ライフサイエンスコーパス: steroid

1 factor, and 21 patients were treated with a steroid.

2 harides, disaccharides, an amino acid, and a steroid.

3 phthalmitis were less likely to receive oral steroids.

4 igned to modulate the bioavailability of sex steroids.

5 impaired lung function despite high doses of steroids.

6 s associated with calcineurin inhibitors and steroids.

7 in ECs are more likely to be targets of sex steroids.

8 ycophenolate mofetil and rapid withdrawal of steroids.

9 complex, an effector of response to ovarian steroids.

10 1.68 (95% CI 1.66-1.69, p < 0.001) for oral steroids.

11 potential marker of exposure to prenatal sex steroids.

12 rst comprehensive (TW)CCS(N(2)) database for steroids.

13 in or clinical outcomes with the addition of steroids.

14 olism of drugs and can also oxidize numerous steroids.

15 Most patients (86%) were treated with steroids.

16 % remdesivir, 21% tocilizumab, and 24% bolus steroids.

17 s but influenza predicted receiving systemic steroids.

18 roids, and later, tacrolimus, sirolimus, and steroids.

19 acute rejections, and none were resistant to steroids.

20 ndary adrenal suppression as side effects of steroids.

21 ere asthma that is not controlled by inhaled steroids.

22 miltefosine, with 10 of them improving with steroids.

23 ites for several inhibitory and potentiating steroids.

24 tory (TW)CCS(N(2)) database was built for 87 steroids (142 ions).

25 roquine (84%), azithromycin (75%), augmented steroids (44%), tocilizumab (19%), and remdesivir (9%).

26 Human steroid 5alpha-reductase 2 (SRD5A2) is an integral membr

27 alpha5betaP can accommodate the potentiating steroid 5alphaTHDOC.

28 bile acids, which creates a complex pool of steroids(8) with a range of physiological functions(9).

29 ed drug class by volume, followed by topical steroids (86%) and nonsteroidal anti-inflammatory drugs

30 udy of a molecular test for detection of sex steroids administration in calves, based on quantificati

31 Most patients who received steroids after diagnosis were steroid naive (n = 231).

32 ation in the presence of transmitter and the steroid allopregnanolone.

33 Treatment with steroids allowed a rapid improvement in symptoms.

34 A recently published CCS database for 300 steroids allowed one to observe experimentally significa

35 teroids and NSAIDs had no added benefit over steroids alone.

36 To date, it is unclear if other prenatal steroids also contribute to autism likelihood.

37 t has been increasingly appreciated that sex steroids also play an important role in the propensity o

38 Postoperative treatment with steroids among patients undergoing uncomplicated catarac

39 Plasma steroid analyses revealed a complete lack of testosteron

40 Older patients, those using steroid and antiglaucoma agents, and those with ocular a

41 nosuppression was based on CNI (tacrolimus), steroids and alternatively mycophenolic acid (MPA; n = 3

42 Anti-inflammatory steroids and bronchodilators are the gold-standard thera

43 Maintenance steroids and calcineurin inhibitors (CNIs) at discharge

44 Combination therapy of steroids and NSAIDs had no added benefit over steroids a

45 Treatment with combination therapy of steroids and NSAIDs showed no added benefit over steroid

46 th a poor prognosis; however, treatment with steroids and plasma exchange for acute attacks and with

47 ntibiotics, oral acyclovir, low-dose topical steroids and systemic steroids were started.

48 amination-aromatization of natural products, steroids and terpene feedstocks.

49 be successfully treated with topic and oral steroids and the underlying therapy for IBD can reduce o

50 a-reduced steroids, sulfated or carboxylated steroids, and beta-estradiol, whereas many 5alpha-reduce

51 ratively were tacrolimus, mycophenolate, and steroids, and later, tacrolimus, sirolimus, and steroids

52 Intravenous immunoglobulin, steroids, and other immunomodulatory agents have been us

53 sex, use of disease-modifying therapies and steroids, and prior optic neuritis.

54 ing convalescent plasma, hydroxychloroquine, steroids, and/or tocilizumab.

