ライフサイエンスコーパス: stem cell self-renewal

1 estern blots for Bmi-1 expression (marker of stem cell self-renewal).

2 gulates organ size, tissue regeneration, and stem cell self-renewal.

3 bitors, suggesting an autocrine mechanism of stem cell self-renewal.

4 racted with multiple target genes related to stem cell self-renewal.

5 atin-modifier proteins that is essential for stem cell self-renewal.

6 n of cell cycle, senescence, DNA damage, and stem cell self-renewal.

7 e G1-S transition to promote rapid embryonic stem cell self-renewal.

8 n increased cell proliferation and decreased stem cell self-renewal.

9 lators in many cellular processes, including stem cell self-renewal.

10 central mechanism of organ size control and stem cell self-renewal.

11 fy peptide surfaces that sustain pluripotent stem cell self-renewal.

12 roliferation, differentiation, and embryonic stem cell self-renewal.

13 e functions, including organ development and stem cell self-renewal.

14 niche cells to control germ line and somatic stem cell self-renewal.

15 enitor cells, may also be crucial for cancer stem cell self-renewal.

16 critical for the regulation of hematopoietic stem cell self-renewal.

17 gulation previously shown to be critical for stem cell self-renewal.

18 e receptors that are essential for embryonic stem cell self-renewal.

19 ly re-isolated, providing evidence of muscle stem cell self-renewal.

20 at such regulation is required for germ line stem cell self-renewal.

21 e required for maintaining cell identity and stem cell self-renewal.

22 epigenetic cellular memory, pluripotency and stem cell self-renewal.

23 gesting that mago nashi is not necessary for stem cell self-renewal.

24 ignaling pathway that has been implicated in stem cell self-renewal.

25 nical Wnt signaling pathway, which regulates stem cell self-renewal.

26 -chromosome inactivation, tumorigenesis, and stem cell self-renewal.

27 f-renew, and are a model system for studying stem cell self-renewal.

28 light on the molecular mechanisms underlying stem cell self-renewal.

29 he testis and is required for spermatogonial stem cell self-renewal.

30 determines the efficiency of mouse embryonic stem cell self-renewal.

31 tic mechanisms that govern tissue repair and stem cell self-renewal.

32 l mouse mutant luxoid affects adult germline stem cell self-renewal.

33 ing genes in stem cells in order to maintain stem cell self-renewal.

34 nt signaling to ensure a balanced control of stem cell self-renewal.

35 testis act as a cellular niche that supports stem cell self-renewal.

36 pate in basic stem cell functions, including stem cell self-renewal.

37 K-STAT pathway, thereby defining a niche for stem cell self-renewal.

38 Notch signaling in regulating hematopoietic stem cell self-renewal.

39 PSTKi) impaired AML cell growth and leukemic stem cell self-renewal.

40 cision via ZRSR2 loss enhances hematopoietic stem cell self-renewal.

41 as a coactivator for OCT4/SOX2 critical for stem cell self-renewal.

42 ltransferase, is required for spermatogonial stem cell self-renewal.

43 In C. elegans, PUF proteins promote germline stem cell self-renewal.

44 d identify miR-99 as a critical regulator of stem cell self-renewal.

45 rated by Wnt signaling are proliferation and stem cell self-renewal.

46 of genes involved in fetal hematopoiesis and stem cell self-renewal.

47 d a key transcription factor for pluripotent stem cell self-renewal.

48 gether with its assembly factor CAL1, drives stem cell self-renewal.

49 ant for normal mammary gland development and stem cell self-renewal.

50 ent creates an essential "niche" to maintain stem cell self-renewal.

51 h and metastasis by regulating breast cancer stem cell self-renewal.

52 p to further dissect the networks underlying stem cell self-renewal.

53 ay to identify regulators of human embryonic stem-cell self-renewal.

54 roduction of oocytes by maintaining germline stem cells self-renewal.

55 enes contributing to aberrant haematopoietic stem cell self-renewal(4,5).

56 cytosine (5-hmC) and increased hematopoietic stem cell self-renewal accompanied by defective differen

57 ic deregulations, and impairs haematopoietic stem-cell self-renewal activity and regenerative potenti

58 t signaling pathways that regulate mammalian stem cell self-renewal, adhesion, and migration.

