ライフサイエンスコーパス: striated muscle

1 C is a thick filament protein of vertebrate striated muscle.

2 ter of the sarcomere, the structural unit of striated muscle.

3 sly reported to be specifically expressed in striated muscle.

4 indistinguishable from those in an arthropod striated muscle.

5 ve stress in a variety of tissues, including striated muscle.

6 filament pointed-end dynamics and length in striated muscle.

7 n, a major actin-binding filament protein of striated muscle.

8 b-Girdle muscular dystrophy 1B mainly affect striated muscle.

9 for excitation-contraction (EC) coupling in striated muscle.

10 RLC) also controls contraction of vertebrate striated muscle.

11 of length dependence of force generation in striated muscle.

12 (SR), the major calcium storage organelle in striated muscle.

13 response factor (SRF) regulatory axis within striated muscle.

14 in contraction and regulation of vertebrate striated muscle.

15 growth cone guidance receptors expressed in striated muscle.

16 soforms play overlapping and unique roles in striated muscle.

17 ll death known to be abundantly expressed in striated muscle.

18 (myosin containing) filaments of vertebrate striated muscle.

19 itical role in regulating the contraction of striated muscle.

20 pregnancy induced adaptations in smooth and striated muscle.

21 otein associated with the thick filaments of striated muscle.

22 periodic sarcomeric organization similar to striated muscle.

23 omponent of the membrane repair machinery in striated muscle.

24 ogen accumulation in all tissues, especially striated muscle.

25 new opportunity for clonal analysis of adult striated muscle.

26 process of membrane fusion and exocytosis in striated muscle.

27 ling regulators as TNC expression targets in striated muscle.

28 ins that organizes contractile structures in striated muscle.

29 arcomeres are the basic contractile units of striated muscle.

30 e C-zeta/lambda and AMP-kinase activities in striated muscle.

31 channels, several of which are expressed in striated muscle.

32 P-C) is a component of the thick filament of striated muscle.

33 ein surrounding the contractile apparatus in striated muscle.

34 eads to sarcomere disassembly and atrophy in striated muscle.

35 metabolic demand and functional dynamics of striated muscle.

36 e assembly of ryanodine receptor clusters in striated muscle.

37 pal regulator of the contractile behavior of striated muscle.

38 xtend our understanding of titin function in striated muscle.

39 allowing excitation-contraction coupling in striated muscle.

40 ding protein that is abundantly expressed in striated muscle.

41 h, which are also expressed in the body-wall striated muscle.

42 drolysis to generate force and shortening in striated muscle.

43 standing of the development and mechanics of striated muscles.

44 mooth muscles is also different from that in striated muscles.

45 rganization of the sarcoplasmic reticulum in striated muscles.

46 ement controlling active force generation in striated muscles.

47 processes, including the pathophysiology of striated muscles.

48 ure proper sarcomere-membrane interaction in striated muscles.

49 on of contractile and membrane structures in striated muscles.

50 ar muscle and at higher levels than in other striated muscles.

51 egulating membrane trafficking and fusion in striated muscles.

52 s in vertebrate smooth and many invertebrate striated muscles.

53 oviding structural support and located under striated muscles.

54 that were co-opted for a similar purpose in striated muscles.

55 he smallest functional unit of myofibrils in striated muscles.

56 are the primary actin isoforms expressed in striated muscles.

57 Adjacent myosin filaments in striated muscle A-bands are cross-linked by the M-band.

58 Furthermore, striated muscle activator of Rho signaling (STARS), an a

59 STARS (STriated muscle Activator of Rho Signaling) is a sarcome

60 development and pregnancy mediate smooth and striated muscle adaptations through SMTNL1 and MYPT1.

61 ignalosomes for regulating MEF2D activity in striated muscle, affirming mAKAPbeta as a nodal regulato

62 To engineer gene vectors that target striated muscles after systemic delivery, we constructed

63 is caused by the progressive degeneration of striated muscles aggravated by sterile inflammation.

