ライフサイエンスコーパス: stepwise

1 omponent and cannot be effectively performed stepwise.

2 ic species, which subsequently rearrange via stepwise [1,3]- or concerted [3,3]-sigmatropic shifts, u

3 isoniazid resistant and during treatment it stepwise accumulated resistance mutations to eight addit

4 is a heterogeneous disease that develops via stepwise accumulation of well-characterized genetic and

5 ssic Eocaecilia, both of which exemplify the stepwise acquisition of apomorphies.

6 n revealed the historical contingency in the stepwise acquisition of genetic perturbations leading to

7 s, the dynamics of active sites and even the stepwise activation barriers were obtained, which would

8 n which the resident macrophages underwent a stepwise activation program.

9 re are still many gaps of knowledge in AR-V7 stepwise activation.

10 into multiple compartments for orchestrating stepwise adult stem cell development and has also provid

11 Increased air velocities and stepwise ageing regime had no effect (P > 0.05) on dry-a

12 A stepwise algorithm incorporating both vasodilators can a

13 of 10,000 adults with diagnosed asthma, the stepwise algorithm resulted in removal of the diagnosis

14 ly associated with survival using a backward stepwise algorithm.

15 to basal heart rates(p<0.01).At multivariate stepwise analysis including age, male gender, paroxysmal

16 associated using multiple linear regression stepwise analysis.

17 ential formation of (4 + 2) products by both stepwise and concerted mechanisms involving regioselecti

18 irions with the host lipid membrane though a stepwise and highly sophisticated process.

19 The biosynthesis of FeMo-co is performed stepwise and involves molecular scaffolds, metallochaper

20 ied chemically or electrochemically, in both stepwise and one-pot manners.

21 gorithm, designated "BBB Score", composed of stepwise and polynomial piecewise functions, is herein p

22 ure of when a S(N)Ar reaction proceeds via a stepwise and when via a concerted mechanism has not yet

23 mpirically supported treatment guidelines, a stepwise approach of pelvic floor physical therapy and c

24 t maintenance therapy in accordance with the stepwise approach to asthma treatment at step 4.

25 reporting of animal research by supporting a stepwise approach to implementation.

26 The stepwise approach to pharmacological treatment in adult

27 tional-level World Health Organization (WHO) Stepwise Approach to Surveillance (STEPS), or other simi

28 In a stepwise approach toward a clinical application, we have

29 In addition to this stepwise approach, we also demonstrate an in situ synthe

30 rs as reference materials were obtained by a stepwise approach.

31 le to affect it, or both, was developed by a stepwise approach.

32 d be more time efficient compared to current stepwise approaches.

33 esses several limitations of the traditional stepwise approaches.

34 onally, IFE differentiation is thought to be stepwise as reflected in sharp boundaries between its ba

35 mer of two different origami structures, and stepwise assembly of purified structures with coiled-coi

36 ifferent from the crystals obtained from the stepwise assembly of the intermediate superstructures.

37 This systematic evaluation includes a stepwise assessment of left ventricular size and functio

38 c time-in-state cohort model that compared a stepwise asthma verification algorithm on the basis of s

39 In patients, both stepwise backward elimination and Bayesian model selecti

40 iable regression model, which was reduced by stepwise backward selection to only keep variables signi

41 strates in which the C-H bond is weak, while stepwise carboxylate oxidation and hydrogen atom transfe

42 the analysis of the step signal because the stepwise change of the particle-by-particle current is p

43 Overall, our results suggest a mechanism of stepwise changes in ESCRT-III filament structure and mec

44 cks into hierarchical architectures or using stepwise chemical processes that sequentially deposit in

45 n is a ring nuclease, whereby bound cA(4) is stepwise cleaved initially to ApApApA>p and subsequently

46 After process optimization, a finely tuned, stepwise click approach has emerged as a workable, on-de

47 analysis, principal component analysis, and stepwise-cluster analysis.

