ライフサイエンスコーパス: stemness

1 3 phosphorylation and increased cancer cell "stemness".

2 sufficient to induce cancer metastasis and "stemness".

3 ll functions (which are collectively termed 'stemness').

4 and S18-2 is essential for maintaining cell stemness.

5 , whose product regulates genes that control stemness.

6 CCL20, which promoted tumor progression and stemness.

7 ncy transcripts, resulting in increased cell stemness.

8 o enhance chemoresistance via increased cell stemness.

9 of cMET and glycolysis reverses EGFL9-driven stemness.

10 r uncoupling ECM signals that support cancer stemness.

11 AF was associated with increased cancer cell stemness.

12 ssion of Wnt5a that plays important roles in stemness.

13 potential to regulate cell tumorigenicity or stemness.

14 f CA-MSC to induce STAT3 phosphorylation and stemness.

15 ssion of NANOG and other genes that regulate stemness.

16 ciated fibroblasts and regulates cancer cell stemness.

17 TNBC cells attenuates obesity-augmented TNBC stemness.

18 dentity factors, thereby promoting exit from stemness.

19 of T cell effector function while preserving stemness.

20 sensitivity to BRAF inhibitors or degree of stemness.

21 tion factor TCF7, which promotes cancer cell stemness.

22 treatment for modulating the TME and cancer stemness.

23 ling via IL6 and LIF and increase tumor cell stemness.

24 ancreatic cancer by regulating ER stress and stemness.

25 ated with cancer progression and cancer cell stemness.

26 through the induction of cell plasticity and stemness.

27 covered that Qki is a major regulator of NSC stemness.

28 atastrophe, multinucleation, and the loss of stemness.

29 f RS-hAFSCs to revert to an earlier state of stemness.

30 s and early-stage breast cancer invasion and stemness.

31 Inflammatory mediators may induce tumor cell stemness.

32 EMT and the acquisition of cell motility and stemness.

33 specific pathways driving CSC emergence and stemness.

34 presses PUMA in these cells, promoting tumor stemness.

35 actors (OCT4, SOX2, KLF4 and MYC) and drives stemness.

36 activity of FGF signaling and regulates NPC stemness.

37 supported cell viability, proliferation, and stemness.

38 essed CD24 translation and colorectal cancer stemness.

39 ed ST6Gal-I, suggesting a novel biomarker of stemness.

40 in this context, SIX1 failed to maintain NPC stemness.

41 rs and the role of telomeres in pluripotency/stemness.

42 suggest that TGF-beta induced EMT and cancer stemness acquisition could be associated with activation

43 epithelial-mesenchymal transition (EMT) and stemness acquisition in NE differentiated prostate cance

44 aluate functional characteristics of EMT and stemness acquisition.

45 y organized and well characterized model for stemness analysis.

46 ctive HDAC11 inhibitors that not only target stemness and adherence independent growth of lung cancer

47 ablish intron retention as a hallmark of PCa stemness and aggressiveness.

48 rvasive negative associations between cancer stemness and anticancer immunity.

49 1 elicits epithelial-mesenchymal-transition, stemness and cellular-plasticity.

50 gBFP(High)) exhibited elevated expression of stemness and chemoresistance genes and demonstrated incr

51 3A as a critical regulator of ovarian cancer stemness and cisplatin resistance by inducing the expres

52 f innate immune components that drive cancer stemness and contribute to therapy resistance.

53 suggest an important role for S18-2 in cell stemness and differentiation and potentially also in can

54 ing phosphatidylserine, which controlled AML stemness and differentiation by modulating toll-like rec

55 lays a fundamental role in the regulation of stemness and differentiation of somatic stem cells.

56 The mechanism by which stemness and differentiation signaling emerge in lung ca

57 common target genes involved in trophoblast stemness and differentiation.

58 tally investigated the role of S18-2 in cell stemness and differentiation.

59 veal a role for mTOR in the stabilization of stemness and drug resistance of breast cancer cells and

60 Our results establish that the dichotomy of stemness and effector function underlies the heterogeneo

61 chanisms underlying the relationship between stemness and EMT programs, which may represent therapeut

62 use lung tumor cells, although reduced their stemness and EMT-like features, still formed tumors and

63 rexpressing cells through exacerbating their stemness and epithelial-to-mesenchymal phenotypes and en

64 nderlying molecular mechanisms governing SSC stemness and growth properties remain elusive.

