ライフサイエンスコーパス: stromal

1 ial cells (89.1%) but also immune (6.2%) and stromal (4.7%) cells with distinct cellular proportions

2 morphogenesis in the mammary gland, whereby stromal ACKR2 modulates levels of the shared ligand CCL7

3 vestigated, the sequential events that drive stromal activation and fibrosis by hematopoietic-stromal

4 Markers of stromal activation entirely surrounded pancreatic intrae

5 Thus, IHH induces stromal activation of the canonical Hh signaling pathway

6 Prox1-proficient tumors, it promoted further stromal activation, angiogenesis, and invasion in Prox1-

7 includes extracellular matrix and supporting stromal and endothelial cells that both maintain stem ce

8 hway additionally mediates crosstalk between stromal and endothelial cells via VEGF granules, develop

9 from BM-derived fibrocytes after epithelial-stromal and endothelial-stromal injuries.

10 em, informed by insights into the control of stromal and immune cell functions.

11 ts upregulation in tumor cells as well as in stromal and immune cell subsets within the tumor microen

12 th their tumor microenvironment particularly stromal and immune cells are characterized.

13 actions between cancer cells and surrounding stromal and immune cells through autonomous and non-auto

14 of CRC tumors characterized by expression of stromal and neural associated genes.

15 al spread was demonstrated, involving mainly stromal and vascular endothelial cells within the tissue

16 n aggressive malignancy typified by a highly stromal and weakly immunogenic tumor microenvironment th

17 mpact on the metabolic activities of immune, stromal, and tumor cell types, there is emerging interes

18 t the transmembrane glycoprotein Bone marrow stromal antigen 2 (Bst2) expression was reduced in OASIS

19 these changes followed a robust increase in stromal apoptosis.

20 at generates both thylakoidal APX (tAPX) and stromal APX (sAPX) through alternative splicing.

21 ciated with modifications of the bone marrow stromal architecture through relocalization and increase

22 B segregation and a partially differentiated stromal architecture.

23 Total choroidal area, luminal area and stromal area were all significantly decreased with age (

24 omal features, namely stromal clustering and stromal barrier, which represented the melanoma stromal

25 These findings suggest that stromal beta-catenin activation results in histological

26 be complicated by tumor-associated or normal stromal blood vessels yet its significance may differ fr

27 pecimens reveal a strong correlation between stromal CAF content and MYC protein level in the neoplas

28 CXCL4 ameliorates the MPN phenotype, reduces stromal cell activation and BM fibrosis, and decreases t

29 ith well-characterized biological effects on stromal cell activation, angiogenesis, and osteoclastoge

30 ent exosome populations mediate diversity in stromal cell behavior.

31 l cells alone resulted in tumor formation or stromal cell condensation respectively, without inductio

32 Furthermore, we introduce a mesenchymal stromal cell derived from human olfactory tissue, which

33 tained intracellular pH influence cancer and stromal cell function, their mutual interplay, and their

34 Cationic interfaces elicit stromal cell infiltration, peripherally derived inflamma

35 al irregularity and complexity of the cancer-stromal cell interface significantly increased in tumor

36 ricyte, neuron-astrocyte, and diverse cancer-stromal cell pairs.

37 differentiation of a unique IL-33-producing stromal cell population specific to the male VAT, which

38 progression; however, genetic alterations in stromal cell populations remain largely unexplored.

39 ent genetic alterations in colorectal cancer stromal cell populations.

40 actions between malignant cells and a single stromal cell type, often along a single pathway.

41 c milieu characterises functionally distinct stromal cell types and states, including a subset of imm

42 oid cells and T cells were the most abundant stromal cell types in tumors and adjacent lung tissues.

43 croenvironments (TMEs) together with various stromal cell types.

44 h differing capacities for interactions with stromal cell types.

45 ic vascular endothelial growth factor (VEGF)-stromal cell-derived factor 1 (sdf1) signaling, leading

46 dentify a niche in the neonatal airway where stromal cell-derived insulin-like growth factor 1 (IGF1)

47 ed tumor microenvironment stiffness leads to stromal cell-mediated TGF-beta family signaling relying

48 Moreover, the expression of stromal cell-specific ISLR and ETS1 significantly increa

49 ces (ECM) alone or together with bone marrow stromal cells (BMSC).

50 ghtened osteogenic commitment of bone marrow stromal cells (BMSCs).