55 food antigens; broad applications of topical steroids; and, eventually, pathway-specific biologic the

56 ABAergic modulators such as barbiturates and steroid anesthetics have provided insight into the modes

57 ut remained significant after adjustment for steroids (aOR, 1.25 [95% CI, 1.09-1.43] and 1.27 [95% CI

58 bulin (HDIVig), alone or in combination with steroids, appeared to be quite effective in nonsevere ca

59 Sex steroids are critical for peak bone mass acquisition in

60 membranes (PPROM), antibiotics and antenatal steroids are effective evidence-based interventions, but

61 ion, supplemental oxygen, bronchodilators or steroids at 28 days or discharge.

62 arly 39% (n = 1326) were prescribed systemic steroids at some point during the analysis period, versu

63 A 10 day steroid-based immunosuppression protocol and a splenecto

64 Here, we identified steroid-binding sites in purified human alpha1beta3 and

65 E treatment with regard to swallowed topical steroids, biological agents, dietary approaches, and nov

66 Metagenomic pathway analysis identified steroid biosynthesis as the most underrepresented metabo

67 decreased cell proliferation, inflammation, steroid biosynthesis, neutrophils and macrophages infilt

68 YP7B1, and corresponding proinflammatory and steroid biosynthetic gene networks, may represent biomar

69 It is known that a truncated steroid biosynthetic pathway in lampreys produces two pr

70 gent selection algorithms, we identified the steroid bufalin (from Chinese toad venom) and the alkalo

71 articipants, 2 623 327 who received a single steroid burst were included.

72 dverse effects, but the risk from brief oral steroid bursts (<=14 days) is largely unknown.

73 ority (n = 4) among those with postoperative steroids, but this was not statistically significant (P-

74 boxaldehyde, a biologically active synthetic steroid, by using a 1,3-dipolar cycloaddition reaction (

75 of AD severity and responsiveness to topical steroids, calcineurin inhibitors and step-up treatment.

76 Our study demonstrates that steroids can act independently in mixtures; the sum of i

77 in indicates that individual amounts of free steroids can be detected in aqua as low as; 0.17 ng/uL,

78 ) species, with high concentrations of toxic steroids (cardenolides), provide a potent source of exog

79 gests that steroids covary within and across steroid classes (i.e. glucocorticoids, progestogens, sex

80 The profile of steroid congeners was evaluated in Caspian seals Pusa ca

81 ription of the key properties of the various steroids considered.

82 and compared those with ESW with those with steroid continuation (SC).

83 assay readout, three major chemical classes (steroids, coumarins, flavonoids) were identified from th

84 Factor analysis suggests that steroids covary within and across steroid classes (i.e.

85 eed for post-operative options for long-term steroid delivery to prevent disease recurrence.

86 Moreover, these steroid derivatives undergo functionalization in the for

87 The prescription of postoperative steroids did not make a significant difference in clinic

88 Two diastereomeric crystalline steroid dimers were obtained by acid-catalyzed double ac

89 The use of systemic steroids does not seem to worsen long-term outcomes of e

90 Age, gender, and initial steroid dose did not contribute significantly to recover

91 orable changes in clinical symptom measures, steroid dose required to manage symptoms, and marginal c

92 ationship between fungal airway presence and steroid dose, asthma severity or control.

93 er use of rabbit anti-T-cell globulin; lower steroid doses for the management of grade 2 acute GVHD w

94 sights suggest new therapeutic strategies in steroid-driven cancers.

95 ds analysis to determine the contribution of steroid duration on the status of complete recovery.

96 ses (i.e. glucocorticoids, progestogens, sex steroids), emphasizing the modularity and interconnected

97 A prenatal sex steroid environment of high prenatal testosterone and lo

98 Steroid estrogens modulate physiology and development of

99 estradiol (E2) or androstenedione (A4), each steroid exhibited its own expression profile.

100 In addition, sirolimus therapy spares steroid exposure and allied toxicity, does not compromis

101 ht and left 2D:4D (biomarker of prenatal sex steroids exposure) and primary lung cancer in women and

102 d with significant pretransplant exposure to steroids, factors that when combined may contribute to a

103 rce of essential bioactive compounds such as steroids, flavonoids and phenylpropanoid glycosides etc.

