ライフサイエンスコーパス: striatal

1 rs correlating with information derived from striatal (11)C-DTBZ data using the DSI Studio toolbox.

2 ts were significantly associated with higher striatal (11)C-DTBZ distribution volume ratios (least af

3 se analyses to identify group differences in striatal [(18) F]-fluorodopa uptake (K(i) ).

4 However, at baseline and over time, striatal [(18) F]-fluorodopa uptake in mutation carriers

5 l or clozapine counteracted the reduction of striatal A(2A)R-D(2)R heteromers.

6 prognosis and subtyping based on functional striatal abnormalities (FSA).

7 entration, which coincides with elevation of striatal acetylcholine (ACh) levels.

8 Striatal activation could be augmented by circulating se

9 Decreased striatal activity may have been due to decreased cortica

10 dystonic patients or to the normal levels of striatal activity reported in healthy animals.

11 understand the mechanisms supporting proper striatal activity.

12 The cerebral cortex is the main striatal afferent, and progressive cortico-striatal disc

13 ession differentially in layers II/III and V striatal afferents from motor cortex and that cortical B

14 cortical and subcortical regions with known striatal afferents.

15 tivity and the latter with dorsal cingulate, striatal and anterior insular activity.

16 ts in ASD and to a hyperconnectivity between striatal and cortical brain areas.

17 sure synaptic DA availability in CHR both in striatal and extra-striatal brain regions.

18 r responses to stimulation of SNr-projecting striatal and GPe neurons, including biphasic and excitat

19 for genes expressed in T-cells, but also in striatal and hippocampal neurons.

20 -containing varicosities diffusely innervate striatal and mesolimbic networks, including the nucleus

21 Together, our data reveal that ventral striatal and midbrain reward networks form a reinforcing

22 FC (DPFC), insula and their mesial temporal, striatal and posterior connection sites, as well as in t

23 ntified structural and functional changes in striatal and prefrontal brain regions, among others.

24 Multimodal MRI in vivo indicates cortico-striatal and thalamo-striatal functional network deficit

25 n three-dimensional cultures to form cortico-striatal assembloids.

26 n-coupled receptor 88 (GPR88) in a number of striatal-associated disorders.

27 ly altered with respect to the activation of striatal astrocyte G protein-coupled receptor (GPCR) sig

28 Furthermore, selective striatal astrocyte stimulation of the G(i)-GPCR pathway

29 The striatal astrocyte-converted neurons showed action poten

30 characterize neurogenesis by Notch-depleted striatal astrocytes in vivo.

31 elevance to the striatum, we discovered that striatal astrocytes mount context-specific molecular res

32 cal HFS increases calcium (Ca(2+)) levels in striatal astrocytes through activation of metabotropic g

33 After stroke, however, striatal astrocytes undergo neurogenesis in mice, trigge

34 induce impairment of motor coordination and striatal atrophy.

35 acts connecting midbrain somatodendritic and striatal axonal compartments of dopaminergic neurons.

36 atially distant midbrain somatodendritic and striatal axonal compartments.

37 While most research has focused on striatal-based feedback learning, open questions remain

38 xhibited Pb-related alterations in behavior, striatal BDNF levels, frontal cortical Th total percenta

39 icit was defined as less than 65% of putamen striatal binding ratio expected for the individual's age

40 To identify whether striatal brain regions are activated in Npas2 mutant fem

41 across the nervous system, including in the striatal brain regions.

42 ailability in CHR both in striatal and extra-striatal brain regions.

43 s with respect to frontocortical, limbic and striatal brain volume, functional activation elicited by

44 Using an HD mouse striatal cell model and HD mouse organotypic brain slice

45 transcriptomic analyses of caudate/putamen (striatal) cell type-specific gene expression changes in

46 neuro2a neuroblastoma cells and mouse brain striatal cells, and performed gene expression profiling.

47 effect on normal HTT protein levels in mouse striatal cells, human cells and HD mouse models.

48 d exerts critical sex-specific influences on striatal cellular estrogenic mechanisms.

