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1 mote repair and regeneration in concert with stromal cell derived factor.
2 or CXCR4 to induce chemotaxis in response to stromal cell derived factor 1 and abolished the activati
3 (P = 0.04), stem cell factor (P = 0.05), and stromal cell-derived factor 1 (P = 0.03) compared to tho
4 nished hypoxia response, including decreased stromal cell-derived factor 1 (P<0.005) and vascular end
5 cells express alpha-smooth muscle actin and stromal cell-derived factor 1 (SDF-1) and are tumorigeni
6 study was to analyze the role of a chemokine stromal cell-derived factor 1 (SDF-1) and its receptor C
7 bular joint (TMJ) and to explore the role of stromal cell-derived factor 1 (SDF-1) and regulated on a
8 ation-dependent chemotaxis to their ligands, stromal cell-derived factor 1 (SDF-1) and VCAM-1, which
10 hibit significantly enhanced chemotaxis to a stromal cell-derived factor 1 (SDF-1) gradient and adher
11 the chemokine receptor CXCR4 by its agonist stromal cell-derived factor 1 (SDF-1) has been associate
12 wn that T cells move away from the chemokine stromal cell-derived factor 1 (SDF-1) in a concentration
15 ic chondrocytes, while its ligand, chemokine stromal cell-derived factor 1 (SDF-1) is expressed in th
18 scular endothelial growth factor (VEGF), and stromal cell-derived factor 1 (SDF-1) than cells from un
20 ndertaken to investigate the hypothesis that stromal cell-derived factor 1 (SDF-1), a CXC chemokine (
22 opoietic progenitors, it (1) potentiates the stromal cell-derived factor 1 (SDF-1)-dependent chemotax
23 dly and dose-dependently inhibited basal and stromal cell-derived factor 1 (SDF-1)-induced BMC migrat
24 ween GPI+ and GPI(neg) NK cells and impaired stromal cell-derived factor 1 (SDF-1)-induced chemotaxis
26 tumor cells through their ability to secrete stromal cell-derived factor 1 (SDF-1); CAFs promote angi
27 ating evidence indicates that interaction of stromal cell-derived factor 1 (SDF-1/CXCL12 [CXC motif,
29 he hypothesis that chemokines in general and stromal cell-derived factor 1 (SDF-1; CXCL12) in particu
32 CD20 is directly upregulated by CXCR4 ligand stromal cell-derived factor 1 (SDF-1alpha, CXCL12) produ
33 afish has shown that the interaction between stromal cell-derived factor 1 (SDF1) and its G-protein-c
35 ic vascular endothelial growth factor (VEGF)-stromal cell-derived factor 1 (sdf1) signaling, leading
36 o the tumor invasive fronts and secretion of stromal cell-derived factor 1 (SDF1) that triggered tumo
37 1-deficient MKs in response to a gradient of stromal cell-derived factor 1 (SDF1), a major chemokine
38 nly in muscles atrophying because of cancer: stromal cell-derived factor 1 (SDF1), adenylate cyclase
39 C chemokine ligand 12 (CXCL12, also known as stromal cell-derived factor 1 [SDF-1]), a chemokine prev
40 on 1 (PLCepsilon1) as a crucial regulator of stromal cell-derived factor 1 alpha (SDF-1alpha)-induced
41 hic factor (GDNF), sonic hedgehog (Shh), and stromal cell-derived factor 1 alpha (SDF1alpha), providi
42 that interactions between the CXC chemokine stromal cell-derived factor 1 and its receptor CXC chemo
43 ith significantly upregulated mRNA levels of stromal cell-derived factor 1 and platelet-derived growt
44 rain derived neurotrophic factor (BDNF), and stromal cell-derived factor 1 and promoted neurite outgr
45 many T lymphocytes migrate away than towards stromal cell-derived factor 1 and their directional migr
46 eased vascular endothelial growth factor and stromal cell-derived factor 1 expression in fibroblasts;
47 s provided suggesting that downregulation of stromal cell-derived factor 1 expression in the bone mar
48 ng osteogenic differentiation and decreasing stromal cell-derived factor 1 in the bone marrow that fa
50 rn to that of CD34(+) cells, and opposite to stromal cell-derived factor 1 plasma levels and correspo