104 nd guidelines do not support use of systemic steroids for acute respiratory tract infections (ARTIs),

105 Despite the effective clinical use of steroids for the treatment of Diamond Blackfan anemia (D

106 reatment has been made: (1) new EoE-specific steroid formulations optimizing mucosal deposition have

107 ratio (PT-INR) levels were also lower in the steroid group (p = 0.03 and 0.04 respectively).

108 ssigned to the placebo group (n = 49) or the steroid group (topical prednisolone phosphate; n = 57);

109 and uveitis was significantly shorter in the steroid group compared with the placebo group even thoug

110 verse event) was significantly longer in the steroid group compared with the placebo group.

111 te if the prescription of oral postoperative steroids has an effect on clinical outcomes of horizonta

112 acids, prodrugs, and vesicular delivery for steroids have been investigated.

113 At puberty, gonadal steroids have stimulatory effects on the activation of g

114 Estrogen receptors (ER) are activated by the steroid hormone 17beta-estradiol.

115 t partially mediated by the male-synthetized steroid hormone 20-hydroxyecdysone (20E), which is packa

116 processing and slows down the release of the steroid hormone 20E from the mating plug.

117 It is also a major site of sex steroid hormone action.

118 was to elucidate the mechanism by which the steroid hormone androgen regulates YAP1 nuclear entry an

119 The active ovaries of the fly produce the steroid hormone ecdysone, which stimulates the division

120 nfection, have been well documented, as have steroid hormone effects on the microbiome, which is know

121 suggest a transporter-mediated mechanism of steroid hormone entry into the CNS, which may provide im

122 Cortisol is an important steroid hormone in human physiology.

123 serve as the major source of progesterone, a steroid hormone known to affect the replication of some

124 lopment, connecting glucose, cholesterol and steroid hormone metabolism with early embryonic cell mov

125 brain development and behavior by regulating steroid hormone permeability across the BBB.

126 The blubber steroid hormone profiles of 52 female humpback whales mi

127 The protein FKBP52 is a steroid hormone receptor coactivator likely involved in

128 ysine 4 (H3K4me1/2)(5,6), but also acts as a steroid hormone receptor coactivator through mechanisms

129 rgetable vulnerabilities in MBC, we examined steroid hormone receptors and tumor-infiltrating immune

130 by facilitating the access to chromatin for steroid hormone receptors, such as androgen receptor and

131 the context of transcriptional regulation by steroid hormone receptors, this review focuses on gene-s

132 n and biochemical assays to the evolution of steroid hormone receptors, we show that an ancient hydro

133 function in mice and possibly adrenocortical steroid hormone secretion in humans, beyond its recently

134 Thus, endogenous steroid hormone signaling in CD8(+) TILs promotes dysfun

135 al drugs pravastatin and artemether, and the steroid hormone testosterone.

136 the predominant "simple diffusion" model of steroid hormone transport across cell membranes.

137 The insect steroid hormone, ecdysteroid, coordinates growth and mat

138 rine gland that synthesizes and secretes the steroid hormone, progesterone, which is vital for establ

139 enolone or estrogen, another major mammalian steroid hormone.

140 Steroid hormones are pivotal modulators of pathophysiolo

141 Steroid hormones control various aspects of brain develo

142 relevant circuit.SIGNIFICANCE STATEMENT Sex steroid hormones drive changes in brain circuits in all

143 It is generally believed that steroid hormones freely diffuse through the plasma membr

144 tective, but mechanistically unclear role of steroid hormones in female colorectal cancer patients, o

145 Sex steroid hormones such as 17beta-estradiol (estradiol) re

146 ral neuromodulators of memory processes, sex steroid hormones such as the potent oestrogen 17beta-oes

147 Maternal exposure to increased steroid hormones, including estrogens, androgens or gluc

148 to changing photoperiod and circulating sex steroid hormones.

149 of the uterus to decidualise in response to steroid hormones.

150 The formation of the fullerene-steroid hybrids proceeds with preference for the Re face

151 useful tool to study suspected cases of sex steroid illicit administration in veal calves, complemen

152 analysis to investigate the role of systemic steroid in the recovery of efferent dysfunctions in HZO.

153 Direct detection of free steroids in a raw water mixture, from aquaculture, witho

154 Thus, while predators can affect steroids in adults, including mothers, the link between

155 quences via, for example, maternally-derived steroids in eggs.

