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2 Two additional subclasses were prepared: bis(steroidal)-4,7-ACQ derivatives and bis(4,7-ACQ)cholate d
3 ty and is structurally similar to endogenous steroidal 5alpha-reductase substrates, such as testoster
5 an 100 Food and Drug Administration-approved steroidal agents are prescribed daily for indications in
8 even the best clinically approved synthetic steroidal agonists are prone to cross-reactivity and off
13 terribilis frogs sequester lethal amounts of steroidal alkaloid batrachotoxin (BTX) in their skin as
15 -Cortistatin A (dCA), an analog of a natural steroidal alkaloid from a marine sponge, inhibits Tat-me
18 fic tropane (l-hyoscyamine, scopolamine) and steroidal alkaloids (alpha-solanine, alpha-chaconine) in
19 resin acids, mefenamic acid, oxybenzone, and steroidal alkaloids in the bile or plasma, and there wer
21 samples of 2 and 3 with those of appropriate steroidal analogues [e.g., petromyzonol sulfate (PS, 1,
23 echanisms, EDCs interfere with the action of steroidal and non-steroidal receptors, and alter enzymat
25 ophore that, over some 20 years, have led to steroidal and nonsteroidal drugs in numerous preclinical
26 al function and the electronic properties of steroidal and nonsteroidal estrogens by analysis of the
27 new rational template for drug discovery of steroidal and nonsteroidal glucocorticoids that can be s
28 d work to date underlying the development of steroidal and nonsteroidal receptor ligands, including t
29 In this study, we show that although the steroidal and nonsteroidal SERDs target ERalpha for degr
31 me, the inhibitory activities of a series of steroidal and nonsteroidal sulfamate derivatives against
33 We describe two structurally similar 4-aza-steroidal androgen receptor (AR) ligands, Cl-4AS-1, a fu
36 netic pathway and uniquely revealed that non-steroidal anti-inflammatories (NSAIDs) rank just as high
38 an interesting alternative to the use of non-steroidal anti-inflammatories and/or opioids for the con
39 ketamine, physical exercise, and certain non-steroidal anti-inflammatories have been shown to alter k
41 ant concentrations of ibuprofen (IBF), a non-steroidal anti-inflammatory agent and prevalent environm
42 e-1IC50/anti-cyclooxygense-2IC50>1) than non-steroidal anti-inflammatory agent ibuprofen (0.44) descr
43 rugs can easily be conjugated to another non-steroidal anti-inflammatory agent, leading to easy synth
46 s currently on the market, including the non-steroidal anti-inflammatory blockbuster drug celecoxib.
47 Define the effectiveness of a topical non-steroidal anti-inflammatory drug (NSAID) added to topica
49 se (GERD), Barrett's esophagus (BE), and non-steroidal anti-inflammatory drug (NSAID) bleeding prophy
50 The unprecedented polymorphism of the non-steroidal anti-inflammatory drug (NSAID) flufenamic acid
53 ow that inhibition of endogenous PGE2 by non-steroidal anti-inflammatory drug (NSAID) treatment in mi
55 mine-gallic acid hybrid molecule against non-steroidal anti-inflammatory drug (NSAID)-induced gastrop
59 to 70%-80% of patients with a suspected non-steroidal anti-inflammatory drug hypersensitivity (NSAID
64 (DOX) and carprofen (CPF), a veterinary non-steroidal anti-inflammatory drug, have synergistic antim
66 andomisation was stratified by asthma or non-steroidal anti-inflammatory drug-exacerbated respiratory
67 ose and regularity of aspirin use, other non-steroidal anti-inflammatory drugs (NSAID), and the effec
69 that underlie the antitumour activity of non-steroidal anti-inflammatory drugs (NSAIDs) against color