51 ced molecule 1 ligand chemokine) and CXCL12 (stromal cell-derived factor 1) have not been established
52 inting to the potential role of a chemokine (stromal cell-derived factor 1) in lymphomagenesis, and s
53 Recent progress has implicated CXCR4-SDF1 (stromal cell-derived factor 1) signaling in regulating n
54 ested the hypothesis that blockade of SDF-1 (stromal cell-derived factor 1), a key stem cell mobilize
56 Chemokines such as CXCL12, previously called stromal cell-derived factor 1, are known to activate cel
57 <em>CXCL12</em>, which encodes a chemokine, stromal cell-derived factor 1, that is expressed in card
58 and increased renal expression of its ligand stromal cell-derived factor 1, thus favoring mobilizatio
59 actors, transforming growth factor alpha and stromal cell-derived factor 1, was not affected by 100 p
60 sustained delivery of a synthetic analog of stromal cell-derived factor 1-alpha (engineered stromal
62 cell subsets revealed that migration toward stromal cell-derived factor 1/CXC ligand 12 (SDF-1/CXCL1
63 sed CXCR4-mediated chemotaxis in response to stromal cell-derived factor 1/CXCL12 and abolished the p
65 hypoxic preconditioning are mediated by the stromal cell-derived factor 1/CXCR4 axis, and that thera
67 hematopoietic compartment is associated with stromal cell-derived factor 1/CXCR4-dependent vasculogen
68 onstitutively expressed in the CNS (known as stromal cell-derived factor 1; SDF-1), regulates cleavag
69 r adhesion molecule 1; interleukin 6 [IL-6]; stromal cell-derived factor 1; tissue inhibitor of metal
70 tor-alpha; chemokine (C-X-C motif) ligand 1; stromal cell-derived factor 1; transforming growth facto
72 t examples of positive and negative signals: stromal-cell derived factor 1 (Sdf1/Cxcl12) and class3-S
73 molecule E-selectin and the chemoattractant stromal-cell-derived factor 1 (SDF-1) in discrete, disco
74 selective activation of chemokines, such as stromal-cell-derived factor 1 (SDF-1), macrophage inflam
76 fibroblasts to secrete much higher levels of stromal-cell-derived factor 1 and vascular endothelial g
80 The C-X-C chemokine receptor type 4 (CXCR4)/stromal cell derived factor-1 (SDF-1 or CXCL12) interact
82 ypoxia-inducible factor-1alpha (HIF-1alpha), stromal cell derived factor-1 (SDF-1), matrix metallopro
83 The chemokine receptor CXCR4 and its ligand, stromal cell derived factor-1 alpha (SDF1 alpha) regulat
86 to activate fibrocytes, probably by inducing stromal cell-derived factor-1 (also termed CXCL12), one
87 ed that GC T cells would actively migrate to stromal cell-derived factor-1 (CXCL12), the CXCR4 ligand
90 ment, where evidence points to the chemokine stromal cell-derived factor-1 (SDF-1 or CXCL12; expresse
92 the interaction between the HIF-1-dependent stromal cell-derived factor-1 (SDF-1) and its receptor,
94 ression of both the EPC mobilizing chemokine stromal cell-derived factor-1 (SDF-1) and of vascular ep
108 Based on a short hairpin RNA library and stromal cell-derived factor-1 (SDF-1) migration screenin
110 tion of chemokines, the role of signaling by stromal cell-derived factor-1 (SDF-1) through its recept
111 ly and reversibly antagonizes the binding of stromal cell-derived factor-1 (SDF-1) to its receptor CX
114 higher plasma levels of the chemokine CXCL12/stromal cell-derived factor-1 (SDF-1) were achieved in a
115 eta-1, can strikingly stimulate secretion of stromal cell-derived factor-1 (SDF-1), also known as CXC
116 flammatory mediators, such as the chemokine, stromal cell-derived factor-1 (SDF-1), and factors that
117 ), a HIF-1alpha-independent up-regulation of stromal cell-derived factor-1 (SDF-1), as well as endoth
118 stology and immunohistochemical detection of stromal cell-derived factor-1 (SDF-1), beta-actin, vascu
119 receptor 4 (CXCR4), the primary receptor for stromal cell-derived factor-1 (SDF-1), is involved in bo
120 Here, we show that its cognate chemokine, stromal cell-derived factor-1 (SDF-1), promotes the surv