64 Mutations in striated muscle alpha-tropomyosin (alpha-TM), an essenti

65 heptad repeat positions were mutated in rat striated muscle alphaTm and expressed in Escherichia col

66 and challenges the paradigm that smooth and striated muscles always have distinctly different compon

67 st that Wingless-mediated cross-talk between striated muscle and adipose tissue controls obesity in D

68 ies, that affect distinct tissues, including striated muscle and adipose tissue.

69 anization of the central contractile unit of striated muscle and also as a mechanosensitive signaling

70 carnitine palmitoyltransferase 1B (CPT1B) in striated muscle and BAT.

71 The ancient MYH7b gene, expressed in striated muscle and brain, encodes a sarcomeric myosin a

72 y of formins contributes to contractility of striated muscle and cell motility in several contexts.

73 s, fruits, legumes, and whole grains than by striated muscle and cow milk.

74 re of the 200 kDa alpha-actinin-2 dimer from striated muscle and explore its functional implications

75 adin (MYPN) is a Z-disc protein expressed in striated muscle and functions as a structural, signaling

76 However, cardiac muscle is also a subtype of striated muscle and is similarly affected in many of the

77 biomarker for a number of diseases affecting striated muscle and may also be a schizophrenia risk gen

78 highlights the central role of obscurin A in striated muscle and neural development.

79 cked neutrophils in vivo in venules of mouse striated muscle and revealed how endothelial permeabilit

80 eal the first direct mRNA targets of FXR1 in striated muscle and support translational repression as

81 keletal stiffness and mechanotransduction in striated muscle and that targeting this post-translation

82 hesion plaques and dense bodies (Z-disks) of striated muscles and attachment plaques of smooth muscle

83 in protein present in the thick filaments of striated muscles and is involved in both sarcomere forma

84 orm lengths, including the thin filaments of striated muscles and the spectrin-based membrane skeleto

85 n complex in the Ca(2+)-regulatory system of striated muscle, and among their muscle type-specific is

86 ents of the sarcoglycan-sarcospan complex in striated muscle, and did not develop muscular dystrophy.

87 assay and Western blot; AChR, MuSK, and anti-striated muscle antibodies were detected using a standar

88 The barbed ends of actin filaments in striated muscle are anchored within the Z-disc and cappe

89 Myosin folding and assembly in striated muscle are mediated by the general chaperones H

90 Striated muscles are relaxed under low Ca(2+) concentrat

91 eres, the functional units of contraction in striated muscle, are composed of an array of interdigita

92 (CPM) origin, however ESM are unusual among striated muscles as they are established in the absence

93 s," mainly affect mesenchymal tissues (e.g., striated muscle, bone, and fibrous tissue).

94 ding cassette exons upregulated in brain and striated muscle but depleted in other tissues.

95 Conditional deletion of LAP1 from striated muscle causes muscular dystrophy; this patholog

96 s troponin can be exchanged in permeabilized striated muscle cell preparations, and tested the hypoth

97 length dependence of tension differs between striated muscle cell types during submaximal activations

98 Caenorhabditis elegans striated muscle cells attach to basement membrane and tr

99 Here, we demonstrate that striated muscle cells form a continuous myofibrillar mat

100 Mitochondrial dynamism is rare in striated muscle cells, so cardiac-specific genetic manip

101 s Xin and XIRP2 are exclusively expressed in striated muscle cells, where they are believed to play a

102 ent of the cell membrane repair machinery in striated muscle cells.

103 ate meshwork that organizes myofibers within striated muscle cells.

104 intolerance, and impaired glucose uptake in striated muscle cells.

105 pen ER ryanodine-receptor Ca(2+) channels in striated-muscle cells.

106 on actin are important for the regulation of striated muscle contraction and could also be important

107 the Ca(2+) activation of myofilaments during striated muscle contraction and relaxation.

