ライフサイエンスコーパス: stiff

1 n stoichiometry in MSCs versus osteogenesis (stiff).

2 This causes them to be unusually stiff.

3 igidities ranging from very flexible to very stiff.

4 by solution processing, is known to be very stiff.

5 lls located in tumor regions predicted to be stiff.

6 To study 3D migration under confinement in a stiff (1.77 MPa) environment, we use soft lithography to

7 Keratocytes cultured on stiff (10 kPa) gels or collagen-coated glass coverslips,

8 ons, such as sparse plating and culturing on stiff 2D substrates.

9 Time-lapse microscopy revealed that a stiff 3D niche significantly increased the proportion of

10 ions of high cell pre-stress with culture on stiff (7.5 kPa) polyacrylamide gels (with or without tra

11 uous actin bundling to generate mechanically stiff actin super-bundles.

12 ticity of the intima of compliant, young, or stiff, aging arteries.

13 -binding energy to mold these catalysts into stiff and active forms.

14 ever, most touch pads are developed based on stiff and brittle electrodes with the lack of the import

15 it charge transport can render the materials stiff and brittle.

16 nfigurations - the structures are relatively stiff and can carry load in each - without any mechanica

17 xible and entropically rich ground states to stiff and catalytically active Michaelis complexes.

18 A stiff and healable polymer is obtained by using the dyna

19 that the ILK-mediated phenotypes induced by stiff and hypoxic microenvironments are regulated by PI3

20 Here we report that stiff and hypoxic microenvironments promote the developm

21 egans is challenged by its cuticle, which is stiff and impermeable to antibodies.

22 Crumpling a sheet creates a unique, stiff and lightweight structure.

23 centrations drives ssDNA to a unique, highly stiff and more compact state.

24 vealed a quite heterogeneous distribution of stiff and soft regions, resembling that of typical compo

25 hese composite scales can transition between stiff and soft states by straddling the temperatures acr

26 us cancer stem cells (CSC) into mechanically stiff and soft subpopulations.

27 arthritis (RA) is characterised by painful, stiff and swollen joints.

28 This stiff and thin polymeric layer encases the plasma membra

29 de (TlSe), which is comprised of intertwined stiff and weakly bonded substructures and exhibits intri

30 bes the flutter phenomenon observed in both "stiff" and "flexible" materials for flow driven energy h

31 The as-prepared polymer is very strong and stiff, and can bear a load of more than 450 times its we

32 lessons for the development of low-density, stiff, and damage-tolerant cellular ceramics.

33 The abdominal skin was thinner and less stiff as compared to back skin.

34 c challenge, lymph nodes become mechanically stiff as immune cells activate and proliferate within th

35 Whereas billfish bone material is as stiff as mammalian bone (unlike the bone of other fishes

36 ng-range order, is birefringent, is twice as stiff as the constituent linear polymer, and delaminates

37 in which a subset of parameters emerges as "stiff" as a function of time or space.

38 essential for cochlear amplification in the stiff basal turn, possibly through maintaining cochlear

39 r the structural elements of the glycocalyx: stiff beams and flexible chains.

40 rdiomyocytes, which become hypertrophied and stiff because of low nitric oxide and cyclic guanosine m

41 ound to increase in size even when the BM is stiff because of pressure induced by growing tumor clust

42 and +4.9%, respectively) were induced by the stiff (Bi,Sm)(2)O(3) nanopillars embedded.

43 The layered architecture of stiff biological materials often endows them with surpri

44 as bone, silk or nacre are often built from stiff blocks bound together using thin interfacial soft

45 e is positioned at the interface between the stiff brush border and soft cytoplasm suggesting a mecha

46 The filaments, arranged in stiff bundles by fascin, are constrained to point toward

47 We find that stiff but well distributed networks of plates are requir

48 its mechanical properties, CNM is strong and stiff, but also nontoxic, biodegradable, and sustainable

49 neutrophils exhibit attenuated spreading on stiff, but not soft, substrates.

50 pleomorphic adenoma was also interpreted as stiff by elastosonography suggesting that the elastosono

51 pfp-1 was localized at the interface between stiff byssus and the soft tissue by immunochemical stain

52 ckle cells, and even to interactions of soft/stiff cancer cells with macrophages.

