ライフサイエンスコーパス: stress protein

1 ession of the uspA gene encoding a universal stress protein.

2 doxin is a ubiquitous redox control and cell stress protein.

3 ng functional conservation of this important stress protein.

4 presentative of a third and unique family of stress proteins.

5 ins including circulatory, cytoskeletal, and stress proteins.

6 stresses by producing a large set of general stress proteins.

7 half, a hallmark of the superfamily of small stress proteins.

8 ially enhanced accumulation of two oxidative stress proteins.

9 irect the synthesis of more than 100 general stress proteins.

10 ppaBalpha may be considered to be one of the stress proteins.

11 species and increased abundance of oxidative stress proteins.

12 induced the synthesis of the hsp72 and hsp90 stress proteins.

13 e inosine shows reduced expression of folate stress proteins.

14 gest that Ty3 VLPs are destroyed by cellular stress proteins.

15 ons corresponding to in vivo induction of ER stress proteins.

16 of phase II defence enzymes and antioxidant stress proteins.

17 pB intergenic region, encoding two universal stress proteins.

18 r annotated with homologs encoding oxidative stress proteins.

19 itochondrial proteins and an upregulation of stress proteins.

20 nction and is known to occur in mechanically stressed proteins.

21 mmediate early response protein IEX-1, small stress protein 1 (HSPB8), and tumor necrosis factor-asso

22 otein phosphatase and Microtubule-Associated Stress Protein 1 (MASP1) differed in their stoichiometry

23 Of these, Microtubule-Associated Stress Protein 1 (MASP1), an uncharacterized protein, in

24 e named PASS1 (protein associated with small stress proteins 1).

25 could be attributed to its higher content of stress proteins (19%).

26 ased on the Haemophilus influenzae universal stress protein (1JMV), highly similar to E. coli UspA, w

27 f transgenic mice in which the heat shock or stress protein 70 is increased, there is a marked tolera

28 Known as osmotic stress protein 94, or Osp94, this 2935-base pair cDNA en

29 edoxins and several genes encoding Universal Stress Protein A domain proteins.

30 teins with similarity to the USPA (universal stress protein A of Escherichia coli) domain of bacteria

31 ng for ethanolamine utilization, a universal stress protein, a ferritin-like protein, and a phosphotr

32 o decreased heat-induced radical generation, stress protein accumulation, and cellular injury in the

33 a FAD-dependent, two-domain multifunctional stress protein acting as a Phase II enzyme, activating c

34 and temporal induction of some of these key stress proteins after ischemia.

35 roteins is a popular approach to follow post stress protein aggregation, inclusion formation and disa

36 and the drug was also found to induce key ER stress proteins, albeit in a manner dissimilar to, and a

37 A major stress protein, alpha-crystallin, functions as a chapero

38 tor homologue-HBZ17); and (5) genes encoding stress proteins (alphaB-crystallin and mu-crystallin).

39 hypothesis invoking RpoS and UspA (universal stress protein, also significantly elevated in minimal g

40 knockdown of Herp (Homocysteine-inducible ER stress protein), an ER stress-inducible protein with an

41 the chaperoning of antigenic peptide by the stress protein and (b) the binding of the stress protein

42 The stress protein and endoplasmic reticulum chaperone, immu

43 These results suggest that the stress protein and molecular chaperone alphaB-crystallin

44 -regulated protein 170 (Grp170), the largest stress protein and molecular chaperone, is highly effici

45 g of the key interaction between the sigma38 stress protein and the beta-flap of the bacterial core R

46 nce of an association between levels of this stress protein and the proinflammatory cytokine, TNFalph

47 reased ERAD, while increasing maladaptive ER stress proteins and cell death.

48 Viral infection can stimulate synthesis of stress proteins and particular associations of viral and

49 iber is wide enough to accommodate oxidative stress proteins and RNA polymerase subunits identified b

50 Many stress proteins and their cognates function as molecular

51 ity induces the expression of a novel set of stress proteins and triggers the general stress response

52 5 h later, includes the induction of various stress proteins and ubiquitin, which are important in pr

53 amycin, thapsigargin, or A23187 expressed ER stress proteins and were resistant to subsequent H2O2-in

54 n involves stimulation of the expression of 'stress proteins' and neurotrophic factors.

