ライフサイエンスコーパス: store-operated

1 proteins or STIM2 overexpression results in store-operated activation of Imin channels, whereas STIM

2 terminal truncations than Orai1 in retaining store-operated activation.

3 itch the regulation of Imin channels between store-operated and store-independent modes.

4 Ca(2+) release, or SKF96365, an inhibitor of store-operated and TRPC channel-mediated Ca(2+) entry.

5 To assess the relative contributions of store-operated and voltage-gated Ca(2+) channels to this

6 ization with Orai1, the predominant membrane store operated Ca(2+) channel that cooperates with the e

7 tion in the expression of a component of the store operated Ca(2+) channel, TRPC1 blocks MTI-101 indu

8 small molecule inhibitor of Ca(2+) entry via store operated Ca(2+) entry (SOCE) channels formed by st

9 Store operated Ca(2+) entry (SOCE) via the Ca(2+) releas

10 IM1) and the Ca(2+) channel Orai1 as well as store operated Ca(2+) entry.

11 Store-operated Ca(2)(+) entry (SOCE) in skeletal muscle

12 blastoma cell line, we found that endogenous store-operated Ca(2)(+) entry (SOCE), which is critical

13 d in CD4(+) T cells, where it acted as a non-store-operated Ca(2+) channel and contributed to T cell

14 endoplasmic reticulum and activation of the store-operated Ca(2+) channel Orai1, enabling plasma-mem

15 4b closely associated with both POST and the store-operated Ca(2+) channel Orai1.

16 Here we demonstrate that a store-operated Ca(2+) channel subunit, Orai1, is require

17 Orai1 is a pore subunit of a store-operated Ca(2+) channel that is a major molecular

18 Here, we report that mice lacking the store-operated Ca(2+) channel, Orai1, in the brain show

19 our results demonstrate the pivotal role of store-operated Ca(2+) channel-mediated Ca(2+) influx in

20 r stromal interaction molecule 1 (STIM1) and store-operated Ca(2+) channels (e.g., the Orai1 channel)

21 es have also determined the relevant role of store-operated Ca(2+) channels (SOCC) in vascular tone r

22 Store-operated Ca(2+) channels (SOCs) are voltage-indepe

23 Ca(2+) influx by store-operated Ca(2+) channels (SOCs) mediates all Ca(2+

24 Therefore, our data support the concept that store-operated Ca(2+) channels in hPECs and prostate can

25 mechanism for delivering Ca(2+) entering via store-operated Ca(2+) channels to specific target sites,

26 4P was suppressed when Ca(2+) influx through store-operated Ca(2+) channels was inhibited.

27 tive stores followed by Ca(2+) entry through store-operated Ca(2+) channels, and the latter selective

28 e acutely inhibited by YM58483, which blocks store-operated Ca(2+) channels.

29 Both 4 and 10 elicited a store-operated Ca(2+) current I(CRAC) in patch-clamped c

30 c fluxes in SANCs, including activation of a store-operated Ca(2+) current, a reduction in L-type Ca(

31 (2+) leads to overactivation of the neuronal store-operated Ca(2+) entry (nSOC) pathway in YAC128 MSN

32 glandin D(2) increased Ca(2+) influx through store-operated Ca(2+) entry (SOCE) accompanied by the up

33 STIM/ORAI proteins mediate store-operated Ca(2+) entry (SOCE) and drive fibro-proli

34 or deletion of both ESYT1 and ESYT2 reduced store-operated Ca(2+) entry (SOCE) and ORAI1-STIM1 clust

35 mal interaction molecule 1 (STIM1) regulates store-operated Ca(2+) entry (SOCE) and other ion channel

36 sis were dependent on TRPC4 channel-mediated store-operated Ca(2+) entry (SOCE) and sequential activa

37 ially regulates activation of STIM1-mediated store-operated Ca(2+) entry (SOCE) between cervical canc

38 Orai1, a store-operated Ca(2+) entry (SOCE) channel, was previous

39 Store-operated Ca(2+) entry (SOCE) channels are highly s

40 Store-operated Ca(2+) entry (SOCE) channels are importan

41 reticulum (ER) and subsequent activation of store-operated Ca(2+) entry (SOCE) channels in the plasm

