ライフサイエンスコーパス: stress granule

1 type of the latter compartment, known as the stress granule.

2 the second branch point are recruited to RNA stress granules.

3 facilitates the recruitment of hnRNPA1 into stress granules.

4 e into non-membrane-bound structures such as stress granules.

5 ore mRNAs in protein-rich condensates called stress granules.

6 rodegeneration and promotes the formation of stress granules.

7 nelles involved in RNA metabolism, including stress granules.

8 ger coalescence of RNA-binding proteins into stress granules.

9 ave more than 50% of their mRNA molecules in stress granules.

10 s a novel function for Rbfox2 in cytoplasmic stress granules.

11 protein is crucial for its localization into stress granules.

12 G-ALS variants also lack the ability to form stress granules.

13 ved measurements of ACTB mRNA trafficking to stress granules.

14 these pathological inclusions are related to stress granules.

15 and function of RNA-protein condensates like stress granules.

16 the cytoplasm and participate in assembly of stress granules.

17 relocalization also of hEndoV to cytoplasmic stress granules.

18 icating that mutant VCP delayed clearance of stress granules.

19 ch as nucleoli, the nuclear pore complex and stress granules.

20 ct specific translation factors in cytosolic stress granules.

21 e effect on PrLD assembly and recruitment to stress granules.

22 within the host cells associated with human stress granules.

23 ng to the formation of eIF2alpha-independent stress granules.

24 oning of cardiac biomolecules and fused with stress granules.

25 f translation initiation and the assembly of stress granules.

26 maintenance are independent of conventional stress granules.

27 ultiple RNP granules, including P-bodies and stress granules.

28 AfrLEA6-transfected insect cells behave like stress granules.

29 ng VCP's activity and ability to disassemble stress granules.

30 such as the nucleolus, processing bodies or stress granules(1,2).

31 acking techniques to examine how mRNAs enter stress granules, a new study shows that mRNAs make trans

32 reviously uncharacterized RBPs that modulate stress granule abundance, highlighting the applicability

33 In cells expressing GR36, stress granule accumulation was accompanied by decreased

34 coincides with translational repression, and stress granules actively signal to mediate cell fate dec

35 RNA immunoprecipitation with the known stress granule aggregates TIAR and G3BP1 was performed o

36 tamine metabolism restrained the assembly of stress granules, an indicator of chemoresistance.

37 Upon DNA damage, p53 mRNA is released from stress granules and associates with polyribosomes to inc

38 disrupted the formation of arsenite-induced stress granules and changed the subcellular distribution

39 tients are associated with an enhancement of stress granules and disrupted RNA metabolism.

40 and distinct from other RNA granules such as stress granules and GW- or P-bodies.

41 otein-protein interactions and links between stress granules and human diseases and identifies ATP-de

42 s reveal similarities between P granules and stress granules and identify intrinsically-disordered pr

43 The crosstalk between stress granules and inflammasomes and how this informs c

44 Although both stress granules and inflammasomes can be triggered by th

45 nistic insight into the relationship between stress granules and LLPS, for example, in the context of

46 PFK-1.1 condensates do not correspond to stress granules and might represent novel metabolic subc

47 We also immunopurify and compare the RNAs in stress granules and P-bodies under arsenite stress and c

48 m functional membrane-less organelles (e.g., stress granules and P-bodies) in the mammalian cell cyto

49 form condensates that share components with stress granules and P-bodies, membrane-less organelles e

50 We observed single mRNAs interacting with stress granules and P-bodies, with mRNAs moving bidirect

51 sates-including the nucleolus, Cajal bodies, stress granules and P-bodies-implying that the compositi

52 anistically, we show that ULK1/2 localize to stress granules and phosphorylate VCP, thereby increasin

53 Unlike other cytoplasmic structures, such as stress granules and processing bodies, inclusion bodies

54 ress signals and choose between pro-survival stress granules and pyroptotic ASC specks.