53 ations (<<1 angstrom) at high frequency, and stiff cantilevers, we show how modulated nano/ angstrom-

54 Combining polymers with small amounts of stiff carbon-based nanofillers such as graphene or graph

55 -behaving animals, they tend to be bulky and stiff, causing damage to the tissue they are implanted i

56 rements are able to discern between soft and stiff cells across the cell cycle and demonstrated sharp

57 dicate profound differences between soft and stiff cells regarding their protection mechanisms agains

58 and metastatic propensity flowed out, while stiff cells remained trapped.

59 We show that follicular dendritic cells are stiff cells that promote strong B cell pulling forces an

60 phic chondrocytes are the least mechanically stiff cells within the growth plate.

61 Notably, only the soft, but not the stiff cells, isolated from CD133(+) , ALDH(+) , or side

62 Structural reinforcement of the wall by stiff cellulose microfibrils is central to contemporary

63 xternal fields can be bound permanently into stiff chains through electrostatic or van der Waals attr

64 This is due to the stiff challenge in purifying the inherently flexible GPC

65 We group the measured cells in a soft and a stiff cohort and find that softer cells show an increasi

66 echanical mapping reveals the formation of a stiff coiled filamentous structure underneath the capsid

67 ibuted to the reconfigurable 3D network from stiff collagen nanofibers and flexible proteoglycans.

68 hrough Src, PI3K, and Rac1, and increasingly stiff collagen promoted dispersive epithelial cell invas

69 teeth, protein and chitin fibers establish a stiff compact outer shell enclosing a less compact core.

70 Marine bacterioplankton face stiff competition for limited nutrient resources.

71 compared to a single-level hierarchy and the stiff constituent, respectively.

72 with higher SP-A1 and thinner CCT (thin and stiff corneas) showed accelerated RNFL thinning by 0.72

73 al SPs and lower CCT, suggestive of thin and stiff corneas, are at greater risk of progression.

74 Expansion on stiff culture substrates activates pro-fibrotic cell pro

75 rogels do not promote FAK signaling and that stiff D- and N-hydrogels are constrained for vascular mo

76 in poorly performing molecular diodes, while stiff, densely packed SAMs result in well-performing mol

77 ause they often involve highly nonlinear and stiff differential equations as well as many experimenta

78 This sensitization was reversed when the 'stiff' differentiated nucleus was softened and was enhan

79 umber of parameter combinations, defined as 'stiff' dimensions, while it is insensitive to many other

80 Within nucleosomes, stiff DNA sequences confer spontaneous partial unwrappin

81 -molecular acceptors (SMAs) by introducing a stiff donor that also shows low miscibility with the non

82 rotational and linear joints that integrate stiff double-stranded DNA components and flexible single

83 rdering in aqueous solutions of monodisperse stiff double-stranded DNA fragments is known not to occu

84 Further investigation revealed that a stiff ECM increased Robo1 levels by down-regulating miR-

85 Contractile cells on stiff ECM normally exhibit low phosphorylation and slow

86 we identify that elevated collagen creates a stiff ECM which in turn triggers cancer stem-like progra

87 onectin fibrillogenesis, and production of a stiff ECM with oriented fibers.

88 ustaining proliferation and migration within stiff ECM.

89 and suggest that utrophin may function as a stiff elastic element in series with titin at the myoten

90 This stiff, elastic response required the presence of vimenti

91 bstrates for globally deformable yet locally stiff electronics.

92 r, the arrangement of soft/flexible and hard/stiff elements into particular geometries can permit sur

93 junction between the OSCP and the apparently stiff, elongated alpha-helical b-subunit and associated

94 The constant change between a soft and a stiff endothelial surface is imperative for proper funct

95 older adults, the large-arterial wall is not stiff enough in youth to alter BP levels during young ad

96 Although the dense/stiff environment in mCol1a1 recipients did not alter th

97 Exposure to a stiff environment leads cells to establish a mechanical

98 ubsequently, cell migration is diminished in stiff environments.

99 production of multimaterial parts containing stiff epoxide networks contrasted against soft hydrogels

100 and secrete and concomitantly reorganise the stiff extracellular matrix (ECM).

