ライフサイエンスコーパス: stereogenic center

1 similar, but differ only with regard to one stereogenic center.

2 inversion of absolute configuration at C(5) stereogenic center.

3 l moiety and bears a tert-butyl group at the stereogenic center.

4 pyran products containing a tetrasubstituted stereogenic center.

5 th full stereocontrol of the newly generated stereogenic center.

6 acks a cyclopropane but retains a quaternary stereogenic center.

7 in good yields without epimerization at the stereogenic center.

8 employ asymmetric catalysis to introduce the stereogenic center.

9 the reaction generates an additional carbon stereogenic center.

10 distinct transition structures owing to the stereogenic center.

11 that bear an N-substituted quaternary carbon stereogenic center.

12 s bearing an N-substituted quaternary carbon stereogenic center.

13 olute stereochemistry of the C-10 quaternary stereogenic center.

14 te combinations that result in more than one stereogenic center.

15 tiary alcohol moiety and set the C-2' methyl stereogenic center.

16 absolute configuration at the alpha-methoxy stereogenic center.

17 ansformation leads to the formation of a new stereogenic center.

18 tituted alkenes to generate arenes with beta-stereogenic centers.

19 enzofuran and indene, each generating 12 new stereogenic centers.

20 ontrolled formation of two new bonds and two stereogenic centers.

21 azabicycle, two N,O-acetal linkages, and six stereogenic centers.

22 ed drug-like properties and incorporates two stereogenic centers.

23 d isochroman products with fully substituted stereogenic centers.

24 tituted alkenes, affording quaternary carbon stereogenic centers.

25 delity at the alkyl halide and ether bearing stereogenic centers.

26 allows for full control over the two vicinal stereogenic centers.

27 boxylates to give products with two or three stereogenic centers.

28 pirocyclic compounds in controlling multiple stereogenic centers.

29 ihydropyran frameworks with three contiguous stereogenic centers.

30 the synthesis of carbon chains that bear 1,5-stereogenic centers.

31 ne- and hydroxyl-substituted tertiary carbon stereogenic centers.

32 hains bearing multiple contiguous quaternary stereogenic centers.

33 alized tetracyclic core and introduces three stereogenic centers.

34 chains adjacent to nitrogen and up to three stereogenic centers.

35 -cyclopentaneoxindoles with four consecutive stereogenic centers.

36 cular complexity and formation of quaternary stereogenic centers.

37 forming process, which generates two vicinal stereogenic centers.

38 stall the desired stereochemistry at the key stereogenic centers.

39 ar Michael addition reaction to form two new stereogenic centers.

40 odology for the generation of vicinal alkane stereogenic centers.

41 chloroazetidines containing three contiguous stereogenic centers.

42 carbo- and heterocycles that contain two new stereogenic centers.

43 gree of structural complexity and up to five stereogenic centers.

44 eoselective construction of three contiguous stereogenic centers.

45 ent diastereoselective introduction of other stereogenic centers.

46 the same time the control of an array of new stereogenic centers.

47 ore, which necessitated an inversion at both stereogenic centers.

48 ounds containing a pyrrolidine ring with two stereogenic centers.

49 nce of numerous methyl- and hydroxyl-bearing stereogenic centers.

50 action to form lactam products with multiple stereogenic centers.

51 ylic acids containing tertiary or quaternary stereogenic centers.

52 the iterative installation of the requisite stereogenic centers.

53 nner to afford products with up to three new stereogenic centers.

54 es two new carbon-carbon bonds at contiguous stereogenic centers.

55 able assignment of absolute configuration of stereogenic centers.

56 nno-series and provides derivatives with new stereogenic centers.

57 ized core, possessing a series of contiguous stereogenic centers.

58 ereoisomers of a given product with multiple stereogenic centers.

59 ssing several functional groups and multiple stereogenic centers.

60 and (S)-propylene oxide as the source of the stereogenic centers.

61 rbon bonds and all the associated quaternary stereogenic centers.

62 ity from a trivial acyclic substrate with no stereogenic centers.

63 rt concomitant stereocontrol over additional stereogenic centers.

64 carbon-carbon bonds, two new rings, and 3-7 stereogenic centers.