55 coding for cell-surface-maintenance enzymes, stress proteins, and generalized efflux pumps.

56 mycin increased ERAD, as well as adaptive ER stress proteins, and minimally affected cell death.

57 ted expression of endoplasmic reticulum (ER) stress proteins, and reduced unfolded protein response a

58 All organisms have stress proteins, and universally conserved stress protei

59 ependent classes of binding sites for LRP-2, stressed proteins, and unstressed ligands, respectively,

60 dehydrogenase, a glycolytic enzyme; HSP72, a stress protein; and glutamine synthetase, an excitotoxic

61 proteins, carbonic anhydrase, and oxidative stress proteins; and functional groups involved in prote

62 Attempts to model the other stress protein antibodies were not successful.

63 s and loss-of-function mutations of a key ER stress protein are associated with disruption of membran

64 superfamily of mammalian small heat shock or stress proteins are abundant in muscles where they play

65 Although extracellular stress proteins are considered as indicators of the stre

66 Multiple ER stress proteins are likely to be involved in this tolera

67 tes global protein synthesis, mRNAs encoding stress proteins are more efficiently translated.

68 Members of the Hsp100 family of heat stress proteins are present in species throughout the ba

69 Heat shock proteins (HSPs) or stress proteins are synthesized by cells in response to

70 Upon encountering oxidative stress, proteins are oxidized extensively by highly reac

71 ly, and (ii) the binding sites for LRP-2 and stressed proteins are likely to be in parts of the molec

72 isplay lower viability, and express elevated stress protein as they mature.

73 Using stress proteins as direct drug targets would be clinical

74 ovokes increased expression of 27- and 70-kD stress proteins as well as manganese superoxide dismutas

75 sion of different endoplasmic reticulum (ER) stress proteins associated with MPTP- and PD-related neu

76 03720 (similar to Escherichia coli universal stress protein); At3g54870 (armadillo-repeat containing

77 intake; and physiological influences such as stress, protein balance, energetics, and metabolism.

78 Acr is a stress protein believed to be involved in the bacillary

79 In addition, cardiac stress protein biomarkers, such as calmodulin-dependent

80 Following the demonstration that the stress protein, BiP, prevented induction of collagen-ind

81 the excess buildup of acetyl-CoA upregulates stress proteins but excess formate depletes acetyl-CoA a

82 The role of the pro-apoptotic stress protein C/EBP homologous protein (CHOP) in MCD-me

83 6 and greater increases in expression of ER stress proteins C/EBP homologous protein and spliced XBP

84 e stress proteins, and universally conserved stress proteins can be regarded as the minimal stress pr

85 When used as vaccines, tumor-derived stress proteins can elicit antitumor immune responses.

86 Several studies have confirmed that certain stress proteins can function as potent vaccines against

87 t demonstrates that Gadd45, a p53-responsive stress protein, can facilitate topoisomerase relaxing an

88 The absence of ER stress protein CCAAT enhancer-binding protein homologous

89 binds to a wide variety of partly unfolded, stressed proteins.Clusterin also binds to many different

90 The stress response and stress proteins confer protection against diverse forms

91 or 1 (IGF-1) and clusterin, an extracellular stress protein, constitute this regulatory system.

92 nducible members of the heat shock family of stress proteins correlates with increased cellular prote

93 ges in dopamine (DA) distribution, oxidative stress, protein damage, and cell death.

94 Instead, a combination of oxidative stress, protein damage, and prophage-mediated cell lysis

95 and reared them in normal (within hives) or stressed (protein-deficient, asocial) conditions.

96 colysis, translational inhibition, oxidative stress, protein degradation, and amino acid catabolism.