101 ensional culture model of breast cancer that stiff extracellular matrix induces a tumorigenic phenoty

102 ith confinement of all of the cells within a stiff extracellular matrix.

103 The use of few stiff fibers to control the deformation of dielectric el

104 oblast population, and may contribute to the stiff fibrotic microenvironment through their own stiffn

105 tentacles carry pinnules, each with a row of stiff filamentous structures interpreted as very large c

106 Here we study voltage-driven dynamics of the stiff filamentous virus fd with experiments and simulati

107 and indentation modulus of ultra-thin ultra-stiff films, including CVD diamond films (~1000 GPa stif

108 s, including coarse-grained ceramics, rocks, stiff foams, fiber composites, wood, and sea ice, the ef

109 l work by Maxwell and others on criteria for stiff frames, we extend the concept of connectivity in n

110 sufficient to drive a fluid material into a stiff gel within a few seconds.

111 bility to sense substrate stiffness for very stiff gels.

112 t less cell-to-cell noise than homogeneously stiff gels.

113 A stiff guidewire and a large sheath distorted the anatomy

114 ers of 0.89 mm (0.035 inch) for standard and stiff guidewires and 0.36 mm (0.014 inch) for micro guid

115 Awns are stiff, hair-like structures which grow from the lemmas o

116 eased plasma volumes and significantly heavy stiff hearts.

117 Microtubules, the dynamic, yet stiff hollow tubes built from alphabeta-tubulin protein

118 The stiff human foot enables an efficient push-off when walk

119 By contrast, on a stiff hydrogel matrix, hESCs show elevated integrin-depe

120 divide faithfully when confined underneath a stiff hydrogel, conditions in which normal cells and cel

121 re induced by interactions with TGF-beta1 or stiff hydrogels are accompanied by the accumulation of e

122 demonstrate that when a material composed of stiff inclusions embedded in a fibrous network is compre

123 that a more detailed computational model of stiff inclusions in a subisostatic semiflexible fiber ne

124 The system of stiff inclusions periodically distributed in a soft elas

125 ionally soft, a braided fiber is torsionally stiff, indicating that supercoiling on chromatin substra

126 eme limits of molecular confinement, where a stiff inorganic phase confines the polymer chains to dim

127 sis that manipulating ankle-foot gearing via stiff-insoled shoes will change the force-velocity opera

128 Stiff insoles appear to add an extra gear unavailable to

129 Stiff insoles increased leverage of the foot upon the gr

130 Furthermore, stiff insoles resulted in a 15.9% increase in average fo

131 associates nuclear rupture with dilution of stiff lamin-B filaments, loss of repair factors, and ent

132 seizures, and a wide-based, spastic, and/or stiff-legged gait.

133 yses of macrophages on soft (like marrow) or stiff (like solid tumors) collagenous gels demonstrated

134 tion that mimicked the early-onset twisting, stiff limbs and tremor that is observed in dystonia, a d

135 y 50% toughness enhancement is achieved in a stiff load-bearing polymer network, demonstrating the ut

136 s the phenotype under conditions of fibrotic/stiff lung.

137 e deformation, while the angular geometry is stiff, maintaining local correlations even under strong

138 We previously reported that stiff materials promote nuclear localization of the Yes-

139 iffness and high toughness is challenging as stiff materials tend to be brittle.

140 es have attracted attention for decades, yet stiff materials that can resiliently tolerate extreme fo

141 re to evaluate the Young's modulus of highly stiff materials with greater accuracy than previously po

142 entury's robotic systems have been made from stiff materials, and much of the developments have pursu

143 Compared to "stiff" materials, which has a flow velocity-independent

144 e high epithelial STAT3 activity and develop stiff, matricellular-enriched fibrosis associated with h

145 associated chromatin, that cells cultured in stiff matrices displayed more accessible chromatin sites

146 deficient murine mammary epithelial cells on stiff matrices like fibrillar collagen.

147 In contrast to stiff matrices where cells migrated continuously in a tr

148 lly cultured through cycles of compliant and stiff matrices.