156 tures of 5-, 8-, and 13-different classes of steroids in exposure concentrations of 10-10,000 ng/L.

157 and quantification of non-conjugated (free) steroids in fish tank water samples.

158 s demonstrate that direct actions of gonadal steroids in GHRH neurons modulate growth and puberty and

159 cineurin inhibitors, and 36% did not receive steroids in maintenance.

160 There may be a role for perioperative steroids in patients with a history of uveitis who prese

161 s study was to evaluate the role of systemic steroids in post-procedural endophthalmitis as the role

162 system and be metabolised to other bioactive steroids in the fetus.

163 n risk affects a suite of maternally-derived steroids in threespine stickleback eggs across nine Alas

164 endophthalmitis as the role of intravitreal steroids in treatment algorithms of endophthalmitis rema

165 e in the prior year and an extensive list of steroid-indicated conditions, including asthma, chronic

166 tically significant reduction in the risk of steroid-induced IOP elevation after corneal transplantat

167 The median time from antifungal treatment to steroid initiation was 6 weeks.

168 ed home exercise programme supplemented by a steroid injection.

169 val, followed by manipulation, with optional steroid injection.

170 ons with early structured physiotherapy plus steroid injection.

171 Steroids, iNO, and HFOV were associated with comorbiditi

172 d allergic airways disease (AAD) model and a steroid-insensitive model combining ovalbumin-induced AA

173 Steroids, intravenous immunoglobulin, or plasma exchange

174 Specifically, the bioactive steroid is released for 4 weeks from poly(lactic-co-glyc

175 ed ophthalmoplegia (HZORO) in which systemic steroid led to complete resolution of external ophthalmo

176 The substrates range from vitamins, steroids, lipids, and ions to peptides, proteins, polysa

177 hydroxychloroquine, azithromycin, high-dose steroids, lopinavir/ritonavir, and tocilizumab.

178 of DGF with the use of ESW versus continued steroid maintenance across KT centers, and quantified th

179 molecules such as the endogenous cardiotonic steroid marinobufagenin (MBG) and nicotine.

180 2 (SRD5A2) is an integral membrane enzyme in steroid metabolism and catalyzes the reduction of testos

181 ation, matrix remodeling, wnt signaling, and steroid metabolism.

182 iosyntheses, apoptosis, lipid synthesis, and steroid metabolism.

183 analyze effects of different combinations of steroid mixtures in zebrafish embryos to assess their jo

184 Gonadal steroids modulate growth hormone (GH) secretion and the

185 thus may be considered the first crystalline steroid molecular rotor without the alkyne axle.

186 Patients were treated with steroid monotherapy (28.9% of cases), NSAID monotherapy

187 oids and NSAIDs showed no added benefit over steroid monotherapy (HR 1.11, 95% CI 0.68-1.80, P = .674

188 redation risk experienced by mothers and the steroids mothers transfer to their eggs.

189 ard-of-care group given basiliximab, tapered steroids, mycophenolate mofetil, and tacrolimus.

190 s who received steroids after diagnosis were steroid naive (n = 231).

191 Serum samples from 39 steroid-naive DMD boys 4 to <7 years enrolled into a cli

192 lasses of distinct, nonoverlapping sites for steroids, one each for the inhibitory steroids pregnanol

193 ndophthalmitis that either received systemic steroids or did not around the time of diagnosis.

194 the past year requiring antibiotics or oral steroids or hospitalization, for whom ICS is conditional

195 with adrenal suppression as a side effect of steroids or loss of QOL.

196 growth factor [VEGF], focal laser treatment, steroids, or observation), no treatment, and not followi

197 asthma diagnosis, bronchodilator or inhaled steroids, or unscheduled clinical evaluation for respira

198 grafted bone was found with the addition of steroids (P-value > 0.05).

199 ed with improved patient and graft survival (steroids: patient survival hazard ratio [HR] 0.37 [0.27-

200 ceptor, it maintains a rich and multifaceted steroid pharmacology.

201 beta-estradiol, whereas many 5alpha-reduced steroids potentiate the receptor.

