ライフサイエンスコーパス: stress-induced

1 t recapitulates schizophrenia, whereas adult stress induced a depression-like hypodopaminergic state.

2 HNT stress induced a significant reduction in starch concent

3 NCED3 encodes a rate-limiting enzyme for stress-induced ABA synthesis.

4 proach suggests adversity-rearing produces a stress-induced aberrant neurobehavioral processing of th

5 n plant response to salt stress by affecting stress-induced accumulation of ABA and proline.

6 R3008H abrogated DNA damage- and oxidative stress-induced activation of ATM without consistently af

7 ongly supports the possibility that reducing stress-induced activation of beta2-ARs could help to ove

8 Since stress-induced activation of fatty acid amide hydrolase

9 These data suggest that stress-induced activation of the LC increases BLA spike

10 Consistent with stress-induced activation of the medial prefrontal corte

11 Stress-induced activation of the sympathetic nervous sys

12 ces of fear learning, stress reactivity, and stress-induced affective responses.

13 cruited to and required for the clearance of stress-induced aggregates, whereas ectopic expression of

14 aturally occurring aggression, and traumatic stress-induced aggression increase.

15 al modeling to characterize specific chronic stress-induced allostatic adaptations in the HPA network

16 Furthermore, we examined chronic variable stress-induced alterations in vHIP-NAc activity in vivo

17 type mice, it reverses chronic unpredictable stress-induced anhedonia and behavioral despair, indicat

18 Here, we show in a mouse model for stress-induced anhedonia and passive coping that these p

19 This molecular signature of vulnerability to stress-induced anhedonia and the active nature of resili

20 ncrease in DRv TPH2+ neurons and ameliorated stress-induced anhedonia in susceptible rats.

21 Stress-induced anhedonia was assessed in adult male rats

22 novel molecular marker of susceptibility to stress-induced anhedonia, a core symptom of depression,

23 eated forced swim stress decreased resulting stress-induced anhedonia.

24 ed escape deficits and chronic social defeat stress-induced anhedonia.

25 effects of endocannabinoids and reverses the stress-induced anxiety state in a cannabinoid receptor-d

26 rtex is a core neurobiological substrate for stress-induced, anxiety-like behaviors.

27 ecting multiple myeloma cells from oxidative stress-induced apoptosis.

28 ls increased the beta cell sensitivity to ER stress-induced apoptosis.

29 affecting catecholamine levels, and rescued stress-induced arousal along with challenge-induced beha

30 ate that many yeast PrLDs are sufficient for stress-induced assembly into microscopically visible foc

31 that the chronic endoplasmic reticulum (ER) stress-induced ATF4-CHOP-GADD34 pathway is activated in

32 itive variant that exhibits constitutive and stress-induced autophagic defects at permissive temperat

33 mal S6 kinase 2) plays a critical role in ER stress-induced autophagy in breast cancer cells.

34 This stress-induced behavior corresponded with increased mRNA

35 Antidepressant treatment ameliorated stress-induced behavioral abnormalities and affected key

36 prior to the induction and reinstatement of stress-induced behavioral deficits.

37 receptor in the hippocampus was critical for stress-induced behavioral deficits.

38 K and (2R,6R)-HNK protected against distinct stress-induced behaviors in both sexes, with (2S,6S)-HNK

39 This HSC loss was also exacerbated by stress induced by 5-fluorouracil injections.

40 eactive nitrogen species as well as cellular stress induced by antibiotics.

41 Organs and cells must adapt to shear stress induced by biological fluids, but how fluid flow

42 microtubules against the repeated mechanical stress induced by ciliary motility.

43 tudy of its pathophysiology under myelotoxic stress induced by drugs, radiation or genetic mutations.

44 ial DNA (mtDNA) damage and nuclear oxidative stress induced by dysfunctional mitochondria, there was

45 nts defective in response to the replication stress induced by hydroxyurea.

46 ssion of the copper importer CTR1, and redox stress induced by manipulating intracellular glutathione

47 ensatory glycolysis in response to oxidative stress induced by psychological distress.

48 onse to psychologic stimulation based on the stress induced by public speaking.

49 rigenesis, due in part to profound metabolic stress induced by RAS activation.