97 after hypoglycemia, only one of 15 oxidative stress proteins differed and this was not seen in contro

98 DNA replication but is dependent on the cell stress protein DLK.

99 egin a molecular genetic analysis of a major stress protein, DnaK/Hsp70, to begin to understand how s

100 eins (ProX, OppA, DegQ, MalB, and MglB), and stress proteins (DsbA, Tig, and UspA).

101 gated the early expression of cytoprotective stress proteins during ischemia-reperfusion induced by P

102 hock proteins) and mitochondrial adaptive or stress proteins (e.g. manganese superoxide dismutase, mi

103 th tumor protein Ags (e.g., gp100) and large stress proteins (e.g., hsp110 and grp170) with exception

104 s well as laboratory progress on the role of stress proteins, estrogen and a few other potential adju

105 eptide-related sequence A and B (MICA/B) are stress proteins expressed by cancer cells, and antibody-

106 e vaccine targets the MICA and MICB (MICA/B) stress proteins expressed by many human cancers as a res

107 Associations between microbial virulence and stress protein expression have been identified in other

108 ted potential functions of DJ-1 in oxidative stress, protein folding, and degradation pathways.

109 ly related cellular processes of response to stress, protein folding, and ubiquitin-dependent protein

110 f cellular pathways that include response to stress, protein folding, microtubule stability, and cell

111 This suggests that domains exist on the stress protein for each function.

112 Stress proteins from autologous normal tissue components

113 Expression of the global stress protein gene (gspA) is induced during the intrace

114 st in strains harbouring a lesion in htrA, a stress protein gene.

115 The protective potential of stress proteins generated following 4-TBP exposure was e

116 ependent increase in expression of all major stress protein genes, including groES, dnaKJ, hsp18, and

117 General stress proteins, Gls24 and GlsB, were previously shown t

118 creased respiration, and increased oxidative stress proteins, glutathione, and reactive oxygen specie

119 Circulating biomarkers of nitrosative stress/protein glycoxidation have potential diagnostic u

120 The glucose-regulated stress protein (GRP) chaperones are subsequently induced

121 Stress protein GRP78/BiP is highly induced in progressiv

122 s to the therapy of cancer via regulation of stress protein GRP78/BiP.

123 Prior ER stress induces expression of the ER stress proteins Grp78, Grp94, and calreticulin and rende

124 that overexpress Mr 78,000 glucose-regulated stress protein (GRP78) are resistant to topoisomerase II

125 Because the stress protein GRP94 can augment presentation of peptide

126 rly, the heterologous expression of two cold-stress proteins had no profound influence on stress tole

127 To determine if this unique stress protein has a critical role in meiosis, we used g

128 Recently Gadd45, a p53-regulated stress protein, has been implicated in the activation of

129 ins and particular associations of viral and stress proteins have been documented.

130 Several ER stress proteins have been suggested to counteract the de

131 Stress proteins have three immunological regulatory func

132 tly, heat shock proteins (also known as heat stress proteins) have mostly been regarded as intracellu

133 This study was focused on the role of stress protein heat shock protein (HSP)70 for translatin

134 The stress protein heat shock protein 60 (Hsp60) induces sec

135 Delivery of the CD8 peptide epitope by stress protein, heat shock protein (hsp)70, results in e

136 gous, but not identical, to an intracellular stress protein, heat shock protein 60.

137 studies of two long-recognized but unstudied stress proteins, heat shock protein (hsp) 110 and glucos

138 ry transferrin receptor, integrin beta7, the stress protein heme oxygenase and the lymphocyte-specifi

139 nstrate that selective overexpression of the stress protein heme oxygenase-1 (HO-1) in astrocytes of

140 The stress protein heme oxygenase-1 (HO-1) is induced in end

141 Expression of the antioxidative stress protein heme oxygenase-1 (HO-1) was determined by

142 The induction of the stress protein heme oxygenase-1 (HO-1) was studied in th

143 32,000, similar to the well-known oxidative stress protein heme oxygenase-1 (HO-1).

144 to c-jun in MAPK pathway that regulates the stress protein, HO-1, expression.