49 We focus on simulation at the striatal cellular/microcircuit level, in which the molec

50 These results indicate that striatal ChIs are essential for the control of complex m

51 Synchronized pauses in the activity of striatal cholinergic interneurons (ChINs) are correlated

52 ctivity of VP neurons, GPe cells (actor) and striatal cholinergic interneurons (critic) while monkeys

53 d laterodorsal tegmental nuclei synapse with striatal cholinergic interneurons and give rise to excit

54 pamine D2 receptor it is highly expressed in striatal cholinergic interneurons and therefore is poise

55 omplex movement control in rodents, and that striatal cholinergic interneurons are an essential node

56 Habit formation is modulated by striatal cholinergic interneurons.

57 M(4)-autoreceptor-Galpha (i/o) signaling in striatal cholinergic interneurons.

58 ssociated with losses of basal forebrain and striatal cholinergic neurons, suggesting that falls refl

59 Baseline PANDAS sera decreased activity of striatal CINs, but not of parvalbumin-expressing GABAerg

60 baseline sera did not alter the activity of striatal CINs.

61 voxels were not matched to any mouse cortico-striatal circuit (mouse->human: 85% unassigned; mouse->m

62 ed response to anticipation across a cortico-striatal circuit (striatum, ACC, insula).

63 n positive affect and identify a hippocampal-striatal circuit associated with this bidirectional rela

64 pport a novel mechanism for the selection of striatal circuit components, where fluctuating levels of

65 uggest that the identified trans-species ACC-striatal circuit relationship with nicotine dependence s

66 e relationships between regions of a cortico-striatal circuit supporting reward processing and both c

67 modulate the activity of a specific cortico-striatal circuit to ameliorate motor symptoms and recove

68 ore global hyporeactivity across the cortico-striatal circuit.

69 s demonstrates adaptations in insula-ventral striatal circuitry and metabolic regulatory hormones tha

70 ty fingerprint matching, we compared cortico-striatal circuits across humans, non-human primates, and

71 Striatal circuits must be modulated for behavioral flexi

72 frontal and ventromedial prefrontal cortical-striatal circuits-pathways critically implicated in goal

73 ntributor to cholinergic transmission in the striatal complex.

74 prefrontal cortical, anterior cingulate, and striatal connections and the different methodologies use

75 y may have been due to decreased cortical to striatal connectivity consistent with glutamatergic and

76 Ketamine thus normalized fronto-striatal connectivity in TRD participants but disrupted

77 ia, as well as a significant upregulation of striatal D(2)R without changes in A(2A)R expression in P

78 By combining RNAseq of striatal D2R neurons and histological analyses, we ident

79 male rats with dual cortical cholinergic and striatal DA losses (DL rats) exhibit cued turning defici

80 ession, degeneration of LC fibers, decreased striatal DA metabolism, and age-dependent behaviors remi

81 Striatal DA signals can be evoked by direct activation o

82 ally, despite decreased DAT levels in males, striatal DA uptake was enhanced, but was not due to enha

83 The striatal damage and progression of HD are associated wit

84 striatum attenuates brain atrophy, preserves striatal DARPP32 levels and reduces mutant HTT (mHTT) ag

85 Following intra-striatal delivery, pathological mHTT-positive protein ag

86 perturbations of histamine levels can impact striatal development.

87 Similarly, SP-immunostained terminals from striatal direct pathway neurons were more abundant in gl

88 coincident decreased distal spine density in striatal direct pathway striatal projection neurons.

89 n striatal afferent, and progressive cortico-striatal disconnection characterizes HD.

90 Striatal dopamine (DA) is critical for action and learni

91 tible with a haloperidol-induced increase in striatal dopamine (e.g., because of a presynaptic mechan

92 Striatal dopamine activity was assessed as K(i)(cer) val

93 present a novel form of interaction between striatal dopamine and acetylcholine dynamics.

94 Data suggest that aberrant striatal dopamine and cortico-thalamic dysconnectivity a

95 ng, calcium signals at somata and axons, and striatal dopamine concentrations.

96 Striatal dopamine D2 receptors (D2Rs) are important for

97 ngs demonstrate significant heterogeneity of striatal dopamine function in schizophrenia.

98 cannabis use affects either acute or chronic striatal dopamine is inconclusive.

99 odels declines in concert with extracellular striatal dopamine levels rather than insufficient dopami

100 We hypothesized that aberrant striatal dopamine links topographically with aberrant co

101 While some evidence suggests altered striatal dopamine may underlie the association, direct e

102 magnetic resonance imaging to determine how striatal dopamine release shapes local and global respon

103 triatal stimulation is sufficient to inhibit striatal dopamine release, and that a novel mGlu(1) posi

104 ns and medial prefrontal cortex, and ex vivo striatal dopamine reuptake.