48 xpected selectivities may be observed if the stepwise complex formation constant, K(ILn), is not suff

49 This study presents a novel stepwise concept for comprehensive diagnosis of patholog

50 mined the rate constants associated with the stepwise condensation, thereby providing critical inform

51 826 unique gene-metabolite pairs, but, after stepwise conditional analyses, 90% were dominated by a s

52 Stepwise conditioning identified 67 non-MHC genes, of wh

53 ndicate that the most favorable pathway is a stepwise conjugate addition-Aldol sequence via the dual

54 Combining connectome gradient and stepwise connectivity analysis based on task-free functi

55 This unprecedented stepwise control of dye assembly via hierarchical dipole

56 yntheses of all five dilactone isomers along stepwise, controlled, and high-yielding routes via porph

57 sample with minimal false positives using a stepwise convergent solution.

58 to uncover RNA regulatory strategies during stepwise conversion between pluripotent and rare totipot

59 the CuL(2) fragment subsequently mediates a stepwise Cope rearrangement of the doubly dearomatized i

60 vides a sufficient driving force for facile (stepwise) cycloaddition.

61 ultimately led to the development of a novel stepwise cyclobutane assembly by an allylboration/Zweife

62 Using the new stepwise de novo assembling method presented in the pape

63 icantly among locations, though a consistent stepwise decrease from healthy tissues from healthy colo

64 galactose residues could be interpreted as a stepwise decrease in the migration time.

65 had severe asthma after 3 years; there was a stepwise decrease in the proportion meeting severe asthm

66 Stepwise decreases in hospital and 1-year mortality were

67 of the Y (or W) in large populations or the stepwise degeneration of several small non-recombining s

68 n the yeast nuclear genome combined with the stepwise deterioration of an intracellular virus, which

69 nstitutes a CBH that can only dissociate via stepwise dethreading.

70 The stepwise development of a chromatin-accessible WRKY33-bi

71 tes revealed four subtypes at sequential and stepwise developmental stages.

72 e sensation with a biological basis, using a stepwise discovery, prioritization, validation, and test

73 Then, using a stepwise discovery, prioritization, validation, and test

74 ty criteria and low power, contribute to the stepwise efficacy decline of stroke treatments from expe

75 ed mechanism, while LCuCl and LCuBr follow a stepwise electron transfer-halide transfer pathway.

76 with a speculative conceptual model for the stepwise emergence of betalain pigmentation.

77 MRX-Sae2 catalyzes 5'-DNA end degradation by stepwise endonucleolytic DNA incisions, followed by exon

78 Here, we describe a stepwise engineering approach to generate a set of affin

79 tidylglycerols with longer acyl chains, with stepwise enrichment in premalignant tissues.

80 erate to determine unjamming transitions and stepwise epithelial fluidization towards, ultimately, ce

81 s two sequential acid treatments followed by stepwise ethanol precipitation.

82 duplication of new vertebrate genes with the stepwise evolution of a defining vertebrate novelty.

83 tion genetic events that occurred during the stepwise evolution of invasive S. Typhimurium across Afr

84 resent in ferns and lycophytes, indicating a stepwise evolutionary acquisition of this pathway.

85 AM, focusing on the increasingly predictable stepwise evolutionary integration of anatomy and biochem

86 overcome this barrier and promote release by stepwise exchange of hydrogen bonds.

87 We stepwise exchanged the blood of male Wistar-rats with me

88 The catalysis proceeds through two stepwise excited-state redox events-atypical of the curr

89 heterochromatin establishment relies on the stepwise expression and regulated activity of SUV39H enz

90 osterior sensors, alpha power decreased in a stepwise fashion from 500 ms onward, first from CR to IR

91 immune connective tissue diseases arise in a stepwise fashion from asymptomatic preclinical autoimmun

92 ent used Akaike's information criterion in a stepwise fashion to build logistic regression models, wh

93 istic regression analysis was performed in a stepwise fashion to determine independent predictors of

94 aduated set of recommendations to respond in stepwise fashion to the challenges posed by these condit

95 Thereafter, microglia develop in a stepwise fashion, reaching complete maturity after birth

96 s suggested that mutations are acquired in a stepwise fashion: mutant genes with high variant allele

97 Starting from a set of 2284 genes, stepwise filtering for expression in styles, differentia

98 w that the colonization of the infant gut is stepwise, first mainly by temperate bacteriophages induc

99 ing the solvent polarity, we demonstrate the stepwise folding from partially folded monomeric and dim

100 We apply a stepwise (forward-backward) procedure based on meta-anal

101 Rates of this outcome increased stepwise from 10% among infants without bronchopulmonary

102 s necessitate a long learning curve trough a stepwise fulfillment of difficulties.