59 s abnormalities including a severe defect in stem cell self-renewal, alterations in thymocyte maturat

60 olecular mechanisms governing spermatogonial stem cell self renewal and hierarchical differentiation.

61 nscription factors such as Oct4 that control stem cell self renewal and multipotency.

62 a new avenue for investigating mechanisms of stem cell self-renewal and achieving clinically signific

63 Conversely, Yap overexpression increases stem cell self-renewal and blocks terminal differentiati

64 ological processes associated with embryonic stem cell self-renewal and cell fate determination.

65 nanog, and sox-2, which are associated with stem cell self-renewal and developmental potential.

66 Stem cell self-renewal and differentiation along neurona

67 the transcriptional changes associated with stem cell self-renewal and differentiation and followed

68 r stem cells in functional assays for cancer stem cell self-renewal and differentiation and form uniq

69 of mechanisms that drive the neuroepithelial stem cell self-renewal and differentiation and preserve

70 ors, are known to influence murine embryonic stem cell self-renewal and differentiation behavioral re

71 in the cell and molecular biology of neural stem cell self-renewal and differentiation between inver

72 The search for genes that regulate stem cell self-renewal and differentiation has been hind

73 The niche controls stem cell self-renewal and differentiation in animal tis

74 Although the principles that balance stem cell self-renewal and differentiation in normal tis

75 ory networks that control the switch between stem cell self-renewal and differentiation in the germli

76 The signals that regulate stem cell self-renewal and differentiation in the lung r

77 The balance between stem cell self-renewal and differentiation is controlled

78 Neural stem cell self-renewal and differentiation is orchestrat

79 isms that ensure the correct balance between stem cell self-renewal and differentiation is poorly und

80 However, the mechanism that regulates Leydig stem cell self-renewal and differentiation is unknown.

81 he effects of prematurity on the programs of stem cell self-renewal and differentiation of the upper

82 ional role of matrix mechanics in regulating stem cell self-renewal and differentiation processes.

83 Although biochemical signals that modulate stem cell self-renewal and differentiation were extensiv

84 ll understanding of the networks controlling stem cell self-renewal and differentiation, however, has

85 tissue development and homeostasis depend on stem cell self-renewal and differentiation, the mechanis

86 echanism for controlling the balance between stem cell self-renewal and differentiation.

87 k factors that influence the balance between stem cell self-renewal and differentiation.

88 the mechanisms underlying human pluripotent stem cell self-renewal and differentiation.

89 gene expression, cell cycle progression, and stem cell self-renewal and differentiation.

90 stem cells are vital for proper control over stem cell self-renewal and differentiation.

91 naling pathway is a key player in regulating stem cell self-renewal and differentiation.

92 ree toward understanding the coordination of stem cell self-renewal and differentiation.

93 nce of translational repression in balancing stem cell self-renewal and differentiation.

94 ays an important role in mammalian germ line stem cell self-renewal and differentiation.

95 plays an essential role in regulating adult stem cell self-renewal and differentiation.

96 actor Prospero, regulates the choice between stem cell self-renewal and differentiation.

97 ttractive system to study how niches control stem cell self-renewal and differentiation.

98 g of molecular controls of the hematopoietic stem cell self-renewal and differentiation.

99 s, including spermatogenesis, metabolism and stem cell self-renewal and differentiation.

100 largely unknown how DNA damage affects both stem cell self-renewal and differentiation.

101 le is known about Mediator function in adult stem cell self-renewal and differentiation.

102 the transcriptional regulation of epidermal stem cell self-renewal and differentiation.

103 genetics plays critical roles in controlling stem cell self-renewal and differentiation.

104 ate normal developmental processes including stem cell self-renewal and differentiation.

105 ral stem cells (neuroblasts) are a model for stem cell self-renewal and differentiation; they divide

106 However, Tspan3 deletion impaired leukemia stem cell self-renewal and disease propagation and marke

107 OXB4 has been shown to enhance hematopoietic stem cell self-renewal and expansion ex vivo and in vivo

108 regulator of essential mechanisms governing stem cell self-renewal and fate decisions through transc

109 tral role in controlling the balance between stem cell self-renewal and fate determination by regulat

110 entire process of neurogenesis, from neural stem cell self-renewal and fate determination to neurona

111 lium provides a unique model to study neural stem cell self-renewal and fate determination.

