ライフサイエンスコーパス: stringently

1 light but axis alignment is determined less stringently.

2 nce are required to test the hypothesis more stringently.

3 y help define ovarian cancer stem cells more stringently.

4 In sensitivity analyses, varying how stringently adherence was defined, expected evaluation r

5 aOR, 1.26 (95% CI, 1.22-1.31) but not in the stringently adjusted model (aOR, 1.04; 95% CI, 1.00-1.08

6 Our objective was to stringently and comprehensively assess expression of PD-

7 hastic models to test biological models more stringently and make predictions for future experimental

8 ily scaled up without any metal additives or stringently anhydrous conditions.

9 to survey nonlymphoid tissues, albeit not as stringently as observed for CD8(+) T cells.

10 We studied 184 stringently ascertained Caucasian multiple sclerosis fam

11 This allowed us to stringently assess the effects of recombinant caveolin-1

12 sis of chronic lymphocytic leukemia (CLL) is stringently associated with a tumor-supportive microenvi

13 ha1, alpha2, or alpha3 collagen isoforms are stringently associated with corneal stromal cell activat

14 athione S-transferase-30-kDa peptide remains stringently associated with ribosomes.

15 e analog discriminates at least 30-fold more stringently between the insulin receptor and mitogenic i

16 oneal) performed since 1995 was conducted to stringently categorize all identified biopsy procedure c

17 It is critical to stringently characterize iPS-RPE using standardized and

18 Using stringently characterized, homogeneous preparations of t

19 for every patient, we separately analyzed 55 stringently classified patients, and the results were si

20 investigate the biology of edited cells and stringently compare editing protocols at a clonal level.

21 echanism assumes nucleophilic catalysis by a stringently conserved active site Cys and general acid-g

22 and general acid-general base catalysis by a stringently conserved active site His.

23 A biologically important region is most stringently conserved among a smaller family of highly s

24 The KDO8PP and KDN9PP orthologs share a stringently conserved Arg residue that forms a salt brid

25 PPDK mutants, in which one of two stringently conserved docking residues located on the N-

26 ed in the protein data bank (PDB) identified stringently conserved elements that stabilize the trigon

27 oop-helix motif of the cap domain contains a stringently conserved Gly (within sequence motif 5), fla

28 residues Lys529 and Thr343, all of which are stringently conserved in the beetle luciferase sequences

29 other pararubulavirus RBPs lack many of the stringently conserved residues required for sialic acid

30 her percentage of mutations occurred at less stringently conserved sites, including silent mutations

31 ithin the phosphonatase subfamily, Asp186 is stringently conserved, while either position 185 or posi

32 smission through integrated DNA networks are stringently constrained by specific design requirements.

33 NA arrays, and use multiplexed regulation to stringently control a heterologous B-carotene pathway.

34 es of SIV replication in rhesus macaques and stringently control highly pathogenic SIV(MAC239) infect

35 function, TspO, together with FnrL and PrrA stringently control photopigment gene expression.

36 We used a stringently controlled 14-d circadian paradigm to assess

37 ex range: 18-28 kg/m(2) ] were enrolled in a stringently controlled 14-day circadian laboratory proto

38 riate localization of the kinase, coupled to stringently controlled activation of PknB, and consequen

39 affinity-tuned CAR-T cells was NFAT activity stringently controlled and restricted to tumors expressi

40 chanisms by which the activation of SARM1 is stringently controlled are unclear.

41 e employed multiple genetic mouse models for stringently controlled biochemical and immunostaining an

42 Gene expression in the IncP-1 plasmids is stringently controlled by a network of four global repre

43 This coordination is stringently controlled by gene networks that contain bot

44 cally localized HSP100/ClpB protein genes is stringently controlled by heat stress in both of the lab

45 p1 transcriptional activity is precisely and stringently controlled by heme.

46 ewal, proliferation, and differentiation are stringently controlled by numerous regulatory pathways.

47 As pyocyanin production is stringently controlled by QS, we examined the effect of

48 B lineage precursors into mature B cells is stringently controlled by stage-specific transcription f

49 ogression in osteoblasts and chondrocytes is stringently controlled by the cell-fate-determining tran

50 e membrane-embedded part of the molecule are stringently controlled by the cytoplasmic domain.

51 -tripods can be reliably synthesized through stringently controlled chemical synthesis and could serv

52 total cholesterol and CSF were assayed under stringently controlled conditions.

53 In Escherichia coli, stringently controlled genes are highly transcribed duri

54 show that the interactions between RNAP and stringently controlled promoters are intrinsically unsta

55 complexes is coupled to the transcription of stringently controlled promoters, and this unique featur

56 (RNAP) (both wild type and mutants) and four stringently controlled promoters.

