ライフサイエンスコーパス: strand breakage

1 detectable levels or caused significant DNA strand breakage.

2 hat regulates apoptotic cell death after DNA strand breakage.

3 major specific effect on the rate of double-strand breakage.

4 osomal rearrangement initiated by DNA double-strand breakage.

5 aks, and pronounced susceptibility to single-strand breakage.

6 SIN-1 but not SNAP induced DNA single-strand breakage.

7 he phosphoryl transfer reaction that induces strand breakage.

8 to 48 hours and resulted in significant DNA strand breakage.

9 somal rearrangements initiated by DNA double-strand breakage.

10 excision, which generates an abasic site for strand breakage.

11 the DNA-methylating agent MMS and to the DNA strand breakage agent phleomycin, with conjugational rec

12 mbilical vein endothelial cells (HUVEC), DNA strand breakage (alkaline unwinding assay), PARS activat

13 r Ca(2+) chelators also inhibited DNA single-strand breakage and activation of poly(ADP-ribose) synth

14 oposed the importance of oxidant-induced DNA strand breakage and activation of the nuclear enzyme pol

15 DNA single strand breakage and activation of the nuclear enzyme pol

16 mechanisms in cultured cells and causes DNA strand breakage and an increased lesion burden in cecal

17 participates in multiple steps of DNA single-strand breakage and base excision repair.

18 on of mitochondrial respiration, induced DNA strand breakage and caused an activation of PARS.

19 roducts with several abasic sites, producing strand breakage and duplex melting, respectively.

20 anticancer drug cisplatin, which causes DNA strand breakage and is highly recombinogenic in some mod

21 ecombinase in three different reactions: DNA strand breakage and joining, and two types of RNA cleava

22 ar and molecular processes, including double strand breakage and modifications of sugar moieties and

23 l replication making DNA more susceptible to strand breakage and mutations.

24 t that inflammatory cell injury involved DNA strand breakage and PARS, triggering an energy-consuming

25 DNA strand breakage and perturbation of cell-cycle progressi

26 A cytotoxic cycle triggered by DNA single-strand breakage and poly (ADP-ribose) synthetase activat

27 nomic rearrangements that result from double-strand breakage and rejoining in cells of the skin in wh

28 led DNA through a concerted mechanism of DNA strand breakage and religation.

29 lthough more complex models involving double-strand breakage and repair could produce reciprocal exch

30 We show here that an active strand breakage and reunion activity is required for for

31 in cells exposed to ONOO- is mediated by DNA strand breakage and the subsequent activation of the DNA

32 LEDGF protected DNA from single-strand breakage and upregulated the expression of Hsp27.

33 increase in peroxynitrite formation and DNA strand breakage, and a decrease in intracellular NAD+ co

34 ating in oxidative DNA adduct formation, DNA strand breakage, and cell death.

35 links to both proteins and DNA, are prone to strand breakage, and inhibit DNA replication and transcr

36 mtDNA in older animals along with increased strand breakage, and that this results in its selective

37 To investigate the role of DNA strand breakage as the molecular lesion responsible for

38 se deficiencies may perpetually generate DNA strand breakage as we have found chromosomal abnormaliti

39 d hyphal DNA fragmentation, primarily single-strand breakage, as shown by increased electrophoretic m

40 romatin domains flanking sites of DNA double-strand breakage associated with gamma-irradiation, meiot

41 ion (HR) is crucial to prevent excessive DNA strand breakage at activation-induced cytidine deaminase

42 f oligonucleotide fragment sizes produced by strand breakage at the damaged sites.

43 sociated AP lyase activity also catalyze DNA strand breakage at the resulting or preexisting AP site

44 reakage data, extracting the rates of single-strand breakage at two dye staining ratios and measuring

45 [V(D)J recombination] begins with DNA double-strand breakage by the RAG1 and RAG2 proteins, acting at

46 Finally, the DNA strand breakage elongation assay showed that Tpo inhibit

47 e rapid activation of PARP-1 at sites of DNA strand breakage facilitates DNA repair by recruiting the

48 ts could be explained by drug-induced double-strand breakage followed by trimming, templated patching

49 used by reduced susceptibility to DNA double-strand breakage for IR makes double-strand breaks (DSBs)

50 of mitochondrial respiration and DNA single strand breakage in response to peroxynitrite.

51 d by AP endonuclease 1, introducing a single-strand breakage in the hairpin loop.

52 Within 2 h, etoposide caused marked DNA strand breakage in xenograft tumor-derived endothelial c

53 dUTP-biotin nick end labeling of DNA double-strand breakage, indicative of late stages of apoptosis,

54 sterol oxidation and supercoiled plasmid DNA strand breakage inhibition induced by both peroxyl and h

55 Therefore accumulation of strand breakages is avoided.

56 increased phosphorylation of the DNA double-strand breakage marker H2AX and augmentation of clonogen

57 may be explained by a lesion-specific double-strand breakage mechanism involving the RAG complex acti

58 a C1'-oxidized abasic site implicated in DNA strand breakage, mutagenesis, and formation of covalent

59 TTAGGG)81 human telomere insert, 7-fold more strand breakage occurred in the restriction fragment wit

60 Double-strand breakage occurs only when these proteins are boun

61 ur-containing amino acid that can induce DNA strand breakage, oxidative stress and apoptosis.

62 cemia, intravascular oxidant production, DNA strand breakage, PARP activation and a selective loss of

63 These data indicate that DNA strand breakage per se does not necessarily lead to chro

64 ralleled by a dose-dependent increase in DNA strand breakage, reaching its maximum at 20-30 min after

65 arkers of cell cycle activity and DNA double-strand breakage, respectively, associated with neuron de

66 Activation of PARS by ONOO--mediated DNA strand breakage resulted in a significant decrease in in

67 NA by a conserved mechanism of transient DNA strand breakage, rotation, and religation.

68 DNA double strand breakage triggers the DNA damage response network

69 lso led to a replication blockade and double-strand breakage using an SV40 in vitro replication assay

70 Neither histone staining nor DNA strand breakage was observed in freshly isolated PBTs; h

71 ent of (N7 guanine)-DNA adducts leads to DNA strand breakage, we were able to determine the site of a

72 itric oxide (NO) and superoxide, induces DNA strand breakage, which activates the nuclear enzyme poly

73 ve oxygen species are potent triggers of DNA strand breakage, with subsequent activation of the nucle

74 s of 4.5 to 18 x 10(9) W m(-2), to determine strand breakage yields and the frequency and pattern of