112 s are implicated in regulating pluripotency, stem cell self-renewal and fate specification.

113 g hematopoietic stem cell (HSC) and leukemic stem cell self-renewal and functions in the context of t

114 Bmi1 is implicated in the control of stem cell self-renewal and has been shown to regulate ce

115 l during development that may participate in stem cell self-renewal and hematopoietic differentiation

116 ates that FTO plays critical roles in cancer stem cell self-renewal and immune evasion and highlights

117 Nanog facilitates embryonic stem cell self-renewal and induced pluripotent stem cell

118 Balancing stem cell self-renewal and initiation of lineage specifi

119 that stem cell-niche adhesion is crucial for stem cell self-renewal and is dynamically regulated.

120 Wnt/beta-catenin can promote stem cell self-renewal and is dysregulated in colon carc

121 respectively, elucidates new key players in stem cell self-renewal and leukemic transformation.

122 At the heart of stem cell self-renewal and lineage commitment decisions

123 key known transcription factors which govern stem cell self-renewal and lineage commitment decisions.

124 Both stem cell self-renewal and lineage differentiation are c

125 e an attractive model in which to study both stem cell self-renewal and lineage differentiation at th

126 the DNA damage-mediated disruption of adult stem cell self-renewal and lineage differentiation, and

127 However, regulation of stem cell self-renewal and maintenance of its potentiali

128 ely 10-15 somatic cells that is required for stem cell self-renewal and maintenance.

129 iation 4 (ID4) is a key regulator of mammary stem cell self-renewal and marks a subset of BLBC with a

130 urther dissecting the signalling pathways of stem cell self-renewal and may help develop more effecti

131 relevant to the regulation of hematopoietic stem cell self-renewal and megakaryocytopoiesis in the b

132 tion coordinately to regulate haematopoietic stem cell self-renewal and mobilization.

133 onserved pathway that promotes hematopoietic stem cell self-renewal and multipotency by limiting stem

134 ling has been found to be a key regulator of stem cell self-renewal and myogenesis in normal skeletal

135 reatly diminished progenitor pools, impaired stem cell self-renewal and nearly complete loss of compe

136 show here that Wnt7a is essential for neural stem cell self-renewal and neural progenitor cell cycle

137 recent advances in the regulation of neural stem cell self-renewal and neurogenesis by microRNAs.

138 ox 2 (Sox2), a well established regulator of stem cell self-renewal and neurogenesis.

139 y postnatal lethality with defects in neural stem cell self-renewal and neuronal/glial cell fate spec

140 nt are known to be critical for development, stem cell self-renewal and oncogenic progression.

141 amily of RNA binding proteins act to promote stem cell self-renewal and oppose cell differentiation p

142 c transcription factors play a major role in stem cell self-renewal and pluripotency, their integrati

143 enetics of ECs will reveal genes involved in stem cell self-renewal and pluripotency.

144 The niche controls stem cell self-renewal and progenitor differentiation fo

145 adult stem cells and progenitors by altering stem cell self-renewal and proliferation.

146 urine development and its role in regulating stem cell self-renewal and proliferation.

147 m low to moderate ROS levels is required for stem cell self-renewal and proliferation.

148 We conclude that Brat suppresses neuroblast stem cell self-renewal and promotes neuronal differentia

149 sashi-2 (Msi2) RNA-binding protein maintains stem cell self-renewal and promotes oncogenesis by enhan

150 as a major regulatory pathway in controlling stem cell self-renewal and quiescence.

151 feration, migration, invasion, angiogenesis, stem cell self-renewal and regulation of other tumor sup

152 ant mitochondrial stress can lead to loss of stem cell self-renewal and requires the surveillance of

153 r Arf from Bmi-1(-/-) mice partially rescued stem cell self-renewal and stem cell frequency in the CN

154 er the niche is compartmentalized to control stem cell self-renewal and stepwise progeny differentiat

155 neuroblasts are a model system for studying stem cell self-renewal and the establishment of cortical

156 ance and immune evasion as well as in cancer stem cell self-renewal and the tumour microenvironment,

157 ower in unearthing new molecules that govern stem cell self-renewal and tissue-regenerative potential

158 hways therefore confer temporal changes upon stem cell self-renewal and tumor suppressor mechanisms.

