ライフサイエンスコーパス: streptolysin S

1 ence factors, including the potent cytolysin streptolysin S.

2 to the promoter region of the gene encoding streptolysin S.

3 cular insight into the chemical structure of streptolysin S.

4 ion of a small peptide toxin by GAS known as streptolysin S.

5 ag promoter, which directs the expression of streptolysin S, a hemolysin that can damage the membrane

6 hat resembled the biosynthetic machinery for streptolysin S, a key virulence factor from group A Stre

7 e demonstrate the in vitro reconstitution of streptolysin S activity.

8 lting strain, JRS470, produced no detectable streptolysin S and showed a drastic reduction in cell su

9 ption of ska (encoding streptokinase), sagA (streptolysin S), and speMF (mitogenic factor) but did no

10 The amounts of streptokinase, streptolysin S, and capsule paralleled the levels of tra

11 ificantly reduced the haemolytic activity of streptolysin S, and dramatically reduced the pathology i

12 (capsule, cysteine protease, streptokinase, streptolysin S, and streptodornase).

13 s necessary and sufficient for production of streptolysin S, another GAS virulence factor, is also ne

14 resulted from enhanced transcription of the streptolysin S biogenesis operon.

15 a genetic locus immediately upstream of the streptolysin S biosynthetic operon in several GAS genome

16 Skin infection sites of streptolysin S-deficient MGAS2221 DeltasagA were full of

17 n unrelated second streptococcal haemolysin, streptolysin S, during infection of keratinocytes.

18 Although it has been widely held that streptolysin S exerts its lytic activity through membran

19 For the streptolysin S hemolysin, a dramatic increase in hemolyt

20 sing high-resolution live cell imaging, that streptolysin S induces a dramatic osmotic change in red

21 CvfA(-) mutant), SpeB, mitogenic factor, and streptolysin S (less abundant).

22 ergrational mutagenesis demonstrate that the streptolysin S-like gene cluster from Clostridium sp. is

23 s provide key insights into the mechanism of streptolysin S-mediated haemolysis and have implications

24 d genes encode the key GAS virulence factors Streptolysin S, PrtS (IL-8 degrading proteinase), and Sp

25 otypes: decreased beta-hemolysis mediated by streptolysin S, reduction in the activity of a secreted

26 ated hasABC operon, streptokinase (ska), and streptolysin S (sagA) during growth in the presence of 1

27 Increased transcript levels of sagA and streptolysin S (SLS) activity during exponential-phase g

28 acid capsule synthesis and exotoxins, e.g., streptolysin S (SLS) and pyrogenic exotoxin B (SpeB).

29 ranscription of sagA, a gene associated with streptolysin S (SLS) and speB, the gene encoding pyrogen

30 We also compared the abundance of streptolysin S (SLS) and streptolysin O (SLO) production

31 et-activating factor acetylhydrolase Sse and streptolysin S (SLS) have synergistic contributions to i

32 ugh the toxicity of streptolysin O (SLO) and streptolysin S (SLS) in purified group A streptococci (G

33 Streptolysin S (SLS) is the cytolytic factor that create

34 The oxygen-stable hemolysin streptolysin S (SLS) of Streptococcus pyogenes is encode

35 Streptolysin S (SLS) produces the hallmark beta-haemolyt

36 Notably, the entire sag operon necessary for streptolysin S (SLS) production was under CcpA-mediated

37 ually all group A streptococci (GAS) produce streptolysin S (SLS), a cytolytic toxin that is responsi

38 nt phosphotransferase system (PTS) exhibited Streptolysin S (SLS)-mediated hemolysis during exponenti

39 elated genes that control biofilm formation, streptolysin S (SLS)-mediated hemolysis, and localized u

40 factors produced by GAS is the peptide toxin streptolysin S (SLS).

41 es a powerful cytolytic bacteriocin known as streptolysin S (SLS).

42 s secretes a highly cytolytic toxin known as streptolysin S (SLS).

43 ccus sag operon encoding the beta-haemolysin streptolysin S (SLS).

44 ficient in expression of the cytolytic toxin streptolysin S (SLS-) and evaluated events that occur du