ライフサイエンスコーパス: sterol 27-hydroxylase

1 he mitochondrial activity is associated with sterol 27-hydroxylase, a cytochrome P450 (CYP27A1); howe

2 ylase activity decreased 68% (P < 0.01), but sterol 27-hydroxylase activity increased 66% (P < 0.05)

3 We suggest a mechanism whereby abolished sterol 27-hydroxylase activity leads to vascular changes

4 In contrast, sterol 27-hydroxylase activity rose 58% after three days

5 Hepatic sterol 27-hydroxylase activity was unaffected.

6 lpha-hydroxylase activity but did not affect sterol 27-hydroxylase activity.

7 significant change of bile acid pool size or sterol 27-hydroxylase activity.

8 increased hepatic cholesterol and stimulated sterol 27-hydroxylase and alternative bile acid synthesi

9 including cholesterol 7alpha-hydroxylase and sterol-27-hydroxylase, and the oxysterol nuclear recepto

10 liver, suggesting that LPS may down-regulate sterol 27-hydroxylase by decreasing the binding of HNF-1

11 Sterol 27-hydroxylase (CYP27) participates in the conver

12 thway of bile acid synthesis is initiated by sterol 27-hydroxylase (CYP27) with subsequent 7alpha-hyd

13 "alternative" (acidic) pathway, initiated by sterol 27-hydroxylase (CYP27).

14 Mitochondrial sterol 27-hydroxylase (CYP27A1) catalyses sterol side-ch

15 cholesterol 7alpha-hydroxylase (Cyp7a1) and sterol 27-hydroxylase (Cyp27a1) double knockout (DKO) mi

16 -limiting step in the classical pathway, and sterol 27-hydroxylase (CYP27A1) initiates the hydroxylat

17 Sterol 27-hydroxylase (CYP27A1) is required for bile aci

18 binding cassette transporter A1 (ABCA1), and sterol 27-hydroxylase decreased during progression from

19 A cDNA library prepared from hepatic mRNA of sterol 27-hydroxylase-deficient mice was screened with a

20 rol 7alpha-hydroxylase, and alternative, via sterol 27-hydroxylase) in New Zealand white rabbits fed

21 NF-1), a transcription factor that regulates sterol 27-hydroxylase, in the liver.

22 Sterol 27-hydroxylase is insensitive to the bile acid fl

23 Cytochrome P450 27A1 (CYP27A1 or sterol 27-hydroxylase) is a ubiquitous, multifunctional

24 The IL-1-induced decrease in sterol 27-hydroxylase mRNA expression occurs early, is s

25 rosis factor and interleukin (IL)-1 decrease sterol 27-hydroxylase mRNA levels by 48 and 80%, respect

26 oreover, LPS progressively decreases hepatic sterol 27-hydroxylase mRNA levels by 75% compared with c

27 In vivo IL-1 treatment also lowers hepatic sterol 27-hydroxylase mRNA levels in Syrian hamsters.

28 esterol 7 alpha-hydroxylase (C7 alpha H) and sterol 27-hydroxylase (S27H) and rates of bile acid synt

29 ecular mechanisms of LPS-induced decrease in sterol 27-hydroxylase show that LPS markedly decreases m

30 hepatic cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase that control bile acid synthesis i

31 1) is a ubiquitously expressed mitochondrial sterol 27-hydroxylase that plays an important role in th

32 that LPS markedly decreases the activity of sterol 27-hydroxylase, the rate-limiting enzyme in the a

33 In distinction, hepatic sterol 27-hydroxylase was insensitive to changes in the