ライフサイエンスコーパス: steel factor

1 owth by Stem Cell Factor (SCF, also known as Steel Factor).

2 in tyrosine kinase and the c-kit ligand (the steel factor).

3 1 week in the presence of interleukin-11 and steel factor.

4 elated hemopoietic growth factors, CSF-1 and steel factor.

5 6, granulocyte colony-stimulating factor and Steel Factor.

6 During melanocyte development, the cytokine Steel factor activates its receptor c-Kit, initiating a

7 ts ligand stem cell factor (SCF, kit ligand, steel factor) alter prostate cancer aggressiveness, we u

8 restricted transcription factor, which, like Steel factor and c-Kit, is essential for melanocyte deve

9 crophage colony-stimulating factor (GM-CSF), Steel factor, and Epo.

10 In the absence of Steel factor, caused by either null mutation or antibody

11 reviously published data, show that PGCs are Steel factor dependent from their initial specification

12 We show first that PGCs are surrounded by Steel factor-expressing cells from their first appearanc

13 ured in interleukin (IL)-3, IL-6, IL-11, and steel factor for 0 to 48 h and tested for engraftment ca

14 t, bone morphogenetic proteins, endothelins, steel factor, hepatocyte growth factor, fibroblast growt

15 , transforming growth factor (TGF)-beta, and Steel factor, IL-1 alpha-induced release of IL-6 and G-C

16 d in response to the cytokine combination of steel factor, IL-7, and Flt3 ligand.

17 maintained, demonstrating a primary role for Steel factor in PGC motility.

18 e synergistic interaction between GM-CSF and Steel factor in the regulation of hematopoietic cell pro

19 The antibody did partially inhibit steel factor-induced MK-colony formation, suggesting tha

20 Steel factor is an essential survival and proliferation

21 data show first that changing expression of Steel factor is required for normal midline germ cell de

22 cultured Steel-null early embryos shows that Steel factor is required for normal PGC motility, both i

23 al midline germ cell death, and second, that Steel factor is required for normal proliferation and mi

24 as mast cell growth factor, kit ligand, and steel factor, is the ligand for the tyrosine kinase rece

25 e midline is activated by down-regulation of Steel factor (kit ligand) expression in the midline betw

26 nces the sensitivity of these progenitors to steel factor (KIT ligand) without affecting interleukin-

27 rvive and proliferate rapidly in response to steel factor (Kit ligand).

28 molecular basis of stem cell factor (SCF, or steel factor/kit ligand) expression in Sertoli cells of

29 rvival signaling interaction mediated by the Steel factor/Kit ligand/receptor interaction.

30 yte-macrophage colony-stimulating factor and Steel factor (NSG-3GS mice) than in regular NSG mice 3 w

31 g in vitro expansion with interleukin-11 and steel factor of lineage(-) c-kit(+) Sca-1(+) CD34(-) bon

32 , the cytokine receptor c-Kit, or its ligand Steel factor (S1) result in strikingly similar defects i

33 lulose with interleukin-7 (IL-7), IL-15, and steel factor (SF) formed diffuse colonies that could not

34 Steel factor (SF) is a growth and survival factor for he

35 the presence of varying combinations of TPO, Steel factor (SF), and interleukin-3 (IL-3), CD34+/c-kit

36 ating factor (GM-CSF), interleukin-3 (IL-3), steel factor (SF), and thrombopoietin (TPO) induce a rap

37 mbinations with early acting factors such as steel factor (SF), interleukin (IL)-3, IL-1, IL-6, and g

38 ia with interleukin (IL)-2, IL-7, IL-11, and steel factor (SF), we found mixed colonies consisting of

39 at was supported by a combination of TPO and steel factor (SF).

40 Addition of IL-3 to the combination of steel factor (SF, c-kit ligand) and IL-11 abrogated the

41 rtions similar to or less than c-kit ligand (steel factor, SF).

42 Steel factor (SLF) acts synergistically with various hem

43 Steel factor (SLF) and its cognate receptor, c-kit, have

44 The cells that express Steel factor (SLF) in the gastrointestinal (GI) tract we

45 Steel factor (SLF) increased TF-1 adhesion to fibronecti

46 Steel factor (SLF) is a hematopoietic cytokine that syne

47 actor, transforming growth factors, LIF, and Steel Factor (SLF) mRNAs were upregulated in SyS-1 withi

48 phage colony-stimulating factor (GM-CSF) and Steel factor (SLF) synergistically stimulate Raf-1 kinas

49 LIF synergizes with IL-3, GM-CSF, M-CSF, and Steel Factor (SLF) to promote the colony formation of pa

50 t elevated kinase activity in the absence of Steel factor (SLF), (2) deficient enhancement of tyrosin

51 nts, stromal cell-derived factor (SDF)-1 and steel factor (SLF), and the chemotactic nature of the bo

52 The c-kit receptor and its ligand, steel factor (SLF), are critical for optimal hematopoies

53 crophage colony-stimulating factor (GM-CSF), Steel factor (SLF), or thrombopoietin (TPO).

54 M-07e, with STI 571 before stimulation with Steel factor (SLF).

55 igmented melanocytes in vitro in response to Steel factor (SlF).

56 sis) with the final addition of biotinylated steel factor (SLF-biotin).

57 ony-stimulating factors GM-CSF and G-CSF and Steel factor the latter a member of the tyrosine kinase

58 urvival, and colony formation in response to Steel factor, the ligand for c-kit.

59 efore hindgut colonization, and the roles of Steel factor, using a reporter line in which GFP is driv

60 itro to interleukin (IL)-3, IL-6, IL-11, and steel factor was assessed at 2-4-h intervals of culture

61 cells (PHSC) express c-Kit, the receptor for steel factor, we have phenotypically and functionally se

62 activated in culture with interleukin-11 and steel factor were also CD38(-).

63 have suggested that PGCs become dependent on Steel factor when they colonize the hindgut.

64 st cell growth factor, stem cell factor, and Steel factor), which is a member of the helical cytokine

65 st cell growth factor, stem cell factor, and Steel factor), which is encoded at the Steel (Sl) locus

66 t the myeloid growth factors IL-3, IL-6, and Steel factor, which are normally required in addition to