159 t polycomb repressive complexes also control stem cell self-renewal and tumorigenesis, but so far, no

160 ranscriptional regulation plays key roles in stem cell self-renewal and tumorigenesis.

161 of the Notch signaling pathway and mediates stem cell self-renewal and vascular development.

162 the tissue type, the Wnt pathway can promote stem cell self-renewal and/or direct lineage commitment.

163 mi-1 often overexpressed and participated in stem cells self-renewal and tumorigenesis initiating of

164 that microRNAs (miRNAs) are dispensable for stem-cell self-renewal and neuron production but essenti

165 utionized our understanding of regeneration, stem cell self-renewal, and cancer; yet models for direc

166 ological processes, including embryogenesis, stem cell self-renewal, and postnatal survival.

167 role of miRs in reprogramming and embryonic stem cell self-renewal, and specifically addresses the r

168 that mTORC1 non-cell-autonomously regulates stem-cell self-renewal, and highlight a significant role

169 cal amount of Oct-3/4 is required to sustain stem-cell self-renewal, and up- or downregulation induce

170 C), but the signaling pathways that regulate stem cell self-renewal are largely unknown.

171 The mechanisms that control adult neural stem cell self-renewal are still largely unknown.

172 significant role in enhancing hematopoietic stem cell self-renewal as well as the production and dif

173 ed cells that inhibit stem-cell division and stem-cell self-renewal, as documented in the olfactory e

174 ient stem cells continued to show defects in stem cell self-renewal assays, suggesting a requirement

175 Asxl2 was required for normal haematopoietic stem cell self-renewal, Asxl2 loss promoted AML1-ETO leu

176 ystem is a good model to study mechanisms of stem cell self-renewal because of the well defined cultu

177 The network also controls embryonic stem cell self-renewal but is associated with distinct e

178 adaptor protein LNK suppresses hematopoietic stem cell self-renewal, but its presence and role in the

179 Kruppel-like factor 5 regulates pluripotent stem cell self-renewal, but its role in somatic stem cel

180 Hmga2 thus promotes fetal and young-adult stem cell self-renewal by decreasing p16(Ink4a)/p19(Arf)

181 find that linc-RoR maintains human embryonic stem cell self-renewal by functioning as a sponge to tra

182 roles in cellular proliferation and regulate stem cell self-renewal by maintaining expression of key

183 Thus, although it promotes stem cell self-renewal by repressing a bam-dependent pro

184 Stem cell self-renewal can be specified by local signals

185 cription factor is an important regulator of stem cell self-renewal, cancer cell survival, and inflam

186 se, which directly compromises hematopoietic stem cells' self-renewal capabilities and eventually lea

187 e immunity, the regulation of autophagy, and stem cell self-renewal capacity, where evidence suggests

188 lator in embryonic development that controls stem cell self-renewal, chromatin organization, and the

189 Stem cell self-renewal depends on their ability to divid

190 cell autonomous changes, including increased stem cell self-renewal, differential capacity to generat

191 d on the role of Activin/Nodal signalling in stem cell self-renewal, differentiation and proliferatio

192 hese findings connect sexual identity to the stem cell self-renewal/differentiation decision and high

193 Precise regulation of stem cell self-renewal/differentiation is essential for

194 nes without any drug selection, but enforced stem cell self-renewal divisions can have adverse conseq

195 ediated transcription is a driving force for stem cell self-renewal during adult tissue homeostasis.

196 eins are essential for germline development, stem cell self-renewal, epigenetic regulation, and trans

197 n/ERalpha signalling promotes haematopoietic stem-cell self-renewal, expanding splenic haematopoietic

198 Comparison of GSC regulators with neural stem cell self-renewal factors identifies common and cel

199 Despite expressing stem cell self-renewal factors, intermediate progenitor

200 Ps by attenuating their genomic responses to stem cell self-renewal factors.

201 these models, the negative feedback loop on stem cell self-renewal fails to maintain homeostasis, bo

202 ll lineages that depend on a balance between stem cell self-renewal for continuity and the formation

203 Thus, Bmi-1 dependence distinguishes stem cell self-renewal from restricted progenitor prolif

204 during evolution and play essential roles in stem cell self-renewal, gametogenesis, and RNA interfere

205 ith or without homeobox B4 (HOXB4), a potent stem cell self-renewal gene.