42 Moreover, knockdown of two key store-operated Ca(2+) entry (SOCE) components, Orai1 and

43 1 inhibition or disease mutations potentiate store-operated Ca(2+) entry (SOCE) due to a presenilin 1

44 Store-operated Ca(2+) entry (SOCE) encoded by Orai1 prot

45 Store-operated Ca(2+) entry (SOCE) has emerged as an imp

46 el subunit, best recognized as a mediator of store-operated Ca(2+) entry (SOCE) in nonexcitable cells

47 Store-operated Ca(2+) entry (SOCE) into hCASMCs expressi

48 Store-operated Ca(2+) entry (SOCE) is a Ca(2+)-entry pro

49 Store-operated Ca(2+) entry (SOCE) is a major Ca(2+) inf

50 Store-operated Ca(2+) entry (SOCE) is a ubiquitous pathw

51 Store-operated Ca(2+) entry (SOCE) is a universal Ca(2+)

52 on depletion of intracellular Ca(2+) stores, store-operated Ca(2+) entry (SOCE) is activated.

53 Store-operated Ca(2+) entry (SOCE) is an essential proce

54 ra-2 and Mag-Fluo4) levels are decreased and store-operated Ca(2+) entry (SOCE) is inhibited, whereas

55 Store-operated Ca(2+) entry (SOCE) is the main Ca(2+) in

56 Store-operated Ca(2+) entry (SOCE) is the predominant Ca

57 on enhances extracellular Ca(2+) entry via a store-operated Ca(2+) entry (SOCE) mechanism in skeletal

58 i and fluid secretion and is mediated by the store-operated Ca(2+) entry (SOCE) mechanism.

59 al stem/progenitor cells (NSCs/NPCs) exhibit store-operated Ca(2+) entry (SOCE) mediated by Ca(2+) re

60 y been reported to play an important role in store-operated Ca(2+) entry (SOCE) mediated by ORAI and

61 Store-operated Ca(2+) entry (SOCE) mediates the increase

62 ER Ca(2+) level is in part monitored by the store-operated Ca(2+) entry (SOCE) system, an adaptive m

63 s, KO cells presented a notable reduction of store-operated Ca(2+) entry (SOCE) that was rescued by e

64 Store-operated Ca(2+) entry (SOCE) through Ca(2+) releas

65 Store-operated Ca(2+) entry (SOCE) through Ca(2+) releas

66 Store-operated Ca(2+) entry (SOCE) through Ca(2+) releas

67 Store-operated Ca(2+) entry (SOCE) through Ca(2+) releas

68 Store-operated Ca(2+) entry (SOCE) through sarcolemmal C

69 +) sensor STIM1 is crucial for activation of store-operated Ca(2+) entry (SOCE) through transient rec

70 fibrosis, 17beta-estradiol (E2) may inhibit store-operated Ca(2+) entry (SOCE) to impinge upon airwa

71 (ER) store, organizes as puncta that trigger store-operated Ca(2+) entry (SOCE) via plasmalemmal Ca(2

72 Store-operated Ca(2+) entry (SOCE) was blocked by the SO

73 This store-operated Ca(2+) entry (SOCE) was observed in appro

74 First, we discovered that RASSF4 regulates store-operated Ca(2+) entry (SOCE), a fundamental Ca(2+)

75 Store-operated Ca(2+) entry (SOCE), a major Ca(2+) signa

76 Store-operated Ca(2+) entry (SOCE), a ubiquitous mechani

77 +) levels, agonist-induced Ca(2+) increases, store-operated Ca(2+) entry (SOCE), and store-operated c

78 Store-operated Ca(2+) entry (SOCE), mediated by the endo

79 AT1) expression together with an increase in store-operated Ca(2+) entry (SOCE), SOCE-dependent nucle

80 Store-operated Ca(2+) entry (SOCE), the fundamental Ca(2

81 dulated intracellular Ca(2+) release but not store-operated Ca(2+) entry (SOCE), whereas neutrophil N

82 ORAI1 is an essential pore subunit of store-operated Ca(2+) entry (SOCE), which is a major Ca(

83 ate Orai channels at the plasma membrane for store-operated Ca(2+) entry (SOCE), while classical tran

84 ted Ca(2+) channel subunit, Orai1, underlies store-operated Ca(2+) entry (SOCE).

