ライフサイエンスコーパス: stringent

1 y required for their folding is surprisingly stringent.

2 More stringent 95% and 98% diagnostic accuracy thresholds wer

3 for the same DNA promoters, those with more stringent activation requirements function as repressors

4 , viruses that jump hosts undergo strong and stringent adaptive selection as they maximize their fit

5 pe defined by them provides a quantitatively stringent additivity model for identifying combination e

6 hat promote strong B cell pulling forces and stringent affinity discrimination.

7 Using stringent affinity tags introduced at the Tet2 locus, we

8 Under more stringent age-specific recommendations, only 40 countrie

9 Stringent air pollution control policies are important a

10 From the 1970s to 1990s, more stringent air quality regulations were implemented acros

11 vious functional status were excluded in the stringent analyses.

12 A more stringent analysis indicated that 27 differentially expr

13 Our stringent analysis pipeline was able to detect 18 unique

14 the best practice to ensure that results are stringent and conclusive and analyses replicable?

15 yield (>2) while feasible, are bound within stringent and often extreme operability ranges of cofact

16 work we reported the construction of a very stringent and versatile repressible promoter system for

17 m, at two sparsity thresholds, i.e. top 100 (stringent) and 300 (relaxed) ranked genes were evaluated

18 -knockout (Nrp1(myel-KO)) mice and applied 2 stringent animal models of sepsis: cecal ligation and pu

19 Tolerance induced in stringent animal transplant models using donor-specific

20 r is a pressing need in view of increasingly stringent As drinking water limits in some US states and

21 replication links that was found under more stringent assumptions is the most probable.

22 treatment of cardiovascular events and more stringent avoidance of high cardiac radiotherapy dose.

23 nt particulate matter (PM) are becoming more stringent because of adverse health effects arising from

24 n minimum inhibitory concentration is a more stringent benchmark compared with T greater than 4 x min

25 These studies provide needed stringent benchmarks to use against other all-atom theor

26 ify 98 CpG-protein associations (pQTMs) at a stringent Bonferroni level of significance.

27 Using stringent break points, 93% of isolates were resistant t

28 Stringent chemical methods to profile RNA expression wit

29 Using a more stringent CHMI, with heterologous parasites (different P

30 ge-scale biological CO(2) removal to achieve stringent climate targets remains unclear.

31 Follow-up investigations with a more stringent clinical design are warranted to test whether

32 in part, be explained by the insufficiently stringent clinical screening selection of determining wh

33 These studies employ stringent clinical standards to demonstrate that percept

34 After stringent CNV calling procedures, and standardized FreeS

35 f the literature that few materials meet the stringent CO(2) photocathode requirements, with only 52

36 PSM provides a stringent comparison, as subsamples were created matched

37 mcitabine, busulfan, and melphalan group had stringent complete remission compared with 22 of 174 pat

38 tabine, busulfan, and melphalan who achieved stringent complete remission in accordance with the Inte

39 intention-to-treat population had achieved a stringent complete response (odds ratio 1.60, 95% CI 1.2

40 The primary end point was rate of stringent complete response (sCR) after 8 cycles of KRd

41 The primary end point, stringent complete response (sCR) rate by the end of pos

42 esponse (VGPR) or better and 33.3% achieving stringent complete response after transplantation at a m

43 sone (D-VTd) significantly improved rates of stringent complete response and progression-free surviva

44 The primary endpoint of part 1 was stringent complete response assessed 100 days after tran

45 gous stem-cell transplantation would improve stringent complete response rate in patients with newly

46 rred in (29 [60%] of 48) patients, including stringent complete response/complete response (4 [8%]),

47 onfidence interval, 19 to 35), including two stringent complete responses; 39% of patients had a mini

48 F/IL blends, whereas pore symmetry is a less stringent condition.

49 Using less-stringent conditions (raw P-value < 0.05, log2 fold chan

50 available for Delta(9)D and satisfies fairly stringent conditions required by Nature: the chemo-, ste

51 However, such scenarios require rather stringent conditions.

52 Water availability acts as the most stringent constraint for life on Earth.

53 tem without carbon storage and with the more stringent constraint on carbon dioxide emissions-they pr

54 ort penetration depth of soft X-rays imposes stringent constraints on sample type, preparation, and a

55 healthcare demand and more deaths than early stringent control and depends on continued public will.

56 rugs and one non-specific aptamer, tested as stringent control candidates, caused negligible response

57 ontinuous glucose monitoring facilitates the stringent control of blood glucose concentration in diab

58 A stringent control of lipophilicity ensured that 28 had f

59 Stringent control of NH(3) emissions is being considered

60 nslational precursor maturation allowing for stringent control of peptide biogenesis.