206 gnals that emanate from the niche to specify stem cell self-renewal have been identified.

207 Its specific role in mouse epiblast stem cell self-renewal, however, remains poorly understo

208 Retinoic acid (RA) has been linked to stem cell self-renewal in adults and also participates i

209 irst class of genes known to be required for stem cell self-renewal in diverse organisms.

210 also be involved in the regulation of adult stem cell self-renewal in mammals, including humans.

211 gene shown to be required in germ cells for stem cell self-renewal in mammals.

212 own or ROR overexpression leads to increased stem cell self-renewal in mammary stem cells.

213 a fragment of collagen VI alpha3, increased stem cell self-renewal in mammosphere assays and Wnt sig

214 orphan nuclear receptor TLX regulates neural stem cell self-renewal in the adult brain and functions

215 r Wnt signaling as an important regulator of stem cell self-renewal in the developing brain.

216 d DOM control germline stem cell and somatic stem cell self-renewal in the Drosophila ovary, respecti

217 eir effect on long-term, but not short-term, stem cell self-renewal in vitro.

218 l diversity during development and regulates stem-cell self-renewal in Drosophila and mammals.

219 g molecular mechanisms, like those governing stem-cell self-renewal in general, remain poorly underst

220 ces expression of Bmi-1 (master regulator of stem cell self-renewal) in dental pulp stem cells.

221 ryonal cells and suggest that OCT4 maintains stem cell self-renewal, in part, by recruiting PRC compl

222 gulates the expression of genes critical for stem cell self-renewal, including NOTCH1, and may be lin

223 Pbx1 is required to maintain stem cell self-renewal, including that of mesenchymal st

224 ue to decreased differentiation and enhanced stem cell self-renewal induced by Notch1.

225 nificantly inhibit VEGF secretion, decreased stem cell self-renewal, inhibited tumor growth, and incr

226 Nin regulates neural stem cell self-renewal, interkinetic nuclear migration,

227 The molecular mechanism underlying stem cell self-renewal is a fundamental question in stem

228 hat deregulation of pathways responsible for stem cell self-renewal is a likely requirement for carci

229 lization of small molecules in modulation of stem cell self-renewal is a promising approach to expand

230 Here we evaluated whether hematopoietic stem cell self-renewal is affected by the Notch pathway.

231 Stem cell self-renewal is controlled by concerted action

232 Stem cell self-renewal is controlled by concerted action

233 Because abnormal stem cell self-renewal is frequently observed during tum

234 Stem cell self-renewal is intrinsically associated with

235 Stem cell self-renewal is tightly controlled by the conc

236 erstanding how extrinsic signaling regulates stem cell self-renewal, little is known about how cell-a

237 e employment of gut epithelia as a niche for stem cell self-renewal may provide a mechanism for direc

238 The stem cell self-renewal mediated by SALL4 is linked to ep

239 These findings provide new insights into stem cell self-renewal mediated by SALL4 via epigenetic

240 Germline phenotypes include defects in stem cell self-renewal, meiotic progression, and gamete

241 ciated with (1) embryonic development and/or stem cell self renewal (MSX, MEIS, ID, Hes1, and SIX hom

242 The regulation of stem cell self-renewal must balance the regenerative nee

243 Stem cell self-renewal often relies on asymmetric fate d

244 evelopment of exogenous molecules to control stem cell self-renewal or differentiation has arrived at

245 strate plays a key role in the regulation of stem cell self-renewal or differentiation.

246 cells (SSCs); their progeny either remain as stem cells (self-renewal) or proliferate and differentia

247 Activation in transformed cells of normal stem cells' self-renewal pathways might contribute to th

248 cancers may develop through dysregulation of stem-cell self-renewal pathways.

249 induction of autophagy; augmentation of GBM stem cell self-renewal; possible implications of GBM-end

250 cell functions and are required to maintain stem cell self-renewal potential.