51 arget of mouse and human cardiac mesenchymal stromal cells (cMSC) with progenitor-like features.

52 Engraftment of engineered mesenchymal stromal cells (eMSCs) together with CD34(+) HSPCs create

53 Targeting epicardium-derived stromal cells (EpiSC) by specific ligands might enable t

54 Human mesenchymal stromal cells (hMSCs) are a promising source for enginee

55 Lymph node stromal cells (LNSC) are essential for providing and mai

56 We report that BM mesenchymal stromal cells (MSC) undergo massive damage to their mito

57 precursors, abundantly available mesenchymal stromal cells (MSC) were reprogrammed into induced endot

58 tion and migration of endogenous mesenchymal stromal cells (MSCs) are critical for bone regeneration.

59 Multipotent Mesenchymal Stem/Stromal Cells (MSCs) are widely used in cellular therapy

60 eutic potential of donor-derived mesenchymal stromal cells (MSCs) has been investigated in diverse di

61 tation of mesenchymal stem cells/multipotent stromal cells (MSCs) has been proposed to augment the re

62 Bone marrow mesenchymal stromal cells (MSCs) have been studied for decades as po

63 roaches aim to infuse allogeneic mesenchymal stromal cells (MSCs) to provide a more generalized treat

64 r studies that have transplanted mesenchymal stromal cells (MSCs) without co-administration of a hema

65 Here, we show that Gli1(+) mesenchymal stromal cells (MSCs), previously shown to contribute to

66 leukin (IL)-33 produced by local mesenchymal stromal cells (mSCs).

67 l therapy with human bone marrow mesenchymal stromal cells (MSCs).

68 cell populations, primarily mesenchymal stem/stromal cells (MSCs).

69 contains chondrocytes (OAC) and mesenchymal stromal cells (OA-MSC).

70 nd, importantly, subtypes of VAT mesenchymal stromal cells (VmSCs) that are either immunomodulators o

71 ring vessel-forming cells (human mesenchymal stromal cells [MSCs] and endothelial colony-forming cell

72 rast, Hh-pathway activation in epithelial or stromal cells alone resulted in tumor formation or strom

73 fferentiation stages of H3.3 WT and H3.3 MUT stromal cells and add to H3.3-G34W-associated changes.

74 ed CXCL12 expression in vivo and in vitro in stromal cells and CXCL12 increased stromal migration and

75 Stromal cells and especially cancer-associated fibroblas

76 ting complex interactions among tumor cells, stromal cells and immune infiltrates in the TME.

77 ndings support the immunosuppressive role of stromal cells and T-cell exclusion within the vicinity o

78 ts required simultaneous engagement with OP9 stromal cells and were also stage-specific, with NOTCH1

79 Indeed, when preimplantation endometrial stromal cells are exposed to hypoxic conditions in vitro

80 owever, lineage relationships within cardiac stromal cells are poorly defined.

81 of mice expressing PDGFRbeta(D849V) in their stromal cells as a preclinical model of breast cancer-as

82 ing, we identified Ccl19-Cre(+) fibroblastic stromal cells as critical sources of Delta-like ligands

83 Here we use bone marrow stromal cells as sensors of age-associated changes to th

84 (Hif2alpha), which is induced in subluminal stromal cells at the time of implantation, plays a cruci

85 With implantation, mouse stromal cells begin to transform into epithelial-like ce

86 at carry signaling molecules, from senescent stromal cells can promote tumorigenesis and multidrug re

87 , we found that Gli1(+) PMCs are a subset of stromal cells characterized by active hedgehog signaling

88 c erythroid progenitor cells and mesenchymal stromal cells contribute directly and indirectly to both

89 Tumor and stromal cells cooperated in forming niches; stromal cell

90 Mineralization of WT bone marrow stromal cells cultured with conditioned medium from Hdac

91 Mesenchymal stromal cells did not alter clinical score or survival r

92 ine neurotransmitters and dietary amines, in stromal cells elevates production of reactive oxygen spe

93 the tumour and/or the associated immune and stromal cells enables the dissection of tumour heterogen

94 We find that mesenchymal stromal cells engineered to express membrane-bound FLT3L

95 is in DeltaNC16A mice is through bone marrow stromal cells evidenced by bone marrow transplantation.

96 nt cell tumors of bone where patient-derived stromal cells exhibit gene expression profiles associate

97 ibition of NOTCH1 activity suppresses cancer/stromal cells expansion.