61 ed for catalysis, implying a requirement for stringent control of spliceosome activity within the cel

62 ntial for embryogenesis and homeostasis, and stringent control of the FZD protein level is critical f

63 cle is a cellular process that is subject to stringent control.

64 version luminescence intensification require stringent controls over numerous factors such as composi

65 ected (often by twofold or more) relative to stringent controls.

66 athogenic forms and are therefore subject to stringent controls.

67 in engineered microbes has yet to match the stringent cost targets set by petroleum fuels.

68 in Lima would be cost-effective, even under stringent cost-effectiveness criteria when accounting fo

69 Stringent COVID-19 control measures were imposed in Wuha

70 In the present work, using more stringent criteria and focusing on the analysis of genes

71 an acute myocardial infarction, comply with stringent criteria for product homogeneity, potency, and

72 y sequenced plant genomes were analyzed, and stringent criteria for selection of candidate UGTs were

73 o identify promising TWJ ligands selected on stringent criteria in terms of TWJ-folding ability, affi

74 As we used stringent criteria to diagnose IDC-P, the main limitatio

75 by using a repeated measures model and less stringent criteria to see if the same genes can be found

76 ney and genitourinary disorders will require stringent curation of clinical variant databases and det

77 luated whether HPV type restriction and more stringent cutoffs on Xpert HPV optimise performance char

78 More stringent cycle threshold cutoffs on selected channels i

79 umour DNA platforms, despite the use of very stringent decontamination analyses that discarded up to

80 Stringent decontamination of wood surfaces combined with

81 To assess the sensitivities, a stringent definition of 'true' UTI was used including th

82 surfaces by specular reflections requires a stringent definition of specular; we propose a definitio

83 d maintenance week 44 than placebo when more stringent definitions of histologic improvement were use

84 olymeric self-assembled structures require a stringent degree of control over such aspects as functio

85 ectures for photonic quantum computing place stringent demands on high quality information carriers.

86 s that transmit signals from a kinase show a stringent design tradeoff that hampers their ability to

87 A stringent dFLC response predicts prolonged TNT and impre

88 the impact of posttreatment dFLC < 10 mg/L ("stringent dFLC response").

89 artial response/low dFLC response and with a stringent dFLC response, dFLC 10-40 mg/L, and dFLC > 40

90 Cardiac responses were better in those with stringent dFLC responses (61%) compared with lesser resp

91 Patients with stringent dFLC responses had significantly better OS and

92 treatment at 3 years compared with 84% with stringent dFLC responses.

93 OVID-19 patients are driving efforts to more stringent diagnostic screening for thrombotic complicati

94 ncrease in influent loading or to reach more stringent discharge criteria.

95 espread community transmission has triggered stringent distancing measures with severe socio-economic

96 ymerases replicate the damaged DNA, allowing stringent DNA synthesis by a replicative polymerase to r

97 mitigating climate impacts will require more stringent drought-specific watershed management.

98 The biocontainment strategy is stringent, easily implemented, and applicable to several

99 nefits only to a minority of patients due to stringent eligibility criteria.

100 ) and nitrogen oxides (NO(x)) to comply with stringent emission standards.

101 ed cycle emissions for vehicles meeting more-stringent emission standards.

102 from the flexible TF billboard model to the stringent enhanceosome model.

103 clization step appears to be subject to less stringent enzyme control.

104 a series of nested models where increasingly stringent equality constraints were posited.

105 prediction tasks and multiple networks using stringent evaluation schemes.

106 We found most stringent evidence for genetic interaction between Ube3a

107 s earlier when well-connected countries with stringent existing interventions end their interventions

108 owever, in practice this may not be the most stringent experimental constraint; e.g. the goal may ins

109 n inexpensive wavefront modulator and a less stringent experimental setup.

110 In localized PCa, stringent expression filtering identified commonly alter

111 hrough independent molecular paths involving stringent extrinsic signals.

112 The required stringent fabrication processes to obtain high quality M

113 Using stringent false discovery rate analysis, MMP-10 and MET

114 high confidence positive calls by applying a stringent filter to model-based predictions, then rescor

115 After stringent filtering based on allele frequency, 1.4% of p

116 Stringent filtering for rare and potentially disease cau

117 Integration of a stringent filtering procedure in CNV studies with suitab

118 hment for particular classifications as more stringent filters are applied.

119 Following statistical analysis and stringent filtration, we identified 1429 PSSs, among whi

120 overage may increase public worry about more stringent firearm control and partially drive increases

121 This preference was even more stringent for a superinhibitory PLB variant.

122 with many nearly matched targets, rapid and stringent formation of stable products is challenging.