145 n SA-mediated transcriptional reprogramming, stress protein homeostasis, and cell survival.

146 Stress proteins, however, may have extracellular functio

147 In this study, we show that cellular stress proteins HSF1 and hsp70 play a mechanistic role i

148 ations in TnI or SR gene expression, but the stress protein HSP-70 was variably induced.

149 tochemical staining for the non-constitutive stress protein HSP-72 or neuronal death by acid fuchsin

150 of stress; (iii) induction of heat shock or stress protein (HSP)70 by heat stress was defective in a

151 There is evidence that microbial heat shock (stress) proteins (Hsp) are immunodominant antigens of ma

152 The plant heat stress protein, Hsp101, and the yeast ortholog, Hsp104,

153 ynthesis of numerous proteins, including the stress proteins Hsp60 (GroEL homolog) and Hsp70 (DnaK ho

154 Stress protein HSP70 in turn induced membrane tumor necr

155 red without expression of the inducible heat stress protein, hsp70, as detected by immunocytochemistr

156 The role of the abundant stress protein Hsp90 in protecting cells against stress-

157 Oxidative stress and response to stress proteins (HSPA1A, SOD2 and PRDX2) were further in

158 chaperones such as the heat shock family of stress proteins (HSPs) actively participate in an array

159 Heat shock, or stress, proteins (HSPs) are induced in response to condi

160 activity of alphaB crystallin, an important stress protein in humans, is regulated by physiological

161 t elevated levels of serum antibody to Hsp90 stress protein in individuals colonized with this microo

162 ese observations suggest a new role for this stress protein in protecting the plastid during the dism

163 cts overexpress significant amounts of these stress proteins in both rat neonatal cardiomyocytes and

164 d cell death and investigated the role of ER stress proteins in Ca2+ regulation and cytoprotection af

165 otein synthesis while inducing expression of stress proteins in cells.

166 results in the elevated expression of folate stress proteins in Escherichia coli.

167 e initiated an investigation of the roles of stress proteins in eukaryotic viral life cycles using as

168 nity, thus bridging this ancient function of stress proteins in prokaryotes to their ability to elici

169 disease, it would appear that the role of ER stress proteins in protection from oxidant damage warran

170 as regulatory elements for the expression of stress proteins in the complex stress response network o

171 DHNs, and presumably somewhat similar plant stress proteins in the late embryogenesis abundant and c

172 e observations confirm the role of mammalian stress proteins in the recognition of abnormal proteins

173 in the ER does not increase expression of ER stress proteins in TM cells (P > 0.05 for all variants t

174 However, demonstrations of functions for stress proteins in viral life cycles are few.

175 rted that electromagnetic (EM) fields induce stress proteins in vitro.

176 The folate stress proteins include the universal stress protein, th

177 creasing evidence for the roles of oxidative stress proteins including superoxide dismutase enzymes i

178 cription Factor 6) induces cytoprotective ER stress proteins, including GRP78 and GRP94.

179 a transcriptional inducer of genes encoding stress proteins, including those belonging to the heat s

180 Real-time PCR of ER stress proteins indicated that the expression of the hea

181 structurally and functionally related small stress proteins induced by a variety of insults, includi

182 A member of a gene family encoding stress proteins induced by heat and nitrogen limitation,

183 ssion in glial cells, that IkappaB-beta is a stress protein inducible by hyperthermia or proteasome i

184 pase activity; and (v) more activation of ER stress proteins inositol-requiring enzyme 1 and activati

185 h was accompanied by inhibition of oxidative stress, protein insolubilization, and caspase activity i

186 st that molecular chaperoning is involved in stress protein interactions with APCs, antigen binding,

187 In plants, FDH is regarded as a universal stress protein involved in responses to various abiotic

188 ng whether increased expression of these two stress proteins is able to protect myogenic cells agains

189 ce the signal for the up-regulation of these stress proteins is believed to be the accumulation of mi

190 ress responses, in which the entire array of stress proteins is induced, no increases in HSP40 and HS

191 show that the unfolding of the mechanically stressed protein is nonexponential due to static disorde

192 l a/b/d-binding proteins, including the iron-stress protein IsiA and other paralogous Chl-binding pro

193 Parameters of retinal oxidative stress, protein kinase C activity, and nitric oxides rem

194 hibitors of NF-kappa B (Bay11-7082), oxidant stress, protein kinase C, ERK, and p38 MAPKs.

