ライフサイエンスコーパス: starvation

1 C is destroyed by the UPS following nitrogen starvation.

2 lecules, and organelles for cells to survive starvation.

3 force, osmotic pressure, lipid shortage, and starvation.

4 cellular AMPK activation induced by glucose starvation.

5 isms spend a large part of their lifetime in starvation.

6 activity and also blocked any increase upon starvation.

7 tions to survive to long periods of nitrogen starvation.

8 is predominantly active in response to serum starvation.

9 aling and altered the cellular response to P starvation.

10 hase, resulting in failure to survive during starvation.

11 other constraints, such as predation risk or starvation.

12 exposure to antibiotics and short periods of starvation.

13 CNC1 allows enhanced cell growth under mild starvation.

14 gmentation and cell death following nitrogen starvation.

15 system required for sensitivity to manganese starvation.

16 lled regulator that is upregulated upon iron starvation.

17 specifically experiencing long-term nitrogen starvation.

18 ortant energy providers during acute glucose starvation.

19 treatment with rapamycin, a drug that mimics starvation.

20 LS) levels are highly sensitive to glutamine starvation.

21 in parallel to energy maintenance upon acute starvation.

22 ose and reduced by 2-deoxy-D-glucose-induced starvation.

23 li coordinates biosynthetic processes during starvation.

24 3 protein is unchanged in response to purine starvation.

25 tome of primary cardiomyocytes without serum starvation.

26 nd in both fungi, this SOD was induced by Fe starvation.

27 rease in V-ATPase activity and assembly upon starvation.

28 defining mycobacterial response to histidine starvation.

29 nt-depleted conditions, like amino acid (AA) starvation.

30 energy status and to ensure viability during starvation.

31 under conditions of transferrin-mediated Fe starvation.

32 activity and blocks any further change upon starvation.

33 aintenance without net growth due to extreme starvation.

34 Additionally, we induced autophagy via serum starvation.

35 ites selectively emerged during fixed-carbon starvation.

36 o be required for increasing locomotion upon starvation.

37 sking a potential bet-hedging strategy under starvation.

38 production without an accompanying nutrient starvation.

39 reactive oxygen species levels induced by Pi starvation.

40 vents Rag dimer activation during amino acid starvation.

41 and mammalian metabolism and survival during starvation.

42 ay is crucial for NO production under sulfur starvation.

43 rent 3(rd) instar larva tissues, and neonate starvation.

44 te TORC1 most efficiently following nitrogen starvation.

45 ve response of E. coli to long-term nitrogen starvation.

46 ely reduced Acetyl-CoA levels under nutrient starvation.

47 remodeling is modulated by overnutrition or starvation.

48 rylation is markedly increased upon nitrogen starvation.

49 se pathways ensure long-term survival during starvation.

50 n of the complex in conditions of amino acid starvation.

51 ed by 2-deoxy-d-glucose (2-DG) or by glucose starvation.

52 ally produced in bacteria following nutrient starvation.

53 CP tags, localize to granules upon nitrogen starvation.

54 ependently of de novo gene expression during starvation.

55 coumarins promotes growth by relieving iron starvation.

56 nto the periplasm for storage during glucose starvation.

57 om these two ecotypes during early phosphate starvation.

58 s thaliana) respond differently to phosphate starvation.

59 promotes ER-phagy activation upon prolonged starvation.

60 design effective therapeutics based on tumor starvation.

61 ed in response to various stresses including starvation.

62 pherical, thick-walled cells during nutrient starvation.

63 dentify pathways that ensure survival during starvation.

64 reversibly arrests larval development during starvation [1], but extended early-life starvation reduc

65 nificant pool of dTDP-hexoses delays acute T-starvation; 2) T-starvation destabilizes even nonreplica

66 In response to P starvation, 40% of all protein-coding genes exhibit a tr

67 During prolonged starvation, a fraction of p27 is recruited to lysosomes,

68 normal culture conditions and in response to starvation, a lipolytic stimulus.