72 2 selective inhibitors and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) are associate
77 selective inhibitors versus traditional non-steroidal anti-inflammatory drugs (NSAIDs) has not been
78 The progressive consumption growth of non-steroidal anti-inflammatory drugs (NSAIDs) has progressi
80 sis (FASS) for the determination of five non-steroidal anti-inflammatory drugs (NSAIDs) in bovine mil
83 trials demonstrate that long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) markedly redu
84 opreventive effect for aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) on colorectal
85 inically important errors: non-selective non-steroidal anti-inflammatory drugs (NSAIDs) prescribed to
89 respectively), while anti-infectives and non-steroidal anti-inflammatory drugs (NSAIDs) were frequent
91 al trials have suggested that the use of non-steroidal anti-inflammatory drugs (NSAIDs), including as
96 nsteroidal anti-inflammatory drugs (NSAIDs), steroidal anti-inflammatory drugs (SAIDs), immunosuppres
97 gs in four therapeutic areas: analgesia (non-steroidal anti-inflammatory drugs [NSAIDs]), diabetes (m
99 Although Helicobacter pylori and use of non-steroidal anti-inflammatory drugs are common causes, dem
103 c drugs (DMARDs), or at least 4 weeks of non-steroidal anti-inflammatory drugs for psoriatic arthriti
104 t individuals taking aspirin and related non-steroidal anti-inflammatory drugs have reduced risk of l
105 ve consistently demonstrated that common non-steroidal anti-inflammatory drugs may protect against th
107 vity by the administration of PTH and/or non-steroidal anti-inflammatory drugs or COX-2 selective inh
108 e of such therapies precluded the use of non-steroidal anti-inflammatory drugs or other enzyme inhibi
109 statin, antihypertensive medications and non-steroidal anti-inflammatory drugs therapy) as well as 4
110 should consider the pharmacokinetics of non-steroidal anti-inflammatory drugs to determine the optim
113 diuretics, antivirals, methotrexate, and non-steroidal anti-inflammatory drugs) is organic anion tran
114 tack therapies (eg, simple analgesics or non-steroidal anti-inflammatory drugs) or specific agents wi
115 roenteritis, female sex, smoking, use of non-steroidal anti-inflammatory drugs, and Helicobacter pylo
117 and analgesic properties to traditional non-steroidal anti-inflammatory drugs, but with significantl
118 cancer, and is a key molecular target of non-steroidal anti-inflammatory drugs, compounds that reduce
119 Other agents, such as aspirin, other non-steroidal anti-inflammatory drugs, COX-2 inhibitors, ret
120 tments have been suggested, ranging from non-steroidal anti-inflammatory drugs, drugs for neuropathic
121 ecretase modulators (GSMs), such as some non-steroidal anti-inflammatory drugs, is a promising therap
122 n pharmacotherapies, which have included non-steroidal anti-inflammatory drugs, must take into accoun
123 d PUD was associated with current use of non-steroidal anti-inflammatory drugs, oral steroids or acid
124 In this study we evaluate the effect of non-steroidal anti-inflammatory drugs, such as indomethacin
132 double endocrine targeting approach with the steroidal anti-oestrogen fulvestrant in combination with
133 therapy merits discussion as an alternative; steroidal antiandrogen monotherapy should not be offered
135 tained within this class of molecules is the steroidal antiestrogen ICI182,780 (faslodex), recently a
136 nd isolates at 100 mug/mL was similar to non-steroidal antiinflammatory drugs aspirin, ibuprofen and
137 ablished anticoagulants like heparin and non-steroidal antiinflammatory drugs may have a solid basis.