122 endent cytokine transcription in response to stromal cell-derived factor-1 (SDF-1), the sole chemokin
124 stimulated immature B cells are defective in stromal cell-derived factor-1 (SDF-1)-induced calcium mo
125 al evaluation, 32 efficiently inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulatio
127 r pathway may participate, together with the stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine re
129 cells were found to upregulate production of stromal cell-derived factor-1 (SDF-1)/CXCL12 in human fi
130 ween the upregulation of the chemoattractant stromal cell-derived factor-1 (SDF-1)/CXCL12 in the inju
133 between the chemokine receptor 4 (CXCR4) and stromal cell-derived factor-1 (SDF-1, also known as CXCL
139 CXCR4 is a chemokine receptor that binds stromal cell-derived factor-1 (SDF-1; also known as CXCL
140 chemokine receptor 4 (CXCR4) and its ligand, stromal cell-derived factor-1 (SDF-1alpha or CXC chemoki
144 marrow by vascular endothelial growth factor-stromal cell-derived factor-1 (VEGF-sdf-1) signaling pro
146 R7 by their shared cognate chemokine ligand (stromal cell-derived factor-1 [SDF-1]) in Stx-mediated p
147 4) for the chemokine (C-X-C motif) ligand 12/stromal cell-derived factor-1 alpha (CXCL12/SDF-1 alpha)
148 ted by the chemokine (C-X-C motif) ligand 12/stromal cell-derived factor-1 alpha (CXCL12/SDF-1) via t
149 ross TNF-treated EC monolayers overlaid with stromal cell-derived factor-1 alpha (SDF-1 alpha) and su
150 ence stimulates proliferation, survival, and stromal cell-derived factor-1 alpha (SDF-1 alpha)-induce
151 ed chemotactically to their cognate ligands, stromal cell-derived factor-1 alpha and secondary lympho
152 t to be involved in hemopoietic cell homing, stromal cell-derived factor-1 and its receptor CXC chemo
153 imals have increased chemotactic response to stromal cell-derived factor-1 and macrophage-inflammator
155 Like hemopoietic cell homing, levels of stromal cell-derived factor-1 are high at sites of breas
158 ically associate and form a heterodimer upon stromal cell-derived factor-1 or CXCL12 (SDF-1) stimulat
159 ophic effects of mesenchymal stem cell (MSC) stromal cell-derived factor-1 release on the effects of
161 e of adhesion molecules, CXC receptor 4, and stromal cell-derived factor-1 signaling pathway in the r
162 ediated by E-selectin and can be enhanced by stromal cell-derived factor-1 under different wall shear
163 ue repair and suggest that overexpression of stromal cell-derived factor-1 via gene therapy is a stra
166 d CXCR4 (specific receptor for CXC chemokine stromal cell-derived factor-1) in CLL cells of a patient
167 n-1 receptor 2, programmed cell death-1, and stromal cell-derived factor-1) pathways, as was histolog
169 n-1 receptor 2, programmed cell death-1, and stromal cell-derived factor-1) with consequent myocardia
170 cent staining showed higher numbers of CD31+ stromal cell-derived factor-1+, chemokine receptor type
171 n CXCR4, which binds the chemokine CXCL12 or stromal cell-derived factor-1, a chemokine that has been
172 scular endothelial growth factor-A [VEGF-A], stromal cell-derived factor-1, and matrix metalloproteas
173 n expressions of mitochondrial cytochrome c, stromal cell-derived factor-1, C-X-C chemokine receptor
174 ein 7, macrophage colony-stimulating factor, stromal cell-derived factor-1, tissue inhibitor of metal
175 roblast growth factor, stem cell factor, and stromal cell-derived factor-1, whereas SVPs release high
176 cally augmented along with downregulation of stromal cell-derived factor-1-degrading enzyme dipeptidy
181 e chemokine (SLC)/CC ligand (CCL)21), CXCR4 (stromal cell-derived factor-1/CXCL12), and CXCR5 (B cell
182 in response to the chemokines MIP-3beta and stromal cell-derived factor-1; and 3) significantly incr
183 beta 1-integrin ligand fibronectin regulated stromal-cell derived factor-1 (SDF-1) activation of ERK.