69 Serum starvation abrogated the effect of insulin on YAP phosph

70 Thus, amino acid excess or starvation activate complementary alpha-arrestin-Rsp5-co

71 In bacteria, iron starvation affects a broad range of phenotypes including

72 intracellular catabolic process prominent in starvation, aging and disease.

73 Cell starvation also triggers adaptive responses, like angiog

74 lls and promoted apoptosis due to amino acid starvation and activation of the integrated stress respo

75 d mTORC1 signaling insensitive to amino acid starvation and are found frequently in cancers such as g

76 Autophagy, a cellular stress response to starvation and bacterial infection, is executed by doubl

77 n was specifically up-regulated by iron (Fe) starvation and controlled by the Fe-responsive transcrip

78 d may cause vascular damage, leading to cell starvation and death.

79 ected the global transcriptional response to starvation and downregulated subsets of TFEB targets.

80 ction is increased by energy stress (glucose starvation and endurance exercise) and decreased by a BC

81 Adipose tissue provides a defense against starvation and environmental cold.

82 charomyces cerevisiae in response to glucose starvation and heat shock.

83 hesis and growth, and higher risks of carbon starvation and hydraulic failure.

84 rded as a beneficial commensal, bloomed upon starvation and in a CD8 T cell-dependent manner.

85 actor HapX coordinates adaption to both iron starvation and iron excess and is thereby crucial for vi

86 hetL expression is induced under nitrogen-starvation and is activated by HetR, suggesting that Het

87 be able to curtail anabolic processes during starvation and judiciously activate catabolic pathways.

88 sults showed that OsPHT2;1 was induced by Pi starvation and light exposure.

89 y in Arabidopsis was detected under nitrogen starvation and osmotic stress and can be inhibited by su

90 Atg1 is activated by starvation and other cellular stressors and therefore ca

91 n identified, the intersection between metal starvation and other essential inorganic nutrients has n

92 cues and to physiological conditions such as starvation and oxidative stress.

93 ogram that is critical for surviving both Mn starvation and oxidative stress.

94 ently warm winter soils can lead to labile C starvation and reduced microbial respiration, despite th

95 ers and 6894 APA genes, treated with silicon starvation and replenishment, were identified at nine ti

96 the translation inhibitory response to serum starvation and stalls cell growth.

97 Autophagy induction by starvation and stress involves the enzymatic activation

98 -dT pool, the initial DNA synthesis during T-starvation and the resistance phase.

99 Under Pi starvation and the resulting decreased cellular Pi pool,

100 ibution in single cells at various levels of starvation and to determine translocation rate constants

101 Here, we discovered that starvation and TORC1 inactivation not only lead to the u

102 maintain the delicate balance between metal starvation and toxicity through a complex network of met

103 ular stress conditions, including amino acid starvation and UV irradiation, we show that ribosome col

104 ted to extreme treatments that led to carbon starvation and were small compared to the magnitude of t

105 lowed assessment of the effects of phosphate starvation, and a complex, sterile soil extract represen

106 as fluorescent labeling, temperature change, starvation, and chemical treatment.

107 for FOXO transcription factors during lipid starvation, and identify SOX9 as a critical metabolic me

108 in chromatin-remodeling factor under glucose starvation, and methylated Pontin binds Forkhead Box O 3

109 tance rate, which dropped dramatically after starvation, and particularly recent starvation experienc

110 with a SD prior to exposure to antibiotics, starvation, and surgery.

111 oding IPS1 RNA is highly expressed during Pi starvation, and the sequestration of miR399 molecules pr

112 e normal in basal autophagy but deficient in starvation- and LPS-induced autophagy by disruption of t

113 high-throughput assay to identify potassium starvation as a new and potent inducer of autophagy in t

114 autophagy sensor, an inefficient response to starvation as evidenced by the accumulation of the autop

115 ), which is produced 24 h after the onset of starvation, as detected with NO-sensitive fluorescence p

116 essed transcriptional changes in response to starvation at the single-cell level.