149 al cell types grown in monolayers on soft or stiff matrices: primary human umbilical vein endothelial

150 ling from a soft matrix can substitute for a stiff matrix in stimulating spreading, stress fibre form

151 By contrast, MSC cultured on a stiff matrix secreted prosaposin that promoted prolifera

152 ic and basal-like tumor cells, fostered by a stiff matrix, and critical for tumor cell invasion in ou

153 On a stiff matrix, MSC cultured with conditioned media from m

154 Moreover, stiff matrix-activated ERK increased the protein level a

155 Klf5 or forced expression of Klf4 inhibited stiff matrix-induced cell spreading and proliferation, s

156 lpha expression from hepatocytes cultured on stiff matrix.

157 e down-regulation of Klf4 when cells were on stiff matrix.

158 Stiff mechanical restraint led to formation of an extens

159 rodes, many of which consist of a relatively stiff metal network (or carbon materials) and an underly

160 s crystal lattice and remaining a strong and stiff metal.

161 relies upon changes in Ohmic contact between stiff, micro-structured, anisotropically conductive mean

162 ha-SMA immunofluorescence, suggesting that a stiff microenvironment alone is insufficient to induce m

163 enchymal transition (EMT) to the profibrotic stiff microenvironment and myofibroblast accumulation in

164 Cs in an active state and a tumour-favouring stiff microenvironment.

165 Stiff microenvironments also promoted tumor formation an

166 tional co-activator FHL2 from the nucleus in stiff microenvironments.

167 It is formed by three rows of stiff microvilli-like protrusions of graduated heights,

168 ger hind limbs, extended limb posture, and a stiff midfoot, suggesting improved, human-like economy,

169 on are fundamental properties of elastically stiff molecular materials and are assumed to be the same

170 orks as a route for rational design of ultra-stiff molecular solids.

171 The stiff MR imaging guidewire provided the best support for

172 at muscle hyaluronan content is increased in stiff muscles compared with controls, providing imaging

173 rometre-sized particles that are coated with stiff, nanoscale spikes and exhibit long-term colloidal

174 responds to DNA shape and deformability-the stiff, naturally straight double-helical structure-rathe

175 strointestinal symptoms, and three (11%) had stiff neck.

176 cal mismatch between soft neural tissues and stiff neural implants hinders the long-term performance

177 Stiff nonviable cells directed through the channel are c

178 an also migrate even if it fails to deform a stiff nucleus, but then it has to be able to sufficientl

179 Synthetic nanoparticles and other stiff objects injected into a blood vessel filled with r

180 ated soft tumor cells (< 400 Pa) but not the stiff ones (> 700 Pa) can form a tumor in immunocompeten

181 endothelial cells (ECs) on collagen-coupled stiff or compliant polyacrylamide ECMs to examine the ef

182 dal protocadherin-15 ectodomain can act as a stiff or soft gating spring.

183 te transitions were determined by changes in stiff parameters associated with the activity of a core

184 y an enhanced rate of collisions between the stiff particles and the deformable red blood cells.

185 4 of 34 patients [71%]) and in patients with stiff person syndrome (20 of 28 patients [71%]).

186 ssociated with autoimmune diseases including Stiff Person Syndrome (SPS) and Type 1 diabetes (T1D).

187 Stiff person syndrome (SPS) is characterized by muscle s

188 In stiff person syndrome (SPS), an antibody-mediated impair

189 n a retrospective cohort of 56 patients with stiff person syndrome and related syndromes.

190 Nine patients (26%) had coexisting stiff person syndrome symptoms.

191 phalomyelitis with rigidity and myoclonus or stiff person syndrome, and glycine receptor autoantibodi

192 o-antibody target in human hyperekplexia and stiff person syndrome, respectively.

193 us, and less frequently in other variants of stiff person syndrome.

194 itis with rigidity and myoclonus, and two as stiff person syndrome; five had a limbic encephalitis or

195 previously reported cases had more frequent stiff-person syndrome (74% vs 13%; P = .001) and better

196 with epilepsia partialis continua), four had stiff-person syndrome (one with seizures and limbic invo

197 Stiff-person syndrome (SPS) is characterised by progress

198 viously reported) included presentation with stiff-person syndrome and the presence of a thymic tumor

199 Given that stiff-person syndrome is usually autoimmune, the presenc

200 was a classic PNS, if it was different from stiff-person syndrome or cerebellar ataxia (odds ratio,

201 th several neurological syndromes, including stiff-person syndrome, cerebellar ataxia and epilepsy.