65 -Myb as a pivotal regulator of CD8(+) T cell stemness and highlight its therapeutic potential.

66 oncomitantly displayed CD133-mediated cancer stemness and hybrid epithelial-to-mesenchymal transition

67 Here we demonstrate that stemness and immune evasion are closely intertwined in A

68 tment size at the expense of partial loss in stemness and incomplete differentiation and the activati

69 Genetic inhibition of TAZ reduced stemness and increased differentiation of AML cells both

70 ctional level, and cells displayed decreased stemness and increased drug sensitivity.

71 knockdown of KDM1A using shRNA-reduced GSCs stemness and induced the differentiation.

72 nt Esg-dependent gene repression to maintain stemness and intestinal homeostasis.

73 ggest that these topological changes repress stemness and invasion programs while inducing anti-tumor

74 tional targets mediating its contribution to stemness and malignant features.

75 to better understand how O-GlcNAc influences stemness and may catalyze the discovery of new stem-cell

76 , our results indicate that TBL1XR1 promotes stemness and metastasis in GC, making it a potential pro

77 asis screen, we discovered OTUB2 as a cancer stemness and metastasis-promoting factor that deubiquiti

78 es a long observed genomic alteration to PCa stemness and metastasis.

79 , which collectively contributed to enhanced stemness and metastatic capabilities of HCC cells.

80 anscriptional programs with co-expression of stemness and myeloid priming genes and had prognostic si

81 tral to the establishment and maintenance of stemness and pluripotency, and their altered expression

82 degradation, leading to elevated PCa cancer stemness and poor prognosis.

83 ronment created by myofibroblasts impact the stemness and proliferation of normal ductal epithelial c

84 sion and clinical characteristics related to stemness and quiescence of leukemic cells in acute myelo

85 r regulator of epidermal biology, sustaining stemness and renewal capacity of the proliferating kerat

86 of ECM which increases the levels of cancer stemness and risk of metastatic progression in lung aden

87 filing, we implicate IRF2 as antagonistic to stemness and show that it binds and regulates active cis

88 High levels of OTUD1 inhibit cancer stemness and shut off metastasis.

89 precise mechanism between colorectal cancer stemness and SIRT1 remains to be further clarified.

90 Our findings illuminate mechanisms of cancer stemness and suggest new cancer therapy regimens.

91 ciated transcription factor, in defining the stemness and the aggressive behavior of pancreatic cance

92 our results indicate that it is required for stemness and the preservation of neurogenic potential in

93 cription factor critical for maintaining the stemness and the self-renewal ability of CSCs, resulting

94 am of stromal MAOA, STAT3 also promotes cell stemness and transcriptionally activates expression of c

95 gulation of cyclic AMP signaling involved in stemness and tumor initiation.

96 ls that MBNL1 plays an essential role in GBM stemness and tumor progression, where hypoxic responses

97 tivate pathways in cancer cells that promote stemness and tumor-seeding capacity.

98 ose tissue as a mechanism for promoting TNBC stemness and tumorigenesis during obesity.

99 howing that a high PLD2 expression increased stemness and tumorigenesis.

100 ated in soft tumor cells and regulates their stemness and tumorigenicity.

101 suppressed the growth, invasion, migration, stemness and tumorigenicity.

102 or in combination with gemcitabine decreased stemness and tumorspheres by reducing phosphorylation of

103 cancer cells (PGCCs) acquired embryonic-like stemness and were capable of tumor initiation raised two

104 , including angiogenesis, proliferation, and stemness, and a minor subpopulation (19%) with many over

105 lpha), which is known to promote glycolysis, stemness, and angiogenesis.

106 lthy mitochondria to maintain quiescence and stemness, and becomes increasingly necessary with age to

107 d in cell proliferation, survival, mobility, stemness, and differentiation.

108 tumor growth, survival, evasion, metastasis, stemness, and drug resistance.

