ライフサイエンスコーパス: stearoyl-CoA desaturase

1 ich include ATP citrate lyase, ACC, FAS, and stearoyl-CoA desaturase.

2 id desaturation pathway that is dependent on stearoyl-CoA desaturase.

3 ine motif required for catalytic activity in stearoyl-CoA desaturase.

4 clusions that can be prevented by inhibiting stearoyl-CoA desaturase.

5 tively reversed by Aramchol, an inhibitor of stearoyl-CoA desaturase.

6 oenzyme A synthase, fatty acid synthase, and stearoyl-CoA desaturase.

7 atory element binding protein (SREBP1c), and stearoyl-CoA desaturase.

8 Stearoyl CoA desaturase 1 (SCD1) is a critical lipogenic

9 Stearoyl CoA desaturase 1 (SCD1) is a key enzyme in lipo

10 se 1 (ACC1), fatty acid synthase (FASN), and stearoyl CoA desaturase 1 (SCD1)] to AML and eBL cell li

11 pression of key lipogenic enzymes, including stearoyl CoA desaturase 1 (SCD1/SCD).

12 P-2 (vesicle-associated membrane protein 2), stearoyl CoA desaturase 1, and cAMP-specific phosphodies

13 In contrast, the stearoyl-CoA desaturase 1 (in lipogenesis) mRNA was up-r

14 e obesity-derived adipokine leptin (LEP) and stearoyl-CoA desaturase 1 (SCD), a critical enzyme in fa

15 Herein, we demonstrate that inhibition of stearoyl-CoA desaturase 1 (SCD-1) halts the biosynthesis

16 glucose tolerance, and reduced expression of stearoyl-CoA desaturase 1 (SCD-1).

17 f the mice with a disruption in the gene for stearoyl-CoA desaturase 1 (SCD1) (SCD1-/-) is deficient

18 e model, here we show that expression of the stearoyl-CoA desaturase 1 (Scd1) gene is downregulated i

19 r strategies to combat this growing problem, stearoyl-CoA desaturase 1 (SCD1) inhibition has been pro

20 Stearoyl-CoA desaturase 1 (SCD1) is a membrane-embedded

21 Mice with a targeted disruption of the stearoyl-CoA desaturase 1 (SCD1) isoform are protected a

22 We analyzed the changes in stearoyl-CoA desaturase 1 (SCD1) mRNA to further define

23 ing exercise expressed increased endothelial stearoyl-CoA desaturase 1 (SCD1) that catalyzes anti-inf

24 SREBPs (1a and 2) led to elevated mRNAs for stearoyl-CoA desaturase 1 (SCD1), an isoform that is det

25 wed increased fatty acid synthase (FASN) and stearoyl-CoA desaturase 1 (SCD1), both associated with N

26 r Xenopus kinesin-like protein 2 (TPX2), and stearoyl-CoA desaturase 1 (SCD1), significantly reduced

27 ChREBP overexpression induced expression of stearoyl-CoA desaturase 1 (Scd1), the enzyme responsible

28 the in vitro expression and activity of the Stearoyl-CoA Desaturase 1 (SCD1), the hepatic Delta9-des

29 Stearoyl-CoA desaturase 1 (SCD1), the key enzyme involve

30 oupling of fatty acid synthase activity from stearoyl-CoA desaturase 1 (SCD1)-mediated desaturation.

31 ogenesis and elongase activity and decreased stearoyl-CoA desaturase 1 activity.

32 n as well as reduction in mRNA expression of stearoyl-CoA desaturase 1 and genes associated with fatt

33 lipase, fatty acid synthase, perilipin 1, or stearoyl-CoA desaturase 1 by >90%.

34 that mice with a targeted disruption in the stearoyl-CoA desaturase 1 gene (SCD1-/-) have increased

35 terize SC lipidome alteration in response to stearoyl-CoA desaturase 1 inhibition and, additionally,

36 ntify the antifibrotic effect of Aramchol, a stearoyl-CoA desaturase 1 inhibitor in development for m

37 The lipogenic enzyme stearoyl-CoA desaturase 1 is highly induced in SIRT3KO m

38 Therefore, stearoyl-CoA desaturase 1 may play an unexpected role in

39 seen with genetic deletion or inhibition of stearoyl-CoA desaturase 1 promotes inflammation, TLR4 hy

40 ohydrate response element-binding protein or stearoyl-CoA desaturase 1 resulted in lethality on high

41 pression, most notably reduced expression of stearoyl-CoA desaturase 1, a rate-limiting enzyme in the

42 ary cell line that overexpressed transfected stearoyl-CoA desaturase 1, a rate-limiting enzyme in the

43 n of SFA in the body is tightly regulated by stearoyl-CoA desaturase 1, an enzyme that converts endog

44 , acetyl-CoA carboxylase, ATP citrate lyase, stearoyl-CoA desaturase 1, cluster of differentiation 36

45 crophage LXR/RXR target genes, we identified stearoyl-CoA desaturases 1 and 2 (Scd1 and Scd2), and su

46 Recent evidences suggest that stearoyl-CoA-desaturase 1 (SCD1), the enzyme involved in

47 e could potentially be linked to the role of Stearoyl-CoA-Desaturase 1 in breast cancer.