195 re blocked by specific inhibitors of oxidant stress, protein kinase C, ERK1/2, and p38 mitogen-activa

196 During apoptotic stress, protein kinase Pak2 is cleaved by caspase 3 to f

197 on of multiple signaling pathways, including stress protein kinases as well as certain caspases.

198 ated DCs, was associated with a reduction of stress protein kinases, and attenuated lipopolysaccharid

199 uscle, was reduced following exposure, while stress-protein levels (Hsp70) increased.

200 A novel 14-amino acid peptide, with stress-protein-like sequences, exhibiting neuroprotectio

201 Stress proteins located in the cytosol or endoplasmic re

202 lting in the induction of a collection of ER stress proteins, many of which are protective and functi

203 vacuolation, Rosenthal fibres and associated stress protein markers.

204 reased inflammation, and increased oxidative stress protein markers.

205 (4) Chaperones and stress proteins may play a critical role in transforming

206 The endoplasmic reticulum (ER) stress protein mesencephalic astrocyte-derived neurotrop

207 ed gene ontology terms including Response to Stress, Protein Metabolic Process, Protein Folding, Regu

208 -inflammatory, and anti-apoptotic microsomal stress protein, migrates to the nucleus in a truncated a

209 hanges can elicit endoplasmic reticulum (ER) stress, protein misfolding, and cell death.

210 ex-dependent co-morbidities, such as chronic stress, protein misfolding, traumatic brain injury or ot

211 This task--complicated by cellular stresses, protein misfolding, aggregation, and degradati

212 tively, these data demonstrate that Turandot stress proteins mitigate AMP cytotoxicity to host tissue

213 Pag, also known as macrophage 23-kD stress protein (MSP23), is a member of a novel family of

214 ion of lac operator (LacO) array replication stress protein network identification (BLOCK-ID) in huma

215 The data support roles for oxidative stress, protein nitration and aggregation, and excitotox

216 Gls24 was previously identified as a general stress protein of Enterococcus faecalis.

217 BiP/GRP78 is a lumenal stress protein of the endoplasmic reticulum (ER) that in

218 B-stimulating "danger" signal into the large stress protein or chaperone Grp170 (HYOU1/ORP150) that w

219 ively mild insults through the expression of stress proteins or chaperones such as glucose-regulated

220 The expression of three stress proteins, OsmY, Dps, and UspA, is significantly a

221 aginyl endopeptidase family functioning as a stress protein, overexpressed by TAMs, provides an ideal

222 ein L25 (RplY), and the probable DNA-binding stress protein (PA0962).

223 The ER stress proteins PERK, ATF4, ATF6, IRE1alpha, and CHOP we

224 -months (n=10), changes in mitochondrial and stress proteins persisted whereas cytoskeletal proteins

225 Gadd45, a p53-regulated stress protein, plays an important role in the cell cycl

226 Following exposure to cell envelope stress, proteins present in the extracytoplasmic space b

227 ata support a model in which induction of ER stress proteins prevents disturbances of intracellular C

228 nificantly increased expression of CX3CL1, a stress protein produced by the injured enterocyte, NOD2

229 Stress proteins promote cell survival by monitoring prot

230 urrent progress in identifying mechanisms of stress protein protection from ischemia, in which new me

231 uating several examples, including thermally stressed proteins, proteins at different concentrations,

232 s were compromised for de novo folding, post-stress protein refolding, and in regulated degradation o

233 and metabolic pathway genes, as well as heat stress proteins, remained altered even though pollen cou

234 Herp, an ubiquitin-like domain containing ER stress protein, renders PC12 and MN9D cells vulnerable t

235 Activation of the stress protein response prevented the VEGF-mediated chan

236 icantly decreased by prior activation of the stress protein response with geldanamycin or pyrrolidine

237 These include enhanced stress protein response, attenuation of the inflammatory

238 attenuated in rats by the activation of the stress protein response.

