ライフサイエンスコーパス: store-operated channel

1 hondrial Na(+) /Ca(2+) exchangers, SERCA and store-operated channels.

2 endoplasmic reticulum (ER) Ca(2+) sensor for store-operated channels.

3 eins constitute pore-forming subunits of the store-operated channels.

4 activity without significantly affecting the store-operated channels.

5 association between TRPCs generate distinct store-operated channels.

6 365, suggesting that the influx is via leaky store-operated channels.

7 suggests that they are due to Ca2+ entry via store-operated channels.

8 n-excitable cells Ca2+ influx is mediated by store-operated channels.

9 nce oscillation frequency in addition to the store-operated channels.

10 nnels, mammalian TRP channels, and mammalian store-operated channels.

11 for exploring the physiological functions of store-operated channels.

12 mechanism for distribution and regulation of store-operated channels.

13 ellular Ca2+, rather than directly acting on store-operated channels.

14 ggers Ca(2+) influx through plasma membrane "store-operated" channels.

15 or SKF 96365 (3 x 10(-5) M), an inhibitor of stores-operated channels.

16 Thus, as concluded for store-operated channels, 2APB seems to inhibit TRPC chan

17 nels [5,6] as well as through less selective store-operated channels [7].

18 STIM1 and STIM2 and their different roles in store-operated channel activation are indicative of an a

19 ified either OAG-induced TRPC3 activation or store-operated channel activation in DT40 cells.

20 2+(o)-induced differentiation, but augmented store-operated channel activity and Ca2+ uptake by intra

21 rgin, a known activator of calcium entry via store-operated channels, all increased lung endothelial

22 mammalian Htrp3 protein forms a well defined store-operated channel and so provides a suitable system

23 ound DES to be a very effective inhibitor of store-operated channels and Ca(2+) influx in a variety o

24 tional iPLA(2) is required for activation of store-operated channels and capacitative Ca(2+) influx i

25 To study the effect of DES on store-operated channels and capacitative Ca(2+) influx,

26 ed from Ca(2+)-dependent inactivation of the store-operated channels and does not involve changes in

27 d channels, a gene family that includes Ca2+ store-operated channels and inositol 1,4,5-trisphosphate

28 Both the store-operated channels and the store-independent arachi

29 ticulum, by subsequent calcium entry through store-operated channels, and by increased calcium sensit

30 ther hand, both SKF 96365, a blocker of Ca2+ store-operated channels, and external Na+ removal suppre

31 ut it enters these cells only poorly through store-operated channels, and it is not sequestered by in

32 alcium sensor that initiates the assembly of store-operated channels, and the calcium-independent pho

33 arguing that receptor-stimulated rather than store-operated channels are involved in these sustained

34 ) channels at low agonist concentrations, to store-operated channels at high concentrations.

35 Pharmacological inhibitors of store-operated channels blocked thapsigargin-induced Ca(

36 eins, do not serve as functional subunits of store-operated channels but do function as subunits for

37 critically dependent on Ca(2+) entry through store-operated channels but do not depend strongly on Ca

38 Inhibitors of store-operated channels but not L-type channels diminish

39 hibition is not due to calcium entry through store-operated channels but rather results from calcium

40 eviously we have described the properties of store-operated channel currents (SOCs) in freshly disper

41 pear to possess different characteristics to store-operated channels described in other vascular smoo

42 at birth is related to calcium entry through store-operated channels, encoded by the transient recept

43 h these single-channel openings as amplified store-operated channel events.

44 The Ca2+ store-operated channels formed upon expression of TRPC3

45 TIM2 differ in the ability to activate these store-operated channels; Imin channels are regulated by

46 if TrpC1 protein (encoded by trp1 gene) is a store-operated channel in freshly isolated smooth muscle

47 ular Ca(2+) stores and likely to be a native store-operated channel in vascular smooth muscle cells (

48 ltage-gated channels are less important than store-operated channels in the control of airway smooth

49 -based techniques to investigate the role of store-operated channels in the maintenance of hormone-in

50 t TRPC4 channels behave as receptor, but not store-operated, channels in neuronally derived cells.

51 enhancement of SOCE activities sensitive to store-operated channel inhibitors (SKF-96365 and BTP2) a

52 sed diastolic [Ca(2+)]i, which is blunted by store-operated channel inhibitors.

53 Thus, store-operated channels involving Trp4 and Trp5 can form

54 linked to SOCE, without TRPM7 representing a store-operated channel itself.

55 ed Ca2+ release, followed by activation of a store-operated channel mechanism.