48 ed differences in central adiposity and SCD (stearoyl-CoA desaturase)-1 enzyme activity index.

49 0.37, 95% CI: 0.04, 0.70), 6 desaturase, and stearoyl CoA desaturase-1 (SCD-1) index were directly as

50 evidenced by downregulation of both hepatic stearoyl CoA desaturase-1 and fatty acid synthase.

51 was also a significant downregulation of the stearoyl CoA desaturase-1 gene, which has been associate

52 ed hyperleptinemia without downregulation of stearoyl CoA desaturase-1 or fatty acid synthase and by

53 MP-activated kinase (AMPK) and reduced liver stearoyl-CoA desaturase-1 (SCD-1) activities.

54 several accessory lipogenic enzymes, such as stearoyl-CoA desaturase-1 (SCD-1) and long chain free fa

55 Central leptin also repressed stearoyl-CoA desaturase-1 (SCD-1) RNA and enzymatic acti

56 sed the mRNA levels for fatty acid synthase, stearoyl-CoA desaturase-1 (SCD-1), and epidermal fatty a

57 ting a high activity of the lipogenic enzyme stearoyl-CoA desaturase-1 (SCD-1), has been shown to be

58 RNA levels and enzymatic activity of hepatic stearoyl-CoA desaturase-1 (SCD-1), which catalyzes the b

59 Stearoyl-CoA desaturase-1 (SCD1) catalyzes de novo synth

60 Stearoyl-CoA desaturase-1 (SCD1) catalyzes the synthesis

61 Stearoyl-CoA desaturase-1 (SCD1) catalyzes the synthesis

62 Cool temperatures induce stearoyl-CoA desaturase-1 (SCD1) expression and monounsa

63 cell death effect ORCTL3 targets the enzyme stearoyl-CoA desaturase-1 (SCD1) in fatty acid metabolis

64 Mammalian stearoyl-CoA desaturase-1 (SCD1) introduces a double-bon

65 Stearoyl-CoA desaturase-1 (SCD1) is the rate-limiting en

66 This phenotypic shift was controlled by stearoyl-CoA desaturase-1 (SCD1), an enzyme responsible

67 Inhibiting the activities of stearoyl-CoA desaturase-1 (SCD1), nuclear factor kappaB

68 Chloroquine increased expression of stearoyl-CoA desaturase-1 (scd1), the enzyme mediating f

69 Genetic or pharmacological inhibition of stearoyl-CoA desaturase-1 (SCD1), the enzyme that conver

70 tty acid (FA) synthesis with the activity of stearoyl-CoA desaturase-1 (SCD1).

71 tic expression of lipogenic genes, including stearoyl-CoA desaturase-1 (SCD1).

72 hannels and to decreased hepatic activity of stearoyl-CoA desaturase-1 (SCD1).

73 activate transcription of the genes encoding stearoyl-CoA desaturase-1 and -2, thereby markedly enhan

74 erides or in the exercise-suppressed hepatic stearoyl-CoA desaturase-1 and peroxisome proliferator-ac

75 r-activated receptor gamma2 (PPARgamma2) and stearoyl-CoA desaturase-1 and up-regulated PPARalpha ind

76 We identify stearoyl-CoA desaturase-1 as a MSI1 target, revealing a

77 n in wild-type mice increased PPARgamma2 and stearoyl-CoA desaturase-1 mRNA and hepatic triglyceride

78 yl-CoA carboxylase, fatty acid synthase, and stearoyl-CoA desaturase-1 were all elevated markedly, as

79 yl-CoA carboxylase, fatty-acid synthase, and stearoyl-CoA desaturase-1 were increased in apoB/BATless

80 d-type mice, with the induction of the Scd1 (stearoyl-CoA desaturase-1) gene preceding that of other

81 e, glycerol-3-phosphate acyltransferase, and stearoyl-CoA desaturase-1) showed a complete failure of

