ライフサイエンスコーパス: stem cell niche

1 ive cells in the labial cervical loop (LaCL, stem cell niche).

2 different specialized cell types in the root stem cell niche.

3 adjacent cells and patterns the surrounding stem cell niche.

4 ddress fundamental questions about the adult stem cell niche.

5 Cs) that undergo neutral competition for the stem cell niche.

6 r suppressor by regulation of the intestinal stem cell niche.

7 SVZ, thereby altering cellular output of the stem cell niche.

8 the assembly and function of the SVZ neural stem cell niche.

9 ting to the basement membrane as part of the stem cell niche.

10 e after excision of their tip, including the stem cell niche.

11 h1 activity improves myotube's function as a stem cell niche.

12 re known to contribute to the spermatogonial stem cell niche.

13 opsis procambial cells, defines the vascular stem cell niche.

14 viding targets within the neoplastic gastric stem cell niche.

15 hy such complex regulation exists within the stem cell niche.

16 lose proximity in vivo in the corneal limbal stem cell niche.

17 gative progenitor cells that have exited the stem cell niche.

18 m and retina, as well as in the adult neural stem cell niche.

19 homing of human PAX7+ satellite cells to the stem cell niche.

20 competitive advantage for occupation of the stem cell niche.

21 ator of quiescence in the V-SVZ adult neural stem cell niche.

22 itch that modulates QC divisions at the root stem cell niche.

23 , PCs serve as a component of the intestinal stem cell niche.

24 ltipotent), and can be found in a recognized stem cell niche.

25 lically dormant state within the bone marrow stem cell niche.

26 the importance of the spatial aspects of the stem cell niche.

27 g of the central canal that is also an adult stem cell niche.

28 n is largely undefined, they may represent a stem cell niche.

29 ues for patterning the WUS domain within the stem cell niche.

30 na shoot apical meristem (SAM) to maintain a stem cell niche.

31 rvation in maintaining stem cells and/or the stem cell niche.

32 F-beta receptor pathway acts in the germline stem cell niche.

33 ioning of the centrosome with respect to the stem cell niche.

34 ly similar to the distal tip cell (DTC)-germ stem cell niche.

35 network, and muscle fiber within the muscle stem cell niche.

36 hat influenced their ability to colonize the stem cell niche.

37 l differentiation to establish an epithelial stem cell niche.

38 ch they derive, including the formation of a stem cell niche.

39 ere they presumably hijack the hematopoietic stem cell niche.

40 l growth and proliferation and maintains the stem-cell niche.

41 nd rhythmic modulation of the haematopoietic stem-cell niche.

42 athetic nerves that innervate the melanocyte stem-cell niche.

43 a cluster of somatic cells that organize the stem-cell niche.

44 hich enables them to contribute to the adult stem-cell niche.

45 Wnt and RSPO ligands in the intestinal crypt stem-cell niche.

46 actors that are considered key regulators in stem cell niches.

47 the HAM family is essential for all of these stem cell niches.

48 d to reproduce structures found within adult stem cell niches.

49 ly with WUS in the control of shoot and root stem cell niches.

50 nd how mesenchymal cells contribute to other stem cell niches.

51 reasing body of work has focused on defining stem cell niches.

52 ons during mouse corticogenesis and in adult stem cell niches.

53 s), known self-renewal regulators in various stem cell niches.

54 e in the identification of potential hepatic stem cell niches.

55 onditions that emulate characteristics of 3D stem cell niches.

56 ronans, type III collagen, laminin) found in stem cell niches.

57 cial components of hematopoietic bone marrow stem cell niches.

58 eration that may be conserved in other adult stem cell niches.

59 role during the establishment of vertebrate stem cell niches.

60 deconstructing similar hierarchies in other stem cell niches.

61 , transit-amplifying cells, and residents of stem cell niches.

62 derstanding of the cellular diversity within stem cell niches.

63 studies of wound healing, angiogenesis, and stem-cell niches.