184 ent evidence demonstrates that the chemokine stromal-cell derived factor-1 (SDF-1, also known as CXCL
186 11, leukemia inhibitory factor (LIF), gp130, stromal cell derived factor-1a (SDF-1a), and thrombopoie
187 MKP-1-null mice had higher levels of plasma stromal cell-derived factor-1a, which negatively correla
189 of vascular endothelial growth factor D and stromal cell-derived factor 1alpha (P = .037 and .025, r
192 CXCR4 is the receptor for the chemokine stromal cell-derived factor 1alpha (SDF-1alpha) and elic
193 tor for the normal physiological function of stromal cell-derived factor 1alpha (SDF-1alpha) and the
194 gration toward formyl-Met-Leu-Phe (fMLP) and stromal cell-derived factor 1alpha (SDF-1alpha) as well
195 s the ability to cleave the chemokine CXCL12/stromal cell-derived factor 1alpha (SDF-1alpha) at its p
196 droxypropyl-beta-cyclodextrin (BCD) inhibits stromal cell-derived factor 1alpha (SDF-1alpha) binding
198 inhibitors for monocyte migration induced by stromal cell-derived factor 1alpha (SDF-1alpha) or fMLP.
200 otent chemotactic responses to the chemokine stromal cell-derived factor 1alpha (SDF-1alpha), indicat
204 gulating secretion of the angiogenic factors stromal cell-derived factor 1alpha (SDF-1alpha)/CXCL12,
205 y, the migration of MKs toward a gradient of stromal cell-derived factor 1alpha (SDF1alpha) and the f
207 rts have identified a role for the chemokine stromal cell-derived factor 1alpha and its receptor CXC
209 eptor CXCR4 expressed by the CTL and CXCL12 (stromal cell-derived factor 1alpha) secreted by tumor ce
211 cyte growth factor, placental growth factor, stromal cell-derived factor 1alpha, and basic fibroblast
212 s involved in the signaling cascade of IL-2, stromal cell-derived factor 1alpha, and type I interfero
213 is induced by constitutively active Rac1 and stromal cell-derived factor 1alpha-induced ERM dephospho
216 ded EPCs underwent ex vivo modification with stromal cell-derived factor-1alpha (100 ng/mL) to potent
217 and signaling studies with the CXCR4 agonist stromal cell-derived factor-1alpha (chemokine (CXC motif
218 f trans-endothelial migration in response to stromal cell-derived factor-1alpha (CXC chemokine ligand
219 okine receptor CXCR4 and its cognate ligand, stromal cell-derived factor-1alpha (CXCL12), regulate ly
220 lly, exogenous administration of recombinant stromal cell-derived factor-1alpha (SDF) enhances neovas
221 is process, particularly when activated with stromal cell-derived factor-1alpha (SDF), known to be th
224 ignificantly reduce the extent of subsequent stromal cell-derived factor-1alpha (SDF-1alpha [CXCL12])
226 ction by examining chemotaxis in response to stromal cell-derived factor-1alpha (SDF-1alpha) as well
228 through the trophic effects of the chemokine stromal cell-derived factor-1alpha (SDF-1alpha) binding
229 rred after a necessary switch in bone marrow stromal cell-derived factor-1alpha (SDF-1alpha) expressi
231 ression of HIF-1alpha, CXCR4, and its ligand stromal cell-derived factor-1alpha (SDF-1alpha) in heman
235 To investigate the effects of the chemokine stromal cell-derived factor-1alpha (SDF-1alpha) on VLA-4
237 in diabetes is due to decreased wound level stromal cell-derived factor-1alpha (SDF-1alpha), a chemo
238 and plasma levels of its endogenous ligand, stromal cell-derived factor-1alpha (SDF-1alpha), correla
239 otein-coupled receptor for the ligand CXCL12/stromal cell-derived factor-1alpha (SDF-1alpha), plays a
242 ophage inflammatory protein II (vMIP-II) and stromal cell-derived factor-1alpha (SDF-1alpha), were sy
243 we show that the secreted signaling protein stromal cell-derived factor-1alpha (SDF-1alpha), which a
244 appeared additive and distinct from that of stromal cell-derived factor-1alpha (SDF-1alpha), which i
245 s secrete several chemo-cytokines, including stromal cell-derived factor-1alpha (SDF-1alpha), which t