139 To compare time to progression (TTP) with a steroidal aromatase inhibitor (AI) atamestane (ATA) comb
140 double-blind clinical trial to evaluate the steroidal aromatase inhibitor exemestane as extended adj
141 omised trial that compared the switch to the steroidal aromatase inhibitor exemestane with continuati
142 e) Flutamide + ATD (androgen antagonist plus steroidal aromatase inhibitor); or (f) dihydrotestostero
145 serves bone in postmenopausal women, but non-steroidal aromatase inhibitors accelerate bone loss and
146 ent inhibitors than lead compound 1, whereas steroidal backbone (A-ring) change led to identifying pr
151 ails of the structure determination of these steroidal bis-sulfates [petromyzosterol disulfate (PSDS,
153 t of diosgenin and several structure-related steroidal compounds on the growth of faecal anaerobes is
155 The review deals with an expanding number of steroidal compounds that are capable of forming a metall
156 ns of mixtures of laser dyes and mixtures of steroidal compounds were performed to illustrate the cap
162 The stereoselective construction of C20 in steroidal derivatives by a highly diastereoselective Ir-
165 , fast, and reliable biochemical read out of steroidal drug pharmacodynamics could enable a rapid and
168 s in mixture experiments and resulted in the steroidal endocrine disrupting compounds in higher K(sw)
169 straightforward access to geometrically pure steroidal enol tosylate and enol triflate intermediates
171 These results show that beta-LGND2, a non-steroidal ERbeta selective agonist, could be a useful th
174 harmaceutical compounds (carbamazepine), and steroidal estrogens (estrone, 17-beta-estradiol, estriol
175 n in vitro ER activity and concentrations of steroidal estrogens after correcting for the in vitro po
177 tion reagents to enhance the sensitivity for steroidal estrogens in liquid chromatography electrospra
179 tipes) were exposed to solutions of singular steroidal estrogens or to the estrogenic extract of an a
181 Phytoestrogens were often more abundant than steroidal estrogens, but contributed minimally toward to
182 t known to increase in vivo potency in other steroidal estrogens, into the (17alpha,20E)-21-(trifluor
183 ed site-specific C-H oxyfunctionalization of steroidal ethers with periodate or bromate as terminal o
184 ed 1,2-dioxines along with a 1,3-dialkyl and steroidal example, with yields ranging from moderate to
185 bitors (AIs) letrozole, anastrozole, and the steroidal exemestane were approved in the U.S. in the la
186 ar affinity towards other hormones of the E2 steroidal family and excellent discrimination against po
189 tors 7E and 7Z, consisting of two androstane steroidal frameworks linked by the D rings by triple bon
191 atory drugs may offer a safer alternative to steroidal glucocorticoids in the treatment of inflammato
192 cs in wild tomato unreveal potential role of steroidal glyco-alkaloids and phenylpropanoids during ea
193 and provided a genomic basis for the lack of steroidal glycoalkaloid compounds in the Capsicum genus.
196 antitative trait loci (mQTL) for flavonoids, steroidal glycoalkaloids and further specialized metabol
197 s (and adverse effects), of polyphenolic and steroidal glycoalkaloids in the diet there is a growing
198 Two putative mQTL for flavonols and one for steroidal glycoalkaloids were cross-validated by evaluat
199 nding of the accumulation of polyphenols and steroidal glycoalkaloids, and how this knowledge may be
200 triggered metabolic changes were active from steroidal glycol-alkaloid (SGA), lignin and flavonoid bi
202 ytochemicals like polyphenols, saponins, and steroidal glycosides, but its crop is greatly affected b
205 Trenbolone acetate (TBA) is a high-value steroidal growth promoter often administered to beef cat
206 ounds-all of which are spiroketal-containing steroidal heterodimers-that inhibit the proliferation of
208 expression induction after exposure to other steroidal hormones (11-ketotestosterone approximately te
209 n of endocrine-disrupting chemicals, such as steroidal hormones and 4-nonylphenol, that can disrupt e
212 important group of molecular fossils is the steroidal hydrocarbons (steranes), which are the diagene
213 eroidal dexamethasone is as effective as non-steroidal ibuprofen for preventing or controlling postop
216 ndrosta-1,4-diene-3,17-dione) is a synthetic steroidal inhibitor of the aromatase reaction that catal
217 ence of either abiraterone, a first-in-class steroidal inhibitor recently approved by the US Food and
219 duction of these enones gave the pentacyclic steroidal ketones 2 alpha,3beta- (8) and 2 alpha,3 alpha
221 thesize a large array of biologically active steroidal lactone triterpenoids called withanolides.
