ライフサイエンスコーパス: stiffening

1 , such as degradation, matrix deposition, or stiffening.

2 in the form of hoop reinforcement and strain stiffening.

3 sponse to morphological changes and membrane stiffening.

4 esponse to morphological change and membrane stiffening.

5 ng evidence for a significant role for polar stiffening.

6 motility and proliferative responses to ECM stiffening.

7 geing is associated with marked large artery stiffening.

8 of cellular ageing, is linked with arterial stiffening.

9 ion is the structural feature that causes HA stiffening.

10 focal adhesion maturation, and intracellular stiffening.

11 first: blood pressure elevation or arterial stiffening.

12 ng, thickening of dermal fibrils, and tissue stiffening.

13 ibit nonlinear elasticity, undergoing strain stiffening.

14 ular resistance, and arterial remodeling and stiffening.

15 ven though conventional wisdom only suggests stiffening.

16 d and is characterized by progressive matrix stiffening.

17 used by endothelial dysfunction and arterial stiffening.

18 s accompanied by segmental infrarenal aortic stiffening.

19 l, leading to tissue growth, thickening, and stiffening.

20 ol1a2, leading to medial fibrosis and aortic stiffening.

21 h age and that this increase leads to tendon stiffening.

22 tion, or extracellular matrix deposition and stiffening.

23 nflammation and mechanical stretch in aortic stiffening.

24 eukin 17a were also protected against aortic stiffening.

25 t HSP27 or alphaB-crystallin suppressed this stiffening.

26 x adhesions, including integrin-induced cell stiffening.

27 time marathon can reverse age-related aortic stiffening.

28 muscle and extracellular matrix function and stiffening.

29 ld be consistent with the hypothesis of body stiffening.

30 ch further perpetuates matrix production and stiffening.

31 eral blood diseases associated with membrane stiffening.

32 ng extracellular matrix (ECM) remodeling and stiffening.

33 es from compression softening to compression stiffening.

34 and gain mesenchymal morphology upon matrix stiffening.

35 y, loss of connexin-43 expression) following stiffening.

36 rong effects of these two stimulants on clot stiffening.

37 calponin exhibited a delayed onset of strain stiffening (10.0% without calponin, 14.9% with calponin)

38 plications including structures with tunable stiffening, 3D structures with gradient and programmable

39 We conclude that titin-based cardiac myocyte stiffening acutely after MI is partly mediated by interl

40 or to increase deformability), diamide (cell-stiffening agent), cilostazol (phosphodiesterase 3 inhib

41 ition of LOX-dependent subendothelial matrix stiffening alone suppressed HG-induced retinal EC activa

42 gate the molecular mechanism by which matrix stiffening alters endothelial barrier function.

43 kers of aging, and impact age-related tissue stiffening and atherosclerotic changes.

44 eversed endothelial dysfunction and arterial stiffening and attenuated vascular oxidative stress and

45 ccelerated in response to microenvironmental stiffening and can be inhibited by softening.

46 However, both the degree of matrix stiffening and culture time before stiffening play impor

47 ichostatin A treatment also resulted in cell stiffening and decreased migratory ability in KFs.

48 on and oxidative stress, results in arterial stiffening and decreased vascular compliance.

49 Aging incurs aortic stiffening and dilation, but these changes are less pron

50 noncooperative process, which results in DNA stiffening and DNA folding depending on protein concentr

51 1 clusters, there is an increase in cellular stiffening and enhanced RhoA signaling compared with ICA

52 ed tumor progression by reducing the stromal stiffening and epithelial contractility induced by loss

53 cellular matrix, which results in myocardial stiffening and eventually leads to heart failure.

54 ECs adherent on collagen display divergent stiffening and focal adhesion growth compared with ECs o

55 isplayed elevated responsiveness to collagen stiffening and force-mediated ECM remodeling through act

56 f solid stresses, extracellular matrix (ECM) stiffening and increased fluid pressure in both intersti

57 Matrix stiffening and myofibroblast resistance to apoptosis are

58 ng of vFLIP or IKKbeta is localized twisting/stiffening and not large-scale rearrangements.

