ライフサイエンスコーパス: stroma

1 r cells and their surrounding nontransformed stroma.

2 hocytes, plasma cells and hyalinized fibrous stroma.

3 stablished tumor cells and/or the associated stroma.

4 tumor center, the invasive margin, and tumor stroma.

5 critical tissue components: endothelium and stroma.

6 on of the 3-dimensional choroidal vessel and stroma.

7 h of tumours thriving within a collagen-rich stroma.

8 s, deposits are found posteriorly in corneal stroma.

9 and 2) upregulation of TGFbeta and activated stroma.

10 ostasis within the nulliparous mammary gland stroma.

11 cells only when co-cultured with bone marrow stroma.

12 with CD8 T cells in compartmentalized tumor stroma.

13 type and the regeneration of damaged corneal stroma.

14 senchymal stem cells (MSCs) located in tumor stroma.

15 ulated by the mechanics of the tumor and its stroma.

16 roduction and secretion into the surrounding stroma.

17 in the central stroma than in the peripheral stroma.

18 nvironment by committed myeloid lineages and stroma.

19 ves but also impact other cells of the tumor stroma.

20 patients expressing high ZEB1 levels in the stroma.

21 al image of wrapping cells in human prostate stroma.

22 umors that lies sequestered within the tumor stroma.

23 concert with alterations in the surrounding stroma.

24 nce of an immunosuppressive tumor-associated stroma.

25 spread gene expression changes in the tumour stroma.

26 lia progenitors (LEPC) but not in underlying stroma.

27 oma were larger than those in the peripheral stroma.

28 fect phenotype observed in cancer-associated stroma.

29 s) in the periphery and center of KC corneal stroma.

30 Cpn60 bound Plsp1 in the stroma.

31 l containing both epithelium and mesenchymal stroma.

32 racterized by a fibroblast-rich desmoplastic stroma.

33 dicated distinct changes in SP-stimulated BM stroma.

34 the anterior to middle layers of the corneal stroma.

35 ts of SP and NK-A are mostly mediated via BM stroma.

36 ng the effects of macrophages on the adipose stroma.

37 pitulate the extensive features of the tumor stroma.

38 ated with the thylakoid membranes facing the stroma.

39 -induced gene expression in aged bone marrow stroma.

40 st the role of IRF3 within leukocytes versus stroma.

41 ment, thus proving the active role of the BM stroma.

42 y acids and are a common component of tissue stroma.

43 on the epithelial compartment of the thymic stroma.

44 sion of MAGP1 throughout the central corneal stroma.

45 , we found Tlr7 is ubiquitously expressed in stroma across all stages of pancreatic neoplasia, but ep

46 Ms) have a significant presence in the tumor stroma across multiple human malignancies and are believ

47 study identifies a novel association between stroma-adjusted ZEB1 expression and tumor immune activit

48 The robust desmoplastic stroma, along with an extensive extracellular matrix (EC

49 lium, a scrambled appearance of the anterior stroma and a heterogeneous stromal reflectivity were obs

50 transiently expressed in developing corneal stroma and a subset of limbal and corneal stromal progen

51 However, the interplay between the stroma and adipose-resident immune cells is less well un

52 ells are important constituents of the tumor stroma and critically take part in this process.

53 vertent perforation of the posterior corneal stroma and Descemet membrane (DM).

54 : mesenchymal stem cells from the limbal eye stroma and epithelial cells from retinal pigment epithel

55 nsights into the signaling crosstalk between stroma and epithelium during tissue regeneration and tum

56 -resolved cell atlas of the small intestinal stroma and exposes Lgr5+ villus tip telocytes as regulat

57 ome evident that the TME, including both the stroma and extracellular component, plays an important r

58 HSCs preferentially located close to Cxcl12 stroma and farther from sinusoids/megakaryocytes.

59 h hyaluronan-rich regions within the adipose stroma and fibrous capsule of the virgin mammary gland.

60 following existing therapies due to abundant stroma and immunosuppressive environment within the meta

61 increase in the abundance of IL-1beta in the stroma and increased the amount of gelatinase activity i

62 a cellular taxonomy of the mouse bone marrow stroma and its perturbation by malignancy.

63 is by fostering tumor cell invasion into the stroma and migration toward the vasculature.