50 atinocytes are highly sensitive to metabolic stress induced by starvation or the antidiabetic drug me

51 Cellular stress induced by the abnormal accumulation of unfolded

52 , sensitize AMPK activation to the energetic stress induced by the dietary transition during fasting.

53 The oxidative stress induced by the Fenton reaction leads to the expos

54 stem cell pool in routine housing and after stress induced by the limited bedding/nesting paradigm i

55 AX function in series to prevent replication stress induced by the MRE11-dependent resection of regre

56 e further investigated whether rereplication stress induced by the unscheduled activation of the APC/

57 ure defects is correlated with the localized stresses induced by a concentration gradient of Li atoms

58 a shallow andesitic reservoir controlled by stresses induced by the topographic load, but not the re

59 The stress-induced c-Jun N-terminal kinase (JNK) controls mi

60 ing to the SDD1 promoter, leading to osmotic stress-induced Ca(2+)/CaM-dependent activation (de-repre

61 ymorphic ventricular tachycardia (CPVT) is a stress-induced cardiac channelopathy that has a high mor

62 ly unrecognized FoxO1-Dio2 signaling axis in stress-induced cardiomyocyte growth and remodeling and i

63 embolism, vasospasm, myocardial bridging and stress-induced cardiomyopathy (Takotsubo syndrome).

64 es included endothelial cell adhesion, shear stress-induced cell alignment, blood pressure measuremen

65 pecies (ROS) buildup, resulting in oxidative-stress-induced cell death when challenged by nutrient st

66 siccation tolerance circumvents destructive, stress-induced cell senescence.

67 R cells, but also mouse and human cells from stress-induced cell-cycle arrest and cell death in a pol

68 on dynamics that may contribute to oxidative stress-induced cellular and tissue responses.

69 (TA) systems that contribute to a variety of stress-induced cellular processes in addition to stabili

70 their potent inhibitory effects on oxidative stress-induced cellular senescence in endothelial cells

71 senchymal stem cells (GMSC-EVs) on oxidative stress-induced cellular senescence in human endothelial

72 between chronic ocular GVHD pathogenesis and stress-induced cellular senescence through the senescenc

73 Hence, we investigated early stress-induced changes in amygdalar synaptic signaling i

74 for mood disorders like depression, but the stress-induced changes in brain circuit function and gen

75 New insight has been gained from examining stress-induced changes in gene expression at a global sc

76 However, systemic studies assessing stress-induced changes in mitochondria-associated genes

77 ed whether locus coeruleus (LC)-NE regulates stress-induced changes in spike firing in the BLA and co

78 Circadian and stress-induced changes in systemic GC levels regulate me

79 Among the stress-induced changes, we observed that vascular Notch

80 MSCs reduced stress-induced circulating proinflammatory cytokines, mo

81 to be one of the major mechanisms underlying stress-induced cognitive impairment.

82 by recurring stress, likely contributing to stress-induced cognitive impairment.SIGNIFICANCE STATEME

83 mouse and human beta cells during metabolic stress-induced compensation but downregulated in dysfunc

84 The ON/OFF switching occurs due to a stress-induced concentration change of oxygen vacancies

85 -brain serotonergic signaling in resting and stress-induced conditions, an effect that was localized

86 of the proposed device by demonstrating the stress-induced conductivity modulation of a perovskite o

87 stressors and therefore can impose temporary stress-induced constraints on the growth-promoting gene

88 Both baseline and stress-induced corticosterone concentrations were lower

89 , which in turn was negatively correlated to stress-induced cortisol increases.

90 trajectory characterized by high, prolonged stress-induced cortisol reactivity and emotional reactiv

91 ell as multiple measures of self-regulation: stress-induced cortisol reactivity and fear-elicited emo

92 ment of cocaine seeking in animal models and stress-induced craving in human studies, guanfacine has

93 to examine the role of neuronal activity in stress-induced CSF1 signaling and microglia-mediated neu

94 mechanism that can be initiated by transient-stress-induced cytosolic de-mixing of TDP-43.

95 ulting increase in deoxyuridine mitigated ER stress-induced cytotoxicity.

96 Fourth, PTMs take part in the repair of stress-induced damage (e.g., by reducing Met and Cys oxi

97 llen and pistil viability will overcome heat stress-induced damage during flowering under current and

98 ar chaperones to protect other proteins from stress-induced damage.