57 This regulation is restricted to stringently controlled promoters.

58 vious small pilot studies, these elegant and stringently controlled results open a new era in leukemi

59 cted CD8+ T cells, and half of the vaccinees stringently controlled SIV post-challenge.

60 ; and (4) repression in mat1-P cells is less stringently controlled than in mat1-M cells.

61 Canonical BMP signaling is stringently controlled through reversible phosphorylatio

62 irus infection, and their activities must be stringently controlled to maintain immune homeostasis.

63 homeostasis and self-tolerance, but must be stringently controlled to permit expansion of protective

64 etween maternal and paternal chromosomes--is stringently controlled to restrict the number of crossov

65 results indicate that TBP binding in vivo is stringently controlled, and that the ability of activato

66 ication, and its level of expression must be stringently controlled.

67 ity of fibroblast growth factor 2 (FGF-2) is stringently controlled.

68 of microRNA (miR) biogenesis is complex and stringently controlled.

69 etics of the deposition of Al(III) were more stringently controlled.

70 y the multitiered regulatory mechanisms that stringently controls its expression and function.

71 FM is stringently coupled to the anagen stage of the hair cycl

72 To stringently define the mode of binding, a global fit of

73 ied by in vitro gel shift assays in order to stringently define their potential role in the ARE-media

74 region enriched in introgressed sequence, a stringently defined 105 kb haplotype, intersecting the c

75 ts were obtained when neurosyphilis was more stringently defined as a reactive CSF VDRL test result.

76 When neurosyphilis was more stringently defined as a reactive CSF-VDRL, the relation

77 When neurosyphilis was more stringently defined as a reactive CSF-VDRL, the relation

78 previous 12 mo; (b) recent condom use, less stringently defined as using a condom with the most rece

79 tricting analysis to individuals with MDD as stringently defined by the Psychiatric Genomics Consorti

80 Stringently defined cCR after gemcitabine, cisplatin, pl

81 nscriptome of bronchial brush cells from 312 stringently defined ex-smoker patients.

82 l plasma-cell [NPC]; n=22) and patients with stringently defined MGUS/smoldering MM (n=24) and sympto

83 Using stringently defined murine models of atopic, nonatopic a

84 nontypeable Haemophilus influenzae (NTHi) in stringently defined otitis-prone (sOP) and non-otitis-pr

85 tudy (GWAS) of anorexia nervosa (AN) using a stringently defined phenotype.

86 Stringently-defined otitis-prone (sOP) children are susc

87 Operator recognition is stringently dependent not only on electropositive residu

88 y of VCC to trigger programmed cell death is stringently dependent on its pore-forming activity.

89 to homeostatic stimuli does not appear to be stringently dependent on TCR-self peptide:MHC interactio

90 DSB unwinding by AdnAB in vitro is stringently dependent on the ATPase activity of the 'lea

91 ed evidence that PTEN-null myeloma cells are stringently dependent on the PI3K/Akt activation for cel

92 whose expression during productive infection stringently depends on ICP4, and positively affected the

93 Pheresis products were stringently depleted of T and B cells by immunomagnetic

94 of heme oxygenase-1 (Hmox1), one of the most stringently deregulated genes in the Bach1 knockout in m

95 Comparing the three clinical series: in the stringently diagnosed Manchester frontotemporal dementia

96 Therefore recombination machineries stringently discriminate between ssDNA and dsDNA lattice

97 sensitively signals target analytes but also stringently discriminates against analogous competing an

98 regulatory subunits (R(CE)) of PKAI(CE) and stringently discriminates against RIIalpha and RIIbeta s

99 used rosiglitazone and primary adipocytes to stringently evaluate a set of biomarkers for brite forma

100 Assemblies are now more stringently evaluated for contamination and for complete

101 ormation experiments, we find that, for even stringently filtered constraints, a large rigid componen

102 2,704 (1.5%) of our 183,605 informative and stringently filtered SNPs demonstrate an average relativ

103 It uses stringently hybridizing primers which carry a fluorescen

104 pipeline, which we have named ORFLine, that stringently identifies smORFs and classifies them accord

105 flow cytometry and serial transplantation to stringently identify HSCs, trafficking patterns of long-

106 ation of the subventricular zone lineage, we stringently identify lncRNAs with potential roles in adu

107 The myoglobin gene is regulated stringently in muscle fibers, such that high myoglobin e

108 could evolve a mechanism that discriminates stringently in their cellular responses between endogeno

109 Thus, the lanthanide ions have to be stringently kept at relatively low concentrations to min

110 ase (IN) transcription units into cells made stringently LEDGF/p75-deficient by RNAi resulted in much

111 chanism by which chronic transfusion of even stringently leukoreduced RBCs may result in sufficient m

112 otion that tissue-restricted stem cells have stringently limited lineage potential and prompts a re-e

113 rsensitive to hydrolysis, a feature that has stringently limited their utility in water.