64 ctively targeted and localized at both tumor stroma and necrotic regions.

65 s a key factor in the cross-talk between the stroma and neoplastic epithelium, functioning to promote

66 highlights the complexity of the bone marrow stroma and paves the way for future in vivo assessment.

67 umor-promoting effects of PADI4 on the tumor stroma and suggest that the balance between opposing tum

68 deconstructing the surrounding desmoplastic stroma and targeting the immunosuppressive pathways have

69 DAC being associated with a dense and active stroma and tumor fibrosis (desmoplasia).

70 itude of dark-induced increases in [Ca(2+) ](stroma) and [Ca(2+) ](cyt) by transcriptional regulators

71 d f(C) were correlated with f(epithelium), f(stroma), and f(lumen) (all P < .001), with Spearman corr

72 ersistence of the hyperreflective underlying stroma, and a demarcation line were observed.

73 poreflective epithelium, a smoother anterior stroma, and a homogenous hyperreflective stroma were see

74 epithelial structures and within the adipose stroma, and are important for mammary gland development

75 lt of altered metabolic pathways, changes in stroma, and autophagy.

76 r CAG epithelium, conjunctival stroma or CAG stroma, and episclera, was evaluated and quantified.

77 nt barriers imposed by the tumour-associated stroma, and from the development of novel approaches to

78 ted, revealing low discordance for tumor and stroma, and higher discordance for more subjectively def

79 ressive marker B7-H4, signatures of fibrotic stroma, and poor outcomes.

80 aight line or wavy), distance from posterior stroma, and presence or absence of a tear with any scrol

81 SAFE1 is localized in the chloroplast stroma, and release of (1)O(2) induces SAFE1 degradation

82 stinct phenotypes and secretomes inhabit the stroma, and that targeted depletion of particular fibrob

83 the anterior to middle layers of the corneal stroma, and the disease is primarily a keratitis rather

84 in dedifferentiated tumor cell areas, tumor stroma, and tumor-infiltrating blood vessels.

85 subset of stromal cell lines and primary AML stroma; and increased FGF2/FGFR1 signaling is associated

86 sues compared to uninvolved normal and tumor stroma; and is associated with worse overall survival.

87 ence of a robust, reactive, and desmoplastic stroma; and the crosstalk between the different tumor co

88 various types of cancer cells, immune cells, stroma, angiogenic molecules, and the vasculature.

89 tent and fiber organization within the tumor stroma are major contributors to biomechanical changes (

90 The constituents of the TME stroma are multiple and varied, however cancer associate

91 Functional roles of the reactive tumor stroma are not fully elucidated; however, recent studies

92 s (PSCs) and consequent development of dense stroma are prominent features accounting for this aggres

93 ending on tumor type, both the tumor and the stroma are sources of sIL-15 complexes.

94 Myofibroblasts produce desmoplastic stroma around tumors and have emerged as therapeutic tar

95 edema was present, typically in the corneal stroma at the time of netarsudil initiation.

96 comprehensive atlas of the mouse bone marrow stroma based on single-cell RNA-sequencing data.

97 comprehensive atlas of the mouse bone marrow stroma based on single-cell RNA-sequencing data.

98 gs to not only tumor supporting cells in the stroma, but also to cancer stem-like cells in necrotic/h

99 al Hh signaling pathway is activated in lung stroma by Hh ligands secreted from transformed lung epit

100 demonstrate an effective modulation of that stroma by irreversible electroporation (IRE), a local ab

101 lso review the potential mechanisms by which stroma can confer resistance to immune-based therapies f

102 rounding the tumor, and this accumulation of stroma can contribute to therapy resistance.

103 Thylakoid transmembrane proteins in the stroma can interact with Cpn60 to shield themselves from

104 vity of stroma is a major mechanism by which stroma can promote tumor progression and confer resistan

105 year safety and efficacy outcomes of corneal stroma cell therapy.

106 This property was dependent on stroma cell-derived Notch ligands.

107 ease of several cytokines by cultured thymic stroma cells in response to rATG was analyzed via multip

108 posure activated NRF2 in both epithelial and stroma cells of chimeric human prostate grafts and induc

109 ted inflammatory proteins released by murine stroma cells.

110 nistration or overexpression of Rspo3 in the stroma clears H. pylori from the gastric glands.