105 ized by motor and nonmotor symptoms, reduced striatal dopamine signaling, and loss of dopamine neuron

106 Sub-chronic ketamine increased striatal dopamine synthesis capacity (Cohen's d = 2.5) a

107 Striatal dopamine synthesis capacity at presentation pre

108 Patients with schizophrenia show increased striatal dopamine synthesis capacity in imaging studies.

109 Results demonstrate that reduced striatal dopamine synthesis capacity links topographical

110 Striatal dopamine synthesis capacity predicted the worse

111 ort was greater for participants with higher striatal dopamine synthesis capacity, whereas methylphen

112 nderwent an [(18)F]DOPA PET scan to quantify striatal dopamine synthesis capacity.

113 er based on 18F-DOPA-PET was used to measure striatal dopamine synthesis capacity; correlation coeffi

114 s reveal distinct neuromodulatory actions of striatal dopamine that extend well beyond its sites of p

115 is suggested by theoretical models based on striatal dopamine's topographic modulation of cortico-th

116 order is associated with blunted presynaptic striatal dopamine.

117 duces the cost of mental labor by increasing striatal dopamine.

118 tergic neuron hyperactivity drives increased striatal dopaminergic activity, which underlies the deve

119 orrelational tractography) and the degree of striatal dopaminergic denervation based on (11)C-DTBZ PE

120 o investigate interindividual variability of striatal dopaminergic function in patients with schizoph

121 FSA revealed a spectrum of severity in striatal dysfunction across neuropsychiatric disorders,

122 In study 2, this specific prefrontal-ventral striatal dysfunction was associated with fewer days of a

123 FSA scores provide a personalized index of striatal dysfunction, ranging from normal to highly path

124 d anxiety-like behavior], dopamine function [striatal expression of tyrosine hydroxylase (Th)], gluco

125 These findings suggest that striatal fast spiking interneurons play an important rol

126 These data causally implicate the minority striatal fast-spiking interneuron population as a key co

127 beta oscillations, we show that networks of striatal fast-spiking interneurons (FSIs) are capable of

128 Parvalbumin-expressing striatal fast-spiking interneurons comprise ~1% of the t

129 Striatal field recordings and electrical stimulation of

130 differences in predispositional insula-based striatal-frontal circuits, highlighting the circuit's po

131 ergic Rit2 expression differentially impacts striatal function and DA-dependent behaviors in males an

132 many important contributions from neurons in striatal function, far less is known about the role of a

133 Ketamine increased fronto-striatal functional connectivity in TRD participants tow

134 vivo indicates cortico-striatal and thalamo-striatal functional network deficits and reduced glutama

135 mTOR signaling as an important regulator of striatal functions through an intricate mechanism involv

136 cytes are emerging as critical regulators of striatal functions.

137 choline/glutamate cotransmission to regulate striatal functions.

138 with intriguing consequences for opioid and striatal functions.

139 Ambient striatal GABA tone on striatal projection neurons can be

140 Past work has shown that striatal GABA tonically inhibits dopamine release, but w

141 that DA release is under tonic inhibition by striatal GABA.

142 GD10, MIA; (3) no alterations in cortical or striatal GAD1 mRNA of polyI:C offspring, but an expected

143 These results suggest that striatal Gadd45b functions as a dopamine-induced gene th

144 However, whether striatal GATs and astrocytes determine DA output are unk

145 To further assess downstream consequences on striatal gene expression, we used next-generation RNA se

146 the cellular and subcellular localization of striatal GluD1 immunoreactivity (GluD1-IR) in mice and m

147 In both species, striatal GluD1-IR displayed a patchy pattern of distribu

148 These results suggest that an increase in striatal glutamate levels may underlie acute cannabis-in

149 sign was used to investigate whether altered striatal glutamate, as measured using proton magnetic re

150 deeper understanding of GluD1 regulation of striatal glutamatergic synapses, but also suggest possib

151 istry for histamine-containing axons reveals striatal histaminergic innervation by the second postnat

152 Loci of striatal hyperactivity recapitulated the spatial distrib

153 We conclude that dorsomedial striatal iMSNs control approach-avoidance conflicts in e

154 ibed a dose-dependent effect of a unilateral striatal injection of vasoconstrictive endothelin-1 (ET-

155 Despite the importance of DA striatal innervation, processes involved in establishmen

156 multiple parallel closed loops that provide striatal input.

