ライフサイエンスコーパス: stop codon

1 at target these mRNAs at sites distal to the stop codon.

2 (SCR) occurs when the ribosome miscodes at a stop codon.

3 that was predicted to result in a premature stop codon.

4 ibosome occupancy at or just before the mRNA stop codon.

5 he zipcode protein in a region distal to the stop codon.

6 at target these mRNAs at sites closer to the stop codon.

7 ve translation start sites downstream of the stop codon.

8 don does not differ from that of a canonical stop codon.

9 genetic variant that introduces a premature stop codon.

10 ions that ultimately resulted in a gain of a stop codon.

11 nonsense frame-shift and the emergence of a stop codon.

12 that does not operate as the canonical opal stop codon.

13 causes a frame shift leading to a premature stop codon.

14 of messenger RNA (mRNA) without an in-frame stop codon.

15 rial ribosomes reach the end of mRNA with no stop codon.

16 corporation of a pseudoexon with a premature stop codon.

17 e, to be integrated just upstream to the Alb stop codon.

18 cess of continuation of translation beyond a stop codon.

19 andard amino acid encoded by UGA, normally a stop codon.

20 nylated at the editing site and thus lacks a stop codon.

21 at detecting and destroying mRNAs lacking a stop codon.

22 ad-through translation across premature Ter5 stop codon.

23 splicing is involved in the selection of the stop codon.

24 y bound mRNAs upstream and downstream of the stop codon.

25 nthesis ends when a ribosome reaches an mRNA stop codon.

26 of the tnaA-lacZ gene construct than the UAG stop codon.

27 RNA and arrested ribosomes than does the UAG stop codon.

28 ) gene resulting in formation of a premature stop-codon.

29 l amino acids (ncAAs) into proteins at amber stop codons.

30 nes by changing single nucleotides to create stop codons.

31 the target gene is disrupted by a series of stop codons.

32 empowers yeast ribosomes to read-through UGA stop codons.

33 RF in bacteria, capable of reading all three stop codons.

34 introduced frameshifts or encoded premature stop codons.

35 d the evolutionary conservation of start and stop codons.

36 er rat thyroid cells stably transfected with stop codons.

37 ulting in frameshifts that lead to premature stop codons.

38 ogrammed with pseudouridylated and canonical stop codons.

39 ow NMD discriminates between PTCs and normal stop codons.

40 s from mutated genes with premature in-frame stop codons.

41 release factor (eRF1) to recognize all three stop codons.

42 curred, leading to frameshifts and premature stop codons.

43 that m(6)A is distributed predominantly near stop codons.

44 09, as critical for recognition of the three stop codons.

45 ressed, and 23% are interrupted by premature stop codons.

46 promotes programmed readthrough on all three stop codons.

47 active in suppression of their corresponding stop codons.

48 ising diversity of natural AAs at reassigned stop codons.

49 t exons than in next-to-last exons harboring stop codons.

50 reference for location of m(6)A sites around stop codons.

51 edly altered protein sequences and premature stop codons.

52 hey are blocked by non-recycled ribosomes at stop codons.

53 nd expressed, but the majority have internal stop codons.

54 ide polymorphism that introduces a premature stop codon, a fraction of African descendents express fu

55 less stable than the same mRNA containing a stop codon, against the general belief in nonstop decay

56 tes RF2 to mediate peptide release without a stop codon, allowing stalled ribosomes to be recycled.

57 ncing or assembly error that gain or abolish stop codons also complicates ORF-based prediction of lnc

58 that alternative splicing and the premature stop codon alter ataxin-3 stability and that ataxin-3 is

59 n-deficient strains, sequencing identified 2 stop codon and 3 IS481 locations disrupting the prn gene

60 One mutation resulted in a premature stop codon and absent protein, while the second mutation

61 tion in the GL4 gene resulted in a premature stop codon and led to small seeds and loss of seed shatt

62 The resulting frameshift causes a premature STOP codon and loss of major higher molecular weight Sha

63 owed a mutation that resulted in a premature stop codon and protein truncation leading to complete lo

64 genes, in which only 1.3% of genes contained stop codons and 4.3% of genes were not expressed in male

65 cteria, Api arrests translating ribosomes at stop codons and causes pronounced queuing of the trailin

66 ycling was inhibited, disomes accumulated at stop codons and could move into the 3' UTR to reinitiate

67 om empirically observed prevalances of start/stop codons and gene lengths, and considers the dependen

68 Our data also show ribosome accumulation at stop codons and in the 3' UTR, suggesting a global defec

69 iminished, 80S ribosomes accumulated both at stop codons and in the adjoining 3'UTRs of most mRNAs.