109 te the epithelial-to-mesenchymal transition, stemness, and mobile features to enhance tumorigenesis a

110 ls included epithelial-to-mesenchymal (EMT), stemness, and oxidative phosphorylation-enriched gene se

111 r cells has been associated with metastasis, stemness, and resistance to therapy.

112 erentiated cells, resulting in the sustained stemness, and subsequent conversion of miPSCs into CSCs

113 nswered questions: how do PGCCs acquire such stemness, and to which stage of normal development do PG

114 to the putative regulatory elements of many stemness- and cell cycle-related genes.

115 ate that specific factors involved in cancer stemness are critical for metastatic conversion of PCA a

116 ly heterogeneous; they contain a subset with stemness-associated features but lower anabolic metaboli

117 tead upregulate TCF-1 expression and acquire stemness-associated features.

118 Similarly, a stemness-associated gene set identified clones with dive

119 B2IP in ovarian cancer significantly altered stemness-associated genes and bioinformatic analysis rev

120 macroH2A1 increased expression of a panel of stemness-associated genes and drove hyperactivation of t

121 and expression of cell cycle regulators and stemness-associated genes, but inhibits cell fusion and

122 roposed miRNA-TF co-regulation in the cancer stemness axis and its cross talk with the surrounding mi

123 to apoptosis (c-KIT and Bcl2), and enhanced stemness (beta-catenin and Lef1).

124 brogated the CAF-mediated increase of cancer stemness both in coculture experiments and in mice.

125 ide in and rely upon their niche to maintain stemness but must balance self-renewal with the producti

126 SIRT1 signaling regulates colorectal cancer stemness by enhancing expression of CD24, a colorectal c

127 This occurred despite high stemness cancers exhibiting increased mutation load, can

128 and YAP is less consequential in regulating stemness characteristics in these cells.

129 this study was to determine whether EMT and stemness characteristics induced by TGF-beta might be as

130 morphology, display molecular and functional stemness characteristics, and can initiate serially re-t

131 EMT is often related with acquisition of stemness characteristics.

132 activation, govern pluripotency network and stemness circuitry.

133 Here, we show that Zeb1 depletion suppresses stemness, colonization and the phenotypic plasticity of

134 chymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis,

135 study provides a regulation mechanism of PCa stemness controlled by phosphorylation-mediated NANOG st

136 he capacity of DNMTi combination to suppress stemness-dependent chemoresistance development in xenotr

137 lished regulators of both differentiation or stemness depending on their target.

138 Using single-cell assays of HSC quiescence, stemness, differentiation potential, and epigenetic stat

139 ighlights the importance of m(6)A in rRNA in stemness, differentiation, development, and diseases.

140 ng tool to provide or deliver cues to retain stemness, direct differentiation, promote reprogramming,

141 vo expression of MUC5AC promotes cancer cell stemness during Kras-driven pancreatic tumorigenesis and

142 naling toward AKT, not SMAD, which activated stemness/EMT phenotypes.

143 Stemness encompasses the capability of a cell for self-r

144 disseminated cancer cells and promote their stemness, endothelial cell-derived angiocrine signals or

145 hat the tailored scaffolding maintained hMSC stemness, engraftment, and led to robust motosensory imp

146 n NFIB and NFIX are genetically removed, the stemness epigenetic landscape is lost.

147 nctional assays showed that TBL1XR1 promoted stemness, epithelial-mesenchymal transition (EMT), and l

148 dentified ZEB1 binding sites within the LIF (stemness factor) promoter region, and demonstrate LIF re

149 Regulation of the stemness factor, SOX2, by cytokine stimuli controls self

150 pletely understood how autophagy connects to stemness factors and the nature of the microenvironmenta

151 ic colonization, underscoring a key role for stemness factors in outgrowth at secondary sites.

152 Besides activating stemness factors, it also directly represses genes promo

153 rks platinum-tolerant cancer cells harboring stemness features and altered glutathione metabolism tha

154 onophosphate (cAMP) signaling and suppressed stemness features of ovarian cancer cells.

155 tly enhanced expression of genes controlling stemness features.

156 n of EMT characteristics, and loss of cancer stemness features.

157 epithelial-mesenchymal transition (EMT) and stemness features.