59 auses vascular pathologies, such as arterial stiffening and perivascular alterations, may impede the

60 idant stress to immune activation and aortic stiffening and provide insight into the systemic inflamm

61 Aortic stiffening and reduced nitric oxide (NO) availability ma

62 s collagen cross-linking and leads to tissue stiffening and scar formation.

63 wever, our system is capable of both dynamic stiffening and softening.

64 is maintained; these results indicate strain stiffening and/or dependence of mechanotype on deformati

65 These data suggest that targeting intimal stiffening and/or the EC response to intima stiffening c

66 induced vascular T-cell infiltration, aortic stiffening, and collagen deposition.

67 n, extracellular matrix (ECM) production and stiffening, and contraction due to the expression of smo

68 be responsible for valvular cusp retraction, stiffening, and formation of calcified nodules.

69 ure; prevented vascular inflammation, aortic stiffening, and hypertension; and prevented DC and T cel

70 echanisms concerning uremic toxins, arterial stiffening, and impaired cardiac function, and the thera

71 In fact, vessel wall stiffening, and microcirculatory endothelial dysfunction

72 disease, the valve cusps undergo retraction, stiffening, and nodular calcification.

73 ern diet (WD) for 16 weeks results in aortic stiffening, and that these abnormalities were prevented

74 OC] and arterial stiffening (aortic pulse wave velocity in young: 3.62 +/

75 e peripheral airways and early onset of lung stiffening are often difficult to detect.

76 anisms of its actions on cusp retraction and stiffening are unclear.

77 We show that initial stress stiffening arises from acceleration of strained filament

78 and t-ferulic acids indicates that the wall stiffening arises from cross-linkage to cell wall polyme

79 d sharp viscoelastic changes due to cortical stiffening around mitosis.

80 These findings implicate BM stiffening as a critical determinant of HG-induced retin

81 s mainly the clinical expression of arterial stiffening as a result of the population's aging.

82 oduces the novel concept of segmental aortic stiffening as an early pathomechanism generating aortic

83 Aortic stiffening, assessed by carotid-femoral pulse wave veloc

84 ine blood samples exhibited significant cell stiffening at 500 mug/mL iron dextran loading concentrat

85 Moreover, the worm exhibits dramatic stiffening at higher stresses-behavior that is also inde

86 ast, lamin A/C levels control nuclear strain stiffening at large extensions.

87 ced nonlinear behavior in the form of strain stiffening at strains from 0 to 15%, followed by strain

88 g heterotopic bone and identified pathologic stiffening at this stage of repair.

89 A was associated with faster rates of aortic stiffening (B = -5.65, 95% CI -9.75, -1.54, Bonferroni-c

90 lied stress, which is consistent with stress stiffening behavior of cells.

91 ess is not explained by the nonlinear strain-stiffening behavior of the material alone and is likely

92 iological tissue, exhibit a nonlinear strain-stiffening behavior when subjected to large deformations

93 al hemodynamic shear stress and blood vessel stiffening both significantly influence the arterial end

94 By contrast, stiffer cells show no stress stiffening but an increasing plasticity with higher forc

95 age of 36 years predicted change in arterial stiffening by a mean age of 43 years, but not the revers

96 tion of the collagen I/III ratio and cardiac stiffening by excess n-6 PUFA represent a novel pathway

97 Results show that hMSCs respond to matrix stiffening by increasing nuclear tension and causing an

98 of the control of extracellular matrix (ECM) stiffening by the mechanosensitive microRNA-130/301 fami

99 cross-links, we demonstrate that the strain stiffening can be caused by two distinctly different mec

100 cs and determine whether exertional arterial stiffening can be mitigated by inorganic nitrite.

101 one (4-HAP), which increased MYH14 assembly, stiffening cells.

102 riplet enables the replication of the strain-stiffening characteristics of jellyfish, lung, and arter

103 in the mouse myocardium, leading to cardiac "stiffening" characterized by impaired transmitral flow i

104 stiffening and/or the EC response to intima stiffening clinically may improve vascular health.

105 edge, increased focal adhesion and cellular stiffening, collectively promoting cancer cell invasion.