108 The molecular regulation of striated muscle contraction couples the binding and diss

109 tropomyosin's Ca(2+)-triggered regulation of striated muscle contraction has advanced greatly, partic

110 Striated muscle contraction in most animals is regulated

111 The regulation of vertebrate striated muscle contraction involves a number of differe

112 Striated muscle contraction involves sliding of actin th

113 Striated muscle contraction is a highly cooperative proc

114 Regulation of striated muscle contraction is achieved by Ca2+ -depende

115 Striated muscle contraction is regulated by Ca(2+) -depe

116 Striated muscle contraction is regulated by the actin bi

117 Striated muscle contraction is regulated by the binding

118 Striated muscle contraction is regulated by the transloc

119 Striated muscle contraction is the result of sarcomeres,

120 Striated muscle contraction occurs when myosin thick fil

121 n in regulating actin-myosin interactions in striated muscle contraction, and dephosphorylation of Ml

122 EGF receptor signaling, circadian exercise, striated muscle contraction, and lipid and carbohydrate

123 MyBP-C is a multidomain modulator of striated muscle contraction, interacting with myosin, ti

124 units of the troponin complex that regulates striated muscle contraction.

125 central to the control of calcium-regulated striated muscle contraction.

126 n C, troponin I, and tropomyosin to regulate striated muscle contraction.

127 olling the troponin I switching mechanism of striated muscle contraction.

128 ficantly after PNT, indicating that urethral striated muscles contribute significantly to continence.

129 well as hind paw flinching, was observed in striated muscle control-transplanted rats, which were no

130 ribe a novel mechanism of nuclear spacing in striated muscles controlled by the cooperative activity

131 The Z-band in vertebrate striated muscle crosslinks actin filaments of opposite p

132 ity with exercise lead to protection against striated muscle damage, oxidative stress and injury.

133 In addition to striated muscle defects, double-null animals and LEM-2-n

134 The demonstration that both types of striated muscle derive from common progenitors comes fro

135 In striated muscle, desmin intermediate filaments interlink

136 scular dystrophy (DMD) is a fatal disease of striated muscle deterioration caused by lack of the cyto

137 critical determinant of cardiac and skeletal striated muscle development and function, with misexpres

138 Striated muscle development requires the coordinated exp

139 lamins, or expression of variants that cause striated muscle disease, did not affect assembly of nesp

140 rmalities in nuclear envelope proteins cause striated muscle disease.

141 ing and mechanosensor and has been linked to striated muscle disease.

142 We find that LMNA mutations causing striated muscle diseases block actin-dependent nuclear m

143 remature aging syndromes, lipodystrophy, and striated muscle disorders.

144 All striated muscle display length-dependent activation prop

145 provides stability to the plasma membrane of striated muscle during muscle contraction.

146 Striated muscle enables movement in all animals by the c

147 ropose that neurons secrete vMSPs to promote striated muscle energy production and metabolism, in par

148 NA-1 (miR-1) is an evolutionarily conserved, striated muscle-enriched miRNA.

149 Masticatory and esophagus striated muscles (ESM) share a common cardiopharyngeal m

150 eceptor channels (RyR) are key components of striated muscle excitation-contraction coupling, and alt

151 t myosin isoforms in the sarcomeres of adult striated muscle (fast IIa, IId, the slow/cardiac isoform

152 of the key characteristics of the different striated muscle fiber types, including maximum shortenin

153 Striated muscle fibers are characterized by their tightl

154 al muscle constructs with parallel arrays of striated muscle fibers.

155 L1 is expressed in smooth muscle and type 2a striated muscle fibers.

156 Striated muscle fibres in the urethral rhabdosphincter a

157 In striated muscle fibres, the binding of myosin motors to

158 the cytoplasmic surface of the sarcolemma of striated muscle fibres.