157 transfer of movement-related cues and their striatal integration with movement sequencing.

158 notable subcortical innovation: an abundant striatal interneuron type in primates that had no molecu

159 No reduction in SP+ striatal perikarya or striatal interneurons was seen in Q175 mice at 18 months

160 icant correlation was found between baseline striatal K(i)(cer) values and time to relapse after anti

161 Consequently, the giant striatal Kv3.3-expressing PV neuron may link compromised

162 vigation (thought to rely on hippocampal and striatal learning mechanisms respectively).

163 Striatal lesion core and globus pallidus of Abeta + ET1

164 d distant regions with synaptic links to the striatal lesion such as white matter (subcortical white

165 the updating of brain activity in prefrontal-striatal-limbic circuits.

166 Morphologically, the complexities of striatal median spiny neurons (MSNs), parvalbumin-positi

167 ion of the dopamine D2 receptor (D2R) in the striatal medium spiny neurons (MSNs) (iMSN-D2RKO).

168 t recordings and dendritic spine analyses on striatal medium spiny neurons (MSNs) in drug-naive rAAV-

169 ough dysregulation of synaptic signalling in striatal medium spiny neurons, adult nigral dopaminergic

170 Galpha (i/o) signaling in SNc DA neurons and striatal medium spiny neurons, respectively.

171 We observed no changes in the morphology of striatal medium spiny neurons, the density of dendritic

172 city between corticostriatal projections and striatal medium spiny neurons.

173 e [(35)S]GTPgammaS binding assay using mouse striatal membranes but was inactive in membranes from GP

174 ine transporter protein, dopamine uptake, or striatal methamphetamine and amphetamine metabolite leve

175 Higher striatal mGluR5 availability in alcohol-dependent users

176 Also, normalization of striatal mGluR5 to control levels was associated with re

177 his paper, we propose a biophysical model of striatal microcircuits that comprehensively describes th

178 RAMINT approach retained only 31 explanatory striatal miRNA-mRNA pairs that are precisely associated

179 es: 1) extended amygdala module, 2) midbrain striatal module, and 3) cortico-hippocampo-thalamic modu

180 tterns for the nucleus accumbens and cortico-striatal motor circuits (posterior/lateral putamen) were

181 d spine density and thin-spine morphology on striatal MSNs; both phenomena mimicking changes seen in

182 We mapped striatal network dysfunction in HD mice to ultimately mo

183 We tested this hypothesis in the fronto-striatal network of nonhuman primates during reversal le

184 underpinned by atrophy in a thalamo-cortico-striatal network.

185 relationship between prefrontal cortical and striatal neural interactions, and cognitive flexibility,

186 demonstrate that Gadd45b knockdown decreases striatal neuron action potential burst duration in vitro

187 n unforeseen heterogeneity in D2R-expressing striatal neuronal populations, underlying specific D2R's

188 rimarily expressed in SNc DA neurons (RGS6), striatal neurons (RGSs 4 and 9), or microglia (RGS10), m

189 that histamine acutely modulates developing striatal neurons and synapses and controls longer-term c

190 Knockout of GluD1 expression in striatal neurons elicits cognitive deficits and disrupts

191 It remains unclear how striatal neurons encode motor parameters and use them to

192 Supporting this theory, many striatal neurons exhibit such graded changes without bur

193 ccurs in the cerebellar granular neurons and striatal neurons in Tubb4a(D249N/D249N) mice.

194 In vitro, dopamine treatment in primary striatal neurons increases Gadd45b mRNA expression throu

195 e postmortem evidence of Nurr1 expression in striatal neurons of l-DOPA-treated PD patients.

196 In medium-size, spiny striatal neurons of the direct pathway, dopamine D(1)- a

197 riatum (DLS) was undetectable in HD mice and striatal neurons show blunted electrophysiological respo

198 rained to self-administer heroin and primary striatal neurons treated with chronic morphine in vitro.