111 Our data shows that tumor-stroma co-cultures consisting of aligned extracellular m

112 nderstanding of the molecular basis of tumor-stroma communications, enabling identification and targe

113 erved also in this invasive tumor model with stroma components a decreased tumor cell growth after CU

114 t solid tumors is dependent upon remodeling 'stroma', composed of cancer-associated fibroblasts (CAFs

115 We investigated the heterogeneous tumor stroma composition and built a TME-based classification

116 We investigated the heterogeneous tumor stroma composition and built a TME-based classification

117 m brain tissue in a compartmentalized cancer-stroma concentric-ring structure that sustains a radial

118 factors altered the composition of the tumor stroma, conferring gemcitabine resistance to cancer-asso

119 The stroma contained a large number of CD11c, CD68, and CD3

120 that cancer cells are embedded into a dense stroma containing fibrogenic cells, lymphatics and a var

121 The cardiac stroma contains multipotent mesenchymal progenitors.

122 ear whether activity in the tumor-associated stroma contributes to malignancy.

123 We derive a stroma-corrected ZEB1-activated transcriptional signatur

124 g to unveil the molecular influence of tumor-stroma cross-talk on invasion.

125 However, the mechanisms by which tumor-stroma crosstalk in thyroid cancer remains poorly charac

126 e, which includes both choroidal vessels and stroma, decrease with age (all P < 0.0001), the CVI and

127 Importantly, p53 ablation in ZEB1 stroma-deleted mammary tumours sufficiently recovers the

128 we review recent advances in identifying the stroma-dependent mechanisms that regulate cancer-associa

129 ished, priming can also be maintained by the stroma-derived homeostatic cytokine IL-7, and priming di

130 ogous ADASc and decellularized human corneal stroma did not show complications at 1 year of follow-up

131 ore the composition of the pancreatic cancer stroma, discuss the network of interactions between diff

132 g light microscopy, the anterior half of the stroma displayed thin and finely vacuolated lamellae, an

133 proaches to move toward normalization of the stroma disrupt physical barriers to effective drug deliv

134 tumours, CBD-IL-12 accumulates in the tumour stroma due to exposed collagen in the disordered tumour

135 hows that inflammatory cells invade only the stroma during an acute attack.

136 pH changes representing those in the plastid stroma during light or dark conditions.

137 of life, by inhibiting specification of the stroma, dysregulates paracrine signals necessary for ute

138 the cellular and molecular crosstalk between stroma, ECM and thymocytes, and offer practical prospect

139 When taken up by normal cells from the stroma EN2 induces the expression of MX2 (MxB), a protei

140 of tumor cell-derived IL1 signaling in tumor stroma enabled intratumoral infiltration and activation

141 Here, we report a stroma-epithelium ISLR-YAP signaling axis essential for

142 d rATG preparations on cultured human thymic stroma, especially thymic epithelial cells (TECs).

143 Stroma events including innate immune responses are key

144 and luminal area fractions (f(epithelium), f(stroma), f(lumen)) quantified in PCa and benign tissue r

145 een (f(A), f(B), f(C)) and (f(epithelium), f(stroma), f(lumen)), and the strength of correlations was

146 in 360o, some with deeper atrophy where the stroma fibers were visualized and only a small punctate

147 VI) involving the outer half of the cervical stroma ( Fig 1 ), and without pelvic lymph node involvem

148 ression in CAFs are an attractive target for stroma-focused anti-cancer intervention.

149 ophages and fibulin-2 levels were reduced in stroma following alpha3 deletion from tumor cells.

150 op the mouse cornea do not require a primary stroma for cell migration.

151 Currently, isolation of TME stroma from patients is complicated by issues such as li

152 Regeneration of corneal stroma has always been a challenge due to its sophistica

153 The acellular component of this stroma has been implicated in PDA pathogenesis and is be

154 ure antagonist fulvestrant, affect the tumor stroma has not yet been elucidated.

155 Studies of the bone marrow stroma have defined individual populations in the stem c

156 the primary cause of mortality to have less stroma, have higher tumor cellularity than primary tumor

157 Pharmacodynamic (PD) analysis referenced stroma/host cell concentrations to prophylactic values;

158 concentrations in luminal fluid, epithelium, stroma/host cells, and blood.

