ライフサイエンスコーパス: stromal interaction molecule

1 In T-lymphocytes, stromal interaction molecule 1 (STIM1) acts as the intra

2 ric, calcium-selective channels activated by stromal interaction molecule 1 (STIM1) after depletion o

3 Upon ER Ca2+ depletion, TRIC-A clusters with stromal interaction molecule 1 (STIM1) and Ca2+-release-

4 ER, a greater degree of interaction between stromal interaction molecule 1 (STIM1) and L-type Ca(2+)

5 Aster-A associated with stromal interaction molecule 1 (STIM1) and negatively re

6 3 enhances the signal-induced association of stromal interaction molecule 1 (STIM1) and Orai1 and is

7 Here, we report that stromal interaction molecule 1 (STIM1) and Orai1 channel

8 We overexpressed stromal interaction molecule 1 (STIM1) and Orai1, the co

9 xpress the two molecular components of SOCE--stromal interaction molecule 1 (Stim1) and Orai1--and ex

10 ulum (ER)-associated Ca(2+)-sensing proteins stromal interaction molecule 1 (STIM1) and STIM2, which

11 ed, whereas the expression of Ca(2+) -sensor stromal interaction molecule 1 (STIM1) and store-operate

12 ditions that induce contacts mediated by the stromal interaction molecule 1 (STIM1) and the Ca(2+) ch

13 the endoplasmic reticulum (ER) Ca(2+) sensor stromal interaction molecule 1 (STIM1) and the Ca(2+) re

14 lcium channel are the Ca(2+)-sensing protein stromal interaction molecule 1 (STIM1) and the channel p

15 the endoplasmic reticulum (ER) Ca(2+) sensor stromal interaction molecule 1 (STIM1) and the plasma me

16 ding the Ca2+ channel ORAI1 or its activator stromal interaction molecule 1 (STIM1) are immunodeficie

17 ORAI1 and stromal interaction molecule 1 (STIM1) are the critical

18 e found that deficiency in the Ca(2+) sensor stromal interaction molecule 1 (STIM1) caused spontaneou

19 Stromal interaction molecule 1 (STIM1) deficiency is a r

20 ls, we bred the 2 Amelx-iCre mice lines with stromal interaction molecule 1 (Stim1) floxed mice to ge

21 Stromal interaction molecule 1 (Stim1) functions as a se

22 Stromal interaction molecule 1 (STIM1) has been identifi

23 Stromal interaction molecule 1 (STIM1) has recently been

24 The stromal interaction molecule 1 (STIM1) has two important

25 A floxed stromal interaction molecule 1 (STIM1) hypomorph mouse m

26 We studied the role of stromal interaction molecule 1 (STIM1) in coupling store

27 rai1 channels, the latter being activated by stromal interaction molecule 1 (STIM1) in response to ER

28 with the endoplasmic reticulum Ca(2+) sensor stromal interaction molecule 1 (STIM1) in response to st

29 Stromal interaction molecule 1 (STIM1) is a Ca(2+) senso

30 Stromal interaction molecule 1 (STIM1) is a Ca(2+)-sensi

31 Stromal interaction molecule 1 (STIM1) is a Ca2+ sensor

32 Stromal interaction molecule 1 (STIM1) is a calcium sens

33 Stromal interaction molecule 1 (STIM1) is a dynamic calc

34 In non-excitable cells stromal interaction molecule 1 (STIM1) is a key element

35 Stromal interaction molecule 1 (STIM1) is a widely expre

36 The stromal interaction molecule 1 (STIM1) is an endoplasmic

37 Stromal interaction molecule 1 (STIM1) is an ER Ca(2+) s

38 Stromal Interaction Molecule 1 (STIM1) is an ER transmem

39 The stromal interaction molecule 1 (STIM1) is an ER-Ca(2+) s

40 Stromal interaction molecule 1 (STIM1) is critical for s

41 asmic reticulum (ER) calcium-sensing protein stromal interaction molecule 1 (STIM1) is critically inv

42 NCE STATEMENT In Purkinje neurons (PNs), the stromal interaction molecule 1 (STIM1) is required for m

43 +) entry mechanism in most cancer cells, and stromal interaction molecule 1 (STIM1) is the endoplasmi

44 Finally, we demonstrate that stromal interaction molecule 1 (Stim1) localizes to ER r

45 d Orai channels activated by their regulator stromal interaction molecule 1 (STIM1) on the ER.

46 ium store depletion, the ER-resident protein stromal interaction molecule 1 (STIM1) physically intera

47 e, we show that Ca