98 Both secretory epithelial and stromal cells expressed Ki67 that was detectable at day

99 retion of ECM protein fibronectin (FN) by BM stromal cells from PMF patients correlates with fibrosis

100 We show that in patient-derived stromal cells H3.3-G34W is incorporated into the chromat

101 K/STAT activation in both megakaryocytes and stromal cells in 3 murine PMF models.

102 p sinuses, T cells latched onto perivascular stromal cells in a manner that was independent of the ch

103 tment and activity of immune cells and other stromal cells in breast cancer remain poorly understood.

104 Deletion of Islr in stromal cells in mice markedly impaired intestinal regen

105 atic aberrations, infiltration of immune and stromal cells in proportions correlated with tumor stage

106 e phenotypic and functional heterogeneity of stromal cells in tumors.

107 lymphoid organs are aggregates of immune and stromal cells including high endothelial venules and lym

108 og (Hh) signaling in adjacent epithelial and stromal cells induces new HFs in adult, unwounded dorsal

109 The transition of synovial stromal cells into autoaggressive effector cells convert

110 Mesenchymal stromal cells mitigated these cognitive and behavioral a

111 The neoplastic stromal cells of giant cell tumor of bone (GCTB) carry a

112 mors tend to be Pfn1-positive selectively in stromal cells only.

113 stromal cells cooperated in forming niches; stromal cells produced predominantly core, structural EC

114 ccharide, conditioned media from mesenchymal stromal cells reduced astrogliosis, interleukin-1beta, a

115 In response to tissue injury, stromal cells secrete extracellular matrix (ECM) compone

116 Stromal cells serve as critical components of the hemato

117 ve skin cell atlas, including epithelial and stromal cells such as fibroblasts, vascular, and immune

118 rsible damage to a population of tolerogenic stromal cells that display peripheral tissue-restricted

119 transcriptional responses in epithelial and stromal cells that interface with the luminal contents o

120 helium ISLR-YAP signaling axis essential for stromal cells to modulate epithelial cell growth during

121 thetic and sensory) interact with tumour and stromal cells to promote the initiation and progression

122 major impact on the capacity of endometrial stromal cells to recruit CD8 cells.

123 Tumor and stromal cells together create distinct ECM niches in bre

124 In addition, tumor and stromal cells together created distinct niches in each t

125 In human PSC, inflammatory and stromal cells trigger PBG activation through the up-regu

126 r progression and metastasis, both tumor and stromal cells undergo rapid metabolic adaptations.

127 tiousness/propagation in human term decidual stromal cells versus trophoblasts.

128 Stromal cells were cultured from human corneas (HCSC) an

129 f tumors of diverse histotypes and increased stromal cells within the tumor microenvironment.

130 prises different, heterogenous compartments; stromal cells within those compartments might have uniqu

131 of ECM deposition, sustained Ki67 levels in stromal cells, and a persistent M2 macrophage response t

132 acting cell types, particularly endothelium, stromal cells, and innate leukocytes.

133 ncluding myogenic stem and progenitor cells, stromal cells, and pluripotent stem cells, have been inv

134 izes its compositional pattern of immune and stromal cells, and reveals S100A8/A9 to be a novel bioma

135 r functionally specialized subpopulations of stromal cells, and, most notably, two distinct populatio

136 that disrupt ER homeostasis in malignant and stromal cells, as well as infiltrating leukocytes.

137 but hallmark features include immune cells, stromal cells, blood vessels, and extracellular matrix.

138 uggests that, together with nonhematopoietic stromal cells, bone marrow (BM) immune cells with unique

139 d extracellular circuits either in cancer or stromal cells, including immune cells, endothelial cells

140 plex mixture of tumor cells and nonmalignant stromal cells, including neurons, astrocytes, microglia,

141 upon damage and is expressed in mesenchymal stromal cells, macrophages, and Paneth cells.

142 ompared with the bulk matrix, mostly made by stromal cells, precise interventions targeting cancer ce

143 Tumor-infiltrating stromal cells, which include macrophages/microglia, cont

144 ay positively correlated with the density of stromal cells.

145 ls without altering viability of bone marrow stromal cells.

146 se contacts with SCF-expressing perivascular stromal cells.

147 well as in vitro-cultured human mesenchymal stromal cells.

148 enetically abnormal cancer cells with normal stromal cells.

149 gnaling, suggesting involvement of nonimmune stromal cells.