159 We propose that striated muscle force is generated by a singular, mesh-l

160 hich in turn anchors IFs, both essential for striated muscle formation and function.

161 While Thbs4 is known to protect striated muscle from disease by enhancing sarcolemmal st

162 al roles during embryonic development and in striated muscle gene expression.

163 role in some mammalian cellular systems, but striated muscle generally is not considered to be among

164 Recent proteomics studies of vertebrate striated muscle have identified lysine acetylation at se

165 We identified mCRP in inflamed human striated muscle, human atherosclerotic plaque, and infar

166 rs transduced liver and kidney in GSD Ia and striated muscle in GSD II mice to replace the deficient

167 sarcomeric protein exclusively localized in striated muscle in humans.

168 dystrophin protein function and stability in striated muscles in vivo.

169 g the dystrophin protein to be long-lived in striated muscles in vivo; however, more rigorous quantit

170 is the principal regulator of contraction in striated muscle, in vitro evidence suggests that some ac

171 In striated muscle, including involuntary cardiac muscle, T

172 ed acute deleterious effects of tamoxifen on striated muscles, including a transient down regulation

173 usually not seen as endocrine ones, bone and striated muscles, influence several physiological proces

174 Striated muscle is activated by myosin- and actin-linked

175 hese results suggest that fast relaxation of striated muscle is an emergent property that reflects mu

176 Tarantula striated muscle is an outstanding system for understandi

177 The scallop's large striated muscle is energy-dynamic but not fully differen

178 evelopment and early postnatal adaptation of striated muscle is largely unknown.

179 arcoplasmic reticulum (SR) Ca(2+) release in striated muscle is mediated by a multiprotein complex th

180 Contraction of striated muscle is tightly regulated by the release and

181 nds of contiguous tropomyosin (Tm) dimers in striated muscle is unknown.

182 The smallest contractile unit in striated muscles is the sarcomere.

183 Troponin C (TnC), present in all striated muscle, is the Ca(2+)-activated trigger that in

184 a sarcomeric protein expressed primarily in striated muscles, is responsible for maintaining the str

185 tomyosin-based force production mechanism in striated muscle, it was originally proposed that contrac

186 schistosome muscles are hybrids, containing striated muscle-like myosin filaments and smooth muscle-

187 uscle-like contractile apparatuses, it has a striated muscle-like regulatory mechanism through tropon

188 e indispensable for normal morphogenesis and striated muscle lineage specification.

189 l iPSC-derived progenitors (MiPs) toward the striated muscle lineages.

190 The mechanism by which striated muscle loss occurs is the tumor release of pro-

191 nuclear membrane that has been implicated in striated muscle maintenance.

192 redictably affect the calcium sensitivity of striated muscle mechanics, providing a novel A-M kinetic

193 Striated muscle mitochondria form connected networks cap

194 ion of this cascade and loop may account for striated muscle mitochondrial defects in mef2a null mice

195 gs are circulating hormones that pattern the striated muscle mitochondrial reticulum.

196 ted ends of actin filaments in sarcomeres of striated muscle myofibrils and in the erythrocyte membra

197 Vertebrate striated muscle myosin filaments have a 3-fold rotationa

198 erone UNC-45B is required for the folding of striated muscle myosin II.

199 sidues plus a leucine zipper) of the scallop striated muscle myosin isoform.

200 nd image processing of nucleotide-free (apo) striated muscle myosin-2 subfragment-1 (S1), possessing

201 A striated-muscle myosin (UNC-54) appears to provide parti

202 le-like myosin filaments containing MYO-3, a striated-muscle myosin isoform.

203 Striated muscle myosins are encoded by a large gene fami

204 schistosome myosin II heavy chain and known striated muscle myosins.

205 ilament lattice in intact (i.e., nonskinned) striated muscle obeys constant volume.

206 Activation of thin filaments in striated muscle occurs when tropomyosin exposes myosin b

207 al rescued expression of the H77C protein in striated muscle of the alpha-sarcoglycan-deficient mice

208 reversed the established pathologies in the striated muscle of the KO mouse.