56 Diversity of store-operated channels might be related to the physiolo

57 nnel, in regulating Ca(2+) entry through the store-operated channels mouse transient receptor potenti

58 , we show that pharmacological inhibition of store operated channels or reduction in the expression o

59 ation of two forms of Orai1, the predominant store-operated channel, Orai1alpha and Orai1beta, raises

60 We conclude that, in contrast to store-operated channels, regulation of ARC channels by S

61 r any of the genes encode native subunits of store-operated channels remains unanswered.

62 Orai1 are the long sought components of the store-operated channels required in T-cell activation.

63 Nevertheless, until recently, no candidate store-operated channel (SOC) had been identified molecul

64 phate (PIP(2)) was studied on a native TRPC1 store-operated channel (SOC) in freshly dispersed rabbit

65 In other cell types store-operated channels (SOC) have been shown to contrib

66 The influx of Ca2+ can be recorded as store-operated channels (SOC) in the plasma membrane or

67 nisms, some have been reported to be calcium-store-operated channels (SOC), and others are activated

68 shown to be essential for the activation of store-operated channels (SOC).

69 e been implicated as the molecular bases for store-operated channels (SOC).

70 Store-operated channels (SOCs) are plasma membrane Ca2+-

71 in mediating activation of Ca(2+)-permeable store-operated channels (SOCs) by noradrenaline in rabbi

72 lls (VSMCs), activation of Ca(2+) -permeable store-operated channels (SOCs) composed of canonical tra

73 asmic reticulum (SR) Ca(2+) stores activates store-operated channels (SOCs) composed of canonical tra

74 tial), is the founding member of a family of store-operated channels (SOCs) conserved from C. elegans

75 In vascular smooth muscle, store-operated channels (SOCs) contribute to many physio

76 This study tested the hypothesis that store-operated channels (SOCs) exist as a discrete popul

77 ion channel that mediates Ca2+ entry through store-operated channels (SOCs) in human endothelial cell

78 anism for coupling between Ca(2+) stores and store-operated channels (SOCs) is an important but unres

79 m ion (Ca2+) stores and plasma membrane (PM) store-operated channels (SOCs) is crucial to Ca2+ signal

80 Store-operated channels (SOCs) mediate Ca(2+) entry sign

81 t receptor potential channel 1 (TRPC1)-based store-operated channels (SOCs) mediates Ca(2+) entry pat

82 or potential channel 1 (TRPC1) protein-based store-operated channels (SOCs) mediates Ca(2+) entry pat

83 or potential channel 1 (TRPC1) protein-based store-operated channels (SOCs) mediates Ca(2+) entry pat

84 Store-operated channels (SOCs) provide an important mean

85 (ER) Ca(2+) stores and plasma membrane (PM) store-operated channels (SOCs) remains elusive [1-3].

86 ked Ca(2+) signal includes activation of the store-operated channels (SOCs) TRPCs and the Orais.

87 POINTS: Depletion of Ca(2+) stores activates store-operated channels (SOCs), which mediate Ca(2+) ent

88 Depletion of Ca(2+) stores activates store-operated channels (SOCs), which mediate Ca(2+) ent

89 egions where it interacts with and activates store-operated channels (SOCs).

90 Ca(2+) influx is mediated by store-operated channels (SOCs).

91 veral members that may serve the function of store-operated channels (SOCs).

92 apacitative Ca2+ entry, which is mediated by store-operated channels (SOCs).

93 the Orai family of highly Ca(2+)-selective "store-operated" channels (SOCs).

94 g Ca(2+) entry through plasma membrane (PM) "store-operated channels" (SOCs).

95 ] connects the ER Ca(2+)-release channel and store-operated channels; strong evidence for either mech

96 release-activated calcium (CRAC) channel, a store-operated channel that is central to Ca(2+) signali

97 nflux in smooth muscle cells, but the native store-operated channels that mediate such influx remain

98 ), enabling stores to empty sufficiently for store-operated channels to activate.

99 xtracellular Ca2+ entry via the plasmalemmal store-operated channel transient receptor potential cano

100 a novel role for mitochondria in regulating store-operated channels under physiological conditions.

101 that in the CK1.4 cells, Ca2+ entry through store-operated channels was counteracted by Na+o-depende

102 common view of the TRP family as comprising store-operated channels, we propose that many TRPC heter

103 channel currents with similar properties to store-operated channels were observed in some patches.

104 and TRPC7 participate in forming heteromeric store-operated channels, whereas TRPC3 and TRPC7 can als

105 nt evidence that they belong to the class of store-operated channels, which are activated upon passiv

106 in DT40 cells was similar to the endogenous store-operated channels, with essentially 100% block of