159 ere, we describe the role of CSCs and tumour stroma in developing therapeutic strategies for PDAC and

160 roscopy images of the anterior and posterior stroma in healed WST-D/NIR corneas and untreated control

161 dies suggest an important protective role of stroma in PDA and urge caution in clinically deploying s

162 t changes in gene expression patterns in the stroma in response to HPV16, some of which were E5 depen

163 ls and prevents the formation of endometrial stroma in rodents, suggesting a progenitor function.

164 This demonstrates the impact of the stroma in shaping tumor architecture by altering inheren

165 measurements in normal tissue revealed that stroma in the high-density breast contains more oriented

166 the multifunctional and critical role of the stroma in tumor protection and survival and demonstrate

167 dy known dark-induced increases in [Ca(2+) ](stroma) in the aerial part of the Arabidopsis thaliana p

168 PDAC typically has a prominent stroma including cancer-associated fibroblasts that expr

169 umor cell killing versus indirect effects on stroma including endothelial cells.

170 ization is strongly influenced by the tumour stroma, including cancer-associated fibroblasts (CAF).

171 nan-associated ECM in the adipose-associated stroma, indicating that resident macrophages are importa

172 h, activates dendritic cells, and alleviates stroma-induced immunosuppression without depleting tumor

173 Ccl5 elaborated from adult marrow stroma inhibited B-lymphoid differentiation of leukemia

174 In addition, ataxia, angiogenesis, and tumor-stroma interaction assays can be applied, and the model

175 Tumor-stroma interaction critically depends on cell communicat

176 lieu of the tumors, possibly affecting tumor-stroma interactions and favoring liver metastasis format

177 notypic model to mechanistically study tumor-stroma interactions by mimicking the spatial organizatio

178 ngs contribute to the understanding of tumor-stroma interactions by showing that miR-149 downregulati

179 An organotypic model of tumor-stroma interactions on a microfluidic chip reveals that

180 colorectal cancer cells as a driver of tumor-stroma interactions that favor formation of metastases i

181 h Cav1 is a central regulatory hub for tumor-stroma interactions through a novel exosome-dependent EC

182 cellular and molecular consequences of tumor-stroma interactions.

183 environment by regulating cell-cell and cell-stroma interactions.

184 opy image analysis data to extract the tumor-stroma interface zone (IZ) of controlled width.

185 proliferative, invasive regions at the tumor-stroma interface, which were marked by increased express

186 In the breast tumor-stroma interplay, paracrine factors such as interleukin-

187 ells mechanically invade through surrounding stroma into peripheral tissues is an essential component

188 e CCL2 that recruits M0-macrophages from the stroma into the tumor.

189 tistep process from primary tumor growth and stroma invasion to metastasis.

190 hat the potent immunosuppressive activity of stroma is a major mechanism by which stroma can promote

191 Stroma is a poorly defined non-parenchymal component of

192 Also, SOX2 expression in the stroma is associated with CRC T invasion and worse progn

193 Mammary stroma is essential for epithelial morphogenesis and dev

194 uamous cell carcinoma (SCC), even though the stroma is fibrotic in both histotypes.

195 In fact, evidence has now shown that the stroma is multi-faceted, which illustrates the complexit

196 aphy techniques, we found that the grana and stroma lamellae are connected by an array of pitch-balan

197 ylakoid membrane protein that is enriched in stroma lamellae fractions with the rubredoxin domain exp

198 The stroma lamellae, finally, contain monomeric PSII as well

199 ical and functional domains called grana and stroma lamellae.

200 tments: the stacked grana core and unstacked stroma lamellae.

201 tion of protein density by exchange with the stroma lamellae.

202 d decellularized donor 120-mum-thick corneal stroma lamina alone (n = 5).

203 tic deficiency of Piezo1 on CCL19-expressing stroma led to profound structural alterations in perivas

204 ression or deposition was observed mainly in stroma, leukocytes, and tumor vasculature, corresponding

205 To better understand how stroma limits response to therapy, we investigated cell-

206 ation model, to segment the nuclei of tumor, stroma, lymphocyte, macrophage, karyorrhexis, and red bl

207 he blood, pHLIP ICG targets tumors and tumor stroma, marking them for surgical removal.