123 In order to meet stringent fuel sulfur limits, ships are increasingly uti

124 he form of a pi-helix, which is required for stringent gating and tight coupling of ion and substrate

125 t under molecular surveillance manifested by stringent gene regulatory control over ORE1 In addition,

126 exposure and is generally associated with a stringent genetic bottleneck.

127 s are highly efficient enzymes that maintain stringent geometric control over shape and orientation o

128 and Drug Administration published new, more stringent guidelines for glucose meter manufacturers to

129 ohort, which was further stratified based on stringent histological characterization, to define "NoNA

130 al network model for view selection ensuring stringent image quality control.

131 ent in accepting younger candidates and less stringent in accepting older candidates.

132 Compared to 2005, programs have become more stringent in accepting younger candidates and less strin

133 e institution that can plausibly become more stringent in the future.

134 updated triennially since 1978, are the most stringent in the nation.

135 the smallest genome, X174, requires the more stringent J protein packaging guide.

136 e (n=1225) was followed by open (n=2482) and stringent joint-analyses (n=1791).

137 s of expression can successfully satisfy the stringent labelling demands of super-resolution SMLM.

138 d EEEV-143 protect against disease following stringent lethal aerosol challenge of mice with highly p

139 duals identified no single variants reaching stringent levels of significance and, despite excellent

140 h modulations at the 10(-19) level we deduce stringent limits of the order of 10(-21) on Lorentz symm

141 Herein, we combined the stringent linear geometric interaction constraints of ha

142 nstrate that countries that adopted the most stringent lockdown measures had faster declines in new r

143 ng lockdown than a country that adopted less stringent lockdown measures.

144 ens, can prevent intravaginal infection in a stringent macaque/SIV challenge model.

145 /6 in Balb/c) and highly (Balb/c in C57BL/6) stringent major histocompatibility complex fully mismatc

146 derlying recommendations, and insufficiently stringent management of conflicts of interest.

147 communication with the patient as well as a stringent management regime.

148 achieve results highly similar to late-onset stringent mandates.

149 ssment, which are refined in an overall more stringent manner.

150 mplementation is limited due to the need for stringent measurement conditions and high-precision read

151 egative ion mode detection that incorporates stringent measures for quality control, including batch

152 nance of a functional NSPC pool necessitates stringent mechanisms to preserve a pristine proteome.

153 head-to-head comparison, we demonstrate more stringent megakaryocyte lineage-specific expression of t

154 uilding management which entails control and stringent monitoring of CO(2) levels to maintain accepta

155 l myxomas, particularly in tumors fulfilling stringent morphologic criteria for myxoma.

156 wed marked protection against lethality in a stringent mouse model of infection.

157 We have chosen for this purpose a highly stringent mouse model of polymicrobial sepsis by cecum l

158 ) treatment for skin allograft survival in a stringent murine skin graft model.

159 Results were confirmed with more stringent NCI classifications.

160 n, to redefine raphe subgroups based on both stringent neuroanatomical landmarks as well as quantitat

161 Adherence to a stringent NPPO-agreed-upon phytosanitary program has pre

162 Stringent numerical model shows that these observations

163 s) outcomes showed stronger evidence using a stringent P value (<10-6).

164 tion fraction, and 1 locus for LV mass) at a stringent P<1x10(-8).

165 To attain the stringent performance characteristics needed for high fi

166 The surface layer of LPS contributes to the stringent permeability properties of the outer membrane,

167 role of PATJ in stroke recovery and consider stringent phenotyping to enrich the information captured

168 ance analysis with assessed effect sizes and stringent PICRUSt2 predicted metabolic pathways.

169 More stringent PM(2.5) reduction targets expedite the phaseou

170 Updated methods include more stringent policies about disclosure of interests and con

171 ns were shown to be vulnerable despite their stringent policy.

172 andom cross-validation, and 0.700 for a more stringent position-based cross-validation.

173 This suggests that more stringent postprison parole supervision (relative to pro

174 Stringent precautions should be taken to avoid COVID-19

175 ion followed by conventional therapy using a stringent primary endpoint (steroid-free clinical remiss

176 With two million peptide and 340,000 stringent protein identifications obtained in a standard

177 Third, using the stringent PSM analyses based on matched subsamples, infa

178 for European countries that quickly imposed stringent public health controls and those for countries

179 of the lower risk subjects exceeded the most stringent published cut-off for subtle parkinsonism of t

180 y brain enhancers show evidence of unusually stringent purifying selection.