114 rganized within the vectors in a manner that stringently maintains tetracycline-dependent regulation.

115 measure conformational heterogeneity of 743 stringently matched pairs of crystallographic datasets t

116 Studies in stringently matched patient cohorts suggest that an epis

117 ing institutional review board approval, two stringently matched subcohorts were derived.

118 t the immunosuppression activity of PD-L1 is stringently modulated by ubiquitination and N-glycosylat

119 repair of blunt and 5' overhang DSBs depends stringently on Ku and the LigD POL domain, but not on th

120 i, the etiologic agent of Lyme disease, rely stringently on regulatory events.

121 Under stringently optimized conditions, only the perfectly seq

122 .59; 95% CI, .35-1.01) and older individuals stringently or not stringently tested (RR, 0.88; 95% CI,

123 Surgical societies should stringently police for appropriate expert witness testim

124 d potent HSC activity that was comparable to stringently purified HSCs.

125 First, nascent RNA is stringently purified through a combination of 4-thiourid

126 ds increase the efficiency of generating and stringently purifying iPSC-derived cardiomyocytes.

127 ive HIV infection (AHI) in whom RCI has been stringently quantified, we found that early ART reduced

128 egs have considerable potential as agents to stringently regulate antibody dynamics in vivo, resultin

129 y linked to the increased ability of IAPs to stringently regulate apoptosis in neuronally differentia

130 Protein kinase signaling networks stringently regulate cellular processes, such as prolife

131 conformation of the chromatin is crucial to stringently regulate gene expression patterns and DNA re

132 termed the blood-brain barrier (BBB), which stringently regulate the entry of molecules into the bra

133 rised of brain endothelial cells (BECs) that stringently regulate the passage of molecules, toxins, a

134 Bacteria stringently regulate the synthesis of their membrane pho

135 rlie discrimination of prospective mates and stringently regulate the transition to courtship in Dros

136 that expression of IgD in primary B cells is stringently regulated and closely linked to IgM expressi

137 s to newly replicated DNA, a process that is stringently regulated and intrinsically linked to replic

138 Kupyaphores are stringently regulated and support Mtb survival under bot

139 Genome evolution is an essential and stringently regulated aspect of biological fitness.

140 d walls, and their biosynthetic pathways are stringently regulated at both biochemical and genetic le

141 Autophagy is stringently regulated at multiple stages, including cont

142 63 from chromosomal, repetitive genes is not stringently regulated at the protein level and can be su

143 MenT toxin activity can be stringently regulated by diverse MenA antitoxins.

144 bination by showing that Sir2 recruitment is stringently regulated by Fob1 phosphorylation at specifi

145 demonstrate that beta-catenin expression is stringently regulated by intrathymic signals, it is expr

146 PanK1beta (IC50 = 10 microm), and PanK3 was stringently regulated by long-chain acyl-CoA (IC50 = 2 m

147 The turnover of c-Myc protein is stringently regulated by post-transcriptional modificati

148 L gene with a C-terminal epitope tag that is stringently regulated by the Escherichia coli lac repres

149 Iron is stringently regulated by the iron regulatory proteins, I

150 s response was associated with transient and stringently regulated changes in gene expression predomi

151 st HMG-CoA reductase isozyme Hmg2p undergoes stringently regulated degradation by machinery that is a

152 in Xenopus eggs by a highly conservative and stringently regulated end-joining pathway, in which all

153 During amino acid starvation, P2 was stringently regulated in relA(+) and relA(S) cells, whil

154 to oligomerize, and finally to detach, in a stringently regulated mechanistic cycle.

155 f their expression involves an intricate and stringently regulated signaling cascade, initiated by re

156 e induction of autoimmune arthritis, is more stringently regulated than is processing of the nonglyco

157 -12 (IL-12) production by human monocytes is stringently regulated through the inducibility of both s

158 le, and it is critical that these enzymes be stringently regulated to avoid compromising the integrit

159 Normal DNA replication is stringently regulated to ensure a timely occurrence no m

160 Here, we show that Runx2 is stringently regulated with respect to cell cycle entry a

161 The PTS is stringently regulated, and a potential mechanism is the

162 during immune responses, IL-12 production is stringently regulated, in part through transcriptional c

163 Here we report the development of a stringently regulated, tetracycline-inducible, lung-spec

164 us, in which expression of the H2 protein is stringently regulated, was unable to replicate without i

165 lyzes sugar phosphorylation/transport and is stringently regulated.

166 heir activity at the synapse is likely to be stringently regulated.

167 ysiology, synthesis of PtdIns(4,5)P2 must be stringently regulated.

168 omous induction of type I interferon must be stringently regulated.