64 ntial source of this loss of function is the stem cell 'niche'-a set of cell-extrinsic cues that incl

65 crucial role for this pathway in the testis stem cell niche, a true physiological function of NOTCH

66 C3-expressing subset demonstrates functional stem cell niche activity by maintaining primitive hemato

67 by somatic cells immediately outside of the stem cell niche acts locally to promote somatic differen

68 of stem cell function, and it is clear that stem cell-niche adhesion is crucial for stem cell self-r

69 ay a part in the reactivation of this latent stem cell niche after injury.

70 dentities and stereotypical structure of the stem cell niche after irradiation, but these cells fail

71 e that allogeneic T cells rapidly access the stem cell niche after transplantation, and this targeted

72 as critical components of the hematopoietic stem cell niche and are thought to protect hematopoietic

73 context to study the spatial aspects of the stem cell niche and cell lineages by organizing into lay

74 duction of DE-cadherin level, GSCs leave the stem cell niche and differentiate.

75 It was recently found that the stem cell niche and epithelium is regenerated after inju

76 P2-lineage progenitors reside in the adipose stem cell niche and express adipocyte progenitor markers

77 ant role in regulating the normal colorectal stem cell niche and facilitating tumor progression.

78 acrophages are fundamental components of the stem cell niche and function coordinately to regulate ha

79 adipogenic progenitors coexist in the tendon stem cell niche and give rise to fibrotic cells, reveali

80 R-activated transcription factor BZR1 in the stem cell niche and high BZR1 levels in the transition-e

81 results support a model in which leaving the stem cell niche and initiating differentiation are activ

82 required for proper regulation of the testis stem cell niche and is a potential feedback mechanism, b

83 ed cell death is limited to the meristematic stem cell niche and its early descendants.

84 lly polarized, functional units with a basal stem cell niche and luminal differentiated cell zone, st

85 tiating cells in organ primordia back to the stem cell niche and that appears to function broadly in

86 The stromal cells that comprise the stem cell niche and the signals that they generate that

87 The stem cell niche and the size of the root meristem in pla

88 essary to establish the boundary between the stem cell niche and the transit-amplifying region.

89 unctional roles of melanocytes in the limbal stem cell niche and their suitability for developing adv

90 molecular contribution of vascular cells to stem cell niches and other brain regions under different

91 uctions uncovered a significant reduction of stem cell niches and progenitor cells.

92 ative changes in tissue-specific stem cells, stem cell niches and systemic cues that regulate stem ce

93 rogeneity of the stromal cells that comprise stem cell niches and the complexity of the signals that

94 transcriptional landscape of the maize shoot stem-cell niche and its differentiating cellular descend

95 ng different cell types within an endogenous stem cell niche, and shed light on the biological functi

96 orm the critical component of a hypothalamic stem cell niche, and that local fibroblast growth factor

97 These cells form the perivascular gastric stem cell niche, and Wnt5a produced from ILCs activates

98 f Foxl1-positive telocytes in the intestinal stem cell niche, and, finally, the current challenges of

99 The inner workings of the intestinal crypt stem cell niche are now well understood.

100 stem cells divide asymmetrically then colon stem cell niches are maintained by more than 8 stem cell

101 Unveiling the mechanisms of how stem cell niches are modulated provides clues for regene

102 Stem cell niches are special microenvironments that main

103 Many stem cell niches are well defined anatomically, thereby

104 al Sertoli cells, the main components of the stem cell niche, are so far unknown.

105 These results support the role of stem-cell niches as a key component for the spreading of

106 erferes with symplastic communication in the stem cell niche, as demonstrated by impaired SHORT-ROOT

107 generation, and perturbed homeostasis of the stem cell niche, as indicated by an increase in SC self-

108 The stem cell niche at the base of the intestinal crypts, as

109 yst stem cells (CySCs) cohabiting a discrete stem cell niche at the testis apex.

110 e leaves and conspicuously excluded from the stem cell niche at the tip of the shoot apical meristem

111 e rounds of regeneration, the Tbx1-deficient stem cell niche becomes progressively depleted.