55 Finally, RNA stress granules and smaller dendritic trees were also ob

56 bulk mRNA molecules accumulate in mammalian stress granules and that only 185 genes have more than 5

57 Stress granules and the NLRP3 inflammasome compete for D

58 toplasmic ribonucleoprotein granules such as stress granules and those seeded by the aggregation of s

59 The ATP stores inside a cell do not overlay stress granules and we suggest that hEndoV is redistribu

60 granules, while RIG-I associates with TRIM25/stress granules and with mitochondrial MAVS.

61 s are associated with mRNA-binding proteins, stress granule, and P-body proteins, which suggests regu

62 or in targeting mRNAs into both P-bodies and stress granules, and during stress, when most mRNAs are

63 tic PrLDs that were efficiently recruited to stress granules, and found that aromatic amino acids, wh

64 nt cellular aggregates including aggresomes, stress granules, and inclusion bodies caused by huntingt

65 e, transient species such as nuclear bodies, stress granules, and myo-granules.

66 polypeptides into two distinct compartments, stress granules, and Q-bodies, is triggered by the exhau

67 oma 1 is the target of Rbfox2 in cytoplasmic stress granules, and Rbfox2 regulates the retinoblastoma

68 erentiating cells, by recruiting aggregates, stress granules, and RNA-binding proteins, directing the

69 s, harboring G4s, preferentially localize in stress granules, and that DHX36 KO results in increased

70 as processing bodies (P-bodies, or PBs) and stress granules, and the ER membrane.

71 These data provide evidence that RNA stress granules are a novel form of epigenetic regulatio

72 Stress granules are condensates of non-translating mRNAs

73 Stress granules are cytoplasmic compartments that enable

74 Although stress granules are hypothesized to be a conduit for see

75 Stress granules are important in the stress response and

76 Defects in the assembly and disassembly of stress granules are linked to neurodegenerative diseases

77 Stress granules are membraneless protein- and mRNA-rich

78 Stress granules are mRNA-protein assemblies formed from

79 Stress granules are mRNA-protein granules that form when

80 d we suggest that hEndoV is redistributed to stress granules as a strategy to create a local environm

81 This establishes stress granules as a viable therapeutic target not only

82 ry cytokines, which instead can be stored in stress granules, as shown for CD86 mRNA.

83 aken together, these observations argue that stress granules assemble through a multistep process ini

84 ATP is required for stress granule assembly and dynamics.

85 This alters stress granule assembly and reprograms translation by al

86 he first insight on how caliciviruses impair stress granule assembly by targeting the nucleating fact

87 roteins in vitro have the opposite effect on stress granule assembly in vivo.

88 inine-rich DPRs in cells induced spontaneous stress granule assembly that required both eIF2alpha pho

89 149, which regulates G3BP1 oligomerization, stress granule assembly, and RNase activity intrinsic to

90 e of DDX3X in driving NLRP3 inflammasome and stress granule assembly, and suggest a rheostat-like mec

91 sses, including gene silencing, translation, stress granule assembly, cell differentiation, retrotran

92 differently, with the CCT complex inhibiting stress granule assembly, while the MCM and RVB complexes

93 slation, and block a cellular process called stress granule assembly.

94 Mutations in a number of stress granule-associated proteins have been linked to v

95 In vitro, stress-granule-associated proteins can demix to form liq

96 L activity induce the formation of antiviral stress granules (avSGs) by regulating activation of doub

97 as knocking down hYVH1 expression attenuated stress granule breakdown during recovery from arsenite s

98 th TDP-43 and its CTD are also known to form stress granules by coacervating with RNA in the cytoplas

99 indicate that ZIKV disrupts the formation of stress granules by sequestering stress granule proteins

100 t with phase separation, including nucleoli, stress granules, Cajal bodies, and numerous additional b

101 effect is mediated by phosphorylation of the stress granule component Npl3.

102 LD-containing yeast protein kinase Sky1 is a stress granule component.

103 elicases and protein remodelers as conserved stress granule components.

104 e overlapping mechanisms for re-solubilizing stress granule components.