70 ine incorporation occurs in response to opal stop codons and is dependent on the presence of a seleno

71 ay (NMD) of transcripts containing premature stop codons and related to the ATM and ATR kinases which

72 ns that cause premature STOP codons, loss of STOP codons and single nucleotide polymorphisms, and sho

73 ed truncated PrP Y145X (where X represents a stop codon) and Q160X mutants converted spontaneously in

74 protein 51 amino acid residues prior to the stop codon, and in concomitant loss of functionally impo

75 tation in the Mc4r gene produces a premature stop codon, and the mutant SIM1 protein lacks transcript

76 codon identity, the nucleotide following the stop codon, and the surrounding mRNA sequence context al

77 ns to frameshift mutations causing premature stop codons, and led to specific differences in grain mo

78 ations were predicted to introduce premature stop codons, and one was predicted to result in read thr

79 n deletions, frameshift mutations, premature stop codons, and transcriptional evidence of decay in th

80 In this compacted mRNA conformation, stop codons are favoured by a hydrogen-bonding network f

81 of transcription in the factory regions when stop codons are introduced near the N terminus of the AT

82 Stop codons are recognized by class I release factors (R

83 y, 3 bp overhangs corresponding to start and stop codons are used to assemble coding sequences into e

84 Expressed genes, some with premature stop codons, are interspersed with nonexpressed genes, g

85 translation termination is triggered when a stop codon arrives at the ribosomal A site.

86 Recoding of stop codons as amino acid-specifying codons is a co-tran

87 PTBP1 can thus mark specific stop codons as genuine, preserving both the ability of N

88 istinguish between the dual functionality of stop codons as stop signals and sense codons, resulting

89 ent CLCNKB mutation that creates a premature stop codon at Trp-610.

90 tion cycle because a mutant virus containing stop codons at the amino terminus of ORF2 does not react

91 An LR mutant virus containing stop codons at the amino terminus of ORF2 does not react

92 The 2stop component is two tandem stop codons at the G gene terminus, preceding the gene e

93 NA so that it stacks on the second and third stop codon bases.

94 ly when the codon frames are aligned can all stop codons be eliminated from the reverse strand by syn

95 focused 16 to 17 nucleotides upstream of the stop codon because of ribosomal pausing during translati

96 The efficiency of competition for the stop codon between release factors (eRFs) and near-cogna

97 Stop codon readthrough-the decoding of a stop codon by a near-cognate tRNA-is employed by viruses

98 able release factors, Api promotes pervasive stop codon bypass, leading to the expression of proteins

99 natural amino acids through suppression of a stop codon can be limited by truncation due to competiti

100 Early stop codons can be introduced in approximately 17,000 hu

101 Separately, canonical stop codons can be recoded to specify standard amino aci

102 ino acid substitution (G299V) or a premature stop codon causing strong virulence attenuation in mice.

103 fic UAG codon relative to UAA, the universal stop codon, compared with the wild type (WT).

104 Ribosomes stalled at the normal stop codon continue to add to the C terminus of C-I30 ce

105 cted by PTBP1 and that PTBP1 enrichment near stop codons correlates with 3'UTR length and resistance

106 s mutation in exon 5, leading to a premature stop codon deleting most of the cytoplasmic tail of LAT,

107 cture reveals that recognition of a modified stop codon does not differ from that of a canonical stop

108 the reading frame, and produces a premature stop codon downstream.

109 s the reading frame, and creates a premature stop codon downstream.

110 ineered a mouse with a premature translation stop codon equivalent to human S324Tfs*3, a recessive mu

111 that in addition to canonical termination on stop codons, eukaryotic release factors contribute to co

112 tant, in which residue G204 is replaced by a stop codon, features a partial reduction in Gbeta1gamma2

113 ture translation termination on out of frame stop codons following ribosome sliding.