106 at change an immunoreceptor chain's entropy (stiffening, confinement to a membrane, and multiple simu

107 Size-dependent wall stiffening constrains diameter definition and limits siz

108 ess that involves platelet adhesion and clot stiffening/contraction in the milieu of fluid flow.

109 which enhanced matrix deposition and tissue stiffening contribute to fibroblast and myofibroblast di

110 Left ventricular (LV) stiffening contributes to heart failure with preserved e

111 Our data suggest that organ stiffening cooperates with TGF-beta to induce fibrosis i

112 milar IAS and discontinuous deformation rate-stiffening despite being a granular composite, not a sus

113 of the intact airway, accounting for strain-stiffening due to collagen recruitment (a large componen

114 Stiffening due to internal stress generation is of param

115 properties of the macrofibrils dominate the stiffening due to the progressive setting up of the cyst

116 We examined whether aortic stiffening during a 4-year follow-up in mid-to-late life

117 r dysfunction, impaired vasodilation, vessel stiffening, dysfunctional blood flow and interstitial fl

118 The mechanism for this compression-stiffening effect is not yet clear.

119 iffens saturated lipid membranes, but has no stiffening effect on membranes populated by unsaturated

120 The phosphorylation extension and stiffening effect provides a peptide-scale physical inte

121 e report a soft composite DEA made of strain-stiffening elastomers and carbon nanotube electrodes, wh

122 ays) and matrix fiber realignment and strain stiffening enables the cells to polarize and develop con

123 , we review the cross talk among vessel wall stiffening, endothelial contractility, and vascular dise

124 tructural redundancy and directional network stiffening ensure robust tissue folding with proper orie

125 Here, we utilize an in vitro model of tumor stiffening, ex ovo culture, and a mouse model to investi

126 ctions can alter stem cell perception of the stiffening extracellular microenvironment.

127 dynamic catch', characterized by abrupt bond stiffening followed by the formation of catch bonds, whe

128 cyte stretch, fibroblast stretch, and matrix stiffening following MI may separately regulate differen

129 lear localization of YAP/TAZ, and subsequent stiffening (from ca. 3.5 to 28 kPa) increased the cell a

130 y mediators and often results in ventricular stiffening, functional deterioration, and development of

131 pose that these cells, via vacuolization and stiffening, gave rise to the chordate notochord.

132 As LV stiffening has been implicated in the pathophysiology of

133 ibit plasticity in Cdc42-mediated mechanical stiffening, histone 3 lysine residue 9 (H3K9) methylatio

134 Together, these data suggest that stiffening hydrogels may be more faithful models for stu

135 Here, we used visible light-mediated stiffening hydrogels to investigate cell mechanotransduc

136 NFAT translocates to the nucleus of CFbs on stiffening hydrogels within 6 h, whereas it remains cyto

137 apeutic target of aortic fibrosis and aortic stiffening in diabetes mellitus.

138 h may play an important role in the observed stiffening in glucose-treated elastin.

139 passive-force levels characterize diastolic stiffening in heart-failure patients, and it is critical

140 inflammation, mechanical stretch, and aortic stiffening in hypertension remains undefined.

141 ts might underlie susceptibility to arterial stiffening in male and female Dahl salt-sensitive rats.

142 indings indicate that faster rates of aortic stiffening in mid-to-late life were associated with poor

143 nalysis revealed that faster rates of aortic stiffening in mid-to-late life were associated with poor

144 dence that elevated BP precedes large-artery stiffening in middle-aged adults.

145 Thus, by promoting cell rounding and stiffening in mitosis, oncogenic Ras(V12) enables cells

146 ed these activities and prevented cells from stiffening in response to forces on E-cadherin.

147 spreading on post arrays as demonstrated by stiffening in response to jasplakinolide and the abrogat

148 al LARG regulating leukocyte behavior and EC stiffening in response to tractional forces generated by

149 Particle inclusions also suppress stiffening in shear deformation; when the particle volum

150 p38 prevented angiotensin II-induced aortic stiffening in vivo.