105 active mRNAs and unanticipated complexity in stress granule composition.

106 of insoluble proteins, overlapped with known stress granule constituents and sHSP-interacting protein

107 Our observations suggest that stress granules contain a stable core structure surround

108 NA-sequencing (RNA-seq) analysis of purified stress granule cores and single-molecule fluorescence in

109 Proteomic analysis of stress granule cores reveals a dense network of protein-

110 mRNA accumulation in stress granules correlates with longer coding and UTR re

111 of mutant FUS and subsequent accumulation in stress granules, dendritic morphology and toxicity in ma

112 oreover, multiple ATP-driven machines affect stress granules differently, with the CCT complex inhibi

113 compensate for defects in chaperone-mediated stress granule disassembly and vice-versa, demonstrating

114 suggest that VCP dysregulation and defective stress granule disassembly contribute to IBM-like diseas

115 and Sky1's kinase activity regulates timely stress granule disassembly during stress recovery.

116 In addition, stress granule disassembly is accelerated by an ULK1/2 a

117 Stress granule disassembly is also a stepwise process wi

118 ess, indicating a possible role for hYVH1 in stress granule disassembly.

119 this study, we investigated the formation of stress granules during Zika virus (ZIKV) infection and t

120 Disturbances in autophagy and stress granule dynamics have been implicated as potentia

121 roles of core autophagy proteins in IBM and stress granule dynamics remain poorly characterized.

122 sport, DNA damage repair, pre-mRNA splicing, stress granule dynamics, and others.

123 we show that casein kinase 2 (CK2) promotes stress granule dynamics.

124 translation initiation and termination, and stress granule dynamics.

125 s generally presumed to be protective, since stress granule dysregulation caused by mutation or agein

126 emonstrate that pharmacological induction of stress granules enhances cell survival in native-tissue,

127 luding nucleoli, Cajal bodies, P-bodies, and stress granules, exist as liquid droplets within the cel

128 ells reveal profound recovery defects, where stress granules fail to disassemble properly, after expo

129 tact sites defined the position where PB and stress granule fission occurs.

130 or exploiting the higher-order regulation of stress granules for therapeutic intervention of IBM and

131 Stress granules form in part through intermolecular RNA-

132 Stress granules form in response to particular environme

133 Finally, as stress granule formation and dendritic loss occur early

134 s trigger phosphorylated-eIF2alpha-dependent stress granule formation and global translational suppre

135 Stress granule formation coincides with translational re

136 estrol analogue that inhibits eIF4A, induces stress granule formation in both an auditory cell line a

137 reduces RNA condensation in vitro and limits stress granule formation in cells.

138 urthermore, we provide the first evidence of stress granule formation in mammalian hair cells in-vivo

139 was both necessary and sufficient to prevent stress granule formation in response to eIF2alpha phosph

140 at PRMT7 is required for eIF2alpha-dependent stress granule formation in the face of various cellular

141 the recruitment of UPF1 to stress granules, stress granule formation is independent of NMD inhibitio

142 Consistent with these findings, stress granule formation is known to regulate mRNA trans

143 Stress granule formation is reversible, and persistent s

144 ation of protein synthesis by downregulating stress granule formation through G3BP1.

145 In contrast, preventing stress granule formation using the small molecule inhibi

146 RNP A1 nucleocytoplasmic mislocalization and stress granule formation, both markers of neuronal injur

147 vely contribute to competent mRNA export and stress granule formation, both self-association domains

148 critical for eukaryotic stress response and stress granule formation, is structurally characterized

149 trinsically disordered protein implicated in stress granule formation, RNA biology, and neurodegenera

150 s (PrLDs), some of which have been linked to stress granule formation.

151 endent lipid production leads to upregulated stress granule formation.

152 where they can regulate translation through stress granule formation.

153 modulate mRNA translation and participate in stress granule formation.

154 ion initiation, translation termination, and stress granule formation.