114 somes, suggesting that targeting of critical stop codons for readthrough may be achievable without ge

115 irmed that in the presence of l-Trp, the UGA stop codon generates higher accumulation of both TnaC-pe

116 We targeted P2ACre to the Slc26a9 stop codon, generating Slc26a9(P2ACre) mice, and observe

117 onical stop codon to a conserved, downstream stop codon, generating VEGF-Ax ("x" for extended), a nov

118 Stop-codon-generating mutations in TcNTR-1 were associat

119 al class I release factors (RFs) in decoding stop codons has evolved beyond a simple tripeptide antic

120 No similar functional prion, skipping a stop codon, has been found in Escherichia coli, a fact p

121 Release factors (RFs) decode the stop codon, hydrolyze peptidyl-tRNA to release the nasce

122 Stop codon identity, the nucleotide following the stop c

123 tes, the rate of translation elongation, and stop codon identity.

124 tion-specific serotonin 2B (5-HT2B) receptor stop codon (ie, HTR2B Q20*) was reported to segregate wi

125 13), in exon 5; this frameshift introduces a stop codon in amino acid 308 of the growth arrest-specif

126 pression difference is caused by a premature stop codon in an ANS-regulating R2R3-MYB transcription f

127 in which read through of a pseudouridylated stop codon in bacteria results from increased decoding b

128 ic receptor 3 (GRM3) gene gained a premature stop codon in BMD cells, and silencing GRM3 in TMD cells

129 an immunodeficiency virus (SIV) containing a stop codon in nef We performed similar studies in 50 rhe

130 sed an attenuated strain of SIV containing a stop codon in nef.

131 f these polymorphisms introduces a premature stop codon in one isoform.

132 t terminate at, or close to, the native qapR stop codon in order for translation of PA5507 to occur.

133 ext, we generated a recombinant MHV68 with a stop codon in ORF46/UNG (DeltaUNG) that led to loss of U

134 identified by linkage analysis: a homozygous stop codon in PI3-kinase p110delta (PIK3CD) and a homozy

135 o cause alternative splicing and a premature stop codon in sweet quinoa strains.

136 277 fimB allele (A->T), creating a premature stop codon in the 33277 fimB open reading frame relative

137 oss of function due to the introduction of a stop codon in the 5' region of the BRCA1 transcript.

138 mRNA channel and substitutes for the absent stop codon in the A site by specifically recruiting rele

139 linked to a substitution causing a premature stop codon in the DMRT3 gene (DMRT3_Ser301STOP) [1].

140 within a single IR1 repeat unit, including a stop codon in the EBNA-LP gene.

141 es the reading frame and creates a premature stop codon in the first PPR domain.

142 ed that they were homozygous for a premature stop codon in the gene encoding nitric oxide synthase 1.

143 y known occurrence of two sense codons and a stop codon in the genome.

144 One variant, which introduces a stop codon in the GHR gene, is relatively frequent in Sa

145 Repair of the premature stop codon in the invasive sclA allele restored the abil

146 leotide polymorphism introducing a premature stop codon in the lysosomal trafficking regulator gene (

147 2R-encoding regions, we observed a premature stop codon in the mouse CB2R gene that truncated 13 amin

148 invasive serotype M3 GAS possess a premature stop codon in the sclA gene truncating the protein.

149 tro translation of mRNAs containing an amber-stop codon in the signal peptide in the presence of the

150 ed a point mutation that creates a premature stop codon in the transcriptional regulator gene SNF2 in

151 and of human L1 loci containing at least one stop codon in their ORF1 sequence.

152 In comparison to NTCs, downstream stop codons in 3'UTRs are recognized less efficiently by

153 Pseudouridylation of stop codons in eukaryotic and bacterial cells results in

154 d1 mutant allele lines introducing premature stop codons in exon 1, as well as obtained an abcd1 alle

155 domains in exon variants 32.1 and 32.2, and stop codons in exon variants 44.1 and 44.2.

156 ble and regulatable suppression of all three stop codons in H. volcanii.

157 s shed new light on how ribosomes can ignore stop codons in messenger RNA.

158 ding editing of 69PUK1-like pseudogenes with stop codons in ORFs.PUK1orthologs and other pseudogenes

159 ortion of the repertoire exhibited premature stop codons in some elderly subjects, indicating that ag

160 ning eRF1 interacting with each of the three stop codons in the A-site.

