1 e for [Ca(2+)] in regulating power output of
stretch-activated A-IFM.
2 Moreover, we found that longitudinal
stretch activated Akt, which up-regulated Ankrd2 express
3 In support of this idea,
stretch-activated and stretch-inactivated channels were
4 There were differences in the
stretch-activated and swelling-activated cation channel
5 Here, we identify the
stretch-activated anion channel MSL10 as necessary for p
6 modulates mechanosensitive (ie, swelling- or
stretch-activated)
anion channels was tested.
7 omoter only by NF-kappaB, whereas transverse
stretch activated Ankrd2 promoter by AP-1.
8 Interestingly, longitudinal
stretch activated Ankrd2 promoter only by NF-kappaB, whe
9 ition of AT(1) blocker to cultures inhibited
stretch-activated apoptosis in both myocyte populations
10 Piezo1 is the
stretch activated Ca(2+) channel in red blood cells that
11 s of Prl receptors, prlr1 and prlr2, and the
stretch-activated Ca(2+) channel, trpv4,decreased at 32
12 Such Hechtian transduction opens
stretch-activated Ca(2+) channels and activates H(+) -AT
13 We also investigated
stretch-activated Ca(2+) entry into atrial HL-1 myocytes
14 Ca(2+), and patch clamping of nuclei reveals
stretch-activated Ca(2+) permeable channels.
15 We have identified and characterized
stretch-activated Ca2+ channels from Lilium longiflorum
16 It has been widely assumed that
stretch-activated Ca2+ channels underlie this influx, bu
17 sensitive manner, suggesting the presence of
stretch-activated Ca2+ channels.
18 The presence of a
stretch-activated calcium channel in gastrointestinal sm
19 e aim of this study was to determine whether
stretch-activated calcium channels are present in gastro
20 Mechanical stimulation of
stretch-activated calcium channels is known to mediate t
21 cium transients arise from the activation of
stretch-activated calcium channels, which triggers an in
22 effects of calcium-induced contractility and
stretch-activated calcium channels.
23 Treatment of cells with the
stretch-activated cation channel (SACC) blocker Gd3+ par
24 elling-activated conductance was produced by
stretch-activated cation channel activity.
25 ed no effect on either swelling-activated or
stretch-activated cation channel activity.
26 Treatment of cells with either the
stretch-activated cation channel inhibitor GdCl3 or the
27 tor potential vanilloid isoform 4 (TRPV4), a
stretch-activated cation channel.
28 stola spatulata, is a selective inhibitor of
stretch-activated cation channels (SACs).
29 nical strain (CMS) increases the activity of
stretch-activated cation channels of osteoblast-like UMR
30 tment or during perinatal development, 90-pS
stretch-activated cation channels that could be blocked
31 We show that gadolinium, an antagonist for
stretch-activated cation channels, downregulates the exp
32 rains of this order are large enough to open
stretch-activated cation channels.
33 e alpha subunit of ENaC is necessary to form
stretch-activated cation channels.
34 on is diminished by pharmacological block of
stretch-activated cation-nonselective channels.
35 ogical block of ATP-inactivated potassium or
stretch-activated cation-nonselective channels.
36 d the ryanodine receptor (RyR) and (iii) the
stretch-activated channel (SAC) in both single myocytes
37 TRP channels may contribute to the increased
stretch-activated channel activity observed in mdx myofi
38 nel blocker) and gadolinium(III) chloride (a
stretch-activated channel blocker) did not alter the lev
39 hypothesis by adding gadolinium chloride (a
stretch-activated channel blocker) to the saline (0.008
40 Piezo1 is a
stretch-activated channel important to muscle contractil
41 is increased proliferation is induced by the
stretch-activated channel Piezo1 and involves calcium-tr
42 cells become too crowded, they activate the
stretch-activated channel Piezo1 to trigger extrusion of
43 tein cochlin with the cell surface bound and
stretch-activated channel TREK-1.
44 Neither
stretch-activated channel was detected in the grain prot
45 al pressure-dependent gating properties of a
stretch-activated channel with a current/voltage plot in
46 s study describes a physiologically relevant
stretch-activated channel, at both the single-channel an
47 tor potential vanilloid isoform 4 (TRPV4), a
stretch-activated channel, is required to maintain ocula
48 Moreover, disruption of a
stretch-activated channel, Piezo1, in zebrafish prevents
49 MscL, a
stretch-activated channel, saves bacteria experiencing h
50 e data show that hypotonic shock generates a
stretch-activated channel-dependent calcium pulse in yea
51 GsMTx-4 indicates its possible identity as a
stretch-activated channel.
52 y acid-activated K(+) channel that is also a
stretch-activated channel.