158 Finally, tumor cell stemness following FAK inhibition was evaluated with ext

159 r data also revealed that MMP2 regulates SSC stemness gene expression and growth properties through a

160 MP2 is a novel regulatory axis governing SSC stemness gene expression and growth properties, offering

161 , and MMP2 work in concert in regulating SSC stemness gene expression and growth properties.

162 ly upregulated miRNAs, miR-486, controls SSC stemness gene expression and growth properties.

163 el miR-486 target gene in the context of SSC stemness gene regulation and growth properties.

164 RP78(+) breast cancer cells are enriched for stemness genes and appear to be a subset of TICs (5) sGR

165 These results indicate that stemness genes are hubs of interaction between multiple

166 nd found TGLI1 to transcriptionally activate stemness genes CD44, Nanog, Sox2, and OCT4 leading to CS

167 onstrate that this gene is co-expressed with stemness genes in GSCs and that CD276 can be targeted wi

168 from these models identified several cancer stemness genes including CD24, EpCAM, and CD133 upregula

169 ntify three major correlated gene sets, with stemness genes LIN28B/KLF4, WNT5A, and LGALS3 enriched i

170 directly binds to super-enhancers of several stemness genes to regulate pluripotency and self-renewal

171 ce of multiple super enhancers to individual stemness genes within individual cells.

172 drives enhancer activation, upregulation of stemness genes, and maintains the pluripotent circuitry.

173 Conversely, on stemness genes, FOXM1 was absent and SCIRT antagonized E

174 EV-treated ESCs continued to express stemness genes, preserving their pluripotency and abilit

175 2alpha), a transcription factor upstream of "stemness" genes such as Oct4, Sox2, and Nanog.

176 argets were enriched for several cancer cell stemness hallmarks and CSC pre-metastatic niche, which s

177 as a previously unknown strategy to maintain stemness in 3D.

178 We show that elevated biosynthesis defines stemness in both LGR5(+) and LGR5(-) tumor cells.

179 romote epithelial-mesenchymal transition and stemness in breast cancer cells-mechanisms critical to t

180 s biologically to maintenance of neurosphere stemness in conjunction with FOXM1 and EZH2.

181 sion of ICMT results in reduced self-renewal/stemness in KRAS-driven pancreatic and breast cancer cel

182 transition (EMT) programs promote SC and CSC stemness in many epithelial tissues.

183 of TAZ activity reduces or eliminates cancer stemness in select cancers.

184 elps glioma stem cells (GSCs) maintain their stemness in suboptimal environments outside their niches

185 degradability affect the maintenance of NPC stemness in the absence of differentiation factors.

186 structures in the former and maintenance of stemness in the latter.

187 al to understand the molecular regulators of stemness in the quest to develop effective cancer therap

188 temness, yet it is unclear how CSCs maintain stemness in the suboptimal environment outside their nic

189 ed that CCT3 promoted cell proliferation and stemness in vitro, while its suppression inhibited TRCs-

190 tion of the gene signatures associated with 'stemness' in AML and Wnt/beta-catenin, Myc pathways.

191 insights into the epigenetic regulation of 'stemness' in CTC clusters.

192 inhibitor orlistat significantly diminished stemness, in part due to induction of endoplasmic reticu

193 ited signatures of immune evasion, increased stemness, increased calcium signaling, transformation, a

194 phosphorylated proteins in modulating cancer stemness induced by gemcitabine exposure based on PPIs m

195 ng via downregulation of WNT5B, an important stemness inducer.

196 remarkably similar to napabucasin, a cancer stemness inhibitor.

197 neity and the limited efficacy of individual stemness inhibitors in cancer treatment.

198 Cancer stemness is a major challenging phenomenon associated wi

199 metabolism, antioxidant defense, and cancer stemness is also reversed upon CXCR4 and hedgehog inhibi

200 ignancies, reveal that senescence-associated stemness is an unexpected, cell-autonomous feature that

201 Cancer cell stemness is essential for enabling malignant progression

202 Thus, stemness is not only a fundamental process in cancer pro

203 stically, miR-128-3p induces mesenchymal and stemness-like properties through downregulating multiple

204 nctional decline was caused by a decrease in stemness-maintaining Wnt signalling due to production of

205 ng proved to be a generalizable strategy for stemness maintenance in 3D.