155 At basal levels, stress-granule formation appears normal in primary and t

156 ion, through a mechanism involving excessive stress-granule formation, or developmental defects, thro

157 ng proteins, confirming a role for HSP101 in stress granule function.

158 ociation between disease-linked proteins and stress granules further implicates impaired stress respo

159 ence and resistance to diverse environmental stresses, granule genesis is poorly understood.

160 ubsequent analysis revealed that astrocytoma stress granules harbor unique mRNAs for various cellular

161 nule formation is reversible, and persistent stress granules have been implicated in a variety of neu

162 RNA partitioning occurs between P-bodies and stress granules have not been addressed.

163 Defects in stress granule homeostasis constitute a cornerstone of A

164 l centrifugation with and without subsequent stress granule immunopurification.

165 e the authors find that p53 mRNA, present in stress granules in activated B lymphocytes, is released

166 and Aurora kinase B (AurkB) are localized to stress granules in human astrocytoma cells.

167 rs of translation, based on the formation of stress granules in human cells, revealed cell cycle-asso

168 synthesis, and reversed the accumulation of stress granules in infected cells.

169 neuronal survival and the ability to induce stress granules in neuronal cell lines.

170 Sky1 is recruited to stress granules in part via its PrLD, and Sky1's kinase

171 and fragile X mental retardation protein on stress granules in response to arsenic treatment.

172 ted gene silencing, and possibly shuttles to stress granules in stressed cells.

173 aneless organelles, including P granules and stress granules in the cytoplasm and nucleoli and parasp

174 ragments ability to trigger the formation of Stress Granules in vivo.

175 s study identifies a novel role of antiviral stress granules induced by RNase L as an antiviral signa

176 ge response.Sequestering mRNA in cytoplasmic stress granules is a mechanism for translational repress

177 studies have suggested that the assembly of stress granules is central in orchestrating stress and a

178 itment and suggest that PrLD localization to stress granules is driven primarily by amino acid compos

179 zation of the factors involved in dissolving stress granules is incomplete.

180 Assembly of stress granules leads to the sequestration of DDX3X, and

181 ion of FUS in the cytoplasm and formation of stress granule-like inclusions.

182 1 or Hrb98DE protein in association with the stress granule marker ROX8 and additional endogenous RNA

183 ements in oxidated proteins but observed the stress granule markers RasGAP SH3-binding protein and ph

184 mber and size of granules co-localizing with stress granule markers.

185 scopically visible foci that colocalize with stress granule markers.

186 These results suggest that stress granules may not represent a specific biological

187 a large set of proteins involved in RNA and stress granule metabolism.

188 ot differentially sequestered in cytoplasmic stress granules nor did they induce a systemic antiviral

189 properties of cellular RNP granules, such as stress granules or amyloid-like condensates.

190 Induction of stress granules or loss of DDX3X in the myeloid compartm

191 se-separated compartments, such as P-bodies, stress granules or neuronal RNA granules.

192 e been used to describe the transcriptome of stress granules or P-bodies, but how these methods compa

193 arated intermediates involving ejection from stress granules or seeding with exogenous fibrils.

194 terature on interactions between viruses and stress granules/P-bodies.

195 whether pharmacological manipulation of the stress granule pathway in the auditory organ, the cochle

196 her mutant VCP triggers dysregulation of the stress granule pathway in vivo, we analyzed skeletal mus

197 muscle but were insufficient to disrupt the stress granule pathway.

198 ubverting different proteins involved in the stress granule pathway.

199 bly, while the MCM and RVB complexes promote stress granule persistence.