246 Surprisingly, Cdc42 was dispensable for stromal cell-derived factor-1alpha (SDF-1alpha)- or B-ly
247 lls by expression of SPA1 or Rap1GAP blocked stromal cell-derived factor-1alpha (SDF-1alpha)-stimulat
252 the ligand for the CXCR4 chemokine receptor stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12),
253 stration of endothelial progenitor cells and stromal cell-derived factor-1alpha analog) could perform
254 and CSCs further enhanced the production of stromal cell-derived factor-1alpha and vascular endothel
255 neurotoxic natural ligands of CXCR4, such as stromal cell-derived factor-1alpha or viral macrophage i
256 (SMM)-chemokine analogs derived from natural stromal cell-derived factor-1alpha or viral macrophage i
259 rleukin-10, Tumor Necrosis Factor alpha, and stromal cell-derived factor-1alpha were reduced in the i
260 the cognate CXC chemokine receptor 4 ligand stromal cell-derived factor-1alpha were unchanged in bot
261 L5551 inhibited CXCR4 binding to its ligand, stromal cell-derived factor-1alpha, and reduced hypoxia-
262 roteinase (MMP) -2, soluble VEGF receptor 1, stromal cell-derived factor-1alpha, and soluble Tek/Tie2
263 d growth factor, epidermal growth factor, or stromal cell-derived factor-1alpha, but not basic fibrob
265 at, in contrast to the natural CXCR4 ligand, stromal cell-derived factor-1alpha, which promotes the e
267 ived factor-1alpha, and reduced hypoxia- and stromal cell-derived factor-1alpha-mediated migration do
270 CXCR4, a receptor for the chemokine CXCL12 (stromal-cell derived factor-1alpha), is a G-protein-coup
271 that the naturally occurring splice variant stromal cell-derived factor 1gamma/CXCL12gamma is the mo
272 hybrid screen that identified rhesus macaque stromal cell-derived factor 2-like protein 1 (SDF2L1), a
274 omal cell-derived factor 1-alpha (engineered stromal cell-derived factor analog [ESA]) induces contin
275 ic oxide bioavailability/cGMP in response to stromal cell-derived factor and resulted in a decrease i
277 steoglycin, epiregulin, proliferins 2 and 3, stromal cell-derived factor, and cathepsins B, F, and Z.
279 is largely governed by interactions between stromal cell-derived factor (SDF)-1 and CXC chemokine re
280 ered chemokine receptor CXCR7 and its ligand stromal cell-derived factor (SDF)-1 are known to be invo
281 aired mobilization was associated with lower stromal cell-derived factor (SDF)-1 expression levels in
282 esis that pancreatic tissue injury induces a stromal cell-derived factor (SDF)-1 gradient to chemoatt
286 ures based on the differential expression of stromal cell-derived factor (SDF)-1alpha and CXCR4 at th
287 creased vascular deposition of the chemokine stromal cell-derived factor (SDF)-1alpha and medial and
288 that ubiquitin and the cognate CXCR4 ligand stromal cell-derived factor (SDF)-1alpha do not share CX
290 runcated ubiquitin antagonizes ubiquitin and stromal cell-derived factor (SDF)-1alpha induced effects
291 y higher in AMI-SDB patients, whereas plasma stromal cell-derived factor (SDF)-1alpha levels were sig
292 f heme oxygenase (HO)-1 and the secretion of stromal cell-derived factor (SDF)-1alpha were upregulate
293 s binding activity was comparable to that of stromal cell-derived factor (SDF)-1alpha, the only natur
294 used to evaluate ATG-mediated inhibition of stromal cell-derived factor (SDF)-1alpha-driven Jurkat T
296 , interferon-induced protein (IP)-10/CXCL10, stromal cell-derived factor (SDF)-1alpha/CXCLl2, monocyt
297 ptor family of proteins, is the receptor for stromal cell-derived factor (SDF-1 alpha) and is a princ
299 -deficient T cells to the chemokines CXCL12 (stromal cell-derived factor [SDF]-1alpha) and CCL19 (mac
300 n the chemokine receptor CXCR4 is engaged by stromal cell-derived factor (SDF1)alpha, it triggers cel