65 h with and without appended ring systems and stereogenic centers, (3) that several other unique chemo

66 Because of the preexisting phosphorus stereogenic center, a mixture of two diastereomers of th

67 ation sequence to install the C(1) and C(13) stereogenic centers, a Petasis-Ferrier union/rearrangeme

68 lylboronate reagent that contains an allylic stereogenic center, additions were exceptionally alpha-s

69 ut any epimerization of the acid/base labile stereogenic center adjacent to the nitro group on the pi

70 troduction of a pseudoaxial substituent at a stereogenic center adjacent to the nitrogen atom in bina

71 These chiral scaffolds contain three stereogenic centers along with orthogonally protected fu

72 ix- or seven-membered cyclic amines having a stereogenic center alpha to nitrogen.

73 from the chiral oxazoline moiety, where the stereogenic center alpha to the oxazoline oxygen atom is

74 etric Mannich reaction to build a quaternary stereogenic center and a rapid cationic Au-catalyzed cyc

75 ohols containing a vicinal quaternary carbon stereogenic center and a versatile alkenylboronic ester

76 ition across conjugated enynes can produce a stereogenic center and an axially chiral allene simultan

77 ary stereochemistries at the newly generated stereogenic center and axially chiral allene.

78 resulted in the creation of the C18 carbinol stereogenic center and chain elongation.

79 used to establish the all-carbon quaternary stereogenic center and the tetracyclic structure of the

80 eso 1,2-diols to furnish products with three stereogenic centers and a terminal alkyne group in one o

81 al beta-tertiary and gamma-quaternary carbon stereogenic centers and an alkenylboron moiety.

82 Products contain two contiguous stereogenic centers and are obtained in up to 91% yield,

83 with concomitant creation of at least three stereogenic centers and complete diastereocontrol.

84 skeleton with simultaneous generation of new stereogenic centers and expansion of the internal cavity

85 y controlled introduction of four quaternary stereogenic centers and guided the assembly of four cycl

86 6H-benzo[c]chromenones with four consecutive stereogenic centers and high enantioselectivity (up to >

87 r the synthesis of acyclic quaternary carbon stereogenic centers and it represents the first example

88 d the synthesis of acyclic quaternary carbon stereogenic centers and provides the first example of th

89 substituted heterocycles that contain three stereogenic centers and up to four fused rings can be ac

90 n of sp(3) -hybridized carbons and number of stereogenic centers) and diverse (as assessed by Tanimot

91 lation protocol is utilized to create the C4 stereogenic center, and regioselective hydrozirconation/

92 Two rings, three stereogenic centers, and a new double bond were generate

93 ), no erosion in optical purity for proximal stereogenic centers, and a tolerance for unprotected alc

94 the production of two new C-C bonds, two new stereogenic centers, and one quaternary carbon center in

95 two new carbon-carbon sigma-bonds, three new stereogenic centers, and two new rings, albeit with the

96 Stereogenic centers are created by functionalizing proch

97 In this process, three new bonds and two new stereogenic centers are created in a single-pot operatio

98 1,2-addition to alkenes, where two adjacent stereogenic centers are created, 1,4-addition across con

99 hiral perylenequinones absent any additional stereogenic centers are described.

100 ntaining boron-substituted quaternary carbon stereogenic centers are disclosed.

101 t enantiopure examples containing quaternary stereogenic centers are extremely rare.

102 ophiles and lead to products having tertiary stereogenic centers are followed by an exceptionally ste

103 tive [4+2] cycloaddition, in which three new stereogenic centers are formed.

104 Arenes with beta-stereogenic centers are important substructures in pharm

105 Cyclobutanones with two stereogenic centers are obtained in good to high yield,

106 B-substituted tertiary or quaternary carbon stereogenic centers are presented.

107 an alpha-halo-substituted quaternary carbon stereogenic center as well as an assortment of 2,2-disub

108 tropyrazolidines containing three continuous stereogenic centers as a single diastereomer in up to 99

109 superior stereocontrol over the C-4 and C-15 stereogenic centers as well as allowing for more functio

110 d the bicyclic products, which possess three stereogenic centers, as single diastereoisomers in high

111 Medicines with a stereogenic center (asymmetric carbon) are mainly presen

112 n solution inversion of configuration of the stereogenic center at C(2) via "the N(1)-C(2) bond cleav

113 tric transfer hydrogenation to establish the stereogenic center at C-1.