99 havioral despair in female mice and enhanced stress-induced decrease in sucrose preference in both se

100 A-allele homozygotes were protected against stress-induced decreases in AEA and negative emotional c

101 zygous mice were similarly protected against stress-induced decreases in AEA, both in the periphery,

102 atergic neurons (nIL-1R1(-/-)) abrogated the stress-induced deficits in social interaction and workin

103 hanism by which GPR158 exerts its effects on stress-induced depression by the complex formation with

104 In mice exhibiting stress-induced depression-like behavior (helplessness),

105 cal status provides vulnerability to develop stress-induced depression.

106 Moreover, we show that prophylactics against stress-induced depressive-like behavior can be developed

107 ear in male mice, and (2R,6R)-HNK preventing stress-induced depressive-like behavior in both sexes.

108 he administration of (R,S)-ketamine prevents stress-induced depressive-like behavior in male mice, pe

109 RS-67,333 was ineffective against stress-induced depressive-like behavior in the forced sw

110 995274 attenuated learned fear and decreased stress-induced depressive-like behavior.

111 nce in Akita (Ak) mice, a rodent model of ER stress-induced diabetes, akin to neonatal diabetes in hu

112 primary products such as nicotinamide during stress-induced dietary states.

113 Interestingly, while adolescent chronic stress-induced differences in relative microbial abundan

114 macokinetics to ameliorate cardiac and renal stress-induced disease with fibrosis.

115 e sensitivity to stress, trauma, and risk of stress-induced disorders such as PTSD.

116 microbiome and reduce host vulnerability to stress-induced disruptions in complex behaviors such as

117 redox-sensitive S70pBcl2 prevents oxidative stress-induced DNA damage and cell death by suppressing

118 ox sensor and modulator to prevent oxidative stress-induced DNA damage and execution.

119 on, and, consequently, increased replication stress-induced DNA damage and genomic instability.

120 To investigate the role of oxidative stress-induced DNA damage and mutagenesis in cellular se

121 tributes to the formation of the replication stress-induced DNA damage markers replication protein A

122 blast stem cells, specifically at regions of stress-induced DNA double helix destabilization (SIDD)(2

123 Stress-induced domain wall mobility was interpreted on t

124 ealed that the RyR is sensitive mainly to ER stress-induced dysfunction, whereas cytokine stress spec

125 evidence suggests that the IED results from stress-induced dysregulation of prefrontal cortical circ

126 he dry season suggest increasing temperature stress-induced emissions due to climate change.

127 ss-induced neural remodeling with studies on stress-induced endocannabinoid dysregulation focusing on

128 We hypothesized that mechanical stress-induced enhancement of CD44-intracellular domain

129 ng dopamine receptors in the VLS blocked the stress-induced enhancement of conditioned responding.

130 identified but are thought to be related to stress induced excitotoxic effects in combination with e

131 bacteria as the commensal essential for the stress-induced expansion of aged neutrophils that enhanc

132 enhancer, which is also required to augment stress-induced expression and to prevent premature hyper

133 Prenatal stress-induced fetal neuroinflammation is thought to und

134 ins displayed significant resistance against stress-induced fibrillation, particularly at the nucleat

135 ced the proto-oncogene BCL2 as a replication stress-induced fragile site.

136 2 D290V in Caenorhabditis elegans results in stress-induced glutamatergic neurodegeneration; this neu

137 In mice, we show that chronic stress-induced Gpr56 downregulation in the blood and pre

138 role(s) of individual FoxO family members in stress-induced growth and remodeling of cardiomyocytes r

139 ds recalled or renovated ancient programs of stress-induced growth arrest that were already present i

140 both at homeostasis and under conditions of stress-induced haematopoiesis.

141 liferation of melanocyte stem cells prevents stress-induced hair greying.

142 ockdown in the NAc reduced susceptibility to stress-induced helplessness and increased NAc neuronal a

143 is identification of naturally occurring and stress-induced hGR isoforms, as well as the establishmen

144 Our results suggest that the oxidative stress induced high mutation frequency on mtDNA can be i

145 nce on innate pro-inflammatory cytokines and stress-induced host ligands through to interaction with

146 s are those with a penalty function based on stress-induced hydraulic failure.

147 A in protecting intestinal mitochondria from stress-induced hyper-fragmentation.

148 Meanwhile, GMSC-EVs restored oxidative stress-induced impairment in proliferation and tube form

149 th male animals exhibiting greater metabolic stress-induced impairments than females.