117 psis (Arabidopsis thaliana), we show that Pi starvation, but not nitrogen starvation, strongly dampen

118 ones were reduced, at different rates, by Pi starvation, but the developmental pattern of Pi concentr

119 govern the bacterial response to amino acid starvation by binding, decoding and reading the aminoacy

120 or Mac1p governs the cellular response to Cu starvation by controlling Cu import.

121 t bacterial adaptation to long-term nutrient starvation can be spatiotemporally coordinated and can o

122 has a complicated dual-host life cycle, and starvation can trigger transition from the replicating i

123 Moreover, glucose starvation caused mitochondrial fragmentation and cell d

124 r for organisms to successfully recover from starvation, cells must be kept in a state of ready so th

125 This work reveals that early-life starvation compromises reproductive development and that

126 s of purine nucleotides following amino-acid starvation, compromising cellular fitness.

127 Our results show that starvation conditions cause increased perinuclear locali

128 ing Bacillus subtilis cells can survive deep starvation conditions for many months.

129 d by staphylococcal strains grown under iron starvation conditions when Isd proteins are expressed.

130 Ssa1 also fail to relocalize in response to starvation conditions, do not associate in vivo with Hsp

131 nbinding of the regulator, which, under zinc-starvation conditions, exists in its metal-deficient non

132 Furthermore, under starvation conditions, flies normally have an increased

133 ivity of cell wall increased during nitrogen-starvation conditions, indicating the thickening of cell

134 Under starvation conditions, Ppt1 expression was significantly

135 ated) apoptosis pathway in these cells under starvation conditions.

136 tRNAs can prevent GCN4 activation under non-starvation conditions.

137 reasing the cellular energy level by glucose starvation decreases leader cell lifetime whereas increa

138 tectomy), antibiotics, and a short period of starvation demonstrate reduced survival (29%) compared t

139 d that PKA and AMPK are not required for the starvation-dependent increase in lysosomal V-ATPase acti

140 Thr kinase (AKT) inhibitor MK2206 blocks the starvation-dependent increase in lysosomal V-ATPase acti

141 y the roles of GABA and insulin signaling in starvation-dependent modulation of olfactory sensory neu

142 dTDP-hexoses delays acute T-starvation; 2) T-starvation destabilizes even nonreplicating chromosomes,

143 By contrast, glucose starvation does not cause unfolded protein response and,

144 In response to serum starvation, eIF6 accumulates in the cytoplasm, and this

145 educed locomotor activity, susceptibility to starvation, elevated glucose, and an almost complete lac

146 ive photoacoustic-imaging-guided synergistic starvation-enhanced photothermal therapy.

147 Starvation enhances olfactory sensitivity that encourage

148 lular protozoa that encyst individually upon starvation evolved at least eight times into organisms t

149 ing anxiety, hyperactivity, and addiction to starvation, exacerbating the dieting and exercising, thu

150 ly after starvation, and particularly recent starvation experience.

151 hrough small-molecule mTOR inhibition, serum-starvation/fasting, and ketogenic diet, increased ASO-me

152 Caenorhabditis elegans MiT/TFE ortholog, to starvation followed by refeeding to understand how this

153 be involved in translational recovery after starvation from stationary phase.

154 not depend on gene expression once nitrogen starvation has set in and occurs indepen-dently of the t

155 r fasting conditions, the liver secretes the starvation hormone FGF21, which induces metabolic respon

156 ast metabolic cycle, meiosis, and amino acid starvation; however, this effect is abolished when cyclo

157 slation of LLO to promote translation during starvation in a phagosome while repressing it during gro

158 GROUNDGiven the heightened tolerance to self-starvation in anorexia nervosa (AN), a hypothalamic dysr

159 mediates the stringent response to nutrient starvation in Borrelia burgdorferi.

160 localized to the cytoplasm, induced by serum starvation in both human and mouse cells, and inhibited

161 criptional and physiological responses to Pi starvation in dark-grown roots.

