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1 and targeting of the protein to the tips of stereocilia.
2 ing on tip-link proteins connecting adjacent stereocilia.
3 mechanosensitive hair bundles formed by the stereocilia.
4 ibrations measured near the mechanosensitive stereocilia.
5 led protein and EGFP-beta-actin into nascent stereocilia.
6 is dispensable for the initial formation of stereocilia.
7 hat sets a blueprint for the location of the stereocilia.
8 le and also to cochlear hair cell nuclei and stereocilia.
9 tein cargos within developing mechanosensory stereocilia.
10 undle's rootlets from the actin cores of the stereocilia.
11 uperfamily, also immunolocalizd to hair cell stereocilia.
12 USH1G and PCDH15 may form another complex in stereocilia.
13 s to the cytoskeleton in immature and mature stereocilia.
14 let structure for anchoring the tip links of stereocilia.
15 0%) is accompanied by the loss and fusion of stereocilia.
16 chanically gated ion channels at the tips of stereocilia.
17 progressive degeneration of outer hair cell stereocilia.
18 d heights, the short, middle-sized, and tall stereocilia.
19 the actin cytoskeleton dynamics of hair cell stereocilia.
20 sduction (MET) channels at tips of hair-cell stereocilia.
21 cellular structures, such as the nucleus and stereocilia.
22 influencing the ionic environment around the stereocilia.
23 progressive degeneration of outer hair cells stereocilia.
24 nd possibly for the continued maintenance of stereocilia.
25 ice develop abnormalities in inner hair cell stereocilia.
26 tributing to the coordinated displacement of stereocilia.
27 Myo7a motors and coordinate force sensing in stereocilia.
28 y the tension of 'tip links' interconnecting stereocilia.
29 ent damage to some surviving outer hair cell stereocilia.
30 ical membrane forms appropriately around the stereocilia.
31 or the growth and function of microvilli and stereocilia.
32 springs, the tip links, connecting adjacent stereocilia.
33 YO3A cargo protein endogenously expressed in stereocilia [2], MYO3B targets and carries ESPN1 to COS7
34 e results in the fusion of the hair bundle's stereocilia, a resorption of the parallel actin bundles
36 Altogether, the data support a model whereby stereocilia actin cores are largely static, with dynamic
37 ively, our analyses support a model in which stereocilia actin cores are stable structures that incor
38 ese models, we perform an unbiased survey of stereocilia actin dynamics in more than 500 utricle hair
41 otransducer (MT) channels at the tips of the stereocilia, activated by tension in interciliary tip li
44 posed of several rows of regularly organized stereocilia and a kinocilium, is essential for mechanotr
47 links that interconnect the mechanosensitive stereocilia and convey force to the transduction channel
48 s tip links that interconnect mechanosensory stereocilia and convey force to yet unidentified transdu
50 earing and the transduction mechanism in the stereocilia and for melanosome transport in the retina,
51 chlear hair cells revealed loss of some tall stereocilia and gaps in the v-shaped bundle, although ti
54 rminal differentiation manifests as immature stereocilia and kinocilia on the apical surface of hair
57 and adaptor proteins: Myo7a/SANS/Harmonin in stereocilia and Myo7b/ANKS4B/Harmonin in microvilli.
58 s; they unexpectedly limit the elongation of stereocilia and of subsequently regressing microvilli, t
60 erminal domain traffics to these specialized stereocilia and prevents disassembly of their actin core
61 s elongations and fusions of inner hair cell stereocilia and progressive degeneration of outer hair c
62 th shortening and fusion of inner hair cells stereocilia and progressive degeneration of outer hair c
64 lls (IHCs), began to lose their third row of stereocilia and showed a reduction in the size of the me
68 s such as the side surfaces of the hair cell stereocilia and the intercalated disks of isolated cardi
69 a stiffness and the gap size between the IHC stereocilia and the tectorial membrane determine the cha
70 proximately 200 nm nanodomain at the tips of stereocilia and this localization requires the presence
71 ate between functionally distinct classes of stereocilia, and are independently required to assemble
72 easure mechanical properties of nodal cilia, stereocilia, and motile cilia-anatomically similar struc
73 ansduction channel is expressed in hair cell stereocilia, and previous studies show that its activity
74 the nine Usher-associated genes have splayed stereocilia, and some show delayed maturation of ribbon
75 uired for long-term maintenance of hair cell stereocilia, and that its dysfunction causes hearing los
76 rs, which are fibrous links joining adjacent stereocilia, and the TM-attachment crowns coupling the t
77 e coat at the upper but not lower regions of stereocilia, and they develop progressive hearing loss.