112 cells (McSCs) in the hair follicle exit the stem cell niche before their initial cell division, pote

113 st synaptic regulator with an implication in stem cell niche biology.

114 have extended implications for understanding stem cell niche biomechanics and its impact on tissue re

115 An intricate stem cell niche boundary formed by finger-like extension

116 Wnt signaling is a crucial regulator of the stem cell niche, but the mechanism that governs Wnt liga

117 s an important component of the adult neural stem cell niche, but whether vascular cells in neurogeni

118 sential components of the corneal epithelial stem cell niche, but, due to difficulties in their isola

119 iescent stem cell state in the hair follicle stem cell niche by controlling Fgf18 expression.

120 matic support cells called the hub creates a stem cell niche by locally activating the Janus Kinase-S

121 132H) mutation in the major adult neurogenic stem cell niche causes a phenotype resembling gliomagene

122 e a critical role for vesicle trafficking in stem cell niche competition and differentiation, and we

123 T cells (Tregs) are emerging as an essential stem cell niche component that promotes wound repair in

124 The shoot stem cell niche, contained within the shoot apical meris

125 The microenvironment within the SVZ stem cell niche controls NSPC fate.

126 Our findings indicate that a stem cell niche develops postnatally in the epiphyseal g

127 e need to be able to probe the hematopoietic stem cell niche directly.

128 cating that Shp2/MAPK signaling might affect stem cell niches directly or via paneth cells.

129 the exception of neurons born from postnatal stem cell niches, do not express detectable paternal Ube

130 tion, the space of Disse may also serve as a stem cell niche during fetal hematopoiesis and constitut

131 These insights into the regulatory stem cell niche during homeostasis and post-injury regen

132 that promote differentiation or disturb the stem cell niche effectively reduced tumor invasiveness a

133 We discovered a mechanism of stem cell niche exit in the canonical C. elegans distal

134 Mutations in the stem cell niche-expressed ASH1-RELATED3 (ASHR3) gene, en

135 of stem cell heterogeneity and evaluation of stem cell niche factor transcription patterns.

136 most potent natural antiangiogenic factor, a stem cell niche factor, and an inhibitor of cancer cell

137 acquisition properties of the production of stem cell niche factors by the mesenchymal cells have no

138 te to the identification of potential limbal stem cell niche factors that are promising targets for r

139 ntify secreted phospholipases A2 (sPLA2s) as stem cell niche factors with context-dependent functions

140 Thus, peripheral nerves serve as a stem cell niche for neuroendocrine system development.

141 of hematopoietic stem cells, the role of the stem cell niche for stem cell aging as well as novel and

142 Identification of a stem cell niche for the OSE may have important implicati

143 rrow endothelial cells in the haematopoietic stem-cell niche form a network of blood vessels that reg

144 In contrast, stem cell niche formation along a free-moving basal lami

145 ulating embryonic DG neurogenesis, DG neural stem cell niche formation, and maintenance.

146 When the stem cell niche forms along a rigid basal lamina, relati

147 on of a closed apical hook that protects the stem cell niche from damage [2, 3].

148 the integration of EGF signaling to regulate stem cell niche function.

149 rimary roots as well as auxin-responsive and stem cell niche gene expression in these mutants.

150 imary roots, as well as auxin-responsive and stem cell niche gene expression.

151 STATEMENT The subventricular zone neurogenic stem cell niche generates highly migratory neuroblasts t

152 The stem cell niche generates signals that regulate HSC self

153 the contribution of pericytes to the neural stem cell niche has not been defined.

154 While approaches to recapitulate the stem cell niche have been explored for directing stem ce

155 e in maintaining and replenishing endogenous stem cell niches have rendered them one of the most heav

156 the hematopoietic system, the ANS regulates stem cell niche homeostasis and regeneration and fine-tu

157 ng auxin distribution patterns necessary for stem cell niche homeostasis.