103 structural modifications of a bicyclic lead, stepwise gains in spectrum of inhibition were achieved,

104 us to mouse development and follows the same stepwise gene-regulatory program.

105 rican fire using the analytical framework of Stepwise Generalized Equilibrium Feedback Assessment (SG

106 liver transplantation and provide practical stepwise guidance.

107 Such comparative data are generated in a stepwise hierarchical process that begins with extensive

108 Using a stepwise hierarchical selection from each cluster, we id

109 at the reaction starts with the Rh-catalyzed stepwise homo Diels-Alder cyclisation of NBD into its ex

110 We have discovered a stepwise homogeneous catalyst-transfer polymerization to

111 oadband rotational-spectroscopy study on the stepwise hydration of the Gly dimer with up to three wat

112 Surprisingly, not only does stepwise hydration of the RCO(2) (-) anion and the [Ca(2

113 ne phosphatases (HP2P) able to carry out the stepwise hydrolysis of phytate.

114 RV dysfunction increased stepwise in relation to RV chamber size (p = 0.007).

115 Effect of air velocities, stepwise in-bag ageing and ageing time on the oxidative

116 of long-term frozen lean beef produced using stepwise in-bag ageing process suggest potential for the

117 3.2% in non-HBR patients (p < 0.001), with a stepwise increase in bleeding risk corresponding to the

118 We found a stepwise increase in DGAT1 protein levels when comparing

119 orm to rare events with two peaks revealed a stepwise increase in g/V during the second peak.

120 There was a stepwise increase in mortality rates according to stagin

121 There was a stepwise increase in risk with each additional metabolic

122 We found flowering involves a stepwise increase in the expression of FLOWERING LOCUS T

123 ategories of financial hardship, there was a stepwise increase in the prevalence of high financial di

124 We also detect a stepwise increase in transcription as cells transit S ph

125 The hydration history, specified by the stepwise increase in water ratio within lower polarity w

126 s in HACRP penalties did not follow the same stepwise increase, instead exhibiting a marked jump with

127 f trans-1,3-diphenylallyl acetate revealed a stepwise increase/decrease in ee, with the configuration

128 There were stepwise increases in risk of CKD and PAD with higher LD

129 g under natural photoperiods is regulated by stepwise increases in the expression of FT1, which respo

130 mulations and by experiments that sequential stepwise increases in the force constant of the bond bet

131 with a planar lipid bilayer, which produced stepwise increases of ion current across the bilayer.

132 feeding relationships changed in response to stepwise increases of sulfide concentrations in a membra

133 xin minimum inhibitory concentrations showed stepwise increases with the number of PR genes affected

134 c to present, which includes ~50- and 100-Ma stepwise increases, has been interpreted as the result o

135 perties of fibroblasts using a protocol with stepwise increasing and decreasing forces.

136 ffusive state switching can be determined by stepwise increasing the time window of averaging over su

137 mensions into hepatic endoderm spheroids and stepwise into hepatoblast spheroids.

138 Furthermore, we identified a series of stepwise intragenic deletions that occurred at different

139 e igneous provinces can produce the apparent stepwise jumps in the isotopic record when coupled to lo

140 le predictions, including how modulating the stepwise kinetics of the Hsp90 cycle-for example, by var

141 Stepwise linear regression analyses were used to investi

142 Stepwise linear regression was applied to select the mod

143 ee, and eXtreme gradient boosting as well as stepwise linear regression.

144 Stepwise linear regressions were performed to estimate b

145 volutionary TrpA and TrpB intermediates that stepwise link LBCA-TS with ncTS were characterized.

146 Pretest predictors were examined using stepwise logistic regression and assessed for discrimina

147 Multivariate stepwise logistic regression and Cox proportional-hazard

148 Two refined signatures were identified using stepwise logistic regression and internally validated wi

149 Stepwise logistic regression selected four features from

150 Extracted features were analyzed via stepwise logistic regression to distinguish between prod

151 Stepwise logistic regression was performed to select the

152 kers and adverse outcomes using logistic and stepwise logistic regression.