114 ng construction of the all-carbon quaternary stereogenic center at C-2 via a thermodynamic aldol reac

115 tereoselective aldol reaction to control the stereogenic center at C13, and a stereocontrolled reduct

116 stereocontrolled reduction to introduce the stereogenic center at C15.

117 addition catalyzed by BphI, the S-configured stereogenic center at C4 is created via attack of a pyru

118 this work suggest that in the presence of a stereogenic center at isoxazolidine C-4', the formation

119 by observed NOE interactions with the known stereogenic center at the 5-position.

120 The absolute configuration of the carbon stereogenic center at the aminal moiety is thermodynamic

121 branched allylic ester to set the quaternary stereogenic center at the core of the spiroimine ring sy

122 ereocontrol in the formation of a quaternary stereogenic center at the ring fusion.

123 rd 1,4-dienes containing a quaternary carbon stereogenic center at their C-3 site, are disclosed.

124 s and constant absolute configuration of the stereogenic centers at all of the peripheral chains (com

125 rongly dependent on the configuration of the stereogenic centers at C-20 and C-22.

126 dies for the final structure assignment, the stereogenic centers at the tetrahydropyran moiety of (+)

127 regard to the absolute configuration of the stereogenic center bearing the secondary hydroxyl group.

128 ey new functionalities, including quaternary stereogenic centers bearing moieties such as fluorine an

129 form products containing allylic quaternary stereogenic centers bearing N.

130 OPEs decreases upon increasing the number of stereogenic centers, being totally canceled for compound

131 der [4 + 2] cycloaddition, in which a single stereogenic center between the diene and the dienophile

132 Moreover, the replacement of one Calpha-stereogenic center by a nitrogen atom results in a signi

133 d anisochronous even when separated from the stereogenic center by up to 24 bonds (in 20c).

134 ropyl-fused pyrrolidine, which contains four stereogenic centers, by employing the N-O tethered carbe

135 c acid A, containing two remotely positioned stereogenic centers, by sequential use of two different

136 yclopentenone ring was key, generating a new stereogenic center (C-2 in 1a).

137 Nine propargylic acetates, bearing a stereogenic center (-C*HXR(2)) adjacent to the electroph

138 Tertiary propargylic cations with a stereogenic center (-C*HXR(2)) in the alpha position wer

139 Highly functionalized amines with multiple stereogenic centers can be efficiently accessed via the

140 ched pyrrolidine products, which contain two stereogenic centers, can undergo rearrangement to yield

141 c methylene group in the alpha-position to a stereogenic center (-CHMeX), and with four chiral cyclic

142 ates the relative configuration of the three stereogenic centers comprised of the branchpoint and of

143 In all cases, a quaternary stereogenic center could be perfectly assembled, with a

144 somers of the product bearing two contiguous stereogenic centers could be accessed by changing the co

145 ium complex to form products with contiguous stereogenic centers derived from the nucleophile and ele

146 l products containing remote, methyl-bearing stereogenic centers [e.g., (R)-tuberculostearic acid], w

147 When the diene contains an additional stereogenic center, effective kinetic resolution can be

148 c epoxy alcohols with up to three contiguous stereogenic centers, enabling the rapid construction of

149 ayed by both enzymes, which ensures that the stereogenic center established by the transaminase is no

150 es at C(8) and C(9) allows assignment of all stereogenic centers (except C(3)) in this unusual tetrah

151 to five-membered carbocycles with all-carbon stereogenic centers following a sequence of iodonium act

152 g the formation of beta-lactones bearing two stereogenic centers from achiral aldehydes (both aromati

153 of halocyclopropyl alcohols with up to four stereogenic centers from achiral starting materials.

154 alpha-amino acid derivatives containing two stereogenic centers from readily accessible N,N-disubsti

155 x molecular architecture with at least three stereogenic centers from relatively simple, achiral prec

156 ts bearing aryl-substituted tertiary allylic stereogenic centers from simple, stable starting materia

157 r the formation of beta-lactones bearing two stereogenic centers, from disubstituted ketenes and achi

158 ctive synthesis of beta-lactones bearing two stereogenic centers, from disubstituted ketenes and alph

159 The products contain three new contiguous stereogenic centers, generated with a high level of ster

160 s reveals a complete inversion of the carbon stereogenic center giving a single diastereomer.