239 An intriguing pattern emerges: stress proteins, ribosomal proteins and tRNA synthetases

240 We identified universal stress proteins, Rv1636 and MSMEG_3811 in Mycobacterium

241 f tyrosine phosphorylation of GRP-75-related stress protein(s) by alpha-thrombin and suggests that th

242 as relevant peptides from apoptotic and cell-stress proteins second mitochondria-derived activator of

243 The cytoplasmic superoxide stress protein SodB was induced by acid, possibly in res

244 hus, Osp94 is a new member of the hsp110/SSE stress protein subfamily and likely acts as a molecular

245 In contrast, calpain has no effect on other stress proteins such as GRP78 or HSP70.

246 nducible transcription factors 1alpha and 2, stress proteins such as heat shock protein 27, and vascu

247 , while promoting the selective synthesis of stress proteins, such as ATF4.

248 Redox regulation of stress proteins, such as molecular chaperones, guarantee

249 together with the appearance of a universal stress protein suggested that the viability of these cel

250 For the late protection, stress protein synthesis may play a role.

251 leukin-10, in turn, induced heme oxygenase-1 stress protein synthesis via an autocrine mechanism.

252 ration, UV resistance, oxidative stress, and stress-protein synthesis relative to the soil microbiome

253 Heme oxygenase-1 (HO-1) is a stress protein that has been suggested to participate in

254 Hsp27 is a small stress protein that has previously been shown to modulat

255 results support the hypothesis that Ub is a stress protein that plays an important role in protectin

256 ck proteins (sHSPs) are virtually ubiquitous stress proteins that are also found in many normal tissu

257 s controls the synthesis of over 100 general stress proteins that are induced by growth-limiting cond

258 ed eye lens alpha-crystallins are ubiquitous stress proteins that exhibit ATP-independent molecular c

259 ous family of low molecular mass (15-30 kDa) stress proteins that have been found in all organisms.

260 folate stress proteins include the universal stress protein, the ferric uptake regulatory repressor,

261 he stress protein and (b) the binding of the stress protein to receptor(s) on antigen-presenting cell

262 The stress protein transglutaminase-2 (TGM2) was also signif

263 Li et al. now identify the pseudokinase stress protein TRIB3 as an important factor in APL disea

264 mitant ablation of the upregulated oxidative stress protein TXNIP substantially negated the effects o

265 Exercise reduced expression of ER stress proteins, TXNIP/NLRP3 inflammasome signaling casc

266 Thrombospondin-1 is a stress protein typically secreted in response to hypoxia

267 ed that the high-level induction of the PspA stress protein under YidC depletion conditions is roughl

268 ses (CHT) and beta-1,3-glucanases (GLU), are stress proteins up-regulated as response to extrinsic en

269 in was identified that contained a Universal stress protein (Usp) domain present in bacteria, protozo

270 ases (HK) of this system contain a universal stress protein (USP) domain which binds to the second me

271 y techniques, we identify specific universal stress proteins (USP) as abundantly expressed cAMP-bindi

272 e of an acidic isoform of both the universal stress protein UspA and carbon starvation protein Csp15,

273 that includes the Escherichia coli universal stress protein UspA, for the MADS-box transcription regu

274 Universal stress proteins (USPs) are present in many bacteria, and

275 sferase (DGAT) (Rv3130c), and many universal stress proteins (USPs).

276 Four- and 10-fold activation of stress protein was detected by a consensus heat shock fa

277 s for CAP160 and CAP85, another spinach cold-stress protein, were introduced into tobacco (Nicotiana

278 ge foam cell formation, and downregulated ER stress proteins without changing blood pressure.

279 Furthermore, mRNAs encoding key soluble stress proteins (XBP-1 and ATF-4) were translated primar