161 disorder are missense mutations or premature stop codons in the coding region of the lactase-phlorizi

162 RFs have structural motifs that recognize stop codons in the decoding center and a GGQ motif for i

163 demonstrate that introduction of equivalent stop codons in the full-length human L1 sequence leads t

164 Unusually, the top 3 hits all contained stop codons in the randomized region of the library, res

165 Release factors recognize stop codons in the ribosomal A-site to mediate release o

166 on skipping are designed to bypass premature stop codons in the target RNA and restore reading frame

167 wed the translational footprint of premature stop codons in Ttn, TTNtv-position-independent nonsense-

168 relates with ribosomes spending more time at stop codons, indicating that the ejection process might

169 base pair (bp) deletion (100% efficiency), a stop codon insertion (36%), and a single nucleotide subs

170 e able to formulate a new model in which the stop codon interacts with eRF1 through the P1 pocket.

171 and recombinant DNA technology, we inserted stop codons into the gH coding region.

172 Furthermore, the premature stop codon introduced by the CHADL frameshift mutation r

173 Premature stop codons introduced by mis-splicing of PgABCA2 pre-mR

174 Despite the two in-frame stop codons introduced by splicing between exons 2 and 4

175 During this process, the stop codon is decoded as a sense codon by a near-cognate

176 On exposure to cre-recombinase a stop codon is generated immediately downstream in exon 6

177 The hypomorphic Delta3A mutant, in which a stop codon is inserted downstream from the first ATG and

178 If a stop codon is not encountered, translation continues int

179 on of nad5 losing both translation start and stop codons is enriched in the mutant.

180 omes translating on messenger RNAs that lack stop codons is one of the co-translational quality contr

181 facilitate gene inactivation by induction of STOP codons (iSTOP), we provide access to a database of

182 When the ribosome encounters a stop codon, it recruits a release factor (RF) to hydroly

183 nucleotide insertion in JPH2 resulting in a stop codon (JPH2-p.E641*).

184 nue with translation through a premature UAG stop codon located in a beta-galactosidase reporter.

185 otein size (due to underlying changes in the stop codon location) or the DNA-binding forkhead domain

186 red sequence variations that cause premature STOP codons, loss of STOP codons and single nucleotide p

187 the +4 nucleotide immediately following the stop codon, modulate readthrough levels, underscoring th

188 An ORF2 stop codon mutant, an ORF2 nuclear localization mutant,

189 d a nonsense mutation leading to a premature stop codon mutation (R533X).

190 that SDHB mRNAs in hypoxic monocytes gain a stop codon mutation by APOBEC3A-mediated C-to-U RNA edit

191 e sequencing revealed a homozygous premature stop codon mutation in the gene encoding MYSM1.

192 ties of Q1412X-CFTR, a severe-form premature stop codon mutation.

193 egulator genes in which multiple independent stop codon mutations have convergently led to culture ad

194 trates are aberrant products of mRNA lacking stop codons [nonstop translation products (NSPs)].

195 The modulation was enriched near the stop codon of mRNAs, including genes related to neuronal

196 d-type AAV2 genome that is found between the stop codon of the cap gene, which encodes proteins that

197 A second mutation was introduced at stop codon of the IL-1R1 gene to allow tracking of the r

198 y, a 2A-GFP reporter was inserted before the stop codon of the MYF5 gene using homologous recombinati

199 fragments must reside between the second and stop codons of an mRNA.

200 variant erroneously read through UAG and UGA stop codons of mRNAs.

201 cross two evolutionarily conserved, in-frame stop codons of MTCH2 using luminescence- and fluorescenc

202 erent ataxin-3 isoforms and of the premature stop codon on ataxin-3's physiological function and on m

203 a point mutation that generates a premature stop codon on exon 3a (3aQ68*); (ii) Ccalpha6(3aAG>AT) c

204 may be due to ribosome migration through the stop codon or 3'UTR mRNA binding to ribosomes on the cod

205 al event because there was no evidence for a stop codon or alternative splicing event.