202 Conversely, stiff pili are much more likely to make contact with the

203 it the bacteria to short jumps forward while stiff pili enable much greater displacements.

204 o found to vary greatly between flexible and stiff pili.

205 d to minimize both the bending energy of the stiff plectonemes and the volume of the DNA coil to acco

206 ayer, composed of cyclic ether groups with a stiff polycyclic main chain, serves as a grafted polymer

207 otein lamin A or we introduce into the cells stiff polystyrene beads with a diameter larger than the

208 cribe the relaxation mode spectra of locally stiff polythiophene chains.

209 During stiff priming, miR-21 levels were gradually increased by

210 Knocking down miR-21 once by the end of the stiff-priming period was sufficient to erase the mechani

211 Our recent work using a stiff probe to displace hair bundles showed that the fas

212 validation, we apply the present scheme to a stiff problem of hypersonic gas flows around a 2D cylind

213 anism with a fast chemical process remains a stiff problem.

214 ntar soft tissues to convert the foot into a stiff propulsive lever.

215 living cells, arising from polymerization of stiff protein filaments against a comparably soft membra

216 ng human blood containing varying healthy-to-stiff RBC fractions.

217 heterogeneous collisions between healthy and stiff RBC pairs, it is found that the stiffened RBC is d

218 ight vessel geometry with varying healthy-to-stiff RBC ratios, a decrease was observed in the red blo

219 d on hydrogels with higher concentrations of stiff regions in a dose-dependent manner.

220 s, directional migration from softer to more stiff regions of a substrate, has been observed for a va

221 (2-7 kPa), with decreased responsiveness on stiff regions of gradients.

222 the spatial organization of the mechanically stiff regions was altered from a regular to randomized p

223 Due to the presence of stiff reinforcing platelets, the hardness of the obtaine

224 two sets of 16 motors on opposite ends of a stiff rod to two binders, each representing 16 motors, r

225 random-coil polymers bind more strongly than stiff rod-like polymers and that flexible polymers nucle

226 Stiff scales adorn the exterior surfaces of fishes, snak

227 segments but increases with increasing MW of stiff segments.

228 Programmable stiff sheets with a single low-energy folding motion hav

229 pha-helical region is found to be remarkably stiff, similar only to structural proteins forming viral

230 n regimes not possible by using conventional stiff skin layers.

231 Recently, stiff skin syndrome (SSS) and a group of syndromes known

232 ubset of missense mutations within TB4 cause stiff skin syndrome (SSS), a rare autosomal dominant for

233 ng cells in different physical environments, stiff, soft, or suspension, induced a phenotypic switch

234 Typically, such a stiff-soft bilayer suffers from wrinkling or folding whe

235 rite growth has been the use of mechanically stiff solid electrolytes(8,9).

236 s considerable promise and paves the way for stiff, solid-state morphing materials.

237 With a stiff spring, however, the force drops to near zero afte

238 When half-sarcomeres were linked to stiff springs (so that they did not shorten appreciably

239 omal regions have been described in two Iowa Stiff Stalk (SS) inbreds.

240 B73 is a founder of the Stiff Stalk germplasm pool, while PH207 is a founder of

241 ference genotype, B73, representative of the stiff stalk heterotic group was recently updated (AGPv4)

242 ble the six chromosomal regions from the Non-Stiff Stalk maize inbred W22 from a single DNA sequence

243 ted by flavonoid abundance, maize varieties (stiff-stalk, nonstiff-stalk, tropical, sweet maize, and

244 Probes in the stiff state were successfully inserted 2 cm-deep into ag

245 n the order of 100 pN were generated using a stiff stilbene force probe.

246 hat selectively binds the trans isoform of a stiff-stilbene (amino-tSS)-a rapidly and reversibly phot

247 rt a novel G4-binding chemotype derived from stiff-stilbene.