161 ed nucleophiles without epimerization of the stereogenic center, giving access to a wide range of 1,2

162 THIQ (+)-1f revealed that the newly created stereogenic center had an absolute S configuration.

163 omplex and easily transformable group at the stereogenic center has been developed via a tandem thio-

164 cts bearing an allylic all-carbon quaternary stereogenic center has been developed.

165 ring either a quaternary or a tertiary alpha-stereogenic center has been investigated in detail.

166 oach complex architectures containing (multi)stereogenic centers has been a long-standing synthetic c

167 ion of diastereomeric derivatives with three stereogenic centers has obvious practical potential and

168 ex natural products bearing halogen atoms at stereogenic centers has underscored this critical gap in

169 ro-1H-benzo[c]azepines with three contiguous stereogenic centers have been assembled by convergent st

170 Complexity and the presence of stereogenic centers have been correlated with success as

171 reactions and the generation of new vicinal stereogenic centers if regio- and stereocontrol can be a

172 new C-C bonds and one new quaternary carbon stereogenic center in a single synthetic step, convertin

173 p is a bioinspired aldol addition to set the stereogenic center in an intermediate that requires only

174 The quaternary stereogenic center in each product is set at the final s

175 a-unsaturated carbonyl compounds that bear a stereogenic center in either the gamma or the delta posi

176 -3,2'-pyrrole] derivatives with a quaternary stereogenic center in generally high enantioselectivitie

177 utanones with a vinyl-substituted quaternary stereogenic center in high enantioselectivities and yiel

178 of the metal syn to the methyl group of the stereogenic center in the 2H-pyran intermediate.

179 l the desired stereochemistry at the crucial stereogenic center in the natural product.

180 dulator, without stereochemical erosion of a stereogenic center in the salicylaldehyde intermediate.

181 cles containing three tertiary or quaternary stereogenic centers in a linear array.

182 , which enables the installation of multiple stereogenic centers in a single operation.

183 e affords six-membered carbocycles with five stereogenic centers in a single step from achiral and ac

184 h total control in the creation of three new stereogenic centers in a single step.

185 tricyclic architectures with four contiguous stereogenic centers in a single step.

186 in a convergent manner, and four of the five stereogenic centers in amphidinolide W were set by asymm

187 hilic attack (C6-C7) on the three contiguous stereogenic centers in good to excellent yield (up to 94

188 cess to lactones containing fluorine-bearing stereogenic centers in high enantio- and diastereoselect

189 the latter that fixes the chirality of five stereogenic centers in one step with 96% ee.

190 g two carbon-carbon bonds and up to four new stereogenic centers in one step.

191 p the stereochemical match between the three stereogenic centers in the corresponding products.

192 the absolute configuration of three adjacent stereogenic centers in the final products.

193 f four stereoisomers due to the two adjacent stereogenic centers in the molecule, complicating furthe

194 e reactions proceed without epimerization of stereogenic centers in the peptide chain.

195 More remote stereogenic centers in the side chain, as in the 8-posit

196 n) reveal the influence of the proportion of stereogenic centers in the side groups connected to the

197 ,gamma-unsaturated diester unit, and vicinal stereogenic centers in up to 67 % yield, 87:13 Z/E ratio

198 oxyboronates containing up to two contiguous stereogenic centers in up to 99:1 e.r. and greater than

199 vatives, formed as single isomers with three stereogenic centers in yields up to 75% in one step.

200 struction of vicinal acyclic ternary/ternary stereogenic centers, in addition to a cyclic ternary/qua

201 ct control of four of the five newly created stereogenic centers including one all-carbon quaternary

202 forms three rings, four C-C bonds, and five stereogenic centers including three contiguous quaternar

203 e with an ether bridge and two ester-bearing stereogenic centers, including a highly unusual glycolat

204 s methodology allows the creation of vicinal stereogenic centers, including adjacent quaternary cente

205 The products bear up to three contiguous stereogenic centers, including quaternary centers and sp

206 method to control the configuration of each stereogenic center independently has been reported.

