ライフサイエンスコーパス: step reaction

1 es the formation of NO via a consecutive two-step reaction.

2 activation of acetate to acetyl-CoA in a two-step reaction.

3 2).(diamine)] can be synthesized in a single-step reaction.

4 ep, rather than the previously described two-step reaction.

5 t the second (rearrangement) step of the two-step reaction.

6 t plasminogen is converted to AS4.5 in a two-step reaction.

7 t this mode of chromatin remodeling is a two-step reaction.

8 analog was prepared similarly, but in a two step reaction.

9 reduced to 1-hexadecanol by LiAlH4 in a one-step reaction.

10 ase A2 and were synthesized in a one-pot two-step reaction.

11 to reversible self-cleavage but was a three-step reaction.

12 ing a one-pot hydrothermal method via single-step reaction.

13 targeted agents were obtained through a two-step reaction.

14 -Cryp) was successfully synthesized by a one-step reaction.

15 in contrast to DB-JBP1, which binds in a one-step reaction.

16 sized in high yields on gram scales in a one-step reaction.

17 Binding of gHgL to integrins is a two-step reaction.

18 entrance and the heme group during the three-step reaction.

19 the transformation of AA to LTA(4) in a two-step reaction.

20 erted into the substrate via a consecutive 2-step reaction.

21 difficult, particularly in complicated multi-step reactions.

22 rkflows to be streamlined into rapid, single-step reactions.

23 location as a sequence of coupled hydrolysis-stepping reactions.

24 Using a one-step reaction, a bifunctional compound was synthesized f

25 The one-pot, two-step reaction also worked with electron-rich hydroxy- an

26 peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stabi

27 ycloisomerization becomes a complex multiple-step reaction and proceeds with a rate-determining barri

28 ystals as reaction vessels for complex multi-step reactions and broadening their utility as functiona

29 ins can be more complex than a simple single-step reaction, and that application of several methods c

30 s of parallel and diverse automated multiple step reactions, and evaluating the binding of the crude

31 ield a single-sized nanomolecule in a single-step reaction are unavailable.

32 hereas the discrimination in the overall two-step reaction arises from very weak binding of noncognat

33 were obtained in quantitative yield in a one-step reaction at ambient temperature from the commercial

34 DnaK-peptide complexes according to the two-step reaction, ATP + DnaK-P if ATP-DnaK-P if ATP-DnaK +

35 parallel, large numbers of non-uniform multi-step reactions, because, even without compound purificat

36 DFT calculations revealed that the multiple-step reaction, being endergonic overall, is facilitated

37 be lock coupling, a simple and selective one-step reaction between interfacial lysine and glutamate o

38 f the reaction course indicate a virtual one-step reaction between the NHC and the silanorbornadiene.

39 Protein splicing proceeds through a four-step reaction but the catalytic mechanism is not fully u

40 ediators formed from arachidonic acid in a 2-step reaction catalyzed by 5-lipoxygenase (5-LOX) requir

41 rom soluble Mn(II) to Mn(IV) oxides is a two-step reaction catalyzed by an MCO-containing complex.

42 reaction is a "simple" extension of the two-step reaction catalyzed by MR: base-catalyzed proton abs

43 iflate salt as an additive under one-pot two-step reaction conditions.

44 mical protocols (if available) regarding the steps, reaction conditions, and scale.

45 , indicating that ester production was a two-step reaction consisting of hydrolysis and esterificatio

46 -chlorobenzoyl-coenzyme A formation in a two-step reaction consisting of the adenylation of 4-chlorob

47 red reaction pathway, compared to the single-step reaction, constitute the key advantages of this tan

48 Additionally, BrxU undergoes a multi-step reaction cycle instigated by an unexpected ATP-depe

49 Our efficient two-step reactions enabled high-throughput synthesis of comp

50 In this two-step reaction, first-strand scission is mediated by a nu

51 the behavior of KIEobs for a reversible two-step reaction for all possible values of the rate consta

52 In this Communication, we describe a two-step reaction for preparing three-dimensional electrodes

53 strate availability, we also developed a two-step reaction for the enzymatic synthesis of UDP-l-rhamn

54 Under a new approach, we developed a one step reaction for the interconversion of artemisinin 1 i

55 g intermediate participates in normal second-step reactions, forming spliced exon and linear intron R

56 ing deterrent that can be formed in a single step reaction from 3-dehydroquinate catalyzed by quinate

57 via Wittig-olefination or via a scalable two-step reaction from nopol (10-hydroxymethylene-2-pinene).