82 y acid synthase, acetyl-CoA carboxylase, and stearoyl-CoA desaturase-1, were reduced in ob/ob-PPARgam

83 Previous studies using stearoyl-CoA desaturase-1-deficient (SCD1-deficient) mic

84 We previously identified stearoyl-CoA desaturase 2 (SCD2) as a new member of the

85 This approach identified stearoyl-CoA desaturase 2 (SCD2) as a new SREBP-regulate

86 Of 24 enzymes screened, stearoyl-CoA desaturase 2 (SCD2) was found to be uniquel

87 Here we report that selective ablation of stearoyl CoA desaturase-2 (Scd2) in aHSC globally suppre

88 Why, then, is stearoyl-CoA desaturase a highly regulated enzyme?

89 secondary analysis, each SD increase of log-stearoyl-coA desaturase activity (16:1n-7/16:0 ratio) wa

90 Peroxisome proliferators induce stearoyl-CoA desaturase activity (EC 1.14.99.5) in liver

91 ester transfer protein and indexes of plasma stearoyl-CoA desaturase activity (SCD).

92 aturated fatty acid (MUFA) biosynthetic gene stearoyl-CoA desaturase, altering the ratio of MUFA-PLs

93 -binding cassette transporter A1 (ABCA1) and stearoyl CoA desaturase, and expression of these genes i

94 Lipocalin 2, haptoglobin, serum amyloid A3, stearoyl-CoA desaturase, and 11beta-hydroxysteroid dehyd

95 the molecular mechanism for the induction of stearoyl-CoA desaturase by peroxisome proliferators.

96 Stearoyl-CoA desaturase catalyzes the rate-limiting step

97 We also found the expression of Stearoyl-CoA desaturase, Desat1 mRNA significantly highe

98 abolism by maintaining the expression of the stearoyl-CoA desaturase FAT-7, an oxygen consuming, rate

99 mutant, acdh-11, in which expression of the stearoyl-CoA desaturase FAT-7/SCD1 is constitutively inc

100 acyl-CoA oxidase (F08A8.1 and F08A8.2), and stearoyl-CoA desaturase (fat-7).

101 Blocking the stearoyl-CoA desaturase - fatty acid-binding protein 4 -

102 Stearoyl-CoA desaturase gene 1 (scd1) mRNA levels were i

103 ) and other fatty acids on the expression of stearoyl-CoA desaturase gene 1 were investigated in full

104 ouse model with a targeted disruption of the stearoyl-CoA desaturase gene-1 (SCD1-/-) have revealed t

105 ce was identified at the N-terminus of mouse stearoyl-CoA desaturase I (SCD I) comprised of (30)KVKTV

106 tin in the cytoplasm of basal sebocytes, and stearoyl CoA desaturase in the cytoplasm of basal and lu

107 ly advances concerning the important role of stearoyl-CoA desaturase in metabolism.

108 onse-element-binding protein-1 (SREBP-1) and stearoyl-CoA desaturase in the immortalized sebaceous gl

109 ineralization of CVCs, whereas inhibition of stearoyl-CoA desaturase induced mineralization.

110 Strikingly, and with the exception of stearoyl-CoA desaturase, most drug targets are not regul

111 ssion of galectin-12, resistin, SREBP-1, and stearoyl-CoA desaturase mRNAs in SZ95 sebocytes.

112 III; medium chain acyl-CoA dehydrogenase; or stearoyl-CoA desaturase mRNAs.

113 From the crystal structure of the mouse stearoyl-CoA desaturase (mSCD1) it was proposed that Tyr

114 Analysis revealed that four of the genes [stearoyl-CoA desaturase; NADH-ubiquinone oxidoreductase

115 ameliorated by pharmacologically inhibiting stearoyl-CoA desaturase or by conditioning the cells in

116 is toxicity can be ameliorated by inhibiting stearoyl-CoA desaturase or by saturated fatty acid condi

117 erilipin-5, adipose triglyceride lipase, and stearoyl-CoA desaturase protein was higher in the NWA gr

118 The lipogenic enzyme stearoyl CoA desaturase (SCD) plays a key role in tumor

119 that YTX-7739, a clinical-stage inhibitor of stearoyl CoA desaturase (SCD), triggers lipotoxicity in

120 NcDase(-/-) mice display reduced stearoyl-CoA desaturase (SCD) 1 expression with a compos

121 were examined to investigate TR4 target gene stearoyl-CoA desaturase (SCD) 1 regulation.

122 saturase (D5D), Delta6 desaturase (D6D), and stearoyl-CoA desaturase (SCD) activity and T2D risk.