209 he outer edge of the A-band in the obliquely striated muscle of the nematode.

210 PMO) dramatically enhanced ASO delivery into striated muscles of DM1 mice following systemic administ

211 outh opening during feeding, and oesophageal striated muscle (OSM), which is crucial for voluntary sw

212 n complex compared to 11 residues in the HMW striated muscle overlap complex.

213 ostnatal cardiac function and reinforces the striated muscle phenotype by regulating both transcripti

214 epair into the load-dependent control of the striated muscle phenotype.

215 l-linked glycoprotein expressed in liver and striated muscle, plays a central role in systemic iron b

216 Hoip is expressed in striated muscle precursors within the muscle lineage and

217 Striated muscle preferentially expressed protein kinase

218 Striated muscle preferentially expressed protein kinase

219 e role of newly identified JMC protein SPEG (striated muscle preferentially expressed protein kinase)

220 ght the functional relevance of a smooth and striated muscle progenitor dialogue for ESM patterning.

221 gene delivery intervention with tropism for striated muscle reduced the serum concentrations of Acti

222 ely induced apoptosis, we report evidence of striated muscle regeneration in vivo in mice by human Mi

223 etween calcium and the regulatory site(s) of striated muscle regulatory protein troponin switches on

224 The mechanisms that limit the speed at which striated muscles relax are poorly understood.

225 ebulin to reinforce and temporally fine-tune striated muscle relaxation-contraction cycles.

226 Therefore, TnT potentially contributes to striated muscle relaxation; however, the in vivo functio

227 To generate force, striated muscle requires overlap between uniform-length

228 Excitation-contraction coupling in striated muscle requires proper communication of plasmal

229 h Sco1 was specifically deleted in heart and striated muscle, respectively.

230 All striated muscles respond to stretch by a delayed increas

231 We show that striated muscle-restricted HA-TEAD-1 expression induced

232 ecific loss of the integrin beta1 subunit in striated muscle results in a near complete loss of integ

233 Physiologically, loss of Lmods in striated muscle results in cardiomyopathy or nemaline my

234 taining cytoplasmic tyrosine phosphatase, in striated muscle results in severe dilated cardiomyopathy

235 Genetic inactivation of murine E4f1 in striated muscles results in viable animals that show low

236 In striated muscle, sarcoglycans interact with dystrophin a

237 butes to the mechanical stabilization of the striated muscle sarcomere and cell contacts within the c

238 sponges found to induce Ca(2+) release from striated muscle sarcoplasmic reticulum (SR).

239 II filament-based contractile structures in striated muscle, smooth muscle, and nonmuscle cells cont

240 Replacement of the striated muscle specific exon 9a-encoded C-terminus with

241 function, the authors generated and compared striated muscle specific knockouts (KOs) with progressiv

242 early myogenesis, but the functions of this striated muscle-specific enzyme in more differentiated s

243 rates, a general cell isoform, unc45a, and a striated muscle-specific isoform, unc45b.

244 Xin is a striated muscle-specific protein that is localized to th

245 ion of an unrelated peptide derived from the striated muscle-specific protein titin.

246 phosphorylation state of two Z-disc kinases (striated muscle-specific serine/threonine protein kinase

247 ociated with CNM, and it has been shown that striated muscle-specific Speg-knockout (KO) mice have de

248 ferentiation of myogenic cells obtained from striated muscle-specific Speg-KO mice and compared them

249 We have identified a novel striated muscle-specific splice variant of the formin FH

250 The striated muscle-specific tripartite motif (TRIM) protein

251 libut tissues, whereas capn3 was detected in striated muscles, spleen and ovary, but absent or relati

252 a lineage (including giant axons innervating striated muscles) strongly support an extensive and wide

253 and the importance of the proteins in normal striated muscle structure and function.