58 tegies to achieve naphthyl ketones in single-step reactions from readily available materials is highl

59 The combined two step reaction gave a radiochemical yield of 10-15% (EOB)

60 The overall four-step reaction gave higher yields (57%) than the two-step

61 gens to estrogens through a sequential three-step reaction, generating 19-hydroxy and 19-aldehyde int

62 A mechanism is proposed for the two-step reaction governed by the synthetase, in which His41

63 PASP-IO nanoparticles made by single-step reaction have a core size of 5 nm with a hydrodynam

64 70 complex rapidly binds hsp90 in the second step reaction in a nucleotide-independent manner.

65 Distinct from the one-step reaction in the gas phase, our results show that Cl

66 of highly sulfated keratan sulfate by a two-step reaction in vitro with a mixture of beta3GnT7/beta4

67 ts in tyrosine nitration, catalyzed as a two-step reaction in which nitric-oxide synthase induction i

68 alysis of PCNA opening by RFC revealed a two-step reaction in which RFC binds PCNA before opening PCN

69 Tpt1 performs a two-step reaction in which the 2'-PO(4) attacks NAD(+) to fo

70 This is a two-step reaction in which the enzyme first condenses with G

71 Formation of pyruvate by SDH is a two-step reaction in which the hydroxyl group of serine is c

72 halose biosynthesis in plants involves a two-step reaction in which trehalose-6-phosphate (T6P) is sy

73 onine S-adenosyltransferase) catalyzes a two-step reaction in which tripolyphosphate (PPPi) is a tigh

74 ediate species in total, we map out relevant step reactions in a model size growth reaction from mole

75 channeled current carriers, mediating multi-step reactions in either direction (oxidation or reducti

76 synthetic history-that is, a complete set of step reactions in their synthetic routes.

77 h seven 1,3,5-triazines was studied in a one-step reaction (in situ formation of 3-aminopyrrole) and

78 BP1 binds to J-DNA or glu-5-hmC-DNA in a two-step reaction, in contrast to DB-JBP1, which binds in a

79 tudies demonstrate that PolD catalyzes a two-step reaction, in which AHOAP is first oxidized to 5'-am

80 f class II synthetases and carries out a two-step reaction, in which lysine is activated by being att

81 The advantages of one-pot two-step reactions include operational simplicity, structura

82 xperiments and computations indicate a three-step reaction including isomerization of diazomethane, a

83 y of autodE is demonstrated in complex multi-step reactions, including cobalt- and rhodium-catalyzed

84 tic resonance spectroscopy, with temperature-step reaction initiation, starting from the enzyme-coenz

85 ring progress of the decay after temperature step reaction initiation.

86 sor messenger RNA (pre-mRNA) splicing, a two-step reaction involved in a multitude of RNA structural

87 SAM) donates the methyl group to Hg in a two-step reaction involving a methylcob(III)alamin intermedi

88 ab' fragments was also consistent with a two-step reaction involving fast high-affinity binding and a

89 s the addition of water to epoxides in a two-step reaction involving initial attack of an active site

90 s trinitro-TANG precursor via a one-pot, two-step reaction involving Pd-catalyzed hydrogenation and p

91 slational modification is performed in a two-step reaction involving the addition of a beta-lysine mo

92 Biosynthesis of hypusine is a two-step reaction involving the enzymes deoxyhypusine syntha

93 midation of bioactive peptides through a two-step reaction involving the monooxygenase and lyase doma

94 This two-step reaction is associated to NAD(+) regeneration, esse

95 presence of both catalyst and solvent, a two-step reaction is predicted, corresponding to the stepwis

96 hase (NOS) generates NO via a sequential two-step reaction [l-arginine (l-Arg) --> N-hydroxy-l-argini

97 The elementary step reaction mechanism derived from this comprehensive

98 ld and made it possible to demonstrate a two-step reaction mechanism for des-PPW with K init = 10.4 +

99 d hydrolysis of CH(2)NH follows a unique two-step reaction mechanism involving first proton transfer

100 The data support the proposed four-step reaction mechanism of ACDs, coupling acyl-CoA thioe

101 The two-step reaction mechanism of GH3 proteins provides a poten

102 This two-step reaction mechanism of the widely used Amplex Red, a

103 A five-step reaction mechanism was used to account for the obse

104 inds single-headed myosin VI following a two-step reaction mechanism with formation of a low affinity

105 er the entire temperature range with a three-step reaction mechanism, originally proposed by Ashton e

106 However, kinetic modeling indicated a two-step reaction mechanism, with formation of peroxocarbona

107 sociation of a protein complex follows a two step reaction mechanism, with the first step being the f

108 aBH(4)-sensitive intermediate suggests a two-step reaction mechanism.

109 ng atomic resolution images) reveals a three-step reaction mechanism.

110 However, detailing the progress of multi-step reaction mechanisms from monomeric species to stabl

111 nick, is the rate-limiting step in the multi-step reaction mediated by hNTH1.

112 bed by a single ion-pairing type, with a one-step reaction model independent of the type of cargo, an

113 cient alternative pathway in which the first-step reaction occurs by hydrolysis.