206 olecule Jam-C, which plays a central role in stemness maintenance of hematopoietic and spermatogenic

207 tion, tumor growth, and regulation of cancer stemness, makes Lck a potentially important therapeutic

208 unterparts and expressed lower levels of the stemness marker LIN28.

209 , the identified protein could constitute a "stemness marker" of the normal cell and a possible targe

210 Importantly, the detection of CTCs with stemness markers and CTM provides unique insights into t

211 s of epithelial morphology, up-regulation of stemness markers, and impaired differentiation to all th

212 the incidence of metastasis by affecting key stemness markers, as confirmed by co-localization studie

213 The tumor cells that survived exhibited stemness markers, spheroid formation and tumorigenesis i

214 Among these stemness markers, we identified CD24 as a key driver of

215 growth by reducing the expression of cancer stemness markers.

216 stem cells through epigenetic repression of stemness master transcription factors NANOG and OCT4.

217 In cancer cells, a gain of stemness may have profound implications for tumour aggre

218 ithelial-mesenchymal transition, metastasis, stemness, metabolism, and therapy resistance.

219 xpression of master transcription factors of stemness, NANOG and OCT4, specifically in the cancer ste

220 itiated, expression of genes associated with stemness (Nestin, Sox2) was regulated, and thrombin-indu

221 regulation of CD24- and SIRT1-related cancer stemness networks, marking it a potential therapeutic ta

222 This increase in stemness occurs by Wnt pathway activacion.

223 Genetic lineage tracing revealed that the stemness of a bladder cancer stem cell population was in

224 epithelial-mesenchymal transition (EMT) and stemness of breast cancer cells and increased cell migra

225 metabolic switch between differentiation or stemness of cancer may be coupled to the molecular clock

226 formation of spheroids, resulting in reduced stemness of CSCs.

227 keratinocytes, and a gradual decrease in the stemness of hair follicle stem cells, culminating in hai

228 a is sufficient to repress Hh signaling, the stemness of MaSCs, and the tumor-forming potential of Ma

229 Moreover, gemcitabine can promote the stemness of pancreatic cancer cells.

230 The embryonic-like stemness of PGCCs was associated with nuclear accumulati

231 nhibitory effect on the invasiveness and CSC stemness of TNBC cells.

232 uman embryos by controlling self-renewal and stemness of trophoblast progenitors within the placenta

233 impact of a stem cell-like tumor phenotype ("stemness") on the immunological properties of cancer has

234 s any crucial roles in the control of either stemness or differentiation.

235 mour development without compromising tumour stemness or tumorigenicity.

236 ed gene set identified clones with divergent stemness pathway activation within the same tumor.

237 Identification of this stemness pathway as a unique CSC determinant may have si

238 These findings show that the HIF2alpha stemness pathway maintains leukemic stem cells downstrea

239 to the promoter and activating the HIF2alpha stemness pathway.

240 is work demonstrates for the first time that stemness pathways of long-lived memory CD4(+) T cells ca

241 ked to low AR transcriptional activity and a stemness program-were activated in nonresponders.

242 umber alteration patterns or expression of a stemness program.

243 cing expression of CD24, a colorectal cancer stemness promoter.

244 y relative CD34 expression: CD34(High), with stemness properties (genuine state), and CD34(Low), comm

245 R-1185-1-CD24 axis in both colorectal cancer stemness properties and tumorigenesis but provides a pot

246 These stemness properties are either in a causal or consequent

247 ur study uncovers REST in regulating EMT and stemness properties of NE PCa cells and suggests that RE

248 t the major population of CTCs could possess stemness properties to facilitate tumor cell survival an

249 cells and CSCs; its inhibition could disrupt stemness properties, but translation inhibitors are limi

250 rmined set of chemoresistant AML clones with stemness properties, instead favoring the expansion of r

251 d ROS production in vitro which impaired MSC stemness properties.

252 subpopulations versus subpopulations without stemness properties.

253 role of SOCS2 in leukemia aggressiveness and stemness raises the possibility that the signature might

254 tail our current understanding of leukaemic 'stemness' regulation.

255 is is critical for RAS-induced expression of stemness regulators and maintenance of a cancer initiati

256 , and CXCL10, accompanied by enhancement of "stemness"-related transcription factors.