153 e model predicting mortality using backwards stepwise logistic regression.

154 ies were analyzed using chi-square tests and stepwise logistic regression.

155 Stepwise loss of MSH5B and MSH4D following hybridization

156 HSD17B13 rs72613567:TA was associated with stepwise lower levels of plasma ALT of up to 1.3 U/L in

157 iding novel molecular evidence in support of stepwise malignant transition.

158 Cell suspensions were sheared in a stepwise manner (between 0.3 and 5.0 Pa), with each step

159 hazard of disease evolution in an ascending stepwise manner (overall P = .0002).

160 arity, initiated by aPKC, is transduced in a stepwise manner by E-cadherin to the basal layer.

161 ing accurate release of organic cations in a stepwise manner under light irradiation.

162 We show that bone lymphatics develop in a stepwise manner where regional lymphatics grow, breach t

163 II) is stalled by a nonbulky Gh lesion in a stepwise manner, including the initial lesion encounter,

164 Leukaemogenesis often occurs in a stepwise manner, with genetic and epigenetic changes acc

165 including Crumbs2 (CRB2) and delaminate in a stepwise manner; live imaging shows that as one cell del

166 Together, this stepwise mapping to cell fate transitions shows how an i

167 Despite much progress, the stepwise mechanism by which this PLP-dependent enzyme op

168 ity functional theory calculations reveals a stepwise mechanism featuring a rate determining barrier

169 Mechanistic experiments support a stepwise mechanism in which an intermediate ruthenium ni

170 Release of avibactam follows a stepwise mechanism in which the first stage corresponds

171 ty functional theory calculations indicate a stepwise mechanism involving a double bromine addition f

172 In contrast, the latter stepwise mechanism involving Bronsted acid catalysis hin

173 The stepwise mechanism proceeds through singlet carbene inte

174 teomic analysis of patient muscle suggests a stepwise mechanism where first, the integrated stress re

175 n between ozone and trans-isoprene follows a stepwise mechanism, which is quite distinct from our pro

176 ryl fluoride substrate favors a concerted or stepwise mechanism.

177 urface, as demonstrated by an "interrupted" (stepwise) mechanism, is altered in the presence of a cop

178 By a stepwise method to capture all available adverse events,

179 tie together previous findings regarding the stepwise miRNA targeting process from an initial 'screen

180 strict chromatin modulation is archived via stepwise mlonRNA-initiations.

181 ing findings we propose herein a generalized stepwise model for MCD/C5 and PENLs pathogenesis, whereb

182 By assuming a stepwise model to interpret the ITC data, we found that

183 Stepwise modifications of the nanostructured surface wer

184 We use stepwise modulation of the transforming growth factor be

185 e multiple intermediate cellular states with stepwise modulations of transcription factors.

186 This report outlines a stepwise molecular mechanism of NO reduction to form N(2

187 Here we track the stepwise movement of Pf3 coat through YidC by obtaining

188 roximal vesicle pool, while triggering rapid stepwise movements of distal vesicles along the ribbon a

189 Further stepwise multiple regression analysis confirmed the posi

190 Stepwise multivariable Cox regression and logistic regre

191 We used stepwise multivariable regression to create a metabolomi

192 A stepwise multivariate logistic regression revealed low p

193 In a stepwise multivariate regression model, a VDP greater th

194 le isotopes, each synthesized in-house via a stepwise N-monomethylation synthesis strategy using read

195 on: 1) chimeras with swapped ectodomain, 2) stepwise N-terminal truncations, 3) distinct constitutiv

196 The stepwise nature of isoprene ozonolysis on the aqueous su

197 These results reveal a detailed stepwise O-atom transfer dioxygenase mechanism along wit

198 ate the cost-effectiveness of implementing a stepwise objective diagnostic verification algorithm amo

199 The three-level stepwise OFC with peanut butter is safe for patients wit

200 y applied for on-surface synthesis, distinct stepwise on-surface reactions, including alkynyl cyclotr

201 employing electrochemistry, which suggests a stepwise one proton transfer (PT) and two electron trans

202 allow highly complex spectra to be analyzed stepwise, one small section at a time.