225 e have purified physapubescin, a predominant steroidal lactone, from medicinal plant Physalis pubesce
226 itis elegans nuclear receptor DAF-12 and its steroidal ligand directly activate promoters of let-7 mi
227 was activated in vivo by inclusion of a non-steroidal ligand in the diet, the expression of the mRNA
228 is a great interest in the discovery of non-steroidal ligands able to bind to the ligand-binding dom
230 ved neuroendocrine pathways that converge on steroidal ligands of the nuclear receptor DAF-12, a homo
231 mpanies have been developing a series of non-steroidal ligands that consist of different chemical sca
232 OR7D4, and in vivo olfactory perception of 2 steroidal ligands--androstenone and androstadienone--che
233 F-12 function is regulated by bile acid-like steroidal ligands; however, tools for investigating thei
234 a series of recently published studies, the steroidal lipid, cholesterol, has emerged as a clinicall
238 gesterone acetate to mimic the decidualizing steroidal milieu of the luteal phase and early pregnancy
240 he renoprotective effects of Ly, a novel non-steroidal mineralocorticoid receptor (MR) blocker, throu
241 ndothelin receptors (eg, atrasentan) and non-steroidal mineralocorticoid receptors (eg, finerenone).
242 ound to improve discrimination against other steroidal molecules and to improve colorimetric sensitiv
243 similar blood pressure (BP) reduction as the steroidal MR antagonist eplerenone, providing proof-of-c
245 This effect, however, was restricted to steroidal MR antagonists as a nonsteroidal MR antagonist
248 rine-derived highly potent antiproliferative steroidal natural product, and nine closely related anal
249 The total synthesis of the highly degraded steroidal natural product, aplykurodinone-1 (1), has bee
256 relationship study provided a new potent and steroidal nonestrogenic inhibitor of 17beta-HSD1 named 3
259 Here we describe GDC-0810, a novel, non-steroidal, orally bioavailable selective ER downregulato
261 nkeys, but in contrast to currently approved steroidal PR agonists, it did not suppress estradiol lev
262 stress increased members of the neuroactive steroidal pregnane molecular family; and that Test diet
263 teroids of either enantiomeric series, these steroidal products have been selectively functionalized
264 lin (SHBG) is believed to play a key role in steroidal radiopharmaceutical delivery to target tissues
266 terfere with the action of steroidal and non-steroidal receptors, and alter enzymatic, metabolic and
267 orphan nuclear receptor and demonstrate that steroidal regulation of reproduction, from biology to mo
268 are more photostable but also maintain their steroidal ring structure and therefore may retain some b
271 Collectively, these results indicate that steroidal sapogenins may be a novel class of prebiotics
272 alysis showed that the prebiotic activity of steroidal sapogenins might require structural elements o
273 Existing techniques presently used for Yucca steroidal saponin quantification remain either inaccurat
278 7A1 inhibitor, abiraterone, which contains a steroidal scaffold similar to the endogenous CYP17A1 sub
279 n of polycyclic molecules including modified steroidal scaffolds as well as challenging-to-synthesize
283 gnancy C. sordellii infections suggests that steroidal sex hormones might regulate its capacity to ge
285 alogues, we explored the modification of the steroidal side chain and inserted a methylene moiety in
286 indings suggest a tumor-suppressive role for steroidal signaling by promoting postmitotic fate when l
287 ology for the development of a novel A,B-cis steroidal skeleton system containing a C3-C9 single bond
288 natural products characterized by an unusual steroidal skeleton, which have been found to inhibit dif
289 signaling, we report discovery of novel non-steroidal small-molecule compounds that activate the vit
292 for hormone-independent tumors, such as the steroidal STX140 and nonsteroidal counterparts, acting i