85 d CD95 into a cluster, eliciting a polarized store-operated Ca(2+) entry (SOCE).

86 mal interacting molecule 1 (STIM1) regulates store-operated Ca(2+) entry (SOCE).

87 Ca(2+) channel Orai1 at ER-PM junctions for store-operated Ca(2+) entry (SOCE).

88 showed decreased internal Ca(2+) stores and store-operated Ca(2+) entry (SOCE).

89 Ca(2+) entry across the plasma membrane via store-operated Ca(2+) entry (SOCE).

90 at [Ca(2+)]ER can regulate Ca(2+) influx via store-operated Ca(2+) entry (SOCE).

91 s able to activate Ca(2+) entry by enhancing store-operated Ca(2+) entry (SOCE).

92 ase co-localization of proteins required for store-operated Ca(2+) entry (SOCE).

93 lasma membrane (PM) Orai1 channels mediating store-operated Ca(2+) entry (SOCE).

94 M2 by siRNA or inhibition by G418 suppresses store-operated Ca(2+) entry and agonist-mediated Ca(2+)

95 et-derived growth factor activates canonical store-operated Ca(2+) entry and Ca(2+) release-activated

96 This activity relied on influx via store-operated Ca(2+) entry and Orai channels.

97 These dysfunctions stem from alterations in store-operated Ca(2+) entry and sarcoplasmic endoplasmic

98 We show that hGAAP increased store-operated Ca(2+) entry and thereby the activity of

99 e with a SERCA inhibitor (thapsigargin) or a store-operated Ca(2+) entry blocker (GSK 7975 A) reverse

100 R-resident regulatory protein STIM1 triggers store-operated Ca(2+) entry by direct interaction with t

101 of the pore-forming subunit Orai1, the major store-operated Ca(2+) entry channel in platelets.

102 ently of Ca(2+) entry through the ubiquitous store-operated Ca(2+) entry channel Orai1, global Ca(2+)

103 l channel 4 (TRPC4) comprises an endothelial store-operated Ca(2+) entry channel, and TRPC4 inactivat

104 Orai1-encoded store-operated Ca(2+) entry has recently emerged as an i

105 ped by GlaxoSmithKline, GSK-7975A, inhibited store-operated Ca(2+) entry in a concentration-dependent

106 Additionally, we found no store-operated Ca(2+) entry in control or STIM1 overexpr

107 nflux from the extracellular medium, such as store-operated Ca(2+) entry in fibroblasts and membrane

108 suggest new therapies aiming at attenuating store-operated Ca(2+) entry in the treatment of patients

109 analysis that includes the potential role of store-operated Ca(2+) entry in these processes.

110 Store-operated Ca(2+) entry is a widely encountered mech

111 The STIM1-ORAI1 pathway of store-operated Ca(2+) entry is an essential component of

112 Store-operated Ca(2+) entry is important for cell migrat

113 that with increasing agonist concentrations, store-operated Ca(2+) entry is mediated initially by end

114 Our findings show that store-operated Ca(2+) entry is needed to sustain cytopla

115 tracellular stores, but depended strongly on store-operated Ca(2+) entry mechanisms.

116 Store-operated Ca(2+) entry mediated by STIM1 and ORAI1

117 Store-operated Ca(2+) entry occurs through the binding o

118 e 1 (STIM1) and Orai1, the components of the store-operated Ca(2+) entry pathway, to generate cells w

119 Intracellular Ca(2+) imaging revealed that store-operated Ca(2+) entry played a prominent role in S

120 Our findings indicate that store-operated Ca(2+) entry regulates SGK1 expression in

121 -membrane cytosolic Ca(2+) abundances during store-operated Ca(2+) entry revealed that PMCA4 markedly