208 /+Flt3Cre HSCs proximal to sinusoids, Cxcl12 stroma, megakaryocytes, and different combinations of th

209 loss of luminal epithelial lining and mural stroma necrosis.

210 Stroma normalization can further increase the efficacy o

211 ssue/organ fibrosis as well as the activated stroma observed in various malignancies, characterizing

212 ndritic cells (mDC) coexpressing IL23 in the stroma of cervical squamous cell carcinomas in situ.

213 rystal density of the anterior and posterior stroma of children and adults was 3.37 +/- 0.34 (median:

214 One example are [Ca(2+) ] increases in the stroma of chloroplasts during light-to-dark transitions;

215 are the major nonmalignant cell type in the stroma of human pancreatic ductal adenocarcinoma (PDAC).

216 The stroma of pancreatic ductal adenocarcinoma (PDA) forms a

217 arized donor human corneal stroma within the stroma of patients with advanced keratoconus.

218 roblast phenotype has been identified in the stroma of solid cancers.

219 evealed that in the pre- Descemet's membrane stroma of the periphery, the degenerated CFs and PGs con

220 Blood vessels are embedded in the tumor stroma of which cancer-associated fibroblasts (CAFs) con

221 o additional subtypes each involve the tumor stroma, one of these including the collagen VI interacti

222 l epithelium or CAG epithelium, conjunctival stroma or CAG stroma, and episclera, was evaluated and q

223 III colon cancer and its relation to tumour-stroma-percentage (TSP) and expression of HIF1A and VEGF

224 n insight into the role of OsPHT2;1-mediated stroma Pi, we analyzed OsPHT2;1 function in Pi utilizati

225 depigmentation and discoloration of the iris stroma, pigment dispersion, and deposition of pigment in

226 Innate mechanisms in the tumor stroma play a crucial role both in the initial rejection

227 zation and this suggests that the peripheral stroma plays an important role in the pathogenicity of t

228 ntly to EGFR in the stroma-rich area than in stroma-poor regions, which was confirmed by immunofluore

229 c ductal adenocarcinoma (PDAC), desmoplastic stroma poses a significant obstacle for treatment.

230 Inappropriate activation of the stroma potentiates the growth and transformation of epit

231 be primarily attributed to expansion of the stroma rather than luminal component.

232 In contrast, changes in lumen/stroma ratio in the outer choroid were not found to diff

233 is expressed by CAFs in the pancreatic tumor stroma, reduces growth of pancreatic tumors, increases t

234 l tissue region, and tumor proximal collagen stroma region were imaged, revealing that high-mannose t

235 ent-derived fibroblast cells in 3D tumor and stroma regions, respectively, and combined functional as

236 The tumour stroma regulates nearly all stages of carcinogenesis.

237 We identify increased stroma remodeling and reduced expression of proliferatio

238 vivo, we found higher levels of intratumoral stroma remodeling, determined by fibronectin fiber orien

239 Tumor stroma resembles a fibrotic microenvironment, being char

240 hat critical processes within the amyloplast stroma restrict maximum carbon flow into starch.

241 onsive to chemotactic stimuli present in the stroma, resulting in dramatically lower rates of cancer

242 The tumor-promoting fibrotic stroma rich in tumor-associated fibroblasts (TAF) is dra

243 etuximab is bound differently to EGFR in the stroma-rich area than in stroma-poor regions, which was

244 ctivations in the CNN, we calculated a "deep stroma score," which was an independent prognostic facto

245 bined defect in DM and the posterior corneal stroma seemed to consistently elicit a typical corneal h

246 n from sepsis, whereas chimeras with IRF3-KO stroma showed a substantial degree of protection.

247 a and secretory cell lineages, EP4 cKO colon stroma showed enhanced immune cell infiltration, which w

248 scRNA-seq of the mouse tumor stroma showed enrichment of two subsets of myeloid dendr

249 rs for decades, how PDGFB-to-PDGFRbeta tumor-stroma signaling mediates breast cancer initiation, prog

250 tested the hypothesis that polymorphisms in stroma significantly affect tumorigenicity and experimen

251 uppressed prostate tumor growth in mice in a stroma-specific targeted manner.

252 Highest levels are in classical activated stroma subtype.

253 for solid tumors and current advancements in stroma-targeted therapies.