254 axed, native myosin filaments from tarantula striated muscle, suggesting that such interactions are l

255 ffraction to study the contraction in living striated muscle, taking advantage of the paracrystalline

256 ( approximately 800-kDa), modular protein of striated muscle that concentrates around the M-bands and

257 t constitute a novel regulatory mechanism in striated muscles that acts independently of the well-kno

258 Striated muscles that enable mouth opening and swallowin

259 In striated muscle, the archetype P-type ATPase, SERCA (sar

260 In striated muscles, the actin filaments are anchored at Z-

261 Smooth muscle, striated muscle, their central and peripheral innervatio

262 similar in organization to the sarcomeres of striated muscle, there are intriguing differences in the

263 rotein C (MyBP-C) is an accessory protein of striated muscle thick filaments and a modulator of cardi

264 hat has been implicated in the regulation of striated muscle thin filament assembly; its physiologica

265 The striated muscle thin filament comprises actin, tropomyos

266 Vertebrate striated muscle thin filaments are thought to be thermod

267 at mechanically stabilizes the sarcolemma of striated muscle through interaction with the cortical ac

268 ys using protein extracts of hepatocytes and striated muscle tissue.

269 nd that loss of Fer1l6 led to deformation of striated muscle tissues, delayed development of the hear

270 quantified for the first time the levels of striated muscle TM isoforms in human heart, including a

271 In striated muscles, Tmods prevent actin filaments from ove

272 ucose-regulated protein 94 (GRP94) in murine striated muscle to test the necessity of local IGFs for

273 st that because of high expression levels in striated muscle, TRIC-A produces most of the counterion

274 Missense mutations K15N and R21H in striated muscle tropomyosin are linked to dilated cardio

275 dge) an atomic-level structure of alphaalpha-striated muscle tropomyosin bound to an actin filament t

276 MW overlap complex that is homologous to the striated muscle tropomyosin complex in which the ends ar

277 long the shaft of rotary-shadowed smooth and striated muscle tropomyosin molecules are equivalent to

278 Here, 40 nm long smooth and striated muscle tropomyosin molecules were rotary-shadow

279 Electron microscopy shows that striated muscle tropomyosin primarily consists of single

280 e of cardiac leiomodin and the N-terminus of striated muscle tropomyosin.

281 ccurs despite their weaker interactions with striated muscle tropomyosins.

282 rived progenitors (MiPs) can regenerate both striated muscle types simultaneously in mice.

283 Strategies to target multiple striated muscle types would provide a much-needed improv

284 es that enable regeneration of both of these striated muscle types.

285 Striated muscle was indeed found later in development su

286 scular dystrophy is a severe and progressive striated muscle wasting disorder that leads to premature

287 ophy (DMD) is a uniformly fatal condition of striated muscle wasting resulting in premature death fro

288 mine the specific role of Cypher isoforms in striated muscle, we generated two mouse lines in which e

289 rther understand the function of myospryn in striated muscle, we searched for additional myospryn par

290 e 427-kDa protein dystrophin is expressed in striated muscle where it physically links the interior o

291 ant protein titin is expressed in vertebrate striated muscle where it spans half a sarcomere from the

292 n binding protein C (MyBP-C) is expressed in striated muscles, where it plays key roles in the modula

293 ivotal role in the structure and function of striated muscle, whereas the role of Enigma homolog prot

294 KBTBD13 is a protein expressed in striated muscle whose precise function is unknown.

295 Titin is a giant protein of striated muscle with important roles in the assembly, in

296 Molecules from invertebrate striated muscles with phosphorylation-dependent regulati

297 toskeletal proteins originally identified in striated muscles with structural and regulatory roles.

298 In striated muscle, X-ROS is the mechanotransduction pathwa

299 endent activation is a universal property of striated muscle, yet the molecular mechanisms that under

300 In striated muscle Z-disks, alpha-actinin interacts with N-