151 ing force and show that they exhibit torsion stiffening, in qualitative agreement with experimental f

152 ing other hallmark cellular responses to ECM stiffening including cell spread area, stress fiber form

153 helium-dependent dilatation, EDD) and aortic stiffening (increased aortic pulse wave velocity, aPWV).

154 ressure associated with age-related arterial stiffening increases risk for Alzheimer dementia but the

155 We hypothesized that aortic stiffening increases this previously ignored component o

156 production and apoptosis, and abolishes ECM stiffening-induced increase of proline synthesis and cel

157 Interestingly, stiffening inhibits fibroblast spreading through either

158 n also suppress extrinsic effects by greatly stiffening interface bonding.

159 Responses of the endothelium to stiffening involve integration of mechanical cues from v

160 Accelerated arterial stiffening is a major complication of diabetes mellitus

161 nt extracellular matrix (ECM) deposition and stiffening is a physical hallmark of several solid cance

162 Matrix stiffening is a prominent feature of pulmonary fibrosis.

163 ins, we demonstrate that frequency-dependent stiffening is associated with the striated sheet matrix

164 The early mechanical stiffening is concomitant to an increase in diameter of

165 Carotid stiffening is considered a key element in the pathogenes

166 eas via microcontact printing show that size stiffening is limited to cells of a confluent monolayer.

167 n after MI, suggesting that MI-induced titin stiffening is mediated by elevated levels of the cytokin

168 , we demonstrated that subendothelial matrix stiffening is necessary and sufficient to promote EC act

169 thelial dysfunction and large elastic artery stiffening) is the primary mechanism driving age-related

170 ediated endothelial dysfunction and arterial stiffening, is the primary risk factor for cardiovascula

171 Frequency-dependent stiffening largely disappeared in all three TM mutations

172 he following: vascular dysfunction; arterial stiffening; left ventricular hypertrophy; and worsened m

173 ing of the prognostic importance of vascular stiffening linked to perivascular fibrosis in hypertensi

174 In addition, monitoring segmental aortic stiffening may aid the identification of patients at ris

175 Patients with vascular stiffening may display increased arterial afterload that

176 ss or the endothelial cell response to tumor stiffening may help restore vessel structure, minimize m

177 The detrimental effects of aortic stiffening may result in brain damage as well as heart f

178 This remarkable strain-stiffening mechanism offers fundamental insights for und

179 l twin-boundary dominated indentation strain-stiffening mechanism that produces a large strength enha

180 orsal doming" are thought to facilitate this stiffening mechanism.

181 ture or constituents, suggesting a universal stiffening mechanism.

182 e, can affect the transition between the two stiffening mechanisms and, as such, control the dominant

183 providing a fundamental understanding of the stiffening mechanisms of Pf-infected RBCs, our simulatio

184 usions, known as "knobs," introduce multiple stiffening mechanisms through composite strengthening, s

185 ity lies in the existence of two fundamental stiffening mechanisms.

186 dent feed-forward loop associated with tumor stiffening, mechanosensing, and therapy resistance.

187 H-NS DNA-stiffening mode caused by nucleoprotein filament formati

188 of the DNA chain instead (similar to the DNA-stiffening mode of H-NS proteins).

189 ed ECM production; and 3) progressive matrix stiffening, modeling the mechanical effects of infarct s

190 This size stiffening not only occurs as a consequence of varying c

191 such as nuclear lamina softening, chromatin stiffening, nuclear lamina invaginations, increase in nu

192 ay contribute to the rapid mechanical tissue stiffening occurring in many diseases, including cancer

193 Interventional stiffening of AAA-adjacent aortic segments (via external

194 efect-driven' hypothesis, we clearly observe stiffening of C-S-H with increasing Ca/Si in the range 0

195 ulation of type II fibres and a decrease and stiffening of connective tissue.

196 ises from competition between passive strain-stiffening of ECM and force generation by ASM yielding a

197 Second, directional stiffening of edges oriented orthogonal to the folding a

198 lity given the known effects of large artery stiffening of left ventricular pulsatile load.

199 temperature changes underpin the macroscopic stiffening of nanocomposites.