162 activates the initial adaptive response to N starvation in E. coli These results serve as a paradigm

163 rements of mRNA translation during histidine starvation in fission yeast Schizosaccharomyces pombe.

164 t mitochondrial respiration decreases during starvation in insect stage cells, despite the previously

165 ance to BRAF pathway-targeted inhibitors and starvation in melanoma cells.

166 V-ATPase activity in response to amino acid starvation in mouse fibroblasts.

167 Zinc starvation in mycobacteria leads to remodeling of riboso

168 We further show that starvation in pre-implantation ICM-derived mouse ESCs in

169 ion to iron, phosphate, carbon, and nitrogen starvation in Synechocystis.plantcell;31/12/2912/FX1F1fx

170 ther, this analysis showed that fixed-carbon starvation in the absence of autophagy adjusts the choic

171 on of a large set of tRNA genes during serum starvation, indicating that repression of tRNA genes by

172 autophagy mutants subjected to fixed-carbon starvation induced by darkness.

173 Pi starvation induced the accumulation of barley APL transc

174 SBP-7455 inhibited starvation-induced autophagic flux in TNBC cells that we

175 vels of intracellular Cu are associated with starvation-induced autophagy and are sufficient to enhan

176 ed that the CDK inhibitor p27(Kip1) promotes starvation-induced autophagy by an unknown mechanism.

177 s epigenetic mechanism has a role in glucose starvation-induced cell death and that pharmacologic inh

178 ge (amastigote), and uncover implications of starvation-induced changes in gene expression.

179 The P starvation-induced chromatin dynamics and correlated gen

180 Starvation-induced cytokines were cell type-dependent, a

181 abolomics analysis suggested STP7 is a sugar starvation-induced gene and STP13 has a function in retr

182 Deletion of FXR in T cells prevented starvation-induced loss of lymphocytes and increased eff

183 tNLA, OsNLA1 is not a target of miR827, a Pi starvation-induced microRNA.

184 nslation in response to stress, specifically starvation-induced stress, is lacking.

185 synthesis that is critical for adaptation to starvation-induced stress.

186 etylation, and Sirtuin-mediated silencing of starvation-induced subtelomeric domains.

187 nment changes sleep and wake in flies, e.g., starvation induces waking in Drosophila as it does in ma

188 ell in the face of stressors as different as starvation, infection, or protein misfolding.

189 ons of the mushroom body, while memory under starvation is mediated by medial alpha'/beta' neurons.

190 a coli and show that population growth after starvation is primarily determined by the cells with sho

191 ivation by adapting their metabolism, or, if starvation is prolonged, it can result in cell death.

192 Cellular starvation is typically a consequence of tissue injury t

193 is of reduced fertility following early-life starvation is unknown, and it is unclear how maternal di

194 Upon starvation, JMY shifts to motile, LC3-containing membran

195 ease c-di-GMP levels in response to nitrogen starvation just as well as it increases (p)ppGpp levels.

196 Such nutritional starvation leads to down-regulation of tRNA nuclear impo

197 Our data reveal that starvation leads to production of nontoxic levels of rea

198 Activation of mtOFF induced starvation-like behavior mediated by AMP-activated prote

199 rehalose synthesis increases, resulting in a starvation-like metabolic signature.

200 During starvation, Lkb1, an upstream kinase of AMPK, represses

201 Under long-term starvation (LTS, >24 h), the stress-activated SKN-1a dow

202 Despite the dramatic consequences of N starvation, many free-living and endosymbiotic microalga

203 Ultimately, C starvation may lead to increased mortality vulnerability

204 tomic and epigenomic analyses linked glucose starvation-mediated H2Aub repression to the activation o

205 efends against hypoglycemia in a preclinical starvation model, is permissive for the normal CRR to in

206 During light exposure or nitrogen starvation, MoHMT1 localises to autophagosomes and MoHMT

207 tophagy-inducing stimuli, such as amino acid starvation, nutrient deprivation, rapamycin, and lipopol

208 Starvation of Bacillus subtilis initiates endosporulatio

209 d stratification lead to increasing nutrient starvation of surface waters.