251 controls both physiological and pathological stem cell self-renewal primarily by repressing target mR

252 ocampal NSPCs can provide insight into basic stem cell self-renewal principles important for tissue h

253 ve feedback from differentiated cells on the stem cell self-renewal probability can maintain a stable

254 evealed a loss of the hematopoietic/leukemic stem cell self-renewal program and an increase in the di

255 machinery can play a key role in regulating stem cell self-renewal, proliferation, differentiation a

256 Embryonic stem cell self-renewal properties are attributed to crit

257 d that by providing a humanized environment, stem cell self-renewal properties were better maintained

258 the role for post-transcriptional control in stem cell self-renewal, provide mechanistic insight on A

259 We found that the stem cell self-renewal regulator SOX2 is a novel target

260 The determinants of normal and leukemic stem cell self-renewal remain poorly characterized.

261 e that TLX, an essential regulator of neural stem cell self-renewal, represses the expression of miR-

262 To identify strategies of stem cell self-renewal requires that different models of

263 The piwi family genes are crucial for stem cell self-renewal, RNA silencing, and translational

264 KDM2B (also known as FBXL10) controls stem cell self-renewal, somatic cell reprogramming and s

265 re a powerful model system for investigating stem cell self-renewal, specification of temporal identi

266 ns of the canonical asymmetric vs. symmetric stem cell self-renewal strategies and are distinguished

267 oth challenges and opportunities to identify stem cell self-renewal strategies: while under asymptoti

268 the genes have been implicated in vertebrate stem cell self-renewal, suggesting that this core set of

269 e recently described ability of p53 to limit stem cell self-renewal suppresses tumorigenesis in acute

270 lts elucidate a new role for beta-catenin in stem cell self-renewal that is independent of its transc

271 cation of conditions and factors involved in stem cell self-renewal, the foundation of spermatogenesi

272 en shown to be required for postnatal neural stem cell self-renewal, the role of trxG genes remains u

273 ays a critical role in tooth development and stem cell self-renewal through beta-catenin.

274 Here we show that GV represses melanoma stem cell self-renewal through inhibition of SOX2.

275 maintaining stem cell identity and governing stem cell self-renewal through transcriptional repressio

276 promoter in response to signals stimulating stem cell self-renewal, through activation of the mitoge

277 tem cell function and their consequences for stem cell self-renewal, tissue homeostasis, and regenera

278 However, the progression from stem cell self-renewal to overt signs of early different

279 s define a blueprint for the transition from stem cell self-renewal to terminal differentiation.

280 e of LOCa to modulate aberrant hematopoietic stem cell self-renewal, transcriptional programming, cel

281 y a simple isoform switch to regulate glioma stem cell self-renewal, tumorigenicity, and progression.

282 enriched in the prostate, promoting prostate stem cell self-renewal upon proteolytic activation via a

283 Niches regulate lineage-specific stem cell self-renewal versus differentiation in vivo an

284 as a model to understand how the balance of stem cell self-renewal versus differentiation is achieve

285 Regulation of stem cell self-renewal versus differentiation is critica

286 Stem cell self-renewal versus differentiation is regulat

287 rocess may be favored by cytokines promoting stem cell self-renewal versus differentiation.

288 the different signaling pathways involved in stem cell self-renewal versus lineage-specific different

289 Expression of BMI1, a known regulator of stem cell self-renewal, was modulated by miR-200c.

290 Significantly for the maintenance of stem cell self-renewal, we detected a reduction in the e

291 nsight into mechanisms controlling embryonic stem cell self-renewal, we explore the molecular and cel

292 Low CMA activity promotes embryonic stem cell self-renewal, whereas its up-regulation enhanc

293 Asxl1 deletion reduces hematopoietic stem cell self-renewal, which is restored by concomitant

294 ce and showed that H3.3 K27M enhanced neural stem cell self-renewal while preserving regional identit

295 ed that Bmi1 promotes cell proliferation and stem cell self-renewal with a correlative decrease of p1

296 t the mechanisms that coordinate the rate of stem cell self-renewal with differentiation at a populat

297 In the epidermis, a tissue that balances stem cell self-renewal with differentiation, H3K27me3, o

298 have a loss of maintenance of spermatogonial stem cell self-renewal without a block in normal spermat

299 (SEZ) leads to persistently enhanced neural stem cell self-renewal without sign of exhaustion.

300 tasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal" (Xie et al., 2019).