199 No loss of striatal neurons was seen out to 18 months, but ENK+ and

200 Indeed, rAAV-mediated expression of Nurr1 in striatal neurons was sufficient to overcome LID-resistan

201 to independent effects on oligodendrocytes, striatal neurons, and cerebellar granule cells in the co

202 rected against the nuclei of Purkinje cells, striatal neurons, and hippocampal neurons.

203 nd inhibition of direct and indirect pathway striatal neurons, respectively.

204 the intrinsic excitability of direct pathway striatal neurons.

205 tin (HTT) fragments that preferentially kill striatal neurons.

206 The lack of striatal Nolz1 expression results in nigral to pallidal

207 rats displayed mild LID and no induction of striatal Nurr1 despite receiving a high dose of l-DOPA.

208 These data suggest that striatal Nurr1 is an important mediator of the formation

209 ortical neurons send axonal projections into striatal organoids and form synaptic connections.

210 Striatal oscillatory activity is associated with movemen

211 ation, it's unclear how compartment-specific striatal output is dynamically achieved, particularly co

212 However, it remains unclear how striatal output neurons encode and facilitate movement.

213 ne shift the balance of compartment-specific striatal output.

214 The striatal pathologies resemble those in human HD, but are

215 s of disease burden (r = -0.42 to -0.69) and striatal pathology (r = 0.71-0.60) in individuals with p

216 ments that target this functional prefrontal-striatal pathology could improve early treatment outcome

217 iatal shape deflation and disease burden and striatal pathology in individuals with prodromal Hunting

218 ciations with measures of disease burden and striatal pathology.

219 romote locomotion; however, their effects on striatal pathway function in vivo remain unclear.

220 to impair PDE10A function due to the loss of striatal PDE10A protein levels, but here we show that th

221 No reduction in SP+ striatal perikarya or striatal interneurons was seen in

222 seen out to 18 months, but ENK+ and DARPP32+ striatal perikarya were fewer by 6 months, due to dimini

223 Here, we demonstrated striatal phenotypes in heterozygous Disc1 mutant mice, w

224 he mechanisms behind how mTOR is involved in striatal physiology and its relative role in distinct ne

225 erneurons comprise ~1% of the total neuronal striatal population, are enriched dorsolaterally and are

226 Much is known about frontal and striatal processes that support cognitive control, but f

227 Thalamo-striatal progressive volumetric deficit associated with

228 We show that the ablation of striatal projecting neurons reduces learning speed, wher

229 atal synapses of the direct pathway [cortico-striatal projection neuron (dSPN)] in the dorsolateral s

230 ment, presumably through their modulation of striatal projection neuron (SPN) activity.

231 in nigral to pallidal lineage conversion of striatal projection neuron subtypes.

232 ed mice, (1) D2 dopamine receptor expressing striatal projection neurons (D2-SPNs) discharge at highe

233 activity of D2 dopamine receptor-expressing striatal projection neurons (D2-SPNs), parvalbumin-expre

234 deling and experimental work suggesting that striatal projection neurons (SPNs) are capable of genera

235 adaptations of gamma-aminobutyric acidergic striatal projection neurons (SPNs) evoked by drugs of ab

236 Ambient striatal GABA tone on striatal projection neurons can be determined by plasma

237 interneurons (FSIs) in the striatum to train striatal projection neurons to gate relevant and suppres

238 putative fast-spiking interneurons (FSIs) to striatal projection neurons was enhanced in striosomes c

239 vestigate the effects of dopamine release on striatal projection neurons.

240 tal spine density in striatal direct pathway striatal projection neurons.

241 Cortico-striatal projections are critical components of forebrai

242 ts emphasize an intricate architecture where striatal projections originate from different combinatio

243 ionally determined that in l-DOPA-naive rats striatal rAAV-Nurr1 overexpression (1) increased cortica

244 ficant differences in DA transmission in any striatal region between converters and nonconverters, al

245 or cingulate cortex did as well, but neither striatal region did in either animal.

246 es had good test-rest reproducibility across striatal regions (K(i)(cer) ICC: 0.68-0.94, SUVRc ICC: 0

247 ructural connectivity between prefrontal and striatal regions as critical nodes for action selection.

248 pha exhibits nuclear expression in all three striatal regions before adulthood and disappears in a re

249 S2 regulates reward and activity in specific striatal regions in a sex and time of day (TOD)-specific

250 urthermore, focal activation of two distinct striatal regions induces either licking or turning, cons

251 flow of information between dACC and fronto-striatal regions is secured through different pathways,

252 uron is much larger than PV neurons in other striatal regions, displays characteristic electrophysiol

253 nding dominates models of estrogen action in striatal regions.