150 ialized microenvironments created by sessile stromal cells.

151 indicated Pfn1 positivity in both tumor and stromal cells; however, the vast majority of ccRCC tumor

152 Thymocyte numbers fell subsequent to the stromal changes.

153 Stromal choroid plexus BAMs are also considerably reduce

154 ereas the arrival of cephalic mesenchyme and stromal choroid plexus BAMs was only partially restricte

155 rea (TCA), luminal choroidal area (LCA), and stromal choroidal area (SCA) were analyzed.

156 but showed strong genetic interactions with stromal CLP protease system mutants, resulting in reduce

157 Tumors with increased stromal clustering and barrier were associated with redu

158 oach identified two stromal features, namely stromal clustering and stromal barrier, which represente

159 As the size and organisation of stromal collagen is closely associated with the optical

160 ool for studying organogenesis, cell-to-cell stromal communication and disease.

161 Thus, IRF3 acts principally within the stromal compartment to exacerbate sepsis pathogenesis vi

162 expression in the BM is restricted to the BM stromal compartment where it regulates the HSC niche.

163 that low FAK expression, specifically in the stromal compartment, predicts reduced overall survival.

164 Epithelial and stromal compartments of 23 ICCs were laser microdissecte

165 related proteins in tumor epithelial versus stromal compartments of patient-derived TNBCs (N = 10) u

166 dothelial, mesenchymal and epithelial thymic stromal compartments, mimicking changes seen during earl

167 cation between tumor cells and heterogeneous stromal components in primary and metastatic TMEs and di

168 dney, consisting of blastema, epithelial and stromal components, suggesting tumors arise from the dys

169 uggest molecular and functional diversity of stromal components.

170 s in multiple ratios to mimic variable tumor-stromal compositions and to investigate nanoparticle pen

171 changes in permeability in trophoblasts and stromal cores using a dextran-based fluorescence assay a

172 mal activation and fibrosis by hematopoietic-stromal cross-talk remain elusive.

173 n PC chemoresistance via bidirectional tumor-stromal crosstalk.

174 difying the cytokine profile produced by the stromal/decidual cells.

175 These data establish stage-specific and stromal-dependent roles for Notch in regulating human NK

176 ales and is characterized by acute bilateral stromal depigmentation, without other pathologic ocular

177 The acute attacks and chronic stromal deposits mainly involve the anterior to middle l

178 We find that erythropoietin (EPO) and stromal derived factor-1alpha can attract PCa in vitro.

179 ating siRNA sequences targeting the proteins stromal-derived factor 1 (Sdf1) or monocyte chemotactic

180 with MCD and in those undergoing PK for this stromal dystrophy.

181 Our results show that stromal ecology correlates directly with tumour growth b

182 incomplete and that incorporating markers of stromal ecology would improve prognosis.

183 ally independent PCa may be a result of poor stromal ecology, supporting the concept that purely tumo

184 al determinant of this aggressiveness is the stromal ecology, which can be either inhibitory, highly

185 urvival and pro-death pathways in malignant, stromal, endothelial and immune cells, hence causing a p

186 st TRXs as well as in the rapid oxidation of stromal enzymes upon darkness.

187 ictions fit biological expectations, showing stromal expansion, a reduction of normal acinar tissue,

188 Stromal expression of PDGFRbeta(D849V) also promoted bra

189 at patients with pancreatic cancer with high stromal expression of Prrx1 display the squamous, most a

190 in localization in the endothelium or in the stromal extracellular matrix as well as the frequency of

191 ity gradients, even after RNase treatment of stromal extracts.

192 cpSRP43 is activated by a stromal factor, cpSRP54, to more effectively capture and

193 This approach identified two stromal features, namely stromal clustering and stromal

194 othelial cell HA receptor-1, HA receptors on stromal fibroblasts and Hofbauer macrophages in villous

195 morphology to delineate carcinoma cells from stromal fibroblasts and that quantitates the individual

196 criptional programs in both cancer cells and stromal fibroblasts and ultimately undermines the effica

197 Our data uncover mechanisms whereby stromal fibroblasts regulate cancer cell metabolism inde

198 Stromal fibroblasts represent an abundant cell type in t

199 Microbeads containing endothelial cells and stromal fibroblasts were pre-cultured for 3 days in vitr

200 s the interaction between melanoma cells and stromal fibroblasts, suggesting that TRAF6 is a potentia

201 y T cells, as well as monocytes, B cells and stromal fibroblasts.