203 This study reports a stepwise optimization of switchable liquid-liquid microe

204 incremental prognostic value when modeled in stepwise order of their occurrence in clinical practice

205 tive DNA demethylation involves TET-mediated stepwise oxidation of mC to 5-hydroxymethylcytosine, 5-f

206 hows how this product can be obtained from a stepwise oxidation of SO(2) on TiO(2)(101).

207 ntage of directed evolution, we analyzed the stepwise oxygen-insertion mechanism of tryptophan 2,3-di

208 tional calculations revealed that the common stepwise pathway, which involves the C-H oxidative addit

209 However, this stepwise pattern including the Middle Campanian and end-

210 Whether this stepwise pattern of extinctions occurred locally or glob

211 ssment of cytoplasmic oligomerization, while stepwise photobleaching and single molecule colocalizati

212 Creation of a stepwise plan will allow transplant centers to respond i

213 the ability of one such approach, called the Stepwise Procedure for constructing an Additive and Epis

214 ks sensitive to hippocampal dysfunction is a stepwise process and reflects the gradual maturation of

215 r simulations, here, we uncover a systematic stepwise process driven by the asymmetric flipping-out p

216 op in a field of genetic mutations through a stepwise process of clonal expansion and evolution.

217 We then provide evidence of a stepwise process of symbiont integration, whereby depend

218 In support of a stepwise process regulating biofilm production in mycoba

219 ng-model species, as well as a model for the stepwise process responsible for the origin and evolutio

220 ons described the construction of trust as a stepwise process taking place before, during, and after

221 omatic substitutions (S(N)Ar) reactions is a stepwise process that proceeds via a so-called Meisenhei

222 The OAT step most likely proceeds through a stepwise process with the initial formation of a C(benzy

223 This stepwise process yielded a humanized AAV8 capsid (AAVhum

224 ggest that the reaction does not occur via a stepwise process, leading to the conclusion that C-H act

225 oxidative addition, these reactions involve stepwise processes in which substrate binding to the mai

226 Stepwise processes involving enone conjugate reduction t

227 the IvaP cleavage pattern is consistent with stepwise processing of the N-terminal propeptide, which

228 alized to control stem cell self-renewal and stepwise progeny differentiation.

229 New mouse models recapitulate the stepwise progression of NF1 tumors and will be useful to

230 T cell development involves stepwise progression through defined stages that give ri

231 ulvalene (IF-TTF) unit were synthesized in a stepwise protocol.

232 on among the iron species is accomplished by stepwise proton or electron addition or subtraction, as

233 t into the working details of the underlying stepwise radical pathway for the Co(II)-based C-H aminat

234 igenetic drift, irreversibly accumulate in a stepwise, ratchet-like manner and reduce cellular fitnes

235 , which suggests that separate concerted and stepwise reaction mechanisms are operating, depending up

236 tential energy surface for the concerted and stepwise reactions of tetrafluoroethylene and butadiene

237 The stepwise reactivity of the zwitterion provides new mecha

238 ssembly reveal surprising delays between the stepwise recruitment of ZAP70 and signaling proteins to

239 position plays a key role in controlling the stepwise recruitment, activation, and engagement of prot

240 In the course of the stepwise red-shift induced by more compact, electron-ric

241 nt model of NAFLD, we observed a progressive stepwise reduction in the expression and activity of ure

242 As structural consequence of the stepwise reduction of 1, the central axis of helicene be

243 nted, freely moving male rats (n = 7) during stepwise reduction of the anesthetic desflurane (6%, 4%,

244 The stepwise regression analysis contributed to a metabolomi

245 6 months (r = 0.562; P-Value = 0.01, forward stepwise regression analysis).