122 ated that CRF(2) expressed on MCs suppresses store-operated Ca(2+) entry signaling and MC degranulati

123 identified as a Ca(2+) sensor that regulates store-operated Ca(2+) entry through activation of the po

124 Store-operated Ca(2+) entry through Orai1 channels is a

125 Furthermore, Ca(2+) influx through the store-operated Ca(2+) entry triggered strong, whereas ER

126 Store-operated Ca(2+) entry was not detected in these ce

127 Store-operated Ca(2+) entry was similarly increased by o

128 ctivated calcium modulator (ORAI) 1-mediated store-operated Ca(2+) entry were found to regulate LPS-i

129 ak and that these actions are independent of store-operated Ca(2+) entry, a process that is absent in

130 brane junctions where STIM1, which regulates store-operated Ca(2+) entry, accumulates after depletion

131 STIM1) and Orai1 channels, key components of store-operated Ca(2+) entry, are selectively expressed i

132 s exploit host signaling pathways, including store-operated Ca(2+) entry, autophagy, and inflammasome

133 Store-operated Ca(2+) entry, essential for the adaptive

134 Store-operated Ca(2+) entry, involving endoplasmic retic

135 rnal Na(+) also had no significant effect on store-operated Ca(2+) entry, on cytosolic Ca(2+) oscilla

136 llular media, through a mechanism resembling store-operated Ca(2+) entry, typical of mammalian cells;

137 plasmic reticulum Ca(2+) load independent of store-operated Ca(2+) entry, we hypothesized that it con

138 erface with mitochondria; but also originate store-operated Ca(2+) entry-induced transcellular Ca(2+)

139 Activation of the store-operated Ca(2+) entry-like Ca(2+) influx may be re

140 2+) uptake occurs through a process known as store-operated Ca(2+) entry.

141 oplasm but only transverse tubules supported store-operated Ca(2+) entry.

142 t type I fiber content but not through acute store-operated Ca(2+) entry.

143 ced ER Ca(2+) levels and, in turn, increased store-operated Ca(2+) entry.

144 ease from intracellular stores and driven by store-operated Ca(2+) entry.

145 dent contacts, however, are not required for store-operated Ca(2+) entry.

146 where it activates Orai1 channels, providing store-operated Ca(2+) entry.

147 ous septin proteins as crucial regulators of store-operated Ca(2+) entry.

148 signaling by a mechanism that is upstream of store-operated Ca(2+) entry.

149 ned by voltage-independent Ca(2+) influx via store-operated Ca(2+) entry.

150 regulates cardiac hypertrophy by triggering store-operated Ca(2+) entry.

151 The molecular components of store-operated Ca(2+) influx channels (SOCs) in prolifer

152 Quercetin also rapidly inhibits store-operated Ca(2+) influx stimulated by thapsigargin.

153 ER-plasma membrane (PM) junctions to trigger store-operated Ca(2+) influx.

154 x, Ca(2+)-induced Ca(2+)-release (CICR), and store-operated Ca(2+) influx.

155 Ca(2+) entry through store-operated Ca(2+) release-activated Ca(2+) (CRAC) ch

156 n immune cells, calcium entry occurs through store-operated Ca(2+) release-activated Ca(2+) (CRAC) ch

157 Signaling through the store-operated Ca(2+) release-activated Ca(2+) (CRAC) ch

158 ated, highly calcium-selective channels: the store-operated Ca(2+) release-activated Ca(2+) (CRAC) ch

159 ORAI1 constitutes the store-operated Ca(2+) release-activated Ca(2+) (CRAC) ch

160 Here, we identified store-operated Ca(2+) release-activated Ca(2+) (CRAC) ch

161 Store-operated Ca(2+) release-activated Ca(2+) (CRAC) ch

162 o-exist endogenously in many cell types: the store-operated Ca(2+) release-activated CRAC channels an

163 Store-operated Ca(2+) signaling represents a major signa

164 PC) are involved in receptor-operated and/or store-operated Ca(2+) signaling.

165 d PARK14 disease locus (Pla2g6 gene) and the store-operated Ca(2+) signalling pathway.