150 ILs, their sensitivity to humidity, and the stress induced in frozen liquids inhibit ILs from consti

151 This stress-induced increase in BLA firing was prevented by s

152 Pharmacological inhibition of stress-induced increase in hdac1 activity rescued cldn5

153 We observed a stress-induced increase in in vivo vHIP-NAc activity coi

154 Stress-induced increases in BLA activity mediated by LC-

155 Stress-induced increases in BLA activity mediated by LC-

156 Oxytocin knockdown prevented social stress-induced increases in social vigilance and decreas

157 However, the molecular mechanisms of cell-stress-induced inflammation are poorly understood.

158 y and anti-inflammatory activation during ER stress-induced inflammation to promote hepatic ER stress

159 ors caspase-8, FADD, or RIPK1, suppressed ER-stress-induced inflammation.

160 an unexpected role for TRAIL receptors in ER-stress-induced inflammation.

161 ing may prove a novel target for alleviating stress-induced inflammatory diseases.

162 Furthermore, chemotherapeutic stress-induced inflammatory responses were blunted in DR

163 ocial stress, although little is known about stress-induced inhibitory synaptic plasticity and its re

164 When lipolysis was inhibited, the stress-induced insulin resistance and hyperglycemia were

165 l replication and expansion during metabolic stress-induced insulin resistance with short-term high-f

166 irement for adipocyte lipolysis in promoting stress-induced insulin resistance.

167 Stress-induced interleukin-6 and high-frequency heart ra

168 provide mechanistic insights into early life stress-induced intestinal changes that may translate int

169 ependent extrinsic apoptosis and proteasomal stress-induced intrinsic apoptosis.

170 ctivity that prevented endoplasmic reticulum stress-induced IRE1alpha oligomerization and phosphoryla

171 Mental stress-induced ischemia and activation of other brain pa

172 Mental stress-induced ischemia and other pain processing brain

173 g the endoplasmic reticulum unfolded protein stress-induced ISR, mediated by the related eIF2alpha ki

174 The coupling of reductive stress-induced JH(2)O(2) production to NNT-linked redox

175 eficiency does not prevent activation of the stress-induced JNK-c-Jun signaling pathway.

176 Thus, cellular stress-induced lipid peroxidation specifically attenuate

177 Oxidative stress in combination with heat stress induced loss of its Fe-S clusters followed by sub

178 y in melanocyte stem cells, we find that the stress-induced loss of melanocyte stem cells is independ

179 ated BAG6 knockdown prevented chronic MPP(+) stress-induced loss of PINK1, reversed MPP(+)-provoked m

180 Behaviorally, stress-induced loss of reward sensitivity intensifies ov

181 hagy induction paradigm where mild oxidative stress induced low levels of mitochondrial damage.

182 Pulmonary adaptation during oxidative stress-induced lung injury is mediated by a novel subset

183 eclinical research supports the premise that stress-induced maternal immune activation contributes in

184 eceptor subtype 2 (CRF(2)) as a modulator of stress-induced MC degranulation and associated disease p

185 netoencephalography (MEG), we show that this stress-induced memory control deficit is linked to alter

186 h higher physiological estradiol experienced stress-induced memory impairment and a loss of underlyin

187 rm sex-selective risk for the development of stress-induced mental illness.

188 Here we show that loss of REDD1, a stress-induced metabolic regulator, is sufficient to rep

189 In females, however, this stress-induced metaplasticity is buffered by the presenc

190 This oxidative stress induced microglia activation and redox-sensitive

191 erones are the front line of protection from stress-induced misfolding and aggregation of polypeptide

192 l phenotype which is distinct from oxidative stress-induced mitochondrial fragmentation.

193 tochondrial adaptations, consistent with the stress-induced mitochondrial hyperfusion.

194 These data demonstrate how replication stress-induced mitotic catastrophe signals cell death wi

195 Stress-induced monocyte trafficking to the brain was als

196 ons promotes resilience to CSDS and prevents stress-induced morphological alterations to those neuron

197 Additionally, the discovery of divergent stress-induced mortality based on parental origin in mic

198 to SG assembly, and its regulation of dsRNA stress-induced mRNAs are unknown.