53 ns; 2), increasing the number or activity of
stretch activated channels leads to an increase in perio
54 d be through stimulation of Ca(2+) permeable
stretch activated channels, we hypothesised a role for P
55 nce, is not dependent on Ca2+ influx through
stretch activated channels.
56 inhibited MSHA, whereas other inhibitors of
stretch-activated channels (Gd(3+), ruthenium red, SKF96
57 We tested the hypothesis that both
stretch-activated channels (SACs) and intracellular calc
58 Stretch-activated channels (SACs) have been found in myo
59 Stretch-activated channels (SACs) have been found in smo
60 Stretch-activated channels (SACs) have been shown in oth
61 ns that block voltage-gated Ca(2+) channels,
stretch-activated channels (SACs), or the Na(+)-Ca(2+) e
62 ess via integrated changes in caveolin-3 and
stretch-activated channels (SACs).
63 These results suggest that the opening of
stretch-activated channels allows ions, including Ca2+,
64 Unitary ionic currents from
stretch-activated channels and [Ca2+]i images were recor
65 l Na+ with TEA, Tris or choline, eliminating
stretch-activated channels but suggesting that if transm
66 n its gating mechanism and pharmacology from
stretch-activated channels described previously.
67 ted by a spider venom that is known to block
stretch-activated channels in animal cells, but the spon
68 ther, these data highlight the importance of
stretch-activated channels in pregnancy maintenance and
69 ugh mechanical distention-induced opening of
stretch-activated channels in smooth muscle cells.
70 The entry of Ca2+ through
stretch-activated channels is also amplified by Ca2+ rel
71 This mechanical strain suggests that
stretch-activated channels may constitute a mechanism to
72 Binding of alpha2beta1 integrin and
stretch-activated channels mediate M migration and mecha
73 we show that inhibiting Ca2+ influx through
stretch-activated channels using various compounds, incl
74 The
stretch-activated channels were inhibited by a spider ve
75 imply that Gd3+-sensitive, poorly selective,
stretch-activated channels were not involved.
76 omycin is not useful in the investigation of
stretch-activated channels which may underlie the myogen
77 show that the MEF effects, depending on the
stretch-activated channels' conductances and reversal po
78 h gadolinium (III) chloride (an inhibitor of
stretch-activated channels) only blocked the activation
79 of membrane, Ca2+-permeable cation channels (
stretch-activated channels) opened and a global increase
80 etch in cell-attached patches (i.e. they are
stretch-activated channels), they differ in their abilit
81 involved in creating these signal: Rho/ROCK,
stretch-activated channels, and 'Molecular Strain Gauges
82 ibited by gadolinium (Gd3+), an inhibitor of
stretch-activated channels, but is independent of extrac
83 sMTx4, a lipid-mediated modifier of cationic
stretch-activated channels, eliminated the voltage and d
84 he activation of both ERK1/2 and p38 kinase,
stretch-activated channels, small GTPase proteins, and e
85 Consistent with the presence of
stretch-activated channels, we show that Ca2+ influx is
86 to as mechanoelectrical feedback (MEF), via
stretch-activated channels.
87 ch is eliminated by gadolinium, a blocker of
stretch-activated channels.
88 , but is distinguished by signalling through
stretch-activated channels.
89 -inactivated channels was similar to that of
stretch-activated channels.
90 is abolished by gadolinium, an inhibitor of
stretch-activated channels.
91 modulates mechanosensitive (ie, swelling- or
stretch-activated)
channels was tested.
92 The majority of TM cells exhibited a delayed
stretch-activated current that was mediated independentl
93 Here, we investigated the effects of
stretch-activated currents (ISAC) on alternans using a p
94 ed by poking without considerable effects on
stretch-activated currents (SAC).
95 ransfecting FLYC1 induces chloride-permeable
stretch-activated currents in naive cells, and transcrip
96 Notably,
stretch-activated currents maintained the hallmark featu
97 global changes in [Ca2+]i occurred only when
stretch-activated currents were sufficient to cause memb
98 deled variants result in strongly attenuated
stretch-activated currents when expressed in naive cells
99 -substrate contacts but only PIEZO1 mediates
stretch-activated currents.
100 Synchronized discharges of
stretch-activated EJPs and IJPs were preserved following
101 Although
stretch activated ERK1/2 through a Ras- and PKC classica
102 Mechanical
stretch activated ERKs, with a peak response observed at
103 PCCG-13 also significantly reduced
stretch-activated excitability in the absence of exogeno
104 nd applying weak suction evoked conventional
stretch-activated gating.
105 Cyclic
stretch activated gene expression profiles characteristi
106 Pressure-induced (-40 mm Hg) membrane
stretch activated ion channels in arterial myocyte cell-
107 biological phenomena, notably the gating of
stretch activated ion channels.
108 d in Ussing chambers) revealed 2-fold higher
stretch-activated ion channel conductances in response t
109 found that stretch promotes mitosis via the
stretch-activated ion channel Piezo1 and ERK signaling.