114 spliceosomal and group II introns, the first-step reaction occurs by nucleophilic attack on the 5' sp

115 0 Da poly(propylene fumarate) (PPF) by a two-step reaction of diethyl fumarate and propylene glycol t

116 substituents are synthesized by using a one-step reaction of H(8)BINOL with amino methanols that wer

117 e DFT-level mechanism elucidation of the two-step reaction of non-heteroatom-stabilized carbenes with

118 The one-step reaction of some amino-substituted heterocycles wit

119 One-pot three-step reactions of 50, 51, and 56 provided the desired 3'

120 Resolution of the two-step reactions of AT and AT-Denver with wild-type and mu

121 Resolution of the two-step reactions of AT with the mutant thrombins revealed

122 In the next step, reaction of the sugar-derived (Z)-1-bromo-1-nitroa

123 athway comprising three nucleotidyl transfer steps: reaction of Rtc with ATP to form a covalent Rtc-(

124 s cell is routinely observed to perform side-stepping reactions, one of the most sophisticated maneuv

125 ese redefined modules can be used for single-step reactions or in multistep processes, where modules

126 d carbon dioxide can be produced in a single-step reaction over the catalyst, with no detectable CO (

127 s of ghrelin follows an unprecedented single-step reaction pathway and the single-step acylation proc

128 The single-step reaction pathway for the acylation is remarkably di

129 ab initio free-energy sampling reveals a two-step reaction pathway in which a zwitterion, initially f

130 Mechanistic studies support a two-step reaction pathway involving initial dissociation of

131 s the first time demonstrating that a single-step reaction pathway is possible for an ester hydrolysi

132 population of intermediates along the multi-step reaction pathway of the DASAs without interfering w

133 mechanisms for carbamate formation via a two-step reaction pathway with a zwitterion intermediate und

134 tions provide evidence for an unexpected two-step reaction pathway, which involves dehydrogenative in

135 s an intermediate, shedding light on the two-step reaction pathway.

136 ation process must follow the well-known two-step reaction pathway.

137 ed by changes in the first on rates of a two-step reaction pathway.

138 oselectivity differences thus enabled single-step reaction pathways to an effective collection of dox

139 sition is consistent with a double-well (two-step) reaction potential energy surface, in which the se

140 dual reagents and solvents used during multi-step reaction processes on insoluble polymer matrices),

141 The two-step reaction progress also was monitored in real time b

142 However, the sequential nature of this multi-step reaction renders the mechanism challenging to probe

143 proteins at cysteine residues, but this two-step reaction requires lengthy incubations and produces

144 The proposed derivatization is a one-step reaction, requires no organic solvents, and is safe

145 Polyadenylation of mRNA precursors is a two-step reaction requiring multiple protein factors.

146 midating monooxygenase (PAM) catalyzes a two-step reaction resulting in the C-terminal amidation of p

147 Kinetic studies of the two-step reaction revealed that the variants show a signific

148 en-1-yl phosphonates were prepared in a five-step reaction route from beta-ketophosphonates.

149 fully identified and optimized a novel multi-step reaction route, with up to 40 parameters, that outp

150 e were able to implement 6 independent multi-step reaction routes of up to 5 steps, attempting the sy

151 These observations favor a two-step reaction scheme involving two complete oxidative cy

152 e other as the emitter electrode, a multiple-step reaction scheme was achieved that included consecut

153 ted LiNA-programmed chemistry, including two-step reaction schemes.

154 A three-step reaction sequence has been developed to prepare a v

155 izidine 5,8-epi-indolizidine 223A via a five-step reaction sequence in 32% overall yield.

156 Here we demonstrate a three-step reaction sequence in which a copper complex convert

157 fold diversity has been achieved using a two-step reaction sequence involving allylic substitution an

158 -R species, where R = H or -CH3, using a two-step reaction sequence involving chlorination of H-Si(11

159 7-mer and an 11-mer, were used in the three-step reaction sequence to obtain the sequence-complement

160 An Achmatowicz/Jones/Luche three-step reaction sequence was used to stereoselectively con

161 The seven-step reaction sequence, which generates five bonds and f

162 here carbamyl phosphate is formed in a three-step reaction sequence.

163 t the biaryl bond over the course of the two-step reaction sequence.

164 l isolated yields of up to 62% through a two-step reaction sequence.

165 greement with an ionic mechanism and a three-step reaction sequence.

166 ined in a 6.7% overall yield following an 11-step reaction sequence.

167 ne in good to excellent yields using a three-step reaction sequence.

168 n of 10 to 1 is accomplished through a three-step reaction sequence.