248 tracellular matrix with alternating soft and stiff stripes improves current NMJ-in-a-dish models by i

249 s requires tumor cells to navigate through a stiff stroma and squeeze through confined microenvironme

250 forces are transmitted through mechanically stiff structures, flowing, for example, through cytoskel

251 cultured on profibrotic conditions including stiff substrata and TGF-beta1, and analyzed in terms of

252 ased downstream of integrin-linked kinase on stiff substrata.

253 s erased when cells are first conditioned on stiff substrate, and then transferred onto soft hydrogel

254 In a stiff substrate, such motions were always observed.

255 in the central region and propagate outward (stiff substrate/high friction).

256 ead morphology similar to wild-type cells on stiff substrates and to cells undergoing osteoblastogene

257 whereby the actin cytoskeleton polarized on stiff substrates but not on soft.

258 These data suggest that stiff substrates change intercellular junction protein l

259 xial stretch, valvular interstitial cells on stiff substrates decreased their traction force (from 30

260 bipolarization in vivo and the responses to stiff substrates in vitro require intracellular adaptor

261 Likewise, stiff substrates induce microglial bipolarization and di

262 Stiff substrates shifted force transfer toward the flow-

263 he pro-osteoblastic factor RUNX2 on soft and stiff substrates suggests a predisposition to this cell

264 h-clamp recording were greater in neurons on stiff substrates than on soft substrates.

265 GF-beta1 stimulation and direct contact with stiff substrates, and spontaneously in IPF fibroblasts,

266 t FAs varied linearly with applied force for stiff substrates, and this was disrupted on soft substra

267 bstantially reduces neurogenesis, whereas on stiff substrates, loss of AMOT negates the rescue of neu

268 and the growth of the cells on non-compliant stiff substrates, often display a pro-inflammatory pheno

269 On stiff substrates, the actin modules mediate long-range s

270 re heightened at synapses between neurons on stiff substrates.

271 came greater and more frequent in neurons on stiff substrates.

272 oth amplitude and frequency among neurons on stiff substrates.

273 ed recording was enhanced between neurons on stiff substrates.

274 fibers with a positive feedback loop on very stiff substrates.

275 lular matrix production compared to cells on stiff substrates.

276 nin overexpression prevented polarization on stiff substrates.

277 catenin activity and rescues neurogenesis on stiff substrates.

278 fibroblast spreading because of an apparent stiff surface layer.

279 onses to TGF-beta In contrast to growth on a stiff surface, fibroblast growth on a soft matrix led to

280 AP localization in fibroblasts cultured on a stiff surface.

281 compliant surfaces could be recapitulated on stiff surfaces by adding small-molecule inhibitors of F-

282 deletion enhances ERK1/2 activity, while on stiff surfaces it enhances the activity of NFkappaB, not

283 l force-mediated antigen extraction, whereas stiff surfaces lead to enzyme-mediated antigen release b

284 complicated wave regimes in multi-component, stiff systems by studying simplified, soft systems.

285 imescale and they are inevitably modelled by stiff systems of ordinary differential equations.

286 It is significantly harder (30%) and less stiff than calcite, and retains these properties after h

287 king inner nuclear membrane tethers are less stiff than wild-type nuclei and exhibit increased chroma

288 utron-star equation of state is sufficiently stiff (that is, the pressure increases sharply as the de

289 A stiff three-arm-junction DNA origami tile motif with pre

290 bstrates are static and supraphysiologically stiff; thus, platforms with dynamic and reversible mecha

291 ding sarcomere stretch and the expression of stiff titin isoforms.

292 rmore, we find that the bundle is solid, and stiff to bending, along the long axis, whereas it has a

293 These links are considered far too stiff to represent the gating springs that convert hair

294 fer of human bronchial epithelial cells from stiff to soft substrates causes a downregulation of glyc

295 s followed by condensation into more ordered stiff trimer chains.

296 soft tube and get reflected back at the soft/stiff tube boundaries.

297 Endothelial cells in stiff tumors have more activated Src and higher levels o

298 these microRNAs increased in cells plated on stiff versus soft substrates, consistent with homeostasi

299 rate active tensegrities that are relatively stiff yet resilient with various complexities.

300 r, hepatic malignancies are characterized by stiff, yet fluid tissue properties, whereas surrounding