78 d GPR98 have been reported to form hair cell stereocilia ankle-links, harmonin localizes to the stere
79 l-autonomous role of pejvakin in maintaining stereocilia architecture that is critical for hair cell
82 In developing and mature sensory hair cells, stereocilia are connected to each other by various types
87 Extracellular tip links that interconnect stereocilia are thought to gate mechanosensitive channel
89 the tectorial membrane is detached from OHC stereocilia, arguing that the tuning of radial vibration
90 try to show that PDZD7 is expressed in chick stereocilia at a comparable molecular abundance to GPR98
91 o a highly dissipative serial arrangement of stereocilia at distortion frequencies, precluding their
94 ed an inner hair-cell and an outer hair-cell stereocilia bundle and simulated the effect of probe sti
96 ng frequency, the active motility of the IHC stereocilia bundle reduced the power dissipation in the
98 nated by the viscous friction around the IHC stereocilia bundle--the IHC stereocilia increased the ST
102 ack of PDZD7 leads to the disorganization of stereocilia bundles and a reduction in mechanotransducti
105 we report a design approach inspired by the stereocilia bundles of a cochlea that uses a hierarchica
106 t the ectopic hair cells display specialized stereocilia bundles similar to endogenous hair cells.
107 numerous microvilli or stereocilia, ungraded stereocilia bundles, and bundle rounding and closure.
110 HCN2 protein is immunolocalized to hair-cell stereocilia by both z-stack confocal and pre-embedding E
111 ultrastructural alterations of the hair cell stereocilia by mirroring them on the tectorial membrane.
112 w HCs resided in the outer HC region, formed stereocilia, contained mechanoelectrical transduction ch
113 e arrays of mechanosensitive microvilli-like stereocilia crowning the auditory hair cells, is essenti
115 lved in anchoring these diverse links to the stereocilia dense actin cytoskeleton remain largely unkn
118 chleas, we demonstrated that inner hair cell stereocilia developed in specific stages, where a wideni
119 a potential role in endosomal recycling and stereocilia development/maintenance, and the basolateral
120 addition of new actin filaments to increase stereocilia diameter, and coordinate stereocilia height
121 at Atoh1 plays a crucial role to initiate HC stereocilia differentiation independently of HC viabilit
123 d pressure levels, often it takes >500 nm of stereocilia displacement to saturate hair-cell mechano-t
124 iously showed that GPSM2-GNAI is enriched at stereocilia distal tips and required for their postnatal
127 finding associates Elmod3 deficiencies with stereocilia dysmorphologies and reveals that they might
128 finding connecting ELMOD1 deficiencies with stereocilia dysmorphologies thus establishes a link betw
131 mouse orthologue of GPSM2 affects actin-rich stereocilia elongation in auditory and vestibular hair c
132 8 is essential for the initial elongation of stereocilia, Eps8L2 is required for their maintenance in
133 how that PKHD1L1 is expressed at the tips of stereocilia, especially in the high-frequency regions of
134 the tectorial membrane stimulates hair-cell stereocilia evenly, probes deflect stereocilia unevenly.
137 vident in overt force sensors at the tips of stereocilia for vertebrate hearing and the touch recepto
138 actin-associated proteins are essential for stereocilia formation and maintenance, and their absence
139 only in apical regions, but abnormalities of stereocilia formation were present throughout the cochle
141 By quantifying actin-core dimensions of stereocilia from phalloidin-labeled mouse cochleas, we d
142 bute to stereocilia adhesion or protect from stereocilia fusion, but its molecular identity remains u
144 hair cells depends on the deflection of the stereocilia hair bundle which opens mechano-electric tra
147 kidney and intestinal microvilli, inner ear stereocilia, immune synapses, endocytic patches, adhesio
150 lizes to the tips of the shorter transducing stereocilia in both inner and outer hair cells (IHCs and
152 the rootlet component TRIOBP at the base of stereocilia in injectoporated hair cells, a pattern that
154 protein, is present at the tips of the tall stereocilia in mature hair cells, together with PCDH15 i
160 subunits, and is targeted to the tips of the stereocilia in the sensory hair bundle, where the MET ch
161 lea, involves the anchoring of their tallest stereocilia in the tectorial membrane (TM), an acellular
164 ation in the STS because of the presence IHC stereocilia increased as the stimulating frequency decre
165 n around the IHC stereocilia bundle--the IHC stereocilia increased the STS power dissipation by 50- t
167 volved in limiting the growth of transducing stereocilia.Inner ear hair cells detect sound through de
169 The precise assembly of inner ear hair cell stereocilia into rows of increasing height is critical f
170 orption of the parallel actin bundles of the stereocilia into the cytoplasm of the hair cell, a detac
172 ology; the sequence of structural changes in stereocilia is known, and a modest number of proteins ma
173 Because dimension control of the inner ear's stereocilia is particularly precise, we studied the CAPZ
174 the most abundant actin-bundling proteins of stereocilia is plastin 1, but its function has never bee
175 The height and width of these actin-based stereocilia is tightly regulated throughout life to esta
176 ike (ESPNL), primarily present in developing stereocilia, is also a myosin-III cargo and is essential
180 ly, MYO3A and MYO3B, are thought to regulate stereocilia length by transporting cargos that control a
185 ack transduction, have significantly altered stereocilia lengths and diameters, including a narrowed
189 s (myo7a, calretinin, parvalbumin, myo6) and stereocilia-like structures expressing F-actin and espin
190 ize simultaneously immuno-gold particles and stereocilia links, both of only a few nanometers in diam
191 y rootlets in hair cells and is required for stereocilia maintenance and mechanosensory function of t
194 rimental evidence for the dynamic control of stereocilia morphology by the mechanotransduction curren
195 s believed to provide a rigid foundation for stereocilia motion, but specifics about its function, es
199 ls are gated by tip links, which connect the stereocilia of a hair cell in the direction of their mec
201 dle protein that is localized at the tips of stereocilia of both cochlear and vestibular hair cells.