200 rotein (Pab1 in yeast), a defining marker of stress granules, phase separates and forms hydrogels in

201 Connections between HSP101, stress granules, proteasomes, and ubiquitylation imply t

202 t al. (2019) uncover a surprising role for a stress granule protein and phase separation in axon rege

203 The stress granule protein DDX3X interacts with NLRP3 to dri

204 The stress granule protein G3BP1, known to arrest mRNA trans

205 f purified avSGs showed interaction of a key stress granule protein, G3BP1, with only PKR and Rig-I a

206 Many stress granule proteins contain prion-like domains (PrLD

207 find that m(6)A disrupts RNA binding by the stress granule proteins G3BP1/2, USP10, CAPRIN1, and RBM

208 We also investigated the role of different stress granule proteins in ZIKV infection by using targe

209 s of ZIKV relocalizing and subverting select stress granule proteins might have broader consequences

210 ing Zika virus (ZIKV) infection and the role stress granule proteins play during the viral life cycle

211 formation of stress granules by sequestering stress granule proteins required for replication, where

212 sp90 stabilizes processing body (P-body) and stress granule proteins that contribute to drug toleranc

213 tion, but not the abundance or integrity, of stress granule proteins.

214 critical for phase separation of ALS-linked stress granule proteins.

215 light the flexible sequence requirements for stress granule recruitment and suggest that PrLD localiz

216 prevents their aberrant phase separation and stress granule recruitment in the cytoplasm.

217 nuclear localization, phase separation, and stress granule recruitment of CIRBP in cells.

218 Stress granules regulate RNA translation during cellular

219 P1 was not identified, leaving a key step in stress granule regulation uncharacterized.

220 hat function in translational repression and stress granule regulation.

221 Furthermore, stress granule resolution was impaired on differentiated

222 nor Adar2(-/-) cells displayed a comparable stress granule response following IFN treatment.

223 lling while preserving the effect of nsP3 on stress granule responses and co-localisation with GTPase

224 opolymer assembly, biochemical reactions and stress granule responses to cellular adversity.

225 In live cells, TIA1 mutations delayed stress granule (SG) disassembly and promoted the accumul

226 gh eIF2alpha phosphorylation, which triggers stress granule (SG) formation and promotes translation o

227 n effective antiviral strategy that leads to stress granule (SG) formation and translational arrest m

228 are unknown, but it has been suggested that stress granule (SG) formation is important in this proce

229 s exhibit an increased propensity to trigger stress granule (SG) formation resulting in global transl

230 an essential role for L(pro) in suppressing stress granule (SG) formation.

231 in adaptation to perturbation, most notably, stress granule (SG) proteins, which responded differentl

232 One prominent type of RNP granule is the stress granule (SG), a dynamic and reversible cytoplasmi

233 x helicase 3 X-linked) is a key component of stress granules (SG) and is postulated to affect protein

234 Stress granules (SG) are membrane-less organelles that a

235 es, P-bodies (RNA processing bodies, PB) and stress granules (SG), are important components of the in

236 r and viral translation and the formation of stress granules (SG), which are thought to have antivira

237 ress response by preventing the formation of stress granules (SGs) and modulate viral gene expression

238 ther to daughter cells for translation or to stress granules (SGs) and P-bodies (PBs) for mRNA storag

239 Stress granules (SGs) are an important component of cell

240 Stress granules (SGs) are condensates of mRNPs that form

241 Stress granules (SGs) are cytoplasmic assemblies of prot

242 Stress granules (SGs) are cytoplasmic ribonucleoprotein

243 Stress granules (SGs) are cytoplasmic RNA-protein aggreg

244 Stress granules (SGs) are cytosolic ribonucleoprotein ag

245 Stress granules (SGs) are evolutionarily conserved conde

246 Stress granules (SGs) are large macromolecular aggregate

247 Stress granules (SGs) are membrane-less ribonucleoprotei

248 Stress granules (SGs) are membraneless organelles that f

249 Stress granules (SGs) are non-membrane-bound RNA-protein

250 Processing bodies (PBs) and stress granules (SGs) are prominent examples of subcellu

251 Paraspeckles and stress granules (SGs) are prototypical RNP granules loca

252 Stress granules (SGs) are ribonucleoprotein (RNP) assemb

253 Stress granules (SGs) are ribonucleoprotein aggregates t

254 Recent studies implicate cytoplasmic stress granules (SGs) as hubs that may facilitate TDP-43

255 Mammalian stress granules (SGs) contain stalled translation preini

256 Stress granules (SGs) form during cellular stress and ar

257 Stress granules (SGs) harbour translationally stalled me

258 show that EBOV does not induce formation of stress granules (SGs) in infected cells and is therefore