169 NO from L-arginine, NADPH, and O(2) in a two-step reaction sequence.

170 orts to design selective catalysts for multi-step reactions, such as hydrodeoxygenation (HDO), have e

171 Kinetic studies of single-step reactions suggest that following invader binding, b

172 This conserved three-step reaction terminates in a C-C cleavage step that gen

173 -Hydroxybenzoate hydroxylase catalyzes a two-step reaction that demands precise control of solvent ac

174 on a large scale, in high yield using a one-step reaction that employs commercially available reagen

175 Beetle luciferases catalyze a two-step reaction that includes the initial adenylation of t

176 protein synthase III (FabH) catalyzes a two step reaction that initiates the pathway of fatty acid b

177 osphatidylinositol 4,5 bisphosphate in a two step reaction that involves a cyclic intermediate.

178 Then we perform a simple, two-step reaction that produces mRNA capture probes across a

179 enzymes catalyze mechanistically similar two-step reactions that proceed through an enzyme-bound acyl

180 In the two-step reaction, the activated intermediate, bio-5'-AMP, i

181 In a fast, single-step reaction, the monomeric alkoxide precursors permeat

182 in multigram scale in a remarkably easy one-step reaction, this unique NBA building block offers sco

183 In this simple, one-step reaction, three heavy oxygen atoms are transferred

184 imetric analysis results, which show the two-step reaction to be exothermic by -215 kJ mol(-1), in ag

185 yme of the glyoxalase pathway which is a two-step reaction to convert methylglyoxal (MG), an inherent

186 A two-step reaction to convert terminal alkynes into triboryla

187 orming family of enzymes that catalyze a two-step reaction to first activate a carboxylate substrate

188 d 2,3-diaminopropionic acid allows the first step reaction to form an acyl-enzyme intermediate in whi

189 ch using LCA as a template, along with a two-step reaction to generate sodium 3-hydroxyolean-12-en-30

190 5-lipoxygenase (5-LO), which catalyzes a two-step reaction to produce leukotriene A4.

191 rmined that MEPB reacted with H(2)S in a two-step reaction to yield the thioether-linked dimer (MEPB)

192 mines (-NH2), and this allowed for the multi-step reactions to be carried out in tandem within the MO

193 tegies to access this motif involve multiple-step reactions to install the requisite functionalities

194 This one-step reaction tolerates various functional groups and ca

195 ated actin filaments in an apparently single step reaction upon binding, whereas the stabilization by

196 Our single-step reaction uses a recyclable template, cheap starting

197 oups of hyaluronan are biotinylated in a one-step reaction using biotin-hydrazide.

198 ocked by stoichiometric acetylation in a one-step reaction using sulfosuccinimidyl acetate (S-NHSAc)

199 situ formation of 3-aminopyrrole) and a two-step reaction (using the tetraphenylborate salt and an a

200 dic acid is typically synthesized in a three-step reaction utilizing three enzymes: glycerol 3-phosph

201 ntibodies within minutes in a homogenous one-step reaction visible to the naked eye.

202 te kinetics applicable to realistic multiple step reactions, we present here the successful applicati

203 Concerted and two-step reactions were designed to evaluate (+) strand prim

204 rthermore, the competing elements of the two-step reaction where H-removal from the pro-R configurati

205 Tpt1 catalyzes a unique two-step reaction whereby the 2'-PO(4) attacks NAD(+) to for

206 batteries, whose lithiation undergoes a two-step reaction, whereby intercalation and conversion occu

207 hibitor was shown to bind thrombin via a two-step reaction wherein the initially formed thrombin-inhi

208 MAT catalyzes the two-step reaction which synthesizes S-adenosylmethionine (Ad

209 prevented the elucidation of how these multi-step reactions, which require close coordination among m

210 0 kDa) proteins was accomplished in a single-step reaction with a commercially available bis(2,2'-bip

211 ry in optically pure form using a simple one-step reaction with commercially available reagents.

212 They can be additionally modified in a one-step reaction with functional groups for covalent labeli

213 activation of the E. coli enzyme is a single-step reaction with kon = 1.94 x 10(4) M-1 s-1.

214 dues of enzymes with DAP permits their first-step reaction with native substrates, allowing the effic

215 It is a two-step reaction with one purification in between.

216 ther spliceosomal components, performs a two-step reaction with two short RNA oligonucleotides as sub

217 s of complexes 1 and 2 are classified as two-step reactions with an element of reversibility.

218 emical synthesis methods involve long, multi-step reactions with harsh conditions and are not enantio

219 es RNA 2',3' cyclic phosphate ends via three steps: reaction with ATP to form a covalent RtcA-(histid

220 oth DNA substrates occurs by a minimum three-step reaction, with the bimolecular step followed by two

221 The procedure utilizes a simple one-step reaction, with the derivatising agent N-methyl-bis-

222 coccus triterpene synthases, catalyzes a two-step reaction within a single enzyme unit without interm

223 rom major and minor isomer products of a two-step reaction without any purification.