202 sis has identified residues that disrupt the steroid potentiating effect at the rat GluN1 (G638; I642

203 es for steroids, one each for the inhibitory steroids pregnanolone (3alpha5betaP), 3alpha5betaP sulfa

204 elopment (HR, 4.09; P < 0.001) and continued steroid prescription (HR=2.08, P = 0.014) were taken int

205 k to the epigenetic factors by which ovarian steroids produce negative behavioral effects.

206 the global gene expression identity of these steroid-producing immune cells and gene regulatory netwo

207 athway in the determination of zone-specific steroid production within the adrenal cortex.

208 FDX1, a mitochondrial ferredoxin involved in steroid production, nor other cellular reducing systems,

209 pendently in mixtures; the sum of individual steroid profiles is expressed.

210 igh dose and extended taper of antiviral and steroid prophylaxis for MK in high-risk, vascularized he

211 tryptophan-299 to activate hPXR; 5) recruits steroid receptor coactivator 1 to hPXR; 6) activates hPX

212 proteins, including androgen receptor (AR), steroid receptor coactivator 3 (SRC3) and BRD4, for degr

213 y androgen receptor (AR) and its coregulator steroid receptor coactivator-2 (SRC-2) enhances mitochon

214 B-613, a potent small molecule stimulator of steroid receptor coactivators (SRCs) attenuates patholog

215 s reactivation of mutant p53, stimulation of steroid receptor coactivators, and induction of protein

216 ivate the oestrogen receptor/ER and the worm steroid receptor DAF-12.

217 Steroid receptors activate gene transcription by recruit

218 in two distinct proliferative phases via the steroid receptors EcR and Usp and their downstream targe

219 ins, including MAO, tyrosine kinases, BACE1, steroid receptors, mGlu5 receptors, FFA1/GPR40, and HIV-

220 micry to modulate sirtuin signalling through steroid receptors.

221 ights into the function of integral membrane steroid reductases and may facilitate drug development.

222 RD5A2 and other eukaryotic integral membrane steroid reductases remain elusive due to a lack of struc

223 Patients who develop steroid-refractory acute graft-versus-host disease (aGVH

224 ancies, but the development of severe and/or steroid-refractory acute graft-versus-host disease (aGVH

225 Steroid-resistant or steroid-refractory acute graft-versus-host disease (SR-a

226 allogeneic stem cell transplantation without steroid-refractory acute graft-versus-host disease and w

227 No differences were detected in steroid-refractory acute GVHD, disease-free survival, re

228 aged at least 12 years with grades II to IV steroid-refractory aGVHD were eligible to receive ruxoli

229 mpared with historical data in patients with steroid-refractory aGVHD who otherwise have dismal outco

230 teduglutide, reduced de novo acute GVHD and steroid-refractory GVHD, without compromising graft-vers

231 tures are often associated with more severe, steroid-refractory neutrophilic asthma.

232 tic variations highly significant for sterol/steroid-related phenotypes, in particular the age of sex

233 rs of monoamine neurotransmission as well as steroid-related transcripts.

234 The presence of free steroids released in fish water samples was confirmed vi

235 B cell infiltrates have been associated with steroid resistance and reduced graft survival in some st

236 otably, in the context of DBA, we found that steroid resistance was associated with dysregulated p57K

237 lammation and AHR in a mouse model of severe steroid resistant asthma, potentially through the accumu

238 ew treatment options exist for patients with steroid resistant asthma.

239 vestigated in diverse diseases(1), including steroid-resistant acute graft versus host disease (SR-aG

240 therapeutic agent in allergic and especially steroid-resistant asthma.

241 of albuminuria, glomerular diseases such as steroid-resistant nephrotic syndrome or Alport syndrome

242 lities cause podocytopathies associated with steroid-resistant nephrotic syndrome or severe proteinur

243 formin DAAM2 in four unrelated families with steroid-resistant NS.

244 Steroid-resistant or steroid-refractory acute graft-vers

245 Apart from steroid-responsive subretinal inflammation in patients a

246 Treatment with steroids resulted in significantly lower Nd:YAG capsulot

247 ments involving coapplication of two or more steroids revealed that the receptor contains at least th

248 nucleophile incorporation across the parent steroid's trienone moiety.

249 roductive axes, but the existence of gonadal steroid-sensitive neuronal crosstalk remains undefined.