210 mitochondrial genome increase during culture starvation of T. cruzi for unknown reasons.

211 inhibitors, indolmycin and AN3365, to mimic starvation of Trp and leucine, respectively.

212 th NAC restored the Grh1-dependent effect of starvation on cell growth.

213 e to metabolic stress resulting from glucose starvation or by treatment with pharmacological agents t

214 cts metabolic flux in response to amino acid starvation or cell growth requirements.

215 ate to environmentally resistant spores upon starvation or chemical stress.

216 hemoresistant and G0 leukemic cells by serum starvation or chemotherapy treatment.

217 Accordingly, serine starvation or enforced alpha-ketoglutarate production an

218 ted mice against hepatic steatosis caused by starvation or HFD due to induction of autophagic degrada

219 In contrast, glucose starvation or hyperosmotic shock causes cell shrinking,

220 d GCN2-mediated ISR activation by amino acid starvation or interference with tRNA charging without af

221 sful) growth conditions, but is induced upon starvation or osmotic stresses.

222 ivated and conjugated to tRNA, and thus cell starvation or pretreatment is not required.

223 electively degrade ER domains in response to starvation or the accumulation of aggregation-prone prot

224 hly sensitive to metabolic stress induced by starvation or the antidiabetic drug metformin.

225 onvert to follicle stem cells in response to starvation or upon genetic manipulation, including knock

226 d to, pathogen intrusion, oxygen or nutrient starvation, proteotoxic and organelle stress, and elevat

227 ticipate nutrient repletion after periods of starvation, providing a strong selective advantage.

228 We previously reported that amino acid starvation rapidly increases V-ATPase assembly and activ

229 making the resistance phase a delay of acute starvation, rather than an integral part of thymineless

230 ring starvation [1], but extended early-life starvation reduces reproductive success [2, 3].

231 olog for mammalian RagC/D GTPases, conferred starvation-refeeding lethality, and RAGC-1 overexpressio

232 n is critical for sustaining survival during starvation-refeeding stress via regulating TOR.

233 We suggest that under mitotic arrest and starvation, relative CE levels increase, presumably due

234 lity of rat cardiomyocytes following hypoxia/starvation - reoxygenation.

235 However, as conditions such as starvation require the organism to be awake and active(4

236 he selective endocytosis of four AATs during starvation required the alpha-arrestin family protein Ar

237 Starvation resistance proved to be a weak predictor of f

238 s LD expansion, triacylglyceride production, starvation resistance, and lifespan extension through a

239 port the discovery of an active control of P starvation response (PSR) by a combination of local and

240 Phosphate starvation response (PSR) in nonmycorrhizal plants compr

241 ation of the immune system and the phosphate-starvation response (PSR) system, resulting in either mu

242 ugating (UBC) E2 enzyme, the PHR1 (PHOSPHATE STARVATION RESPONSE 1) transcription factor (TF), IPS1 (

243 that led to the induction of the amino acid starvation response and altered cellular fatty acid comp

244 The alarmones pppGpp and ppGpp mediate starvation response and maintain purine homeostasis to p

245 er) inhibits iron uptake and induces an iron starvation response in Pseudomonas aeruginosa cells by s

246 ppGpp, the starvation response regulator, strongly inhibits the ini

247 a way that depends on the plant's phosphate-starvation response system and phytohormone-mediated imm

248 n genes) closely associated with the silicon-starvation response, girdle bands and valve synthesis, s

249 ibited growth, and induced a GCN4 amino acid starvation response, indicative of uncharged tRNA accumu

250 ese results point to a role for GGCT2;1 in S-starvation-response changes to root system architecture

251 P also inhibits iron uptake and induces iron-starvation responses by this pathogen.

252 -mediated inhibition of iron uptake and iron-starvation responses.