254 ting a dichotomous role of BDNF signaling in striatal regions.

255 t prefrontal, right parahippocampal and left striatal regions; also, a gradient of decreasing respons

256 le in distinct neuronal populations in these striatal-related diseases still remain to be clarified.

257 erfunction, which could be targeted to treat striatal-related monogenic disorders associated with the

258 d individuals showing blunted (hyporeactive) striatal response to monetary rewards.

259 cted functional disruption of the prefrontal-striatal responses to stress images and to alcohol cues

260 r amygdala responsivity to neutral faces, or striatal responsivity to monetary losses.

261 of robust sex differences in prefrontal and striatal resting state networks that may contribute to d

262 t, mood symptoms are associated with blunted striatal reward prediction error signals in a large comm

263 al questions regarding the interpretation of striatal 'reward' signals in the context of effort deman

264 Striatal RGS4 has been shown to exacerbate motor symptom

265 siRNA-mediated knockdown of striatal Rgs4 in DIO-susceptible rats decreased food int

266 and that overweight humans exhibit increased striatal Rgs4 protein.

267 onsolidate reinforcement learning theory and striatal RPEs as key factors subtending the formation of

268 ate of torque development values and greater striatal shape deflation and disease burden and striatal

269 Pathological changes in striatal shape were evaluated using magnetic resonance i

270 indirect SPN pathways by recruiting distinct striatal signaling pathways, epigenetic and genetic resp

271 freely moving animals has revealed opposing striatal signals, with greater response to increasing ef

272 ervate the striatum in both constitutive and striatal-specific Nolz1 mutant embryos.

273 LRRK2 is a kinase expressed in striatal spiny projection neurons (SPNs), cells which lo

274 Whole-cell patch-clamp recordings of striatal spiny projection neurons and histamine superfus

275 Findings were similar using a cortico-striatal staging system and continuous PET measurements.

276 ation of mGlu(1) signaling following thalamo-striatal stimulation is sufficient to inhibit striatal d

277 he critical role of a reduction in prefronto-striatal structural connectivity in accounting for actio

278 ion is associated with a localized effect on striatal structure, having a prior ADI is a strong predi

279 ration between caudate nucleus and putamen-a striatal sub-division unique to primates-with both dopam

280 specific D1R and D2R dysfunction in distinct striatal sub-regions.

281 Distinct striatal subfields are involved in voluntary movement ge

282 SST downregulation in specific cortical and striatal subregions, with additional deficits in somatos

283 e morphological and molecular differences of striatal subregions.

284 a twofold increase in hnRNP H protein in the striatal synaptosome of H1(+/-) mice with no change in w

285 , successfully characterizes the hippocampal-striatal system as a general system for decision making

286 whether ketamine affects the brain's fronto-striatal system, which is known to drive motivational be

287 -SPN plasticity within functionally relevant striatal territories to reshape volitional action.

288 h the following: dysfunction within cortical-striatal-thalamic-cortical (CSTC) brain circuits implica

289 could prevent the initial excitation of the striatal tic focus-a hypothesis we have previously intro

290 Gene-level transcriptome analysis of striatal tissue from 114 kb congenics vs Hnrnph1 mutants

291 analysis of wild-type and Nolz1(-/-) mutant striatal tissue led to the identification of several sec

292 and chemogenetics we show the involvement of striatal tyrosine hydroxylase-expressing interneurons in

293 ently to the "salience" network, the ventral striatal/ventromedial prefrontal "reward" network, and t

294 ile HIV serostatus was associated with lower striatal volume (B = -0.59; 95% CI = [-1.08 - -0.10]), c

295 ADI was independently associated with lower striatal volume (B=-0.73; 95% CI =[-1.36 - -0.09]).

296 However, a large number of human and macaque striatal voxels were not matched to any mouse cortico-st

297 Top striatal weighted edges are enriched in modulators of de

298 o change in baseline extracellular dopamine, striatal whole-tissue dopamine, dopamine transporter pro

299 Accordingly, different striatal zones collect specific combinations of signals

300 s may project in different ways to different striatal zones, which can be targets of specific combina