257 We also contemplated CCT3 as a stemness-related gene.

258 cancer cell lines upregulated expression of stemness-related genes and induced conversion of non-CSC

259 alleled by decreased expression of c-Myc and stemness-related genes.

260 spheroids, and expressed increased levels of stemness-related transcription factors compared with par

261 diminishes ALDH(+) subpopulations, decreases stemness-related transcriptional factor expression, and

262 ate that SOD2(K68Ac) and mtROS are linked to stemness reprogramming in breast cancer cells via HIF2al

263 ival (OS) and refined an established 17-gene stemness score.

264 gulation is hypothesized to account for the 'stemness' - self-renewal and pluripotency - shared betwe

265 lar entities and biologics acting on various stemness signaling pathways, surface markers, efflux tra

266 subtypes of CSCs with specific metabolic and stemness signatures.

267 date regulators for targeting hepatic cancer stemness such as, miR-148a, miR-214, E2F family, MYC and

268 sufficient to repress genes associated with stemness, suggesting that the combination of endocrine t

269 deacetylase (HDAC) inhibitor-induced loss of stemness than the BRCA1-deficient cells are.

270 2(K68Ac) turns on a mitochondrial pathway to stemness that depends on HIF2alpha and may be relevant f

271 ow PAWI-2 is a new approach to reverse tumor stemness that resensitizes CSC tumors to drug inhibition

272 ferentiation is central to tissue repair and stemness, this process inherently carries the risk of ca

273 wn to increase distant metastases and cancer stemness through activation of SDF-1/CXCR4 and AP-1 path

274 we utilized a genetic reporter that assesses stemness to enrich and functionally characterize LSCs.

275 core transcriptional drivers of cancer cell stemness to miR-486-5p-dependent modulation of tumor sup

276 thelial cells acquire migratory/invasive and stemness traits upon conversion to the mesenchymal pheno

277 r in vitro with respect to self-replication, stemness traits, and multipotency.

278 d miRNAs in HCSCs as key suppressors for the stemness traits, but still more details are vague about

279 cellular migration, invasion, angiogenesis, stemness, transcriptional activation, and epigenetic pro

280 downregulation, COX-2 overexpression, cancer stemness, tumor growth, and drug resistance.

281 uding key molecules involved in processes of stemness, tumorigenesis and survival, in silico predicti

282 g with previous hepatobiliary metastasis and stemness, unique stromal properties, and dysfunctional i

283 and hypoxia in the regulation of cancer cell stemness using genetically matched breast cancer cell li

284 romoted PDA growth, invasion, migration, and stemness via inhibiting mitochondrial pyruvate metabolis

285 em cells and was critical in maintaining the stemness via interactions with CD98HC, leading to trigge

286 ived prostaglandin E2, which promoted cancer stemness via the EP2/EP4 signaling pathways.

287 Stemness was also strongly associated with cell-intrinsi

288 t of mTOR inhibitors and/or cisplatin on MEC stemness was examined with salisphere assays, flow cytom

289 l influence of telomeres on pluripotency and stemness, we discuss major opportunities for progress in

290 Notch-Jagged signaling in mediating EMT and stemness, we investigated the microenvironmental factors

291 onnection between Notch-Jagged signaling and stemness, we knocked down JAG1 in hybrid E/M SUM149 huma

292 rated to regulate mouse HSC self-renewal and stemness, we screened small molecules targeting various

293 ithelial-to-mesenchymal transition (EMT) and stemness were also observed in NMK-T-057-treated BC cell

294 molecules related with integrin/membrane and stemness were continuously altered by mechanical environ

295 y mechanisms responsible for integrating the stemness with drug resistance remain poorly understood.

296 sed metrics, we evaluated the association of stemness with immune cell infiltration and genomic, tran

297 These results reveal that PRC1 coordinates stemness with immune evasion and neoangiogenesis and poi

298 nt in canonical pathways included HIF1A, FGF/stemness, WNT signaling, interferon signaling and comple

299 tem cells (CSCs), require niches to maintain stemness, yet it is unclear how CSCs maintain stemness i

300 orectal cancer and is associated with cancer stemness, yet the precise mechanism between colorectal c