246 Using stepwise regression and general linear models that accom

247 tion and reinfection risk, and multivariable stepwise regression identified cytokine ratios associate

248 earning techniques, against more traditional stepwise regression techniques, when developing prognost

249 We used Cox stepwise regression to determine the significant multiva

250 Multivariate backward stepwise regression using Akaike information criterion m

251 e used to build a joint predictive model via stepwise regression, in which the predicted individual s

252 Four modelling techniques (stepwise regression, least absolute shrinkage and select

253 However, in the past decade linear (stepwise) regression methods have been criticized for th

254 were extracted and binary logistic (backward stepwise) regression was performed to identify factors t

255 nslation competence in the cytoplasm through stepwise release of bound assembly factors, and proofrea

256 We comprehensively map the stepwise remodeling of pulmonary arteries in a robust, c

257 It contains three imperfect repeats, and stepwise removal of these repeats slows fibrillation and

258 rther investigation, and we propose a phased stepwise research framework to ensure proper evaluation

259 istant organisms has allowed us to propose a stepwise resolution for the complex mix of concurrent re

260 ensional head displacements characterized by stepwise, saccade-like kinematics.

261 er DELTA-P scores increased the risk of SCLC stepwise (score 0 = 0%, 1 = 18.8%, 2 = 45%, 3 = 55.5%, 4

262 Population-based stepwise screening programmes among people aged 40-69 ye

263 Herein, a stepwise seeded growth method is reported for the synthe

264 Model selection was guided by backward stepwise selection conducted on the model containing all

265 Final models were created with stepwise selection of main effects and interactions and

266 We used a logistic regression model with a stepwise selection procedure to identify baseline and ea

267 Backward stepwise selection procedure was conducted for multivari

268 of the 16 developed models were formed using stepwise selection processes in multivariable analysis.

269 age-specific logistic regression models with stepwise selection to identify significant demographic v

270 y NOTCH1 mutation remained significant after stepwise selection, with a risk of recurrence of 4.5 (HR

271 These observations suggest the stepwise separation of cell identity is temporally coupl

272 Thus, NETosis proceeds by a stepwise sequence of cellular events culminating in the

273 k) and uniform increasing trends in favor of stepwise shifts for explaining increasing complexity.

274 cross-coupling of alpha-haloenones, but this stepwise strategy requires prefunctionalized substrates

275 ic epidermis and is required for its orderly stepwise stratification.

276 The stepwise stwintronisation mechanism may involve duplicat

277 an aluminosilicate nanoclay, halloysite, by stepwise surface modification, including an innovative s

278 gression to advanced AMD was evaluated using stepwise survival analysis.

279 c frameworks (COFs) have been developed by a stepwise synthesis strategy.

280 , and sometimes low yields using traditional stepwise synthetic methods.

281 ately predict AML development and identifies stepwise transcriptomic perturbations that drive leukemi

282 , Stepwise Transection and Sutures (SU), and Stepwise Transection and Glue (STG).

283 ection (ST), Simple Transection & Glue (TG), Stepwise Transection and Sutures (SU), and Stepwise Tran

284 gy, charged intermediates resulting from the stepwise transfer of protons and electrons.

285 In the individual nanoparticle stepwise transients, low-pass filters maintain the step

286 Hence, stepwise transition of Pol II occurs when mammalian life

287 In this process, Ca(2+) binding induces a stepwise transition of the catalytic subunit cavity, con

288 This stepwise transitioning of Grp94's dynamic properties may

289 o its development in fallopian tubes through stepwise tumor progression.

290 ations suggest that these complexes form via stepwise two-electron reductions of three CO molecules,

291 atural product framework without recourse to stepwise Ullmann- and Suzuki-type couplings.

292 otein from the hexon cavity during entry and stepwise uncoating.

293 ) O(2) and (1) O(2) in cancer cells increase stepwise under a programmed alternating magnetic field.

294 In this report, a stepwise unfolding of bovine serum albumin (BSA) with gu

295 ECVS was fundamental to stepwise vagal denervation validation during cardioneuro

296 We find stepwise variations of Z-linked inversions, repeat and g

297 ethered lipid vesicles, the data demonstrate stepwise vesicle disruption and asymmetric membrane defo

298 The event rate increased stepwise with both higher CAC scores and number of vesse

299 ounds produces ketenes by both concerted and stepwise Wolff rearrangements.

300 dystonia-causing genes were prioritised in a stepwise workflow.