259 ell stress efficiently triggers formation of stress granules (SGs) in proliferating, quiescent, and d

260 SV-2) are disrupted in their ability to form stress granules (SGs) in response to oxidative stress an

261 drives the recruitment of the COPII coat to stress granules (SGs) leading to vesiculation of the Gol

262 Others, like cytoplasmic stress granules (SGs) that harbor mRNAs and RBPs, are in

263 ease mRNA molecules from polysomes, and form stress granules (SGs) via a network of interactions that

264 Eukaryotic cells assemble stress granules (SGs) when translation initiation is inh

265 g quantitative reconstitution of cytoplasmic stress granules (SGs) with attached P-bodies in human ce

266 lation initiation and induce the assembly of stress granules (SGs), cytoplasmic ribonucleoprotein com

267 Here we investigated the role of stress granules (SGs), ribonucleoprotein complexes that

268 l, we identified proteins that interact with stress granules (SGs), subcellular structures composed o

269 formation of membraneless organelles termed stress granules (SGs).

270 plexes reversibly assembles into cytoplasmic stress granules (SGs).

271 n of discrete cytoplasmic inclusions, termed stress granules (SGs).

272 of cytoplasmic mRNA and protein foci, termed stress granules (SGs).

273 omplexes (PICs) mediates the condensation of stress granules (SGs).

274 g mRNAs away in cellular compartments called stress granules (SGs).

275 Here we show that the induction of stress granules specifically inhibits NLRP3 inflammasome

276 ough R-DPRs cause the recruitment of UPF1 to stress granules, stress granule formation is independent

277 sordered and phase separated, reminiscent of stress granule substructure or nanoscale liquid droplets

278 al protein synthesis and/or formation of RNA stress granules suggested diminished ribosome recruitmen

279 substructures, referred to as cores, within stress granules that can be purified.

280 pon cell activation with mitogens, including stress granules that contain the RNA binding protein Tia

281 teins (RBPs) that influence the formation of stress granules, the punctate protein-RNA assemblies tha

282 noncoding RNAs (ncRNAs), can be targeted to stress granules, the targeting efficiency varies from <1

283 Rbfox2 is a novel constituent of cytoplasmic stress granules, the translational silencing machinery a

284 eir predominant targets, a feature shared by stress granules to which G3BP1 family proteins localize

285 Here, we compare the analysis of the stress granule transcriptome based on differential centr

286 Here, we describe the stress granule transcriptome of yeast and mammalian cell

287 ion alone gives a first approximation of the stress granule transcriptome, this methodology contains

288 P-body transcriptome is very similar to the stress granule transcriptome.

289 ence features governing PrLD localization to stress granules upon stress.

290 Interestingly, the loss of stress granules was correlated with a decrease in the lo

291 To investigate the role of Rbfox2 in stress granules we used RNA-immunoprecipitation sequenci

292 Interestingly, hYVH1-positive stress granules were significantly smaller, whereas knoc

293 bition of AurkB results in fewer and smaller stress granules when analyzed using high-throughput fluo

294 ptionally induced and localized to cytosolic stress granules, where nuclear factors dock to compensat

295 nducible ADAR1 proteins induced formation of stress granules, whereas neither wild-type (WT) nor Adar

296 s can extend beyond the protein surface of a stress granule, which may facilitate interactions betwee

297 ribonucleoprotein (mRNP) complexes including stress granules, which are known to accumulate as messen

298 cytoplasmic translocation of TDP-43 to form stress granules, which become phosphorylated TDP-43 cyto

299 RNP granules, such as processing bodies and stress granules, which contain translationally repressed

300 ibuted into cytoplasmic dots associated with stress granules, while RIG-I associates with TRIM25/stre