206 (NS), 42% synonymous and 1% gain or loss of stop codon or splice site variant] in 16 751 genes with

207 altered activity or introduce frameshifts or stop codons or disrupt regulatory elements to alter prot

208 s such as messenger RNAs harboring premature stop-codons or short upstream open reading frame (uORFs)

209 nal), an A4G gene end signal preceded by one stop codon, or the 2stop+A4G virulence-associated combin

210 y promoter defects, introduction of in-frame stop codon, or the lack of a polyadenylation signal.

211 e molecular basis of eRF1 discrimination for stop codons over sense codons is not known.

212 allele is predicted to result in a premature stop codon p.(Gln305*), and likely explains the decrease

213 that resulted in a frameshift and premature stop codon (p.Ala174Profs( *)35).

214 stitution (c.565G>T) introducing a premature stop codon (p.Glu189*).

215 This deletion led to a premature stop codon (p.T519X) with truncation of the last 12 amin

216 n carriers of an MC4R mutation introducing a stop codon (p.Tyr35Ter, MAF = 0.01%), who weighed 7 kg m

217 alyzed the properties of annotated start and stop codon positions in detail, and use the inferred pat

218 ing either a wild-type A2 strain G gene (one stop codon preceding a wild-type gene end signal), an A4

219 Addition of a second stop codon preceding the A4G point mutation (2stop+A4G)

220 The genotype consists of two tandem stop codons preceding an A-to-G point mutation in the 4t

221 that skips exon 9, resulting in a premature stop codon predicted to encode a truncated protein.

222 the identity of its stop codon, with the UGA stop codon producing higher expression efficiency of the

223 nterestingly, 70 of its genes have premature stop codons (PSC) and require A-to-I editing during sexu

224 When bound near a stop codon, PTBP1 blocks the NMD protein UPF1 from bindi

225 Drug-induced readthrough over premature stop codons (PTCs) is a potentially attractive therapy f

226 degrading transcripts that contain premature stop codons (PTCs) to mitigate their potentially harmful

227 e (C64T) at codon 22, leading to a premature stop codon (R22X) in the albino robust capuchin monkey.

228 ole-genome sequencing identified a premature stop codon, R255X, in the MYBPHL gene encoding MyBP-HL (

229 Stop codon read-through (SCR) is a process of continuati

230 nslation termination factor, which increases stop codon read-through allowing ribosomes to translate

231 Overexpression of Sup35 decreases stop codon read-through and rescues oxidant tolerance co

232 rmination in which the maximal efficiency of stop codon read-through depends on the interaction betwe

233 s in dystrophin are specifically targeted by stop codon read-through drugs, whereas out-of-frame dele

234 in eukaryotic and bacterial cells results in stop-codon read through.

235 Stop codon readthrough (SCR) occurs when the ribosome mi

236 y standard amino acids in a process known as stop codon readthrough (SCR), producing extended protein

237 s have increased translational miscoding and stop codon readthrough frequencies.

238 Programmed stop codon readthrough is a post-transcription regulator

239 rmalized reporter system, we discovered that stop codon readthrough is heterogeneous among single cel

240 chaperones, substrate reduction therapy, or stop codon readthrough).

241 gene rescue, including alternative splicing, stop codon readthrough, alternative translation initiati

242 Stop codon readthrough-the decoding of a stop codon by a

243 either reduced (K108E) or increased (R116D) stop codon readthrough.

244 erate to control translation termination and stop codon readthrough.

245 lenocysteine (Sec or U) is encoded by UGA, a stop codon reassigned by a Sec-specific elongation facto

246 provide a molecular framework for eukaryotic stop codon recognition and have implications for future

247 termination fidelity is achieved by linking stop codon recognition by RF1 to the change in conformat

248 for deciphering the principles for specific stop codon recognition by RFs identified Arg-213 as a cr

249 Our work highlights the notion that stop codon recognition involves complex interactions wit

250 bosome and then extend their structures upon stop codon recognition.

251 etion of hnRNP L binding sites near the BCL2 stop codon reduces expression of the fusion mRNAs and in

252 One of the genes with premature-stop-codons requiring A-to-I editing to encode full-leng

253 icated regions for RSV A and B, and at the G stop codon resulting in extension of 7 amino acids (22.1

254 nduce translational readthrough of premature stop codons resulting in the production of full-length p

255 (SCA6), whereas MPc splices to an immediate stop codon, resulting in a shorter cytoplasmic tail.

