ライフサイエンスコーパス: streptogramin

1 employed antibiotic classes tetracycline and streptogramin.

2 henicols, oxazolidinones, pleuromutilins and streptogramins.

3 nce proteins that provide protection against streptogramins(2), potent antibiotics against Gram-posit

4 nhibitor madumycin II, an alanine-containing streptogramin A antibiotic, in the context of a function

5 The synergy in the binding of streptogramins A and B appears to result from a reorient

6 Streptogramins A is a class of protein synthesis inhibit

7 The crystal structure of Vat(D), a streptogramin acetyltransferase from a human urinary iso

8 in resistance phenotype and is mediated by a streptogramin acetyltransferase.

9 tified coded against macrolides/lincosamides/streptogramins, aminoglycosides, rifampin and elfamycins

10 23-membered macrocyclic scaffold of group A streptogramins, analogues that overcome the resistance c

11 st abundant, alongside macrolide-lincosamide-streptogramin and aminoglycoside resistance genes.

12 Tetracyclines, macrolides, streptogramins and lincosamides are now accessible throu

13 tetracyclines, macrolides, lincosamides, and streptogramins, and aminoglycosides.

14 itors, the coproduction of type A and type B streptogramins, and the coregulated production and indep

15 The effect of the novel streptogramin antibiotic quinupristin/dalfopristin (syne

16 Streptogramin antibiotics are used clinically to treat m

17 er resistance to macrolide, lincosamide, and streptogramin antibiotics in Gram-positive bacteria and

18 this work will lead to the discovery of new streptogramin antibiotics that overcome previous limitat

19 ort a modular, scalable synthesis of group A streptogramin antibiotics that proceeds in 6-8 linear st

20 sis, and antibacterial evaluation of group A streptogramin antibiotics with extensive structural vari

21 es resistance to macrolide, lincosamide, and streptogramin antibiotics.

22 asses such as aminocyclitols, phenicols, and streptogramins as treatment alternatives.

23 ed hypersensitivity to macrolide-lincosamide-streptogramin B (MLS(B)) antibiotics on strains either c

24 rains contained either macrolide-lincosamide-streptogramin B (MLSB) resistance genes encoded by erm(A

25 l target modification (macrolide-lincosamide-streptogramin B [MLSB] resistance; usually encoded by er

26 Streptogramin B analogs were designed that have an amide

27 er resistance to macrolide, lincosamide, and streptogramin B antibiotics by methylating an internal b

28 target sites for macrolide, lincosamide, and streptogramin B antibiotics.

29 her antibiotics of the macrolide-lincosamide-streptogramin B group (MLS) is methylation of the 23S rR

30 ed antibiotics of the macrolide, ketolide or streptogramin B groups during 50 S subunit reconstitutio

31 ssibility of inducible macrolide-lincosamide-streptogramin B resistance (MLSBi).

32 stitutive or inducible macrolide-lincosamide-streptogramin B resistance phenotype (cMLS(B) or iMLS(B)

33 esistant (constitutive macrolide-lincosamide-streptogramin B resistance) demonstrated either a double

34 ing resistance to macrolide, lincosamide and streptogramin B type (MLS) antibiotics were previously i

35 e inducibly MLS (macrolide, lincosamide, and streptogramin B)-resistant organisms.

36 erring resistance to macrolides-lincosamides-streptogramin B, showing that differential inhibition of

37 red macrolides, lincosamides or analogues of streptogramin B.

38 tracycline, multidrug, macrolide-lincosamide-streptogramin, bacitracin, vancomycin, beta-lactam and a

39 effect on transcripts targeting lincosamide/streptogramin, beta-lactam and phenicol/quinolone antibi

40 The streptogramin class of antibiotics act to inhibit bacter

41 an L-lysine-derived pyridyl moiety found in streptogramin group B antibiotics that are used as part

42 asses tetracycline and lincosamide/macrolide/streptogramin had the strongest positive relationship wi

43 thoprim (J01E), macrolides, lincosamides and streptogramins (J01F), aminoglycoside antibacterials (J0

44 oup A component of natural and semisynthetic streptogramin mixtures is a prerequisite for the strepto

45 glycosides, and macrolides, lincosamides and streptogramins (MLS).

46 Griseoviridin is a group A streptogramin natural product from Streptomyces with bro

47 es were distinct, with macrolide-lincosamide-streptogramin, phenicol, quinolone, and tetracycline ver

48 The occurrence of resistance to the streptogramin quinupristin-dalfopristin in Enterococcus

49 The combination of the streptogramins quinupristin and dalfopristin was approve

50 d carrying the erm(46) macrolide-lincosamide-streptogramin resistance determinant, and of an rpoB(S53

51 PCR was performed to detect the streptogramin resistance genes vatD, vatE, and vgbA and

52 Known streptogramin resistance genes were absent in the majori

53 ifampin, but inducible macrolide-lincosamide-streptogramin resistance in a subset of CA-MRSA could be

54 ptogramin mixtures is a prerequisite for the streptogramin resistance phenotype and is mediated by a

55 rans, M. tuberculosis (macrolide-lincosamide-streptogramin resistance protein, MLSRP), and B. anthrac

56 virginiamycin may increase the potential for streptogramin-resistant E. faecium infection in humans.

57 ogues has excellent activity against several streptogramin-resistant strains of Staphylococcus aureus

58 in constitutive resistance to Er and type B streptogramins (Sg), proving that SgR does not require t

59 omise as an alternative to glycopeptides and streptogramins to treat serious infections due to resist

60 nce to pleuromutilin, lincosamide and type A streptogramin translation inhibitors.

61 fers resistance to the macrolide-lincosamide-streptogramin type B (MLS) antibiotics through the methy

62 ction of ansamycin, benzoisochromanequinone, streptogramin using DoBISCUIT database.

63 Since 1974, another streptogramin, virginiamycin, has been used at subtherap

64 etracycline and MLS (macrolide, lincosamide, streptogramin) were also identified.

65 New methods to chemically modify streptogramins would enable structural optimization to o