166 chondrial, and lysosomal Ca(2+) pools and in store-operated Ca(2+) uptake in JNCL cells.

167 argin (TG), an ER Ca(2+)-ATPase blocker, and store-operated Ca(2+)-entry (SOCE).

168 sine kinases mobilizes Ca(2+) influx through store-operated Ca(2+)-release-activated Ca(2+) (CRAC) ch

169 equired entry of extracellular Ca(2+)through store-operated Ca(2+)channels.

170 We demonstrate that sigma1Rs inhibit store-operated Ca(2+)entry (SOCE), a major Ca(2+)influx

171 itates slow Ca(2+)-dependent inactivation of store-operated Ca(2+)entry (SOCE).

172 The store-operated Ca(2+)entry-associated regulatory factor

173 cking either Nox2 or Stim1 failed to trigger store-operated Ca2+ entry (SOCe) and NFAT nuclear accumu

174 Application of the store-operated Ca2+ entry (SOCE) blockers BTP2 (10 mum)

175 c Ca2+ activity ([Ca2+](i)), accomplished by store-operated Ca2+ entry (SOCE) involving the pore-form

176 Store-operated Ca2+ entry (SOCE) is the major route of C

177 ellular Ca2+ concentrations are regulated by store-operated Ca2+ entry (SOCE) through Ca2+ release-ac

178 (CRAC) channel genes ORAI1 and STIM1 abolish store-operated Ca2+ entry (SOCE), and patients with thes

179 ed cytosolic signals is based on attenuating store-operated Ca2+ entry (SOCE).

180 A common mechanism for Ca2+ influx is store-operated Ca2+ entry (SOCE).

181 plays an essential role in the activation of store-operated Ca2+ entry (SOCE).

182 Although lowering Stim1 levels reduces store-operated Ca2+ entry and inhibits intestinal epithe

183 Store operated calcium entry (SOCE) is thought to primar

184 et al. present compelling evidence that the store-operated calcium (Ca2+) channel Orai1 sustains Th1

185 ied the interaction between calreticulin and store-operated calcium (Ca2+) entry (SOCE) machinery in

186 ude of currents similar to those ascribed to store-operated calcium (SOC) channels, particularly thos

187 synaptotoxic enhancement of STIM2-dependent store-operated calcium (SOC) entry.

188 TRPM7 is not a store-operated calcium channel.

189 Store-operated calcium channels (SOCs) are calcium-selec

190 , the model shows that calcium entry through store-operated calcium channels is critical for calcium

191 ceptors (TCRs) followed by calcium entry via store-operated calcium channels.

192 e have previously demonstrated that neuronal store-operated calcium entry (nSOC) in hippocampal neuro

193 d in an increase in cell proliferation rate, store-operated calcium entry (SOCE) amplitude, cationic

194 um-dependent signaling pathways initiated by store-operated calcium entry (SOCE) are known to regulat

195 In the present study, we report store-operated calcium entry (SOCE) as a novel target of

196 Our previous studies implied store-operated calcium entry (SOCE) as the major pathway

197 Store-operated calcium entry (SOCE) by calcium release a

198 ion of ATLs alters ER morphology and affects store-operated calcium entry (SOCE) by decreasing STIM1

199 elease and were attenuated by inhibiting the store-operated calcium entry (SOCE) channel Orai1.

200 We hypothesized that the store-operated calcium entry (SOCE) channel, Orai1, part

201 e measured resting intracellular calcium and store-operated calcium entry (SOCE) in fast- and slow-tw

202 M1-deficient murine neutrophils show loss of store-operated calcium entry (SOCE) in response to both

203 Store-operated calcium entry (SOCE) is important in the

204 Store-operated calcium entry (SOCE) is involved in vario

205 Store-operated calcium entry (SOCE) is the mechanism by

206 Store-operated calcium entry (SOCE) is the predominant C

207 Transcriptional regulation by Store-operated Calcium Entry (SOCE) is well studied in n

208 By inhibiting store-operated calcium entry (SOCE) or voltage-gated Ca(

209 relaxation required Ca(2+) flux through the store-operated calcium entry (SOCE) pathway and accompan