253 -mediated inhibition of iron uptake and iron-starvation responses.

254 rs plant growth and leads to constitutive Pi starvation responses.

255 ivated sets of host genes regulating N and P starvation responses.

256 t the transcriptional level by the phosphate starvation-responsive Pst/SenX3-RegX3 signal transductio

257 P starvation results in a sharp decrease in LST8 abundance

258 23), all temperatures (alpha-TUB and GAPDH), starvation (RPL12 and alpha-TUB), and dsRNA exposure (al

259 Upon nitrogen starvation, Schizosaccharomyces pombe exit the mitotic c

260 different stress protocols, including serum starvation, serum variation, and restrictive feeding.

261 Release of cells post 24-h serum starvation showed PACS-1 nuclear localization at G(1)-S

262 Under nitrogen starvation, six additional MoATG genes were identified w

263 We suggest that starvation-specific unconventional secretion of antioxid

264 n are dependent on the particular amino acid starvation state.

265 Serum starvation stimulates cilia growth in cultured cells, ye

266 ecreases) of resistance to oxidative stress, starvation stress and sleep indices.

267 metabolites and organismal traits, including starvation stress resistance and male aggression.

268 athogens, and microbes respond through metal starvation stress responses.

269 Upon sensing starvation stress, Caenorhabditis elegans larvae (L2d) e

270 In order to survive starvation stress, organisms must be able to curtail ana

271 t act sequentially or competitively to avoid starvation stress.

272 to map adenine released from bacteria due to starvation stress.

273 nes, including IL-6 and IL-8, in response to starvation stress.

274 P synthase inhibitor), both 2-DG and glucose starvation strongly suppress tumor necrosis factor and i

275 we show that Pi starvation, but not nitrogen starvation, strongly dampens the [Ca(2+)](cyt) increases

276 Under short-term starvation (STS, 3 h), both pheromone and opioid signali

277 ted to be relatively more resistant to serum starvation, suggested that vNr-13 could be involved in p

278 Glucose starvation suppressed H2Aub levels independently of ener

279 Here, we show that glucose starvation suppresses histone 2A K119 monoubiquitination

280 s assay that metabolic blockage by phosphate starvation surprisingly increased IP(6) levels in a ITPK

281 ified new genes and pathways regulated by Pi starvation that were not described previously.

282 Under combined nitrogen starvation, the multicellular cyanobacterium Nostoc PCC

283 We found that glucose starvation transiently activates AMPK, whereas changes i

284 VEGF inhibition enhanced the starvation-triggered cancer cell death and amplified the

285 In response to starvation-triggered phosphorylation of eisosome protein

286 In sum, starvation triggers ROS production and cells respond by

287 Nutrient starvation triggers the autophagic pathway that requires

288 ted KFB(PAL) (s) gene expression, and energy starvation upregulated KFB(PAL) expression, which partia

289 C starvation was a strong correlate of conifer mortality b

290 The response of wild-type seedlings to S-starvation was compared to ggct2;1 null mutants.

291 ivo preclinical PAD model, and hypoxia serum starvation was used as an in vitro model for PAD.

292 obe of E. coli cell function during nitrogen starvation, we demonstrate that Hfq foci have a role in

293 lack of nutrient supply (the equivalent of "starvation") were studied.

294 PHO mRNAs are transcribed during phosphate starvation when lncRNA synthesis abates.

295 s expressing only AKT1 responded normally to starvation, whereas cells expressing only AKT2 displayed

296 Intracellular (p)ppGpp accumulates under starvation, which helps bacteria to survive under stress

297 ts ECA(+) thyA parent does not lyse during T-starvation, while both the dramatic killing and chromoso

298 mplex activities during the cell cycle and N starvation, with a focus on the possible interaction bet

299 an be up-regulated in adipocytes by nutrient starvation without activating cell senescence, apoptosis

300 Upon acute glucose starvation, yeast cells undergo drastic physiological an