207 duction of a side chain with a predetermined stereogenic center into the prostanoid ring, resulting i

208 The construction of this all-carbon stereogenic center involves the use of photoredox cataly

209 The incorporation of fluorine atom into a stereogenic center is a highly challenging transformatio

210 ma-unsaturated ketones that contain an alpha-stereogenic center is disclosed.

211 he transition state of the step in which the stereogenic center is formed from enamine attack on the

212 s how the imine is activated and how the new stereogenic center is formed.

213 has also been found to be inverted when the stereogenic center is moved by one C atom simply from th

214 The C-3 stereogenic center is subsequently exploited to create t

215 etrized trisamides demonstrate that only one stereogenic center is sufficient to achieve a helical or

216 of alkyne-substituted all-carbon quaternary stereogenic centers is reported.

217 rmation of sulfenyl acetals bearing multiple stereogenic centers is reported.

218 351448, a macrodiolide ionophore bearing 14 stereogenic centers, is prepared in 14 steps (LLS).

219 four orthogonal functional groups and three stereogenic centers, is shown to yield considerable dive

220 However, for monomers with two stereogenic centers, it is generally necessary to separa

221 This stereogenic center, lying at the junction of two six-mem

222 ric construction of an all-carbon quaternary stereogenic center of a FLAP inhibitor.

223 eaction proceeds without racemization at the stereogenic center of the amino acid.

224 ing with the R absolute configuration to the stereogenic center of the C6-benzylic position in both c

225 The identical absolute configuration of the stereogenic center of the major enantiomers of the produ

226 s on the strict stereocontrol exerted by the stereogenic center of the pyranone.

227 te side to the 2-phenyl group on the nearest stereogenic center of the pyrrolidine group.

228 the carbohydrate-derived substituent at the stereogenic center of the thiochromene is versatile and

229 d the configurations of the three contiguous stereogenic centers of 1.

230 ost probably due to the mismatch between the stereogenic centers of both components.

231 bles strategic C-C bond constructions at the stereogenic centers of chiral amines.

232 ontaining all the key elements and the seven stereogenic centers of sarain A, has been successfully s

233 ng lactone controlled the formation of other stereogenic centers of the final molecule 1.

234 of the relative stereochemistry of the three stereogenic centers of the final spiranic products.

235 Control of the stereogenic centers of the polyol fragment was performed

236 eaction takes place with generation of a new stereogenic center on the C2 of the five-membered ring,

237 formation of pyrrolidine rings bearing a new stereogenic center on the C2 of the five-membered ring.

238 not able to resolve the chlorine-substituted stereogenic center on the guanidinium side chain of SynO

239 er, this strategy is challenging because the stereogenic center on the TDG is often far from the C-H

240 on 9c and 10c confirmed the influence of the stereogenic centers on their binding modes in the HIV-1

241 such a stereodivergent synthesis of vicinal stereogenic centers, one containing a fluorine atom, by

242 romethyl-2-oxazolines bearing two contiguous stereogenic centers, one of them being a quaternary ster

243 These addition reactions create up to two stereogenic centers, one of which is a quaternary center

244 3-acetoxyindanones possessing two contiguous stereogenic centers, one of which is an all-carbon quate

245 to afford stable norcaradienes bearing three stereogenic centers, one of which is an all-carbon quate

246 , the final product contains two consecutive stereogenic centers, one of which is quaternary.

247 ability increases by lowering the number of stereogenic centers or increasing the temperature.

248 trate the influence exerted by the number of stereogenic centers per monomeric unit and the temperatu

249 In BTAs, increasing the number of stereogenic centers per monomeric unit results in a negl

250 ith complete stereocontrol of a newly formed stereogenic center, provided crude material of high puri

251 bocycles containing an all-carbon quaternary stereogenic center remote from the reaction site in exce

252 . virens, among which 18 compounds contained stereogenic center(s), however, most of them were unknow

253 enantiopure chiral enyne-allene (bearing one stereogenic center) selected as a model for this family

254 rcrowded alkenes with a notable absence of a stereogenic center show potential to function as novel m

255 is(pyridine) substrates bearing a remote pro-stereogenic center substituted with a group capable of h