200 n of strain-concentrating defects and to the stiffening of nanoscale components at high strains, such

201 Controlled stiffening of normal human red blood cells (RBCs) in dif

202 hich promotes the spreading of cells and the stiffening of nuclei as both actomyosin assembly and nuc

203 Here, we show that the nonlinear stiffening of reconstituted type I collagen networks is

204 ough a range of diseases are associated with stiffening of red blood cells (RBCs; e.g., sickle cell a

205 plied to study the morphologies and membrane stiffening of sickle RBCs.

206 We found a substantial stiffening of single filaments above a characteristic tr

207 Finite-element analysis reveals that early stiffening of the aneurysm-prone aortic segment leads to

208 Aging causes disproportionate stiffening of the aorta compared with the carotid arteri

209 We observe stiffening of the aorta in regulator of G protein signal

210 Stiffening of the aortic wall is a phenomenon consistent

211 anization of microtubules and stretching and stiffening of the apical membrane.

212 ement membrane promote tumour budding, while stiffening of the basement membrane promotes folding.

213 around the inclusions cause the softening or stiffening of the biological membranes.

214 other cell differentiating factors, such as stiffening of the collagen gel, did not contribute.

215 degree of strain-induced fiber alignment and stiffening of the collagen matrices.

216 The likely cause is a stiffening of the compressed leaflet, which appears to b

217 An age-dependent stiffening of the cornea has been found and keratoconus

218 amellar stresses; and 3), the passive strain-stiffening of the cytoskeleton.

219 igher forces, indicating a pronounced stress stiffening of the cytoskeleton.

220 We propose a model in which stiffening of the damaged ends by the repair complex, co

221 ologic range of ECM stiffness and found that stiffening of the ECM leads to both cell cycling and cel

222 experimental validations indicated that: (i) stiffening of the extracellular matrix was a prerequisit

223 s in the tumor microenvironment, such as the stiffening of the extracellular matrix.

224 We ascribe this phenomenon to a general stiffening of the framework as a function of TCNQ loadin

225 ive extracellular matrix deposition leads to stiffening of the heart, which can eventually lead to he

226 onal stability of the duplex and the related stiffening of the heterocyclic bases and the sugar-phosp

227 pectrins in the cytoskeletal network and the stiffening of the iRBCs.

228 to adverse changes to arteries that include stiffening of the large elastic arteries (aortic and car

229 The related stiffening of the material follows a power law, typical

230 ional changes that result in fluidization or stiffening of the melt can be induced by crystal growth

231 that binding to actin leads to an allosteric stiffening of the motor-lever junction.

232 on in heart failure patients is evident from stiffening of the passive properties of the ventricular

233 addition, our analysis reveals an unexpected stiffening of the polar regions of the stomata complexes

234 explained by the occurrence of electrostatic stiffening of the polymer chains at large charge densiti

235 Stiffening of the proximal aorta is strongly associated

236 To investigate the contribution of stiffening of the sarcomere (the contractile apparatus o

237 c force microscopy, we quantified a 2.9-fold stiffening of the SC niche at time-points associated wit

238 While the stiffening of the stroma surrounding solid tumors has be

239 d that implementation of frequency-dependent stiffening of the TM in the OHC attachment region facili

240 cell to adhesion structures and facilitates stiffening of the vessel wall, regulating blood flow ret

241 ns as an energy source, and Ca(2+)-dependent stiffening of titin stretched during eccentric muscle co

242 to arterial stiffness, the impact of aortic stiffening on target organs, noninvasive methods for the

243 waves to quantify the effect of aortic arch stiffening on transmitted pulsatility to cerebral vascul

244 n the complete cohort and progressive aortic stiffening over 30 months in a subgroup of 93 patients.

245 ess relaxation is to rapidly diminish strain stiffening over time.

246 s been identified as a promising therapy for stiffening pathologically weakened corneas.

247 of matrix stiffening and culture time before stiffening play important roles in regulating this conve

248 Tissue stiffening plays a critical role in cancer progression.

249 rts the experimental observation that radial stiffening plays a very limited role in stomatal opening

250 ogy emerges from an interplay between strain-stiffening polymer networks and volume-conserving cells

251 model, we demonstrate that segmental aortic stiffening precedes aneurysm growth.