181 Following stringent quality control filtering, the strongest candi

182 Established procedures for stringent quality control were conducted, and two automa

183 chieved in a single run (<3 min/sample) with stringent quality control while avoiding enzyme deconjug

184 directly upon lithium foil, often requiring stringent reaction conditions with indispensable inert e

185 Effective management of mycotoxins rely on stringent regulation and routine surveillance of food/fe

186 Nascently synthesized RNAs are subjected to stringent regulation by sophisticated RNA surveillance p

187 ll divisions and cell-fate decisions require stringent regulation for proper tissue development and h

188 We conclude that stringent regulation of protons in the DSOR active site

189 erminal phosphorylation domain important for stringent regulation of rat CCT1 was apparently missing

190 Stringent regulation of tyrosine kinase activity is esse

191 ociated with imaging DBS devices have led to stringent regulations, limiting the clinical and researc

192 Paediatric dolutegravir doses approved by stringent regulatory authorities (SRAs) for children wei

193 fluorescence photons in this narrow range, a stringent requirement arises that the fluorescence signa

194 esis in cultured cells and in tissues with a stringent requirement for CCTalpha.

195 es remains highly challenging because of the stringent requirement for simultaneous recognition of th

196 or optoelectronic device applications as the stringent requirement of low defect density is eased.

197 igh electrical conductivity, however, sets a stringent requirement on electrodes based on metallic ma

198 y performance ever increasing, more and more stringent requirements are being imposed upon the establ

199 r X-ray diffraction measurements, which have stringent requirements for angular stability.

200 These results highlight the stringent requirements necessary to achieve a closed DNA

201 r AUC to be validated for a GMP environment, stringent requirements need to be satisfied; analysis pr

202 However, due to stringent requirements of anti-commuting reflection symm

203 rning methods cannot simultaneously meet the stringent requirements of resolution, throughput, and un

204 ogeneous structure of insect cuticle imposes stringent requirements on approaches to elucidate its mo

205 features of bacterial promoters that impose stringent requirements on CRISPRa target sites.

206 s proved experimentally challenging owing to stringent requirements on quantum state preparation and

207 This translates into more stringent requirements on the patterning of biological e

208 time, it is this short wavelength that puts stringent requirements on X-ray optics and their metrolo

209 icon photonic chip that addresses all of the stringent requirements.

210 fluent into aquatic bodies are becoming more stringent, requiring some treatment plants to reduce eff

211 Given the stringent resource constraints in quantum computing, inf

212 nes in the arginine deiminase pathway during stringent response activation.

213 ands our understanding of the breadth of the stringent response and suggests promoter sequence featur

214 The stringent response is a stress signalling system mediate

215 The stringent response mediated by the alarmone (p)ppGpp has

216 However, FISH analysis of the starved stringent response mutant showed a bimodal response wher

217 Resistance is not mediated by the stringent response nor the previously described Legionel

218 Stringent response pathways involving inorganic polyphos

219 und that NA inhibited gene expression of the stringent response regulator relA, implicated in the reg

220 The stringent response regulator SpoT is required for HipA-m

221 lucidates that, in addition to function as a stringent response regulator, DksA promotes the transcri

222 he guanosine pentaphosphate (ppGpp) alarmone/stringent response regulator.

223 Our results indicate that the stringent response stimulates biofilm dispersal under nu

224 alarmone nucleotides (p)ppGpp, mediates the stringent response to nutrient starvation in Borrelia bu

225 he antagonistic adaptive mutations repress a stringent response-like transcriptional program, whereas

226 r link between cell envelope homeostasis and stringent response.

227 ranslation and triggers the highly conserved stringent response.

228 all four glycyl codons but does not evoke a stringent response.

229 controlled by ArgR, TrpR, and TyrR, and the stringent-response regulon, controlled by DksA/ppGpp, we

230 d hflX are coregulated by general stress and stringent responses in a temperature-dependent manner.

231 A stringent restriction mechanism prevents T. brucei from

232 e solubility of the chosen salts, imposing a stringent restriction on the number of possible WiS syst

233 4.0% and deceased donor liver by 73.3%; more stringent restrictions were associated with higher regio

234 Using protein-RNA reconstitution and a stringent RNA pulldown assay with human choriocarcinoma

235 protection against sporozoite challenge in a stringent rodent malaria model.

236 As NK cells need to pass stringent safety evaluation tests before clinical use, t

237 al obstacles, pubertal hormonal changes, and stringent safety requirements mandate adaptations in tri

238 e of CDR3alpha and CDR3beta, suggesting more stringent selection against a narrower peptide-MHC-II co

239 Using multiple in vitro fibrosis assays and stringent selection algorithms, we identified the steroi

240 Utilizing a set of stringent selection criteria to filter peptide epitopes,

241 Using stringent selection criteria, we identified 53 novel miR

242 Through prioritization and stringent selection criteria, we selected 24 SNPs for fu

243 adaptation of these bacteria to reduced and stringent selection for endospore formation, as well as

244 ive specificities, it has been proposed that stringent selection mechanisms prevent the development o

245 ment, while sugar content has undergone less stringent selection.