199 We hypothesize that stress-induced mutagenesis is an evolvable adaptive stra

200 circuitry, a comprehensive framework of how stress-induced negative affect may be encoded within key

201 lectrodermal activity, and protected against stress-induced negative affect, measured via facial elec

202 Stress-induced negative affective states are prevented b

203 e of the endocannabinoid system in long-term stress-induced neural remodeling with studies on stress-

204 nerable mice characterized by restoration of stress-induced neuroenergetics alterations and lipid fun

205 findings indicate that modulation of chronic stress-induced neuronal activity limits microglia-mediat

206 ings reinforce the importance of considering stress-induced neurovascular pathology in depression and

207 ocate to the nucleus and thereby sustain the stress-induced NMN/NAD(+) salvage pathway.

208 ning, and these deficits depend, in part, on stress-induced norepinephrine (NE) release in the basola

209 In our monogenic podocyte ER stress-induced NS/FSGS mouse model, the podocyte type 2

210 (2020) investigate stress-induced nuclear condensates of the RNA-binding pr

211 n athermal omega phase was observed, while a stress-induced omega phase reforms within the tertiary t

212 active cleavage product in mammals, and that stress-induced OPA1 cleavage causes mitochondrial fragme

213 oxidant-induced cell death, indicating that stress-induced OPA1 cleavage supports cell survival.

214 o nutrient availability by limiting nutrient stress-induced overactivation of catabolic responses in

215 pplication of ABA or proline could alleviate stress-induced oxidative damage of the mutant and partia

216 We found that high stress-induced PACT-PKR activation inhibits the interact

217 rmacological ablation of microglia prevented stress-induced pain sensitivity.

218 whereby Banf1 is crucial to reset oxidative-stress-induced PARP1 activity.

219 eriod in the adult restores vulnerability to stress-induced pathology resembling schizophrenia.

220 tional importance of MC CRF(2) in modulating stress-induced pathophysiology.

221 ng protein long form of OPA1 (L-OPA1) by the stress-induced peptidase OMA1.

222 The underlying concept, a shear-stress induced permeabilisation of biocatalytic reaction

223 h to study the neurobiology of psychological stress-induced phenotypes.

224 In addition to roles for stress-induced phosphorylation and inositol hexakisphosp

225 Inherited RYR2 mutations and/or stress-induced phosphorylation and oxidation of the prot

226 etween decreased chromatin accessibility and stress-induced photoreceptor cell death in our mouse mod

227 t that a photosensitive mouse model of acute stress-induced photoreceptor degeneration recapitulates

228 Stress-induced pioneer transcription factors are propose

229 , podocyte RyR2 remodeling contributes to ER stress-induced podocyte injury.

230 tly, we reported that Hb-dependent oxidative stress induced post-translational modifications (PTMs) o

231 approach to identify the highly reversible, stress-induced, posttranslational modification (PTM) pro

232 increases fitness under stress by reversing stress-induced protein aggregation.

233 s favored by the reversible binding of small stress-induced proteins to the ribosome to prevent unnec

234 cing stress resilience could protect against stress-induced psychiatric disorders in at-risk populati

235 l yet neuroscience-based training to prevent stress-induced psychopathology.

236 Each stress induced rapid remodeling of the RNA-protein inter

237 In addition, Test diet prevented the stress-induced reduction in microbial alpha diversity ba

238 Oxidative stress-induced reductions in NO-dependent dilation, as w

239 lpha(2a)-AR heteroreceptor deletion disrupts stress-induced reinstatement and that BNST G(i)-DREADD a

240 eroreceptors and BNST G(i)-GPCR signaling in stress-induced reinstatement of cocaine conditioned plac

241 eroreceptors and BNST G(i)-GPCR signaling in stress-induced reinstatement of cocaine CPP and provide

242 While decreasing stress-induced reinstatement of cocaine seeking in anima

243 phine-conditioned place preference (CPP) and stress-induced reinstatement of extinguished morphine-CP

244 oes not increase BNST activity, but prevents stress-induced reinstatement.

245 of low dose guanfacine on BNST activity and stress-induced reinstatement.

246 guanfacine on BNST cFOS immunoreactivity and stress-induced reinstatement.

247 ributions of alpha(2a)-AR heteroreceptors to stress-induced reinstatement.

248 he efficacy of guanfacine as a treatment for stress-induced relapse of cocaine use.