254 ward a more normal physiologic state through stroma-targeting therapy will likely be an instrumental

255 ificantly (p < 0.001) smaller in the central stroma than in the peripheral stroma.

256 review the features of the colorectal tumor stroma that are associated with patient outcomes and dis

257 s posttranslationally, but mechanisms in the stroma that assist their insertion remain largely undefi

258 gated the components of the peritoneal tumor stroma that facilitated nanoparticle-tumor interaction.

259 ifferentiation and cancer progression in the stroma that may be therapeutically targeted.

260 sinophilic deposits in subepithelial corneal stroma that stained negative for Congo-red.

261 y molecular mechanisms operating in the lung stroma that support the development of lung cancer.Metho

262 tion of an extensive vascular network in the stroma that supports embryonic growth and ensures succes

263 carcinoma (PDAC) is associated with fibrotic stroma, the molecular pathways regulating the formation

264 , and describe recent attempts to target the stroma therapeutically.

265 e, which depends on ALL cell adhesion to the stroma through adhesion molecules, including integrins.

266 uired more layers, differentiating them from stroma thylakoids as central chloroplasts matured.

267 no significant difference between cancer and stroma tissue was found.

268 er HCO(3) (-) accumulated in the chloroplast stroma to CAH3 inside the thylakoid lumen.

269 H, rather than SHH, activates the pathway in stroma to drive its tumor suppressive effects-a novel ro

270 subsequently penetrates into the underlying stroma to firmly embed in the endometrium.

271 highlight the important contribution of the stroma to inflammation in pulmonary disease.

272 ey detach from the tumor and migrate through stroma to intravasate.

273 bution from both tumour cells and the tumour stroma to release metastatic cells into the circulation.

274 s-retinoic-acid (ATRA) reprograms pancreatic stroma to suppress pancreatic ductal adenocarcinoma (PDA

275 R1) delivers newly synthesized PAPS from the stroma to the cytosol.

276 s are involved in trafficking MMP-9 from the stroma to the epithelium to promote luminal epithelial r

277 d vascularity index (CVI), and the choroidal stroma-to-vessel volume ratio (CSVR).

278 ering to disrupt these barriers and move the stroma toward normalization using a potent antifibrotic

279 ding organized luminal/glandular epithelium, stroma, vascularized mucosa and two-layered myometrium.

280 T), choroidal vessel volume (CVV), choroidal stroma volume (CSV), choroid vascularity index (CVI), an

281 released by AD-MSC relocated into the tumor stroma was able to significantly counteract tumor growth

282 disease; however, the metastasis-associated stroma was characterized by a highly conserved proteomic

283 ecreased lymphocyte accumulation in adjacent stroma was observed in tumors with low clonal neoantigen

284 ithelial layer, Bowman's layer, and anterior stroma were generated in chick corneas on embryonic day

285 ted lamellae, and keratocytes throughout the stroma were immunopositive for syndecan.

286 PGs area and the density in the central KC stroma were larger than those in the peripheral stroma.

287 ior stroma, and a homogenous hyperreflective stroma were seen.

288 We identify GR2 as essential in the plastid stroma, where it counters GSSG accumulation and developm

289 oliferate in the presence of Lose-expressing stroma, which confers a competitive growth advantage on

290 ancers are characterized by a dense fibrotic stroma, which is considered immunosuppressive in multipl

291 ools of ARC3: one distributed throughout the stroma, which presumably fully inhibits Z-ring assembly

292 osits occurred predominantly in the anterior stroma, while in adults, the crystals were mostly locali

293 that is characterized by a primitive myxoid stroma with cystically dilated bile ducts.

294 Nckap1-depleted tumors displayed fibrotic stroma with increased collagen deposition concomitant wi

295 re mostly localized in the posterior corneal stroma with the depth of crystal deposition showing an i

296 were preferentially localized in the tumour stroma, with well-formed clusters of activated B cells i

297 microglia, which are expected to lie in the stroma within or adjacent to the tumours.

298 sheets of decellularized donor human corneal stroma within the stroma of patients with advanced kerat

299 netic heterogeneity of non-tumor cells (i.e. stroma) within the tumor mass; the extent to which copy

300 ate tumor growth by promoting protumorigenic stroma yet concomitantly suppress Wnt expression, which