246 opmental changes when populations experience stringent selection.

247 Antibody variants isolated using stringent selections for specificity were also enriched

248 nstrate these abilities require a remarkably stringent set of chemical requirements to exist.

249 ther validation using genetic data: the most stringent set of matched signals and shared knowns showe

250 is time-consuming to use in practice due to stringent significance criteria commonly seen in these a

251 trolled false positive rate, although a less stringent significance criterion was adopted.

252 Using a stringent significance threshold (P<7.1 x 10(-9)), GWAS

253 ll but consistent changes when few CpGs pass stringent significance threshold after multiple comparis

254 ly expressed genes were detected at the most stringent significance threshold.

255 Using a highly stringent skin transplant model, the GelMA/anti-IL-6 IMB

256 to provide 100% sterile protection against a stringent sporozoite challenge in rodent models to malar

257 Stringent standard operating procedures were developed a

258 ric macrophage growth locus protein A (MglA)-stringent starvation protein A (SspA) complex and the DN

259 a dedicated bioinformatic pipeline including stringent statistical analysis and 3D visualization.

260 Due to our stringent statistical test, we expect many of the associ

261 With the most stringent statistical tests, GeoNet detected 0.2% to 2%

262 isual presentation of stimuli (P = .04), and stringent statistical threshold (P = .01) were used.

263 annotations (from the baseline-LD model), a stringent step that greatly reduced the number of pathwa

264 th >/= 100 kb length were identified using a stringent strategy based on merging CNVs calls generated

265 istal from the polymerization site, imposing stringent structural and kinetic requirements for effici

266 xperimental design that renders possible the stringent study of judgment propagation.

267 These results signal the need for sustained stringent suppression measures as well as sustained effo

268 However, current SDRC systems require stringent surface designs, which are neither cost-effect

269 Unfortunately, materials must satisfy stringent symmetry requirements to be classified as piez

270 to achieve both high affinity binding and a stringent targeted absorption, distribution, metabolism,

271 aking successful gastric retention in dogs a stringent test for predicting human translatability.

272 This scaling relation poses a stringent test for the validity of the TDT.

273 Triangular cells provide a stringent test for Turing patterning, where there is a b

274 In a stringent test of immunogenicity, focal expression of uU

275 is a daunting methodological challenge and a stringent test of selectivity and reaction scope.

276 As a stringent test, the method achieves RMSE accuracy of 1.4

277 ing threshold that satisfies the third, most stringent test.

278 Modelling of these pulsating stars provides stringent tests of white dwarf models and a detailed pic

279 nd enforcing next-generation standards (more stringent than Euro 6/VI) could nearly eliminate real-wo

280 nts, we infer clonal architecture by using a stringent, the single-cell sequencing validated PyClone

281 To ensure stringent therapeutic testing conditions to replicate li

282 oxide catalysts, simultaneously meeting the stringent thermal stability and catalytic activity stand

283 genome-wide association studies to meet the stringent threshold of genome-wide statistical significa

284 g a precision as high as 60.8 +/- 0.4% for a stringent threshold.

285 alues, indicating that SBL is insensitive to stringent thresholds in significance testing.

286 d detection by monogenic knockout screens at stringent thresholds.

287 f all the side-chain dihedral angles using a stringent tolerance criterion of 20 degrees , compared f

288 oting long-term skin allograft survival in a stringent transplantation model.

289 ty of late stage failure because of the more stringent type 1 error rate employed and the ability to

290 raints as any other genetic study, including stringent type I error control.

291 In total, 49 episodes fulfilled our stringent UTI definition (19.8%).

292 After stringent variant curation, we identify 1,455 individual

293 Using a stringent variant filtering procedure, analysis of WES d

294 gested that only few mutations would survive stringent verification testing and that our data did not

295 the yield of DNA targets, particularly when stringent wash conditions were applied to remove untarge

296 uire two high-affinity antibodies as well as stringent washing to maximize sensitivity and reproducib

297 (representing a progressive populace facing stringent water quality regulations) were interviewed.

298 e findings highlight the importance of using stringent, well-validated, DNA extraction methodologies

299 nalyses showed that each model would be more stringent when evaluating food items that specifically t

300 lower rotavirus mortality estimates and more stringent willingness-to-pay thresholds.