169 ovides a clear need for miR-155 itself to be stringently regulated.

170 en receptor assembly in lymphocytes involves stringently-regulated coordination of specific DNA rearr

171 A program of stringently-regulated gene expression is thought to be a

172 nger tugging forces on the BCR, thereby more stringently regulating antigen binding.

173 ing an inducible virus (iA6) that could more stringently repress A6 expression.

174 ia and cold shock, the Dan proteins are more stringently repressed by oxygen and insensitive to cold

175 nant vaccinia virus in which the A8L gene is stringently repressed by the Escherichia coli lac operat

176 , the hTERT, but not the mTert, reporter was stringently repressed in telomerase-negative human cells

177 LhGR-N was stringently repressed in the absence of exogenous glucoc

178 XRCC4/XLF complexes hold DNA ends together--stringently required for coding end joining, but dispens

179 inhibitors indicates that kinase activity is stringently required for heregulin-dependent, but not 12

180 vidence that the eIF4E-eIF4G complex is more stringently required for plasticity induced by initial l

181 hr209, Gly211, and Gly212 were identified as stringently required for recombinational events in bacte

182 ignificantly by mutations in helix 6 and was stringently required for SRP54M to associate.

183 hey demonstrate a novel mechanism by which a stringently required gene product can be bypassed, even

184 ce the efficiency of initiation, but are not stringently required in vitro.

185 vided evidence suggesting that Rad51 is more stringently required than Rad54 for intersister gene con

186 IP1 contributed to the synergy but were less stringently required than the N-terminal region of GRIP1

187 olic rather than catabolic pathways are more stringently required, likely due to functional redundanc

188 that, conversely, Myc-driven lymphomagenesis stringently requires two intact alleles of miR-17~92.

189 y requirements for Cas1-Cas2 varied, with G1 stringently requiring a 5-nucleotide 3' overhang and G2

190 produces a single transcript of 2.3kb and is stringently restricted in expression to predominantly me

191 ge activity, and resulted in the addition of stringently reviewed miRNAs to miRBase.

192 Participants were stringently screened for hypnotic susceptibility with tw

193 These findings indicate that the SMN complex stringently scrutinizes RNAs for specific structural fea

194 establish an in vivo strategy to evolve and stringently select capsid variants of adeno-associated v

195 introduced to human hematopoietic cells and stringently selected for resistance to killing by the co

196 Epicardial left ventricular biopsies from stringently selected HFpEF patients (HFpEF, n=16) and re

197 Differentially expressed genes stringently selected were used to construct multiple non

198 teins, where training and test datasets were stringently separated with the sequence identity between

199 We found out that the most stringently sequence-based calls of X4 variants (Geno2Ph

200 tential of these new tools in activating the stringently silenced pluripotency gene Oct4 (Pou5f1) in

201 uences although locations of purines are not stringently specified.

202 es in Ire1's RNase activity, which is either stringently splice-site specific or promiscuous.

203 Gene-expression studies and a stringently supervised analysis identified calreticulin

204 se (GVHD) by injecting the cells, along with stringently T cell-depleted donor marrow cells, into let

205 Protection was weaker in children not stringently tested (RR, 0.59; 95% CI, .35-1.01) and olde

206 01) and older individuals stringently or not stringently tested (RR, 0.88; 95% CI, .59-1.31 and RR, 0

207 This could be stringently tested by passive antibody transfer and oral

208 on cosmological length scales has yet to be stringently tested.

209 One novel gene is stringently testis specific and another is expressed exc

210 nd tamoxifen inhibited MCF7 cell growth more stringently than either agent alone.

211 We demonstrate that ClpB requires DnaK more stringently than Hsp104 requires Hsp70 for protein disag

212 yocardial infarction, which was defined less stringently than in previous trials.

213 ions that meet the input specifications more stringently than other published methods, SimBA is also

214 and IN interacts with exogenous donors less stringently than with endogenous elements.

215 not only mean response times but, much more stringently, the observed distribution of these times an

216 ained to individual cone terminals, and more stringently, to individual synaptic contact sites within

217 ants (RR, 0.1; 95% CI, .01-.77) and children stringently tuberculin tested (RR, 0.08; 95% CI, .03-.25

218 Protection appeared greatest in children stringently tuberculin tested, to try to exclude prior i

219 e PTMs were identified of which 106 could be stringently validated.

220 atin and RNA-binding. Additionally, SPACEmap stringently verified chromatin-binding of 403 RBPs and i

221 influence the CTD phosphatase sensitivity of stringently washed complexes.

222 labeled riboprobe complementary to B1R mRNA, stringently washed, and apposed to film and emulsion.

223 s complimentary to ER-alpha or ER-beta mRNA, stringently washed, and opposed to emulsion.