210 The store-operated calcium entry (SOCE) pathway is an import

211 Store-Operated Calcium Entry (SOCE) plays key roles in c

212 Despite recent advances in understanding store-operated calcium entry (SOCE) regulation, the fund

213 4-mediated depletion of ER calcium activates store-operated calcium entry (SOCE) through activation o

214 her major source of [Ca(2+)]cyt elevation is store-operated calcium entry (SOCE) through plasmalemmal

215 more, pharmacological studies suggested that store-operated calcium entry (SOCE), a calcium refilling

216 ic Ca(2+) concentrations in GC cells through store-operated calcium entry (SOCE), and then mediated C

217 Sustained Ca(2+) signaling, known as store-operated calcium entry (SOCE), occurs downstream o

218 initiated in immune cells by the process of store-operated calcium entry (SOCE), where receptor acti

219 such as excitation-contraction coupling and store-operated calcium entry (SOCE).

220 ly conserved Calcium influx pathway known as store-operated calcium entry (SOCE).

221 1) is a Ca(2+) sensor protein that initiates store-operated calcium entry (SOCE).

222 This mechanism is called store-operated calcium entry (SOCE).

223 hannel that has been considered as a part of store-operated calcium entry (SOCE).

224 lar calcium and the subsequent activation of store-operated calcium entry (SOCE).

225 eptor potential melastatin 7 (TRPM7) reduces store-operated calcium entry (SOCE).

226 During store-operated calcium entry activation, calcium depleti

227 Interestingly, the store-operated calcium entry channel inhibitor (SK&F9636

228 ndoplasmic reticulum calcium release-induced store-operated calcium entry contributes to intracellula

229 n vitro, TMEM16A is required for EGF-induced store-operated calcium entry essential for pancreatic ca

230 gated PPZ is based on activation of neuronal store-operated calcium entry in spines.

231 Calcium flux through store-operated calcium entry is a central regulator of i

232 of an additional level in the regulation of store-operated calcium entry pathways.

233 identify the molecular mechanism underlying store-operated calcium entry that replenishes ER stores

234 ionally, the calcium-replenishing process of store-operated calcium entry was impaired in MFN2 knockd

235 represent the primary pathway for so-called "store-operated calcium entry" - the cellular entry of ca

236 We show that STIM1, an activator of store-operated calcium entry, regulates the dynamics of

237 ulum calcium activates STIM1/Orai1-dependent store-operated calcium entry.

238 e result of an acute loss of Orai1-dependent store-operated calcium entry.

239 ai proteins constitute the core machinery of store-operated calcium entry.

240 nd 2 (STIM1 and STIM2) are key modulators of store-operated calcium entry.

241 nctioning to sustain calcium signals through store-operated calcium entry.

242 Our results indicate that the P2Y6/store-operated calcium entry/IL-8 axis is involved in MS

243 om spines depends on STIM2-mediated neuronal store-operated calcium influx (nSOC) and continuous acti

244 ading to depletion of calcium ion stores and store-operated calcium influx.

245 The two key components of the store-operated calcium release-activated calcium channel

246 f a new immunomodulatory drug inhibiting the store-operated calcium release-activated calcium channel

247 d ER Ca(2+) store release, possibly engaging Store Operated cAMP Signaling (SOcAMPS) and activating C

248 STIM1 and STIM2 and their different roles in store-operated channel activation are indicative of an a

249 enhancement of SOCE activities sensitive to store-operated channel inhibitors (SKF-96365 and BTP2) a

250 sed diastolic [Ca(2+)]i, which is blunted by store-operated channel inhibitors.

251 linked to SOCE, without TRPM7 representing a store-operated channel itself.