110 Mechanical forces through the
stretch-activated ion channel Piezo1 link both of the pr
111 expressed in Escherichia coli, MSL1 forms a
stretch-activated ion channel with a slight preference f
112 of TMEM63B, encoding for a highly conserved
stretch-activated ion channel.
113 t a functional interaction between TRPV4 and
stretch-activated ion channels (SACs) is involved in thi
114 We hypothesized that
stretch-activated ion channels (SACs) mediated this incr
115 onapoptotic cells via mechanically regulated
stretch-activated ion channels (SACs).
116 ignals or triggering intracellular cascades,
stretch-activated ion channels allow the cell to respond
117 ed by inhibiting focal adhesion signaling or
stretch-activated ion channels and is independent of cel
118 A calcium influx through
stretch-activated ion channels and the detachment of adh
119 Recently, the Piezo family of
stretch-activated ion channels has been identified as ge
120 Functionally significant
stretch-activated ion channels have been clearly identif
121 Piezo1 ion channels are voltage-modulated,
stretch-activated ion channels involved in a variety of
122 ogical mechanisms underlying associations of
stretch-activated ion channels with human disease is lim
123 The transduction process involves integrins,
stretch-activated ion channels, and IL-4.
124 duce calcium entry (including Gd3+, to block
stretch-activated ion channels, and nifedipine) abolishe
125 Stretch-activated ion channels, caveolae, integrins, cad
126 f NCM to support mechanotransduction through
stretch-activated ion channels.
127 bone cells independently of Ca(2+) flux and
stretch-activated ion channels.
128 Although the role of
stretch-activated ion currents has been investigated usi
129 ce is the activation of mechanosensitive (or
stretch-activated)
ion channels, and a number of mechano
130 ILOT is not voltage- or
stretch-activated,
it has a characteristically long open
131 TREK-1 encodes a component of the
stretch-activated K(+) conductance in smooth muscles and
132 In addition, we find a
stretch-activated K+ channel as well as a spontaneous K+
133 cells expressing in the basolateral membrane
stretch-activated K+ channels demonstrable by the cell-a
134 characterize the expression and function of
stretch-activated K2P channels in the human bladder and
135 otransduction associated with the changes in
stretch-activated K2P channels may underlie myogenic bla
136 X-ray diffraction "movies" from sinusoidally
stretch-activated Lethocerus muscles.
137 rum of ALI models and in cytokine- or cyclic
stretch-activated lung microvascular endothelium.
138 found evidence for myocyte protection via a
stretch-activated mechanism.
139 We describe a method to investigate
stretch-activated mechanotransduction in sensory nerves
140 This interaction may serve as a mechanism of
stretch-activated muscle contraction, and this system co
141 n asynchronous ancestor, still preserves the
stretch-activated muscle physiology.
142 NLP-12 expression is limited to a single
stretch-activated neuron, DVA.
143 Surprisingly, the
stretch-activated NF-kappaB and AP-1 signaling pathways
144 A
stretch-activated,
nifedipine-sensitive calcium channel
145 ompletely blocked the swelling-activated and
stretch-activated nonselective cation channel response t
146 s respond to repetitive strain by activating
stretch-activated,
nonselective cation channels (SA-CAT)
147 Bundles of 8-12 fibers were
stretch-activated on SRS synchrotron x-ray beamline 16.1
148 Selective ablation of the
stretch-activated Piezo2 channels from TRPV1 lineage neu
149 t a Ca(2+) capacitor discharged at low pH by
stretch-activated plasma membrane H(+)-ATPases, hence a
150 However, transverse
stretch activated Ras-GTP, Raf-1, and Erk1/2 proteins, w
151 tivation of NF-kappaB involves activation of
stretch-activated (
SA) channels and the production of fr
152 ouse lung, where elevated CO2 also inhibited
stretch-activated shedding of the ADAM17 substrate TNFR1
153 The
stretch-activated substrate of Fyn and c-Src, p130Cas, i
154 We conclude that
stretch-activated tension of IFM is produced by cross-br
155 on saturated at slightly lower [Ca(2+)] than
stretch-activated tension, such that as [Ca(2+)] increas
156 Both calcium-activated and
stretch-activated tensions increased with increasing [Ca
157 Stretch activated the IkappaB-NF-kappaB pathway, and NF-
158 Here, we assessed the function of Piezo1, a
stretch-activated transmembrane cation channel, within s
159 Animal data suggest that
stretch-activated two-pore-domain (K2P) K(+) channels pl
160 argeted nanoparticles can penetrate and bind
stretch-activated vascular smooth muscles in the media a
161 Arachidonic acid, proton and membrane
stretch activated,
whereas dibutyryl-cAMP inhibited all