158 tant components of the male and female gonad stem cell niches (hubs and terminal filaments/cap cells,

159 rientation (MSO) disrupt the organization of stem cell niches impacting tissue morphogenesis and home

160 invading cells, with later development of a stem cell niche in adenocarcinomas of all stages.

161 ssociated with a decline of the affected SVZ-stem cell niche in aged mice.

162 Our results reveal a role of the stem cell niche in ageing and demonstrate that targeting

163 n of the Sox2(+) labial cervical loop (LaCL) stem cell niche in concert with two signaling centers: t

164 The male germline stem cell niche in Drosophila houses two stem cell popul

165 alignant transformation of the hematopoietic stem cell niche in hematopoietic malignancies.

166 acrine Wnt signaling and restricts the crypt stem cell niche in intestines of mice.

167 ystem plays a central role in regulating the stem cell niche in many organs, and thereby pivotally mo

168 ia (oRG), a fetal cell type that expands the stem cell niche in normal human cortex.

169 specific reporters in the neocortical neural stem cell niche in organotypic brain slices from embryon

170 lts indicate that GL can target the prostate stem cell niche in patient-derived cells, in docetaxel-r

171 feedback from organ primordia to control the stem cell niche in plants have also been hypothesized, b

172 Progressive activation of the mouse hepatic stem cell niche in response to ALIOS correlated with ste

173 Here we demonstrate that the aged stem cell niche in skeletal muscle contains substantiall

174 ng failure of maintaining the spermatogonial stem cell niche in somatic cells.

175 cline of the proliferative capacities of the stem cell niche in the affected subventricular zone (SVZ

176 xpression of WUSCHEL (WUS) defines the shoot stem cell niche in the apical meristems of many angiospe

177 ial cells are key cellular components of the stem cell niche in the bone marrow.

178 Blood vessels are part of the stem cell niche in the developing cerebral cortex, but t

179 ration through modulation of the mesenchymal stem cell niche in the Drosophila midgut.

180 s of the distal tip cell (DTC), the germline stem cell niche in the gonad.

181 e to AEC2s and may therefore contribute to a stem cell niche in the murine lung.

182 as an important component of the epithelial stem cell niche in the rodent lung.

183 ty delineated a potential macroscopic neural stem cell niche in the rostral end of the 3rd ventricle.

184 y morphogenetic events in embryos, maintains stem cell niches in adults, and is dysregulated in many

185 In addition, Bmp signals characterize adult stem cell niches in other tissues where Hopx-mediated in

186 the controlled manipulation of hematopoietic stem cell niches in physiology and pathology.

187 We highlight emerging data that stem cell niches in the bone marrow are not static but i

188 In Arabidopsis, the stem cell niches in the shoot and root meristems are pro

189 ormation may be explained by the presence of stem cell niches in those areas.

190 N-521 and E-cadherin, which both localize to stem cell niches in vivo.

191 Stem-cell niches in mammalian tissues are often heteroge

192 ial stratification are used to study how the stem cell niche influences epithelial morphologies.

193 d a healthy stem cell pool by regulating the stem cell-niche interaction.

194 Stem cell niche interactions have been studied extensive

195 have been used to identify and characterize stem cell-niche interactions and uncover new niche compo

196 effect recovery according to the dynamics of stem cell-niche interactions.

197 llular components to directly model and test stem cell-niche interactions.

198 The stem cell niche is a complex local signaling microenviro

199 The muscle stem cell niche is central for regulating the activation

200 The adult subventricular zone (SVZ) stem cell niche is comprised of multi-ciliated ependymal

201 ogical conditions of the muscle in which the stem cell niche is compromised.

202 e crosslinks and biochemical ligands as a 3D stem cell niche is reported.

203 A largely ignored component of the V-SVZ stem cell niche is the lateral ventricle choroid plexus

204 The stem cell niche is thought to provide signals that suppo

205 concepts of stem cell plasticity and of the stem cell niche is warranted.