250 Fatal asthma cases are hallmarked by poorly steroid-sensitive T2-inflammation associated with severe

251 We investigated the role of hBD2 in a steroid-sensitive, house dust mite-induced allergic airw

252 that extends to the level of alphaGln-242, a steroid sensitivity determinant in the alphaM1 helix.

253 cerbations) have the potential to circumvent steroid sensitivity pathways and decrease mucus plugging

254 Here we report that steroid signalling in Drosophila from the ovaries to the

255 The study shows, for the first time, the steroid sparing effect of cetirizine and montelukast in

256 sion of most genes in different mixtures was steroid-specific except for genes encoding aromatase (cy

257 hysiology and transcriptional alterations of steroid-specific target genes at 96 and 120 h post ferti

258 or photochemical addition into the activated steroid structure.

259 Deletions spanning the STS (steroid sulfatase) gene at Xp22.31 are associated with X

260 tor is negatively modulated by 5beta-reduced steroids, sulfated or carboxylated steroids, and beta-es

261 , was associated with higher levels of three steroid sulfates and co-localized with expression levels

262 Greater deviations were observed for steroid sulfates in complex urine samples of adult bovin

263 cturally unique 13(14 -> 8),14(8 -> 7)diabeo-steroid swinhoeisterol A was developed.

264 und reduced expression of key enzymes in the steroid synthesis pathway and reduced serum progesterone

265 Our meta-analysis suggests that extended steroid taper may aid the recovery of ophthalmoplegia in

266 es that demonstrate an interplay between sex steroids, the intestinal immune response, and the intest

267 ficantly increased within 5 to 30 days after steroid therapy initiation and attenuated during the sub

268 intravenous immunoglobulin, with adjunctive steroid therapy used in one-third.

269 gastrointestinal tract, the patient received steroid therapy, only for 2 months.

270 d within the first month after initiation of steroid therapy.

271 lly, a subset of asthmatics are resistant to steroid therapy.

272 As such, oral steroids, topical nasal sprays or irrigation, and surger

273 predictive for lower capsulotomy rates with steroid treatment over NSAIDs (HR 0.70, 95% CI 0.52-0.88

274 nicians should select suitable CIS cases for steroid treatment to speed neurological recovery.

275 Antibiotic or steroid treatment was not associated with a lower divers

276 ential confounding or effect modification by steroid treatment were examined.

277 All patients required topical steroid treatment, 3 required amniotic membrane transpla

278 lth risks faced by individuals receiving sex steroid treatment.

279 ophthalmologist) and evaluated likelihood of steroids treatment among CSC versus matched control pati

280 transplant, and those with higher cumulative steroid use (per 10 mg/kg) were at greatest risk.

281 after diagnosis into those likely related to steroid use and those likely related to sarcoidosis.

282 In this study, we found that systemic steroid use in ARTI is common with a great geographical

283 We excluded those with systemic steroid use in the prior year and an extensive list of s

284 Oral steroid use was associated with culture-positive endopht

285 -CMI, sex, race, antithymocyte globulin, and steroid use were independent predictors of CS-CMVi, and

286 ving renal failure, hypotension, pressor and steroid use, and variable nutritional support further co

287 analysis showed that age at transplantation; steroid use, chronic graft-versus-host disease; use of f

288 conomic status, IOL model, and postoperative steroid use.

289 the IMI rate and presence of neutropenia or steroid use.

290 There was no effect modification by steroid use.

291 xposure and responsiveness of tissues to sex steroids varies among individuals and between the sexes,

292 ted odds ratio (aOR) of receiving parenteral steroids was 14.48 (95% confidence interval [CI] 14.23-1

293 Use of steroids was also not significantly associated with the

294 Additionally, oral steroids were discontinued.

295 ovir, low-dose topical steroids and systemic steroids were started.

296 suppressive medications and topical and oral steroids were used similarly during treatment with both

297 itive cases were more likely to receive oral steroids, whereas patients with endogenous endophthalmit

298 s association is only partially explained by steroids, which are associated with increased HL risk.

299 the oxidative hydroxylation of six different steroids with pronounced C7 regioselectivities and beta

300 Early steroid withdrawal (ESW) is associated with AR in other