123 ricted activator of the key lipogenic enzyme stearoyl-CoA desaturase (SCD) and that SCD is required f

124 Stearoyl-CoA desaturase (SCD) catalyzes the rate-limitin

125 h arachidonic acid resulted in a decrease in stearoyl-CoA desaturase (Scd) enzyme activity and scd1 m

126 There are four known stearoyl-CoA desaturase (SCD) enzyme isoforms in mouse a

127 ted fatty acids, a reaction catalyzed by the stearoyl-CoA desaturase (SCD) enzyme, resulting in apopt

128 Here, we have shown that repression of stearoyl-CoA desaturase (SCD) enzymes, which regulate th

129 T3-L1 preadipocyte cells are correlated with stearoyl-CoA desaturase (SCD) expression (mRNA and prote

130 f fatty acid uptake and synthesis and higher stearoyl-CoA desaturase (SCD) expression, Ncb5or(-/-) li

131 rationally designed combination therapy of a stearoyl-CoA desaturase (SCD) inhibitor with an isocalor

132 Stearoyl-CoA desaturase (SCD) is a central lipogenic enz

133 Stearoyl-CoA desaturase (SCD) is a key regulator of memb

134 Stearoyl-CoA desaturase (SCD) is a microsomal enzyme req

135 Stearoyl-CoA desaturase (SCD) is a regulatory enzyme inv

136 Stearoyl-CoA desaturase (SCD) is an integral membrane pr

137 Stearoyl-CoA desaturase (SCD) is an integral membrane pr

138 Stearoyl-CoA desaturase (SCD) is conserved in all eukary

139 Stearoyl-CoA desaturase (SCD) is the rate-limiting enzym

140 Stearoyl-CoA desaturase (SCD) is the rate-limiting enzym

141 Remarkably, liver stearoyl-CoA desaturase (Scd) mRNA expression was by far

142 Stearoyl-CoA desaturase (SCD) synthesizes oleate necessa

143 3K cellular screen identified inhibitors of stearoyl-CoA desaturase (SCD) that robustly prevent the

144 esis: four desaturases were induced, and one stearoyl-CoA desaturase (SCD) was strongly repressed.

145 The regulation of stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in

146 in many cellular functions, is regulated by stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in

147 ayers involved in metabolic reprogramming is stearoyl-CoA desaturase (SCD), which converts saturated

148 Upregulation of stearoyl-CoA desaturase (SCD), which synthesises monouns

149 vo lipogenesis, such as fatty-acid synthase, stearoyl-CoA desaturase (SCD)-1, and apoB.

150 atty acid metabolism, including induction of stearoyl-CoA desaturase (SCD)-1, which converts saturate

151 by cancer cells into an active inhibitor of stearoyl-CoA desaturase (SCD).

152 protease exhibits substrate selectivity for stearoyl-CoA desaturase (SCD).

153 The lipogenic gene stearoyl-CoA desaturase (SCD)1 appears to be a promising

154 Stearoyl-CoA desaturase (SCD)1 catalyzes the rate-limiti

155 s carried out by the oxygen-consuming enzyme stearoyl-CoA desaturase (SCD)1.

156 Lipid metabolites of stearoyl-CoA-desaturase (SCD) activity were associated w

157 xicity; suppressing the OA-generating enzyme stearoyl-CoA-desaturase (SCD) was protective.

158 or depletion of the lipid metabolism enzymes stearoyl-CoA-desaturases (SCD) and S-adenosyl methionine

159 sion, its expression was compared to that of stearoyl CoA desaturase (Scd1) in B6 mice exposed to die

160 er Research, Tesfay and colleagues show that stearoyl CoA desaturase (SCD1) is expressed at high leve

161 scle carnitine palmitoyl-transferase (MCPT), stearoyl CoA desaturase (SCD1), and fatty acid transloca

162 Aramchol, a partial inhibitor of hepatic stearoyl-CoA desaturase (SCD1) improved steatohepatitis

163 y, ADAR1-mediated A-to-I editing on 3'UTR of stearoyl-CoA desaturase (SCD1) increases binding of KH d

164 ation by inducing proteasomal degradation of stearoyl-CoA desaturase (SCD1), LXRalpha activation can

165 examined the contribution to ferroptosis of stearoyl-CoA desaturase (SCD1, SCD), an enzyme that cata

166 fatty-acid synthase, acetyl-CoA carboxylase, stearoyl-CoA desaturase, squalene synthase, farnesyl-pyr

167 Moreover, expression of stearoyl-CoA desaturase, the enzyme required for the gen