206 ic method for simulating a metapopulation of stem cell niche lineages, that is, many sub-populations

207 ly members underlie the formation of diverse stem cell niche locations, and the HAM family is essenti

208 Plant meristems, like animal stem cell niches, maintain a pool of multipotent, undiff

209 The stem cell niche maintains a balance among quiescence, pr

210 mones alters the position of new tissues and stem cell niche markers.

211 onical C. elegans distal tip cell (DTC) germ stem cell niche mediated by previously unobserved, thin,

212 gregated to cells in a tenascin-C expressing stem cell niche model better than library-AR modified ce

213 In many tissues, the stem cell niche must coordinate behavior across multiple

214 er-associated fibroblasts, the hematopoietic stem cell niche, myeloid-derived suppressor cells, and t

215 Within the gastrointestinal stem cell niche, nerves help to regulate both normal and

216 at oncogenic mutations are propagated in the stem cell niche not just through cell-intrinsic advantag

217 atic duct near the urethra, a mouse prostate stem cell niche, not only produce multiple Wnt ligands b

218 L1 is preferentially expressed in the limbal stem cell niche of adult human cornea, we assume that CH

219 liary cancer cells freshly isolated from the stem cell niche of human BTCs as well as in CD133+ chemo

220 functionally resembling the immature active-stem cell niche of neonatal animals.

221 ghly expressed in the subventricular zone, a stem cell niche of the adult brain, and in inflammatory

222 The stem cell niche of the Arabidopsis (Arabidopsis thaliana

223 al) epithelium, as a previously unrecognized stem cell niche of the OSE.

224 The stem cell niche of the ovarian surface epithelium (OSE),

225 he role of JAK-STAT signaling in the various stem cell niches of the hair follicle.

226 rganize body axes, regulate growth, maintain stem cell niches, or signal inductively across germ laye

227 involving EphA4 signaling that functions in stem cell niche organization and ultimately neuroblast m

228 However, the precise stem cell niche organization, the intermediate steps and

229 ar approaches could also be applied to other stem cell/niche pairs to advance the understanding of mi

230 Copenhagen in Denmark to participate in 'The Stem Cell Niche', part of the Copenhagen Bioscience Conf

231 Multiple stem cell niches persist in specific anatomical location

232 s-mitotic divisions under the control of the stem cell niche produce nuclei that, upon leaving the ni

233 hysiologic humanization of the hematopoietic stem cell niche proves critical to MDS stem cell propaga

234 Stem cell niches provide a regulatory microenvironment t

235 Stem cell niches provide resident stem cells with signal

236 Stem cell niches provide signals that promote stem cell

237 The stem cell niche provides a supportive microenvironment t

238 The intestinal stem cell niche provides cues that actively maintain gut

239 that maintains the flexibility required for stem cell niche re-establishment during organogenesis.

240 ch in turn regulates the architecture of the stem cell niche, redox homeostasis, and neurogenesis.

241 supporting Wolbachia's targeting of ovarian stem cell niches--referred to as "niche tropism"--as a p

242 Stem cell niche refers to the microenvironment where ste

243 ligand Delta-1 (DL1), a key component of the stem cell niche, regulates human hematopoietic lineage d

244 a have defined individual populations in the stem cell niche regulating hematopoietic regeneration an

245 sts include participation in the peribiliary stem cell niche, regulation of cholangiocyte proliferati

246 nks underlying conserved WUS/WOX function in stem cell niches remain unknown.

247 roenvironment called niche but the nature of stem cell niche remains poorly defined in many systems.

248 roenvironment, or "niche." In this vein, the stem cell niche represents a significant, and largely un

249 rich atmosphere(1); their tissues, including stem-cell niches, require continuous oxygen provision fo

250 t of all multicellular organisms; in plants, stem cell niches reside in meristems.

251 nt center (QC), and, together, they form the stem cell niche (SCN).

252 nd whether this dynamics also occur in plant stem cell niches (SCN), remain elusive.

253 Organ formation in plants is dependent on stem cell niches (SCNs), which are located in the so-cal

254 response to stress induced by depletion of a stem cell niche signal.