249 inalis (BNST), a key brain region in driving stress-induced relapse.

250 lays an important role in cocaine binges and stress-induced relapse.

251 critically regulates negative affective- and stress-induced relapse.

252 fits the artery by assisting the function of stress (-induced) relaxation.

253 RFRP neurons in mediating acute and chronic stress-induced reproductive suppression.

254 A new study identifies a stress-induced response in dendritic cells-the activatio

255 lular signaling in plants that mediate rapid stress-induced responses to changes in the environment.

256 We found that H2A.Z cKO reduced stress-induced sensitization of fear learning and pain r

257 Osmotic stress-induced SG formation and TDP-43 ubiquitylation oc

258 a serve as an essential node for a number of stress-induced signaling pathways and our experiments su

259 lexin-B2-mediated production of tRNA-derived stress-induced small RNA (tiRNA) and transcription of ri

260 sitivity and strongly impaired rapid osmotic-stress-induced SnRK2 activation.

261 ocin neurons plays a key role in controlling stress-induced social anxiety behaviors.

262 /kg) was tested for its potential to reverse stress-induced social deficits.

263 h is common in human breast cancer, prevents stress-induced stabilization of the tumor suppressor p53

264 respond to pre-existing self-molecules after stress-induced structural changes in CD1d-expressing cel

265 xperimental evidence indicates that external stress-induced subcellular adaptation is accomplished th

266 on ablation or silencing did not exhibit the stress-induced suppression in pulsatile luteinizing horm

267 The changes we observe are part of a stress-induced survival strategy, allowing yeast cells t

268 that this activity is broadly predictive of stress-induced susceptibility in both sexes, while prest

269 ventral hippocampus (vHIP) are implicated in stress-induced susceptibility, but little is known about

270 ar bundles of Arabidopsis in mediating light stress-induced systemic signaling and SAA.

271 Stress-induced systemic signaling and systemic acquired

272 ells exposed to pathological conditions from stress-induced tissue damage.

273 t then confer a protective mechanism against stress-induced tissue damages.

274 work presents a resource for chronic social stress-induced, tissue-specific changes in proteins, lip

275 Neil-deficiency elicits an oxidative stress-induced TP53-dependent DNA damage response, which

276 ER-stress-induced TRAIL receptor activation resulted in cas

277 ed that viral and/or cellular factors impair stress-induced transcription and reduce the incidence of

278 Stress-induced transcription arises from antitoxin degra

279 These observations lead us to predict that stress-induced transcription is impaired by factors abun

280 t of G3BP1 and 2 but does not interfere with stress-induced translational inhibition.

281 ach was used to identify proteins that evade stress-induced translational repression in arsenite-trea

282 roteins that are actively synthesized during stress-induced translational repression, irrespective of

283 To circumvent stress-induced translational shutdown, viruses encode IS

284 origenic functions, which we propose promote stress-induced tumour adaptation.

285 otein half-life, and consequent clearance of stress-induced ubiquitinated-insoluble proteins.

286 , we used electron tomography to investigate stress-induced ultrastructural changes in the cytoplasm

287 ic signals and activating tumor-promoting ER stress-induced unfolded protein response and inflammatio

288 Regions of SIDD are conducive to topological stress-induced unpairing of the double helix and have cr

289 enes whose inactivation further increases ER stress-induced up-regulation of C/EBP homologous protein

290 d that GMSC-EVs robustly abrogated oxidative stress-induced upregulation in the expression of cellula

291 Stress-induced upregulation of ABCB1 was mitigated by co

292 Here, we show that stress-induced upregulation of the ROS-generating protei

293 y vs. resilience to chronic stress, and that stress-induced variations in mPFC levels of miR-218 coul

294 We also investigated whether stress-induced variations of miR-218 expression in the m

295 found noise to be associated with oxidative stress-induced vascular and brain damage, mediated by ac

296 ted in high venous pressure- and fluid shear stress-induced vascular hyperpermeability in endothelial

297 ell-inducing gut microbiota markedly reduces stress-induced VOEs.

298 hitecture in a copper matrix through thermal-stress-induced welding between graphene-like nanosheets

299 Here, we demonstrate that the stability of stress-induced wild-type and mutant p53 is regulated by

300 emble with and inhibit IRE1alpha to suppress stress-induced XBP1 splicing, a key mediator of the unfo