256 rd access to other compounds with quaternary stereogenic centers, such as gamma-nitroaldehydes and ga

257 A tertiary stereogenic center that bears two different aryl substit

258 lycopodium alkaloid with seven rings and ten stereogenic centers that shows anticancer activity again

259 exity increases (i.e., all-carbon quaternary stereogenic center), the difficulty in reaching the desi

260 o stereoelectronic effects from a contiguous stereogenic center, the 5' stereochemistry was overwhelm

261 arbocycles, bearing an all-carbon quaternary stereogenic center through remote stereocontrol in high

262 oach leading to the formation of several new stereogenic centers through a combined metalation-additi

263 t in the generation of all-carbon quaternary stereogenic centers through the addition of a vinyl unit

264 ers bearing adjacent quaternary and tertiary stereogenic centers under mild organocatalytic condition

265 t C-C bonds attached at the nitrogen-bearing stereogenic center using multifunctional alkyl iodides 6

266 cule and a tricyclic scaffold featuring five stereogenic centers via a single-enzyme transformation.

267 cid derivatives to functional groups bearing stereogenic centers via cascade processes.

268 reagents for the construction of quaternary stereogenic centers via the aldol addition reaction.

269 y, if one could create all-carbon quaternary stereogenic centers via the creation of several new carb

270 The all-carbon stereogenic center was generated through an intramolecul

271 h four chiral cyclic tetralins, in which the stereogenic center was positioned at carbon atom C2.

272 relative stereochemistry of the two new 1,3-stereogenic centers was achieved through: (1) direct chi

273 n III, a polyenic macrolactone possessing 11 stereogenic centers, was achieved using a convergent str

274 anhydride framework and the majority of the stereogenic centers, was prepared in 13 linear steps (lo

275 rbon-carbon bond-forming processes and three stereogenic centers were established, with the steps fro

276 d to C-C bonds, and three rings and four new stereogenic centers were established.

277 o new sigma-bonds and two vicinal quaternary stereogenic centers were formed under mild reaction cond

278 Three contiguous stereogenic centers were formed with excellent yields, p

279 process, three new sigma-bonds and three new stereogenic centers were generated in a one-pot process.

280 corresponding chromanones bearing quaternary stereogenic centers were isolated in high yields with hi

281 olycyclic amines containing three contiguous stereogenic centers were obtained with excellent stereoc

282 fused azabicyclic scaffolds bearing multiple stereogenic centers were prepared with excellent diaster

283 -S-DABOs carrying two (9c, 10c) or one (10a) stereogenic centers were resolved into their individual

284 (piperazine and trigol) linkers with varying stereogenic centers were synthesized for the first time

285 The isosteres, containing four stereogenic centers, were synthesized in high yield and

286 building blocks containing tetrasubstituted stereogenic centers, which are hard to access traditiona

287 s avail cyclohexenes bearing four contiguous stereogenic centers, while mechanistic studies support o

288 al enolates to form an all-carbon quaternary stereogenic center with an aliphatic-substituted allylic

289 -Prins cyclization to directly set the final stereogenic center with complete cis-stereoselectivity.

290 ich new carbon-bromine bonds are formed at a stereogenic center with high enantioselectivity.

291 nt congener with two A-ring chlorine-bearing stereogenic centers with 'unnatural' configurations, wit

292 -Mannich reaction to establish the first two stereogenic centers with excellent diastereo- and enanti

293 lar Hosomi-Sakurai reactions, to set vicinal stereogenic centers with excellent transfer of chirality

294 bearing tertiary or (all-carbon) quaternary stereogenic centers with exceptional site- (>98:<2 S(N)2

295 uBMe2), the synthesis of adjacent quaternary stereogenic centers with full stereocontrol was successf

296 eation of two new rings and three contiguous stereogenic centers with high diastereoselectivity throu

297 ectively, with the urea axis controlling new stereogenic centers with high fidelity in a variety of n

298 ed to the formation of all-carbon quaternary stereogenic centers with high stereoselectivity.

299 ialkenes or aminodialkynes provide access to stereogenic centers with the position controlled by the

300 the synthesis of compounds containing such a stereogenic center within an array of stereocenters, par