256 d of the protein, which produced a premature stop codon, resulting in production of the N-terminal 34

257 vicinity of start codons and increased near stop codons, revealing complex age-related changes in th

258 utionary analysis of the presence/absence of stop codons, revealing that ASP does impose significant

259 decoding of the third/wobble position of the stop codon set in the unfavorable termination context, t

260 ls to gene editing, which produced premature stop codons specifically within the mutant BEST1 alleles

261 Most RS-exons contain a premature stop codon such that their inclusion can decrease mRNA s

262 A similar conformation of RF2 may occur on stop codons, suggesting a general mechanism for release-

263 T of the start codons and to a lesser extent stop codons, suggesting that subunit tethering mildly af

264 The ongoing maturation of stop codon suppression and related technologies for unna

265 f yeast tRNAs that induce readthrough in the stop-codon tetranucleotide manner when overexpressed, de

266 etection of readthrough levels at all twelve stop-codon tetranucleotides and as a function of the com

267 ense mutation in the FAM136A gene leads to a stop codon that disrupts the FAM136A protein product.

268 e substitution, which results in a premature stop codon that generates a truncated form of the ZDHHC1

269 ing to a frameshift mutation and a premature stop codon that renders a truncated protein prone to deg

270 en reading frame of Ma1 leads to a premature stop codon that truncates the protein by 84 amino acids

271 A full 26% of genes in ST1 have stop codons that are created on the mRNA level by a nove

272 of mammalian IAVs frequently have premature stop codons that are expected to cause truncations of th

273 represented nonsense mutations resulting in stop codons, three of these in a single ApiAP2 transcrip

274 translating ribosomes traverse the canonical stop codon to a conserved, downstream stop codon, genera

275 A somatic second-site mutation reverting the stop codon to a missense mutation (p.Cys150Leu) was dete

276 ing release factor RF2, which normally binds stop codons to catalyze peptide release.

277 translation machinery and can suppress amber stop codons to incorporate selenocysteine with high effi

278 noproteins requires recoding of internal UGA stop codons to the 21st non-standard amino acid selenocy

279 sarium graminearum, we found that two tandem stop codons, UA(1831)GUA(1834)G, in its kinase domain we

280 ncounters one of three universally conserved stop codons: UAA, UAG or UGA.

281 o found tRNA(Sec) species that recognize the stop codons UAG and UAA, and ten sense codons.

282 Bacteria decode stop codons using two separate release factors with diff

283 lso imply that patients carrying a premature stop codon versus missense mutations will likely display

284 ation is performed by eRF1, which recognizes stop codons via its N-terminal domain.

285 eam open reading frames, the over-reading of stop codons via ribosomal frameshifting, the existence o

286 the mouse coding sequence from the start to stop codon was replaced with the corresponding human gen

287 Stop codons were detected in 19.3% of patients (intrapat

288 Mutations leading to premature stop codons were detected in the prfA and inlA virulence

289 ell recognition were not observed, premature stop codons were observed in 7% and 56% of tax sequences

290 is sequence downstream of the canonical AGO1 stop codon, which is sufficient to drive readthrough eve

291 ogy, we observed an increase in detrimental (stop) codons, which confirmed the effectiveness of this

292 *557Gluext*46 resulted in replacement of the stop codon with 46 additional codons at the C-terminus.

293 ression is influenced by the identity of its stop codon, with the UGA stop codon producing higher exp

294 We found that introduction of a premature stop codon within qapR eliminates transcriptional autore

295 ur populations of Arabidopsis to a premature stop codon within TBP-ASSOCIATED FACTOR 4b (TAF4b), whic

296 d from the primary unspliced transcript to a stop codon within the intron unique to HSV-2 gamma34.5.

297 ype (WT) K1, a deleted K1 ORF (KSHVDeltaK1), stop codons within the K1 ORF (KSHV-K15xSTOP), or a reve

298 78 harbouring mutations leading to premature stop codons within the master regulator, Spo0A.

299 ng four codons (CAA, CAG, CGA, and TGG) into STOP codons without DSB formation.

300 scherichia coli enhances translation of UAG (Stop) codons, yet may also extended protein synthesis at