202 a widespread decidualization feature in the stromal fibroblasts.

203 ns' attraction within a layer and across the stromal gap, steric repulsion across the lumenal gap, an

204 Stromal heterogeneity in human triple-negative breast ca

205 Provocatively, adjacent epithelial-stromal Hh-pathway activation induced de novo HFs also i

206 to human disease, we find high activation of stromal HSF1 in CAC patients, and detect the HSF1-depend

207 d to classify cells in the H&E specimen into stromal, immune, or cancer cells.

208 alling predictions, we provide evidence that stromal-immune crosstalk acts via a diverse array of imm

209 conducted spatially explicit analyses of the stromal-immune interface across 400 melanoma hematoxylin

210 ased in a subgroup characterized by distinct stromal infiltration.

211 tes after epithelial-stromal and endothelial-stromal injuries.

212 with the endoplasmic reticulum Ca(2+) sensor stromal interaction molecule 1 (STIM1) in response to st

213 Stromal interaction molecule 1 (STIM1) is a calcium sens

214 The Ca2+ sensor stromal interaction molecule 1 (STIM1) triggers SOCE by

215 culum (ER) Ca(2+) stores, which is sensed by stromal interaction molecule 1 (STIM1).

216 in the plasma membrane and are activated by stromal interaction molecules (STIM) located in the endo

217 The Orai1 channel is regulated by stromal interaction molecules STIM1 and STIM2 within end

218 alk, with potential pathologic epithelial-to-stromal interactions.

219 which the hydrogels were formed in situ over stromal keratectomy wounds without sutures showed that t

220 g immunoinflammatory condition called herpes stromal keratitis (HSK), which involves the loss of corn

221 The time from randomization to resolution of stromal keratitis and uveitis was significantly shorter

222 ecurrent diseases, such as blinding herpetic stromal keratitis.

223 a, myofibroblasts are derived primarily from stromal keratocytes and from BM-derived fibrocytes after

224 ecific criteria as persistent or progressive stromal keratouveitis or an adverse event) was significa

225 Overall, our results demonstrated that stromal Lama5 regulated immune responses through alterin

226 This study delineated a stromal Lama5-T cell receptor axis that can be targeted

227 divided into the stacked grana and unstacked stromal lamellae domains.

228 recruitment of LHCII already residing in the stromal lamellae into PSI-LHCII supercomplexes upon its

229 ed irregular orientation and organization of stromal lamellae, with the presence of macrophages whose

230 ale migration of LHCII from the grana to the stromal lamellae.

231 lasticity is also observed in the N-terminal stromal loop and in protein fragments facing the lumen,

232 cell-derived danger signal mediators thymic stromal lymphopoietin (TSLP) and IL-33 are consistently

233 Thymic stromal lymphopoietin (TSLP) is an epithelial-derived cy

234 -C motif chemokine ligand 26 (CCL26), thymic stromal lymphopoietin (TSLP), Charcot-Leyden crystal (CL

235 ing inflammation via the induction of thymic stromal lymphopoietin (TSLP).

236 uited to inflamed skin via CXCL12 and thymic stromal lymphopoietin (TSLP)/IL-3-dependent upregulation

237 Thymic stromal lymphopoietin and IL-33 signaling reciprocally e

238 onses, along with increased IL-36 and thymic stromal lymphopoietin expression, which were further hei

239 e responses such as IL-25, IL-33, and thymic stromal lymphopoietin, and increasing the epithelial bar

240 miR-1 recruited P-selectin, thymic stromal lymphopoietin, eotaxin-3, and thrombopoietin rec

241 approaches, we identify a distinct resident stromal macrophage subpopulation within the mouse nullip

242 Downstream of stromal MAOA, STAT3 also promotes cell stemness and tran

243 between individual pairs of proteins of the stromal MAOA-induced Twist1/IL-6/STAT3 pathway in clinic

244 t is resistant to apoptosis, degrades normal stromal matrix and is replaced with a fibrotic matrix st

245 Whether the stromal ME is damaged and how it recovers after irradiat

246 Host stromal ME recovery and donor HSPC engraftment were augm

247 HSPC transfer functional mitochondria to the stromal ME, thus improving mitochondria activity in reci

248 ed because of the recovery of the supportive stromal ME.

249 oviding insights into how alterations in the stromal microenvironment may play an active role in tumo

250 omal barrier, which represented the melanoma stromal microenvironment.