205 ein localizes to the plasma membranes of the stereocilia of inner and outer hair cells of the inner e
206 ice, CIB2 is localized to the mechanosensory stereocilia of inner ear hair cells and to retinal photo
207 notransducer channels at the tips of sensory stereocilia of inner ear hair cells are gated by the ten
208 in Pls1 KO, but in young adult animals, the stereocilia of inner hair cells were reduced in width an
214 with immunolocalization of CNGA3 protein to stereocilia of teleost vestibular and mammalian cochlear
215 transduction process occurs in the hair-cell stereocilia of the inner ear, which experience continuou
216 nnels have been localized to tips of shorter stereocilia of the mechanically sensitive hair bundle, l
221 cing, increases protein expression, improves stereocilia organization in the cochlea, and rescues coc
222 In addition, mechanotransducing shorter row stereocilia overgrow in hair cell bundles of both Cib2 m
225 Moreover, widening of the second-tallest stereocilia rank (row 2) occurred simultaneously with th
226 ike filopodia, lamellipodia, microvilli, and stereocilia requires the coordinated activity of many pr
227 g the amount of free PIP2 in inner hair-cell stereocilia resulted in the following: (1) the loss of a
228 hair cells, the hair bundle, is composed of stereocilia rows of graded height, a property essential
235 cellular processes, including maintenance of stereocilia structure, endocytosis, and autophagosome ma
237 es on auditory sensory cells are composed of stereocilia that grow in rows of decreasing height.
238 air cells detect sound through deflection of stereocilia that harbor mechanically-gated channels.
240 ighly organized compartment near the base of stereocilia that is critical for hair cell function and
242 s expressed in the cell bodies and along the stereocilia that project from the cells' apical surface.
243 air cells detect sound through deflection of stereocilia, the microvilli-like projections that are ar
245 y indicates the mechanical stimulus to their stereocilia, the present results suggest that distinct l
246 escently tagged TMCs localize to the tips of stereocilia, the site of the transduction channels.
247 tructures that stimulate the outer hair cell stereocilia, the tectorial membrane and reticular lamina
248 n acellular accessory structure close to the stereocilia, the tectorial membrane, had much higher Ca(
250 ent mice lose their second and third rows of stereocilia, their mechanoelectrical transducer current,
255 P3, and showed weak labelling at P6 with no stereocilia tip labelling, increasing at P9, with specif
258 GA3 specifically to the carboxyl terminus of stereocilia tip-link protein CDH23 +68 (cadherin 23 with
260 100 copies per stereocilium, concentrated at stereocilia tips as hair cell development progressed, si
261 e, we show that BAIAP2L2 localization to the stereocilia tips depends on the motor protein MYO15A and
263 We demonstrate that BAIAP2L2 localization to stereocilia tips is dependent on the motor protein MYO15
265 ng actin, which outside of a small region at stereocilia tips turns over with a very slow, months-lon
266 actively balanced between the bare zone and stereocilia tips, suggesting that early planar asymmetry
267 tion channels are located in the membrane of stereocilia tips, where the base of the tip link is atta
277 and tetraspan membrane protein of hair cell stereocilia (TMHS, also known as lipoma HMGIC fusion par
278 which is consistent with the failure of OHC stereocilia to maintain stable interactions with the tec
280 It might be that only certain components of stereocilia turn over quickly, that rapid turnover occur
282 e abnormally tall and numerous microvilli or stereocilia, ungraded stereocilia bundles, and bundle ro
283 cilia ankle-links, harmonin localizes to the stereocilia upper tip-link density and whirlin localizes
285 y linked to myosin VI at the tapered base of stereocilia, was maldistributed along the cell membrane.
286 hough tip links and staircase arrangement of stereocilia were not primarily affected by Clrn1(-/-) mu
287 in neonatal mice, in vivo and in vitro, the stereocilia were remarkably stable, incorporating newly
289 ells tightly control the dimensions of their stereocilia, which are actin-rich protrusions with grade
290 n tightly controlled numbers of actin-filled stereocilia, which are arranged in defined rows of preci
293 suggest that capping protein participates in stereocilia widening by preventing newly elongating acti
294 ter shortened and disappeared; surprisingly, stereocilia width decreased concomitantly with length.
298 n-binding protein espin causes elongation of stereocilia within 12-24 hours, also suggesting rapid re