252 Recent evidence shows that arterial stiffening precedes the onset of high blood pressure; ho

253 Strategies to prevent arterial stiffening prior to this point may be required to offer

254 Ras(V12)-mediated cell rounding and cortical stiffening promote cell division under confined conditio

255 Extracellular matrix (ECM) stiffening promotes kindlin-2 translocation into mitocho

256 n fibers, responses to applied force, strain stiffening properties of the aligned fibers, aspect rati

257 The mechanical stiffening range of approximately 58 kHz and a more than

258 Moreover, endothelial stiffening reduces nitric oxide production, which promot

259 plus modeling lead us to propose that polar stiffening reflects a mechanical, pectin-based pinning d

260 We speculate that this stiffening reflects the development of particle clusters

261 d softening regime to a stretching-dominated stiffening regime, which occurs before and independently

262 and larger pores exhibited increased strain-stiffening relative to networks with thinner fibers and

263 develop vascular collagen deposition, aortic stiffening, renal dysfunction, and hypertension with age

264 ice eliminated vascular inflammation, aortic stiffening, renal dysfunction, and hypertension; however

265 mportantly, this softening is contrary to TM stiffening reported in glaucomatous human eyes.

266 connection between attenuated stiffness and stiffening response and the increased invasion capacity

267 e for the solid-like behavior and the stress-stiffening response of the soma, whereas neurofilaments

268 rature of PNIPAM, resulting in a macroscopic stiffening response that spans more than 3 orders of mag

269 n decreased stiffness and loss of the normal stiffening response to force applied on integrins.

270 hat result in increased cell stiffness and a stiffening response.

271 hat alpha-SMA inhibition following substrate stiffening resulted in attenuated stellate cell activati

272 diseased lung tissue and determined that ECM stiffening resulted in mechanoactivation of the transcri

273 we demonstrate quantitatively that arterial stiffening seems sufficient to explain age-related emerg

274 These results indicate that ECM stiffening sustains vascular cell growth and migration t

275 Lankan CKDu is associated with less arterial stiffening than defined causes of CKD.

276 ), we identify progressive structural aortic stiffening that precedes the onset of arterial hypertens

277 uced membrane disruptions while mechanically stiffening the associated complexes under the applied me

278 h and G-rich alginates play similar roles in stiffening the cell wall where the tensile stress is hig

279 al of WST-D/NIR therapy as a means of safely stiffening the cornea.

280 packing interactions within the receptor and stiffening the detergent micelle.

281 ered the cuticle biomechanical properties by stiffening the elastic and viscoelastic phase and by red

282 recipitated by infarction through bulking or stiffening the infarct region.

283 rial stiffness, mechanisms leading to aortic stiffening, therapeutic approaches to reduce it, and cli

284 eter-deliverable soft hydrogels with in vivo stiffening to enhance therapeutic efficacy achieve these

285 After hydrogel stiffening to mimic fibrosis, only the R/R cardiomyocyte

286 regimes that exhibit cell softening or cell stiffening to varying degrees.

287 iopolymer networks have shown similar strain-stiffening trends regardless of the differences in their

288 fferent scales to maintain reversible stress stiffening up to large strains.

289 l structure and hydrolysis triggers filament stiffening upon disassembly.

290 have shown softening via photodegradation or stiffening via secondary cross-linking; however, our sys

291 arterial spin labelling scans, faster aortic stiffening was also related to lower cerebral perfusion

292 Matrix remodeling and tumor stiffening were also observed in vivo upon exposure of B

293 t; however, the bonding is more effective at stiffening when the porosity of the mat is low.

294 accurately mimic the onset of gradual matrix stiffening, which is not feasible with conventional stat

295 Large-artery (aortic) stiffening, which occurs with aging and various patholog

296 Large elastic artery stiffening with advancing age is attenuated in healthy a

297 important factor that contributes to tendon stiffening with age and in diabetes.

298 Inorganic nitrite mitigates arterial stiffening with exercise and improves hemodynamics, indi

299 roves hemodynamics, indicating that arterial stiffening with exercise is at least partially reversibl

300 n, hydroxyproline accumulation, and vascular stiffening, without difference in blood pressure.