252 , we show that pharmacological inhibition of store operated channels or reduction in the expression o

253 In other cell types store-operated channels (SOC) have been shown to contrib

254 asmic reticulum (SR) Ca(2+) stores activates store-operated channels (SOCs) composed of canonical tra

255 lls (VSMCs), activation of Ca(2+) -permeable store-operated channels (SOCs) composed of canonical tra

256 or potential channel 1 (TRPC1) protein-based store-operated channels (SOCs) mediates Ca(2+) entry pat

257 t receptor potential channel 1 (TRPC1)-based store-operated channels (SOCs) mediates Ca(2+) entry pat

258 or potential channel 1 (TRPC1) protein-based store-operated channels (SOCs) mediates Ca(2+) entry pat

259 POINTS: Depletion of Ca(2+) stores activates store-operated channels (SOCs), which mediate Ca(2+) ent

260 Depletion of Ca(2+) stores activates store-operated channels (SOCs), which mediate Ca(2+) ent

261 Both the store-operated channels and the store-independent arachi

262 critically dependent on Ca(2+) entry through store-operated channels but do not depend strongly on Ca

263 ltage-gated channels are less important than store-operated channels in the control of airway smooth

264 alcium sensor that initiates the assembly of store-operated channels, and the calcium-independent pho

265 endoplasmic reticulum (ER) Ca(2+) sensor for store-operated channels.

266 TIM2 differ in the ability to activate these store-operated channels; Imin channels are regulated by

267 s signalling power; Ca(2+) microdomains near store-operated CRAC channels in the plasma membrane and

268 ur findings demonstrate that Ca2+ influx via store-operated CRAC channels is essential for CaCC activ

269 ent potassium channels (K(ATP)) or an inward store-operated current (SOC).

270 ses, store-operated Ca(2+) entry (SOCE), and store-operated currents (ISOC) are largely enhanced in t

271 On the other hand, many cell types display store-operated currents different from CRAC.

272 contribute to enhanced SOCE and differential store-operated currents in tumor cells, whereas ORAI2 an

273 e-activated Ca(2+) (CRAC) channel, mediating store-operated currents.

274 effect of NCLX activity on Ca(2+) influx via store-operated entry.

275 aracterized by exquisite Ca(2+) selectivity, store-operated gating, and distinct pore properties and

276 Last, store-operated influx, evoked by ER depletion, was remov

277 Furthermore, generation of store-operated interactions between PIP(2) and TRPC1 and

278 clear whether STIM2 is capable of regulating store-operated non-CRAC channels.

279 hypothesis that pharmacological blockade of store-operated or Ca(2+) release-activated Ca(2+) channe

280 y, these structural requisites were found in store-operated Orai channels.

281 be activated by Ca(2+) nanodomains near open store-operated Orai1 and voltage-gated Ca(2+) channels i

282 Store-operated Orai1 channels are a major mechanism for

283 lular Ca(2+) that accompanies the opening of store-operated Orai1/CRAC channels.

284 In addition, store-operated PIP(2) and TRPC1 interactions were blocke

285 (shRNA) and absent in TRPC1(-/-) cells, and store-operated PKC phosphorylation of TRPC1 was inhibite

286 Store-operated PKC phosphorylation of TRPC1 was reduced

287 quires protein kinase C (PKC) activity, with store-operated PKC-dependent phosphorylation of TRPC1 es

288 SOCs, and U73122 and GF109203X also reduced store-operated PKC-dependent phosphorylation of TRPC1 pr

289 ation of TRPC1-based SOCs and highlight that store-operated PKCdelta activity is obligatory for chann

290 patients reveals a significant deficiency in store-operated PLA2g6-dependent Ca(2+) signalling, which

291 PLCbeta1 with small hairpin RNA reduced both store-operated PLC activity and stimulation of TRPC1 SOC

292 Moreover, store-operated PLCbeta1 activity measured with the fluor

293 Here, we show that the store-operated response in Muller cells, radial glia tha

294 By characterizing the properties of store-operated signaling pathways in Muller cells, these

295 in VSMCs, and a novel role for STIM1, where store-operated STIM1-TRPC1 interactions stimulate Galpha

296 VSMCs, and a novel role for STIM1, in which store-operated STIM1-TRPC1 interactions stimulate PLCbet

297 Store-operated TRPC1 channel activity was inhibited by T

298 Store-operated TRPC1 channel and PLCbeta1 activities wer

299 Store-operated TRPC1 channels were identified by their e

300 Store-operated whole-cell cation currents were blocked b