255 s cellular processes, such as necroptosis or stem cell niche signaling.

256 Stem-cell niche signaling is short-range in nature, such

257 It is unclear if stem cell niche signals coordinate fate decisions within

258 fferences in cortical cell layer patterning, stem cell niche structure, and radial cell division.

259 r half of these gonads switch to form female stem cell niche structures.

260 The human intestinal stem cell niche supports self-renewal and epithelial fun

261 unchecked, the expression of the GRFs in the stem cell niche suppresses formative cell divisions and

262 Here we identify a neural crest stem cell niche that centers around the dorsal midline w

263 shoot apical meristem (SAM), containing the stem cell niche that gives rise to the above-ground tiss

264 promote the survival of constituents of the stem cell niche that initiate recovery.

265 pendyma of the adult spinal cord is a latent stem cell niche that is reactivated by spinal cord injur

266 1-MMP/integrin/YAP/TAZ axis operative in the stem cell niche that oversees SSC fate determination.

267 idermal keratinocytes are a component of the stem cell niche that regulates development and homeostas

268 d destruction of the mitotically compromised stem cell niche that triggers its regeneration, enabling

269 Shoot apical meristems are stem cell niches that balance proliferation with the inc

270 However, the nature of the genetic regime in stem cell niches that centre on WOX gene function has be

271 ction model when delivered in their original stem cell niche-that is, by transplantation of the human

272 In addition to the stem cell niche, the meeting focused on a number of cutt

273 Plant stem cell niches, the meristems, require long-distance t

274 tic regulators for self-renewal in a dynamic stem cell niche: the developing vertebrate retina.

275 recreate important interactions in the liver stem cell niche, those between adult hepatocytes and liv

276 tions, and is thought to establish the shoot stem cell niche through a feedback circuit involving the

277 ncreasing stem cell engraftment by mimicking stem cell niches through ECM application.

278 Maturation of the stem cell niche thus appears to be associated with loss

279 hypoxia as a key external cue to protect the stem cell niche, thus ensuring successful rapid establis

280 further show that response of the urothelial stem cell niche to infection, normally activated to rest

281 target to improve the contribution of the CC stem cell niche to repair.SIGNIFICANCE STATEMENT Ependym

282 Thus, the evolution of stem cell niche topology allows complex pigment patterni

283 gestions of a contribution of Wolbachia from stem-cell niches toward vertical transmission.

284 contacts the ventricular-subventricular zone stem cell niche (VSVZ + GBM) have a distinct survival pr

285 The existence of a 'stem cell niche' was first postulated by Schofield in 19

286 ical consequences of BAX/BAK deficiency in a stem cell niche, we generated Bak(-/-) mice with conditi

287 m cell system, the Drosophila spermatogonial stem cell niche, we reveal daily rhythms in division fre

288 gonadal distal tip cell (DTC), the germline stem cell niche, where it negatively regulates a DAF-3 S

289 This is especially relevant for stem cell niches, where neighbouring cells provide instr

290 , the Drosophila homolog of IGFBP7, into the stem cell niche, which blocks InR activation in CySCs.

291 cells (HSCs) reside in the bone marrow (BM) stem cell niche, which provides a vital source of HSC re

292 sensor and describe the properties of the CB stem cell niche, which support CB growth during acclimat

293 are increasingly recognized as components of stem cell niches, which are best defined in the blood.

294 The Shp2 mutation also expanded Lgr5+ stem cell niches, which could be restricted by activated

295 e labial incisor cervical loop or epithelial stem cell niche, with decreased expression in the differ

296 ials have been developed to recapitulate the stem cell niche within a tissue and to instruct MSC towa

297 In mammals, the stem cell niche within hair follicles is home to epithel

298 mation can differentially influence distinct stem cell niches within a tissue.

299 uniquely affects the formation of the larval stem cell niches, without altering other midgut cell typ

300 f the surrounding stem cells within the root stem cell niche, yet specific molecular players sustaini