251 e of tumor cell lineage in reprogramming the stromal microenvironment.

252 vitro in stromal cells and CXCL12 increased stromal migration and the number of BCR-ABL blasts.

253 traxin 3 levels over various cycles indicate stromal modulation.

254 Cpn60 was present in excess of cpSecA1, the stromal motor of the cpSec1 translocon that inserts unfo

255 pre- and posttreatment of observed anterior stromal necrosis (ASN) after long-term Intacs intracorne

256 ients, along with altered features of the BM stromal niche.

257 also the generation of distant ECM-enriched stromal niches in vivo.

258 With recurring attacks, central oval stromal opacities accumulated.

259 lial hyperplasia, fibroplasia, inflammation, stromal overgrowth, and intraductal cancer-like lesions.

260 The equilibrium stromal oxygen concentration under atmospheric oxygen at

261 ecific immune cells, diverse haematopoietic, stromal, parenchymal and neuronal cell types can store i

262 Computational histology-based stromal phenotypes within the tumor microenvironment are

263 er (CRC) patients negatively correlates with stromal PKCzeta levels.

264 l progenitors were associated with decreased stromal progenitor performance related to connective tis

265 epatobiliary metastasis and stemness, unique stromal properties, and dysfunctional intratumoral immun

266 Understanding the mechanisms regulating stromal recovery after myeloablative stress are of high

267 tion while in vivo AMPK inhibition increased stromal recovery.

268 e of the anterior stroma and a heterogeneous stromal reflectivity were observed.

269 somal ECM deposition not only promotes local stromal remodeling but also the generation of distant EC

270 ects that drive proper epithelialization and stromal remodeling of the wounded area without the need

271 Deep stromal/ring infiltrate was associated with single-file

272 Stromal rubbing confirmed that TPMDs do occur following

273 utamyl peptidase (CGEP) is a homo-oligomeric stromal Ser-type (S9D) peptidase with both exo- and endo

274 ous observations of vesicles adjacent to the stromal side of the inner envelope membrane of the chlor

275 ysis identified the phenotypes of tumour and stromal single cells, their organization and their heter

276 We showed that these stromal states have distinct morphologies, spatial relat

277 eir effects on the differentiation of limbal stromal stem cells to keratocytes or fibroblasts and the

278 o the dysfunction of bone marrow mesenchymal stromal/stem cells (MSCs) during aging.

279 sity supported a causal relationship between stromal stiffness, reduced miR-203, higher levels of the

280 bricate optimal construct that simulates the stromal structure with properties most similar to the na

281 tively in CAFs, drawing interest in FAP as a stromal target.

282 orly understood, limiting the development of stromal-targeted therapies.

283 able PDAC (n = 27), ATRA is re-purposed as a stromal-targeting agent in combination with gemcitabine-

284 ay benefit from antifibrotic drugs targeting stromal TGFbeta1/SMAD3.

285 Corneas with a minimum stromal thickness <375 mum were excluded.

286 Gastrointestinal stromal tumor (GIST) is the most common human sarcoma an

287 In advanced gastrointestinal stromal tumor (GIST), there is an unmet need for therapi

288 , renal cell carcinoma, and gastrointestinal stromal tumor.

289 he targeting and therapy of gastrointestinal stromal tumors (GIST) using nonsticky and renal clearabl

290 tients with oligometastatic gastrointestinal stromal tumors (GIST).

291 ectable PDGFRA D842V-mutant gastrointestinal stromal tumour regardless of previous therapy or gastroi

292 ing knowledge regarding the gastrointestinal stromal tumour treatment paradigm, it was decided by the

293 less of previous therapy or gastrointestinal stromal tumour with other mutations that either progress

294 retrospective clinical-pathological data on stromal tumour-infiltrating lymphocytes, PAM50 subtypes,

295 e in patients with advanced gastrointestinal stromal tumours who were resistant to approved treatment

296 n adenocarcinoma, lymphoma, gastrointestinal stromal tumours, Crohn's disease, and groove pancreatiti

297 reviously treated, advanced gastrointestinal stromal tumours.

298 for patients with advanced gastrointestinal stromal tumours.

299 dvanced PDGFRA D842V-mutant gastrointestinal stromal tumours.

300 patients with unresectable gastrointestinal stromal tumours.

301 RAIL was equally expressed in adipocytes and stromal vascular fraction (SVF), TL1A was mainly express