementary roles in facilitating the acoustic startle and visceromotor reflexes.

36 n addition to the characteristic 'stiffness, startles and stumbles' of hyperekplexia, apnoea attacks

37 ng (measured by prepulse inhibition (PPI) of startle) and mismatch negativity (MMN).

38 al interaction, cognitive function, acoustic startle, and amphetamine sensitivity, with some sex-depe

39 odify anxiety-related phenotypes (avoidance, startle, and conditioned fear), we induced transient for

40 arly microsurgical approaches demonstrated a startling array of regenerative and morphogenetic proces

41 such as grooming, nest building and acoustic startle as early as 1-2 months of age.

42 Upon repeated exposures, this olfactory startle attenuates with the characteristics of habituati

43 efCS presented 6 seconds after the US caused startle attenuation (Study2 and 3) and positively valenc

44 termination elicit appetitive responses like startle attenuation.

45 at 1 or 4 dpf, showed consistent deficits in startle behavior at 7 dpf, including lower responsivenes

46 ay that is essential for the M-cell-mediated startle behavior in larval zebrafish.

47 nal consequences of exposures, we quantified startle behavior in response to acoustic/vibrational sti

48 The neural circuit underlying the C-start, a startle behavior in which the fish forms a "C"-shaped bo

49 cue of major aspects of adult locomotion and startle behavior required octopamine, but a complementar

50 fiber neurons help activate M-cell-mediated startle behavior.

51 of older fathers had reduced exploratory and startle behaviors and exhibited similar brain DNA methyl

52 cover a mechanism for generating alternative startle behaviors; local sensory inputs drive inhibitory

53 activity, Rtkn2 for intensity of reaction to startle, Bmp2 for wound healing, Il15 and Id2 for severa

54 at some species can perform a second type of startle called the S-start [5-7].

55 ticulospinal Mauthner cells (M-cells) of the startle circuit have been considered to be dedicated to

56 We find that pappaa is expressed by startle circuit neurons, and expression of wild-type but

57 the Mauthner cells (M-cells) in the goldfish startle circuit, which receive visual and auditory input

58 (M-cell), the decision-making neuron of the startle circuit.

59 These findings suggest that startle circuits are particularly sensitive to forebrain

60 Progress in DNA sequencing has revealed the startling complexity of cancer genomes, which typically

61 A startle cue decreased intracortical inhibition, but not

62 ad similarly shorter reaction times during a startle cue in all motor tasks.

63 ing stimulus), and the effect of an acoustic startle cue on MEPs elicited by cervicomedullary stimula

64 tasks, reaction times were shorter during a startle cue while performing a power grip but not index

65 An acoustic startle cue, a stimulus that engages the reticular syste

66 An acoustic startle cue, which engages the reticular system, suppres

67 Skin conductance and startle data served as objective psychophysiological ind

68 e is known about circular granular ratchets, startling devices able to convert vertical vibrations in

69 dysfunction underlies neuromotor deficits in startle disease and autism spectrum disorders.

70 yRs) have been linked to human hyperekplexia/startle disease and autism spectrum disorders.

71 on several diseases such as chronic pain and startle disease by targeting glycine receptors (GlyRs).

72 Hyperekplexia or startle disease is a rare clinical syndrome characterize

73 Hyperekplexia or startle disease is a serious neurological condition affe

74 Human startle disease is caused by mutations in glycine recept

75 a1 subunit mutation (Q177K) in a novel mouse startle disease mutant shaky Structural data suggest tha

76 mechanism by which GlyR dysfunction induces startle disease.

77 mechanism by which GlyR dysfunction induces startle disease.

78 it of the glycine receptor (GlyR), cause the startle disease/hyperekplexia channelopathy in man.

79 s disruption triggers a paediatric and adult startle disorder, hyperekplexia.

80 There was a startling diversity within and among species in the type

81 ed PPI disruption without affecting baseline startle; dorsal striatal amylin infusions had no effect.

82 all known beta-lactam-based antibiotics with startling efficiency.

83 ch combining trial-by-trial facial eye-blink startle electromyography and brainstem- and amygdala-spe

84 riables included slopes for fear-potentiated startle (electromyography) and self-reported risk rating

85 ixed stressors did not affect crash rates in startling events, suggesting that the coping mechanism's

86 l value of startle responding and argue that startle-evoked amygdala responding and its affective mod

87 e Drosophila larval sensorimotor decision to startle, explore, or perform a sequence of the two in re

88 The startle eye-blink is the cross-species translational too

89 crucial direct link between electromyography startle eye-blink magnitude and neural response strength

90 From an evolutionary perspective the startle eye-blink response forms an integral part of the

91 The startling finding of this study is that, contrary to the

92 This startling finding suggests that M. tuberculosis may gain

93 ts showed an increase in anxiety-potentiated startle following active but not sham rTMS.

94 Using the fear potentiated startle (FPS) procedure, we examined the effects of fear

95 D in adults, with increased fear-potentiated startle (FPS) serving as a potential intermediate phenot

96 The rapid Defence Cascade (DC) response (startle, freeze) to sudden unexpected stimuli is a poten

97 The startling gist is that even though the atoms have no dip

98 ts of a genetic screen to identify olfactory startle habituation (OSH) mutants.

99 transient CRFOE during development decreased startle habituation and prepulse inhibition, and increas

100 or synaptic depression presumably underlying startle habituation in rats, using patch-clamp recording

101 ome sequencing, that identified 14 zebrafish startle habituation mutants including mutants of the ver

102 eizure susceptibility and decreased acoustic startle habituation.

103 GlyRs that are responsible for a hereditary startle-hyperekplexia disease.

104 ry and prepulse inhibition (PPI) of acoustic startle in Grin1 mutant mice.

105 cal syndrome characterized by an exaggerated startle in response to trivial tactile or acoustic stimu

106 (fear-potentiated startle, affect-modulated startle) in two independent studies (N = 43 and N = 55).

107 However, startle-induced astrocytic Ca(2+) signals did not preced

108 A 14-month-old child developed startle-induced episodes of generalized rigidity and myo

109 Ca(2+) signals did not precede corresponding startle-induced hemodynamic changes.

110 G protein-coupled receptor activation and by startle-induced neuromodulatory responses.

111 ases in startle reactivity and reductions in startle inhibition independently of predator stress in b

112 Prepulse inhibition (PPI) of startle is being explored both as an indicator of target

113 vermis has a crucial role in a delay tactile startle learning paradigm in mice.

114 by eye to provide 'ground truth' measures of startle magnitude and freeze duration which were also es

115 tive affective states often show potentiated startle magnitude and freeze duration.

116 Tests included measures of acoustic startle magnitude and habituation, PPI, MMN, autonomic i

117 Removal of BACE1 affected startle magnitude, balance beam performance, pain respon

118 rating valence information into differential startle magnitude.

119 it/hyperactivity disorder (ADHD) symptoms on startle measures were examined.

120 for a conserved neural pathway for acoustic startle modulation between humans and rodents.

121 We examined the alpha1 startle mutation S270T, at the extracellular end of the

122 e functional consequences of the alpha1S270T startle mutation, which is located at the extracellular

123 Many startle mutations are known, but it is hard to correlate

124 heteromeric GlyRs are less affected by many startle mutations than homomers.

125 ume novel, palatable foods and to approach a startling object.

126 dae, eyespots have been shown to function in startling or deflecting predators and to be involved in

127 135 were assessed using the fear-potentiated startle paradigm to assess fear-related phenotypes of PT

128 ons, decreasing latency time in the acoustic startle paradigm, and decreasing the reinforcement of re

129 ceptor function, is responsible for a lethal startle phenotype in a novel spontaneous mouse mutant sh

130 g scores on the Composite Abuse Scale, SPAN (Startle, Physiological Arousal, Anger, and Numbness), Pr

131 sufficient to induce enduring alterations in startle plasticity and anxiety, while forebrain CRFOE du

132 insic and extrinsic modulatory mechanisms in startle plasticity and sensorimotor gating.

133 of the serotonin 5-HT5A receptor in goldfish startle plasticity and sensorimotor gating.

134 ity in males but did not change avoidance or startle plasticity.

135 Low-GSK did not affect startle potentiation across conditions.

136 eliefCS immediately following the US-induced startle potentiation and negative valence (Study1); 3 se

137 , apomorphine injection was shown to relieve startle potentiation during nicotine withdrawal and cond

138 unpredictable threat (anxiety) but increased startle potentiation during the predictable condition (f

139 High-GSK had no effect on startle potentiation during unpredictable threat (anxiet

140 t with previous findings, alprazolam reduced startle potentiation during unpredictable threat but not

141 imulus, US) provoke defensive responses like startle potentiation, while stimuli associated with pain

142 to warn of a chemical defence and others, to startle predators.

143 s as diverse as sexual and social signaling, startling predators, and advertising toxicity [1], there

144 ocomotor hyperactivity; sensorimotor gating (startle prepulse inhibition) was unaffected.

145 showed that SB-699551 also reduced baseline startle rates (i.e., without prepulse).

146 periments showed a dose-dependent decline in startle rates in prepulse conditions.

147 hyperekplexia characterized by a generalized startle reaction and agoraphobic behavior, our data prov

148 dexed by skin conductance (experiment 1) and startle reactions (experiment 2).

149 CRHOEdev induced robust increases in startle reactivity and reductions in startle inhibition

150 xtual fear learning in females and increased startle reactivity in males but did not change avoidance

151 ycloserine augmentation reduced cortisol and startle reactivity more than did alprazolam or placebo,

152 significant group differences were found in startle reactivity or habituation measures.

153 ales nor females exhibited any impairment in startle reactivity or prepulse inhibition.

154 aine users (DCU) display alterations of PPI, startle reactivity, and habituation.

155 bition of the acoustic startle reflex (PPI), startle reactivity, and spontaneous alternation, but did

156 subjects, PPI of acoustic startle response, startle reactivity, habituation, ADHD symptoms, and coca

157 depressogenic effects), emotion-potentiated startle reactivity, impulsivity (linked with suicidal be

158 PRETATION: Bivalent vaccination has led to a startling reduction in vaccine and cross-protective HPV

159 demonstrate that habituation of the auditory startle reflex (hASR) tested at bedside constitutes a no

160 impaired prepulse inhibition of the acoustic startle reflex (PPI), startle reactivity, and spontaneou

161 O mice displayed marked deficits in acoustic startle reflex amplitude, as well as significant sensori

162 iate PD/AG phenotypes demonstrated increased startle reflex and increased fear network, as well as ge

163 ated inhibition in vitro as well as acoustic startle reflex and social interaction in vivo of the Fmr

164 Prepulse inhibition (PPI) of the startle reflex has been suggested as a candidate endophe

165 expression levels and attenuated PPI of the startle reflex in healthy control subjects.

166 The auditory evoked startle reflex is a conserved response resulting in neur

167 sponses or pupil dilation, modulation of the startle reflex is valence specific.

168 ct seems unaffected in HSP patients, because startle reflex onsets were normal.

169 was evaluated with a gap detection acoustic startle reflex paradigm, while hearing status was assess

170 n lifting by the tail and lacked an enhanced startle reflex response that are characteristic of other

171 rgic antagonist amisulpride, known to affect startle reflex that is correlated with addiction in huma

172 Prepulse inhibition (PPI) of the acoustic startle reflex was tested in healthy individuals (n=690)

173 ycardia/apnea, feeding problems, hyperactive startle reflex), severe postnatal progressive neurologic

174 It makes use of the startle reflex, a defensive response elicited by an imme

175 the auditory brainstem response and acoustic startle reflex, yet tone detection behavior was nearly n

176 and anxiety were assessed using the acoustic startle reflex.

177 ning and prepulse inhibition of the acoustic startle reflex.

178 thdrawal was measured by potentiation of the startle reflex.

179 Prepulse inhibition of the acoustic startling reflex (PPI; a marker of psychotic-like behavi

180 lexia, which is characterised by exaggerated startle reflexes, muscle hypertonia and apnoea.

181 ive into microglia form and function reveals startling regional heterogeneity in number, morphology,

182 y functional calculations indicate that this startling regioselectivity is driven by dispersion inter

183 Startling reports described the paradoxical triggering o

184 idence for the strong translational value of startle responding and argue that startle-evoked amygdal

185 -like behavior as measured using potentiated startle responding does not emerge spontaneously during

186 and blunted circadian variations in baseline startle responding.

187 ffecting the magnitude or habituation of the startle response (all p > 0.13).

188 tion of the zebrafish (Danio Rerio) acoustic startle response (ASR).

189 , neurons reduced prepulse inhibition of the startle response (PPI) and enhanced sensitivity to MK801

190 Prepulse inhibition of the acoustic startle response (PPI) is a behavioral phenomenon studie

191 morphisms may predispose to PD by increasing startle response and agoraphobic cognitions.

192 the histamine H1 antagonist meclizine on the startle response and PPI were investigated in healthy ma

193 he pwi phenotype includes a reduced auditory startle response and reduced visual evoked potentials, s

194 e placebo group, as demonstrated by acoustic startle response and US expectancy ratings.

195 vapor, Drosophila show an olfactory-mediated startle response characterized by a transient increase i

196 e exhibit reduced initiation of the acoustic startle response consistent with hearing impairment, sug

197 the lowest cortisol reactivity and smallest startle response during virtual reality scenes.

198 describe PPI, including that the underlying startle response has a non-Gaussian distribution, and th

199 male and female mice and decreased acoustic startle response in a sex-dependent manner.

200 CVS did not enhance the startle response in cycling females.

201 ted to one basic motor output and the C-type startle response in fish.

202 d whether either determines the precision of startle response initiation is not known.

203 Therefore, the startle response is the most likely evolutionary origin

204 dependent changes in timing and precision of startle response latencies.

205 e been proposed as evolutionary ancestors of startle response neurons of the mammalian reticular form

206 n PPI without affecting the magnitude of the startle response or other physiological variables.

207 tipsychotics and causes a deficient acoustic startle response similar to that observed in schizophren

208 impairs prepulse inhibition of the acoustic startle response suggesting an important behavioural rol

209 ve neuromodulation, manifest in a diminished startle response suppression by hedonic stimuli.

210 smaller prepulse inhibition of the acoustic startle response than goal trackers, suggesting a reduce

211 his patient developed a profound accentuated startle response that did not have a corresponding elect

212 tment where the temperature was not changed: startle response time, the time it took an anemone to re

213 In prepulse inhibition (PPI), the startle response to a strong, unexpected stimulus is dim

214 impairments in motor coordination, increased startle response to acoustic stimuli and hypersociabilit

215 y related to the Lebinthini show an acoustic startle response to high-frequency sounds that generates

216 Startle response was measured using electromyograph reco

217 ative valence (Study1); 3 seconds later, the startle response was slightly less potentiated and the r

218 elevations could be evoked when inducing the startle response with unexpected air puffs.

219 entire sample, there was a reduction in SBR (startle response) during the first minute of clipping.

220 tremor, and seizures (1 case with prominent startle response).

221 For startle response, all animals lengthened their response

222 e burying task, elevated zero maze, acoustic startle response, and forced swim test.

223 ts prepulse inhibition (PPI) of the acoustic startle response, and patients with schizophrenia exhibi

224 as prepulse inhibition (PPI) of the acoustic startle response, are playing an increasingly important

225 of the previously appreciated scaling of the startle response, as well as a scaling of sound processi

226 el, animals show alterations in the acoustic startle response, consistent with altered neuroanatomica

227 This startle response, in which the first movement creates an

228 iated with micro-environmental plasticity of startle response, including Drosophila Hsp90, setting th

229 orphants had no FM1-43 dye uptake and lacked startle response, indicating hair cell dysfunction and g

230 Startle response, PPI, heart rate response, galvanic ski

231 tivity, respiration, tremors, body tone, and startle response, revealed normal responses for Chrna2-n

232 lant-naive control subjects, PPI of acoustic startle response, startle reactivity, habituation, ADHD

233 and applied it to three quantitative traits (startle response, starvation resistance, and chill coma

234 Measures included acoustic startle response, US expectancy, blood glucose levels, a

235 this compound tended to reduce the acoustic startle response, which is consistent with an anxiolytic

236 nxiety-like behaviors, and impaired acoustic startle response, which is distinct from the phenotype o

237 roduce persistent elevations in the acoustic startle response, which may reflect anxiety-like signs i

238 reactivity was strongly associated with the startle response, which was also associated with hypervi

239 Prepulse inhibition (PPI) of the acoustic startle response-a measure of sensorimotor gating-is hig

240 ir response times at higher temperatures for startle response.

241 tion of predators and facilitate an acoustic startle response.

242 atory behavior characteristic of an acoustic startle response.

243 udied using prepulse inhibition (PPI) of the startle response.

244 ed interference of positive emotion with the startle response.

245 closely apposed to neurons that initiate the startle response.

246 maze and open field tests, and increased the startle response.

247 ide), on prepulse inhibition of the acoustic startle response.

248 d tasks and recording of emotion-potentiated startle response.

249 onents of PPI are a function of the baseline startle response.

250 to antipsychotics, and an abnormal acoustic-startle response.

251 s; investigator ratings; PPI of the acoustic startle response; and autonomic, endocrine, and adverse

252 easure of stress in horses, but the initial 'startle' response must be considered when using this par

253 primary SLCs and less frequent, long-latency startle responses (LLCs).

254 Here, we examined short-latency startle responses (SLCs) in larval zebrafish and tested

255 cs and field potential parameters of C-start startle responses allowed for discrimination between sho

256 cs and field potential parameters of C-start startle responses allowed for discrimination between sho

257 in healthy male subjects with high baseline startle responses and low PPI levels.

258 The prepulse inhibition of startle responses by a weaker preceding tone, the inhibi

259 response magnitude and levels of exaggerated startle responses in daily life in PTSD participants (t

260 iciency and exaggerated acoustic and tactile startle responses in mice bearing point mutations in alp

261 measured by inhibitory avoidance, increased startle responses in prepulse inhibition tasks, and incr

262 Latencies of startle responses in sternocleidomastoid and tibialis an

263 ents in the open field test, higher baseline startle responses in the course of the prepulse inhibiti

264 subcellular astrocyte calcium imaging during startle responses in vivo.

265 We evoked startle responses via activation of Channelrhodopsin (Ch

266 Enhanced acoustic startle responses were observed among injected compared

267 chanism that can serve to precisely initiate startle responses when speed is critical for survival.

268 erekplexia is a syndrome of readily provoked startle responses, alongside episodic and generalized hy

269 For speed of initiation of startle responses, FSL would be the more advantageous me

270 uency discrimination, prepulse inhibition of startle responses, or fear conditioning with pure tones.

271 e immediately before the main pulse inhibits startle responses, though the mechanism for this remains

272 encoding for rapid and precise initiation of startle responses.

273 lfactory-driven chemotaxis and touch-induced startle responses.

274 ise acts as a cue that attenuates subsequent startle responses.

275 encoding for rapid and precise initiation of startle responses.

276 impaired learning and memory and exaggerated startle responses.

277 fety learning, with 22.5% of the variance in startle retention accounted for by REM sleep.

278 these differences, and we find that both the startle-scaling and sound-scaling components of PPI are

279 Males and females differ specifically in the startle-scaling, but not the sound-scaling, component of

280 i larval inner ear was near normal, acoustic startle stimuli evoked smaller postsynaptic responses in

281 Control subjects responded to a startle stimulus similarly across tasks.

282 complete chronic cervical SCI responded to a startle stimulus, a test that engages the reticulospinal

283 oluntary release of a planned movement via a startling stimulus that engages the reticulospinal tract

284 nse (shortening in reaction time evoked by a startling stimulus) in the quadriceps femoris muscle in

285 e (a shortening in reaction time evoked by a startling stimulus), and the effect of an acoustic start

286 g of tasks owing, among other things, to its startling structural and functional complexity and its r

287 t cysteine residues are very rare and rather startling structural features which play a variety of fu

288 elevate anxiety-like behavior in an acoustic startle task.

289 essed in the elevated-plus maze and acoustic startle test, including marked attenuation of light-enha

290 eld and pre-pulse inhibition of the acoustic startle tests and are significantly more sensitive to th

291 edented reemergence of Zika virus (ZIKV) has startled the world with reports of increased microcephal

292 uld be countered by sudden disturbances that startled them into a net, such as when we dropped a net

293 h PTSD symptoms (N=187) and fear-potentiated startle to a safety signal (N=135).

294 Eels were 50% less likely and 25% slower to startle to an 'ambush predator' and were caught more tha

295 ck to induce anxiety and anxiety potentiated startle to assess anxiety.

296 and gap-prepulse inhibition of the acoustic startle to assess tinnitus, we recorded spontaneous acti

297 ar environment of budding yeast undertakes a startling transition upon glucose starvation in which ma

298 ontrol, daily mild stress exposure (acoustic startle), voluntary consumption of moderate-level alcoho

299 ovian conditioned stimulus (fear-potentiated startle) was enhanced.

300 tor (CRF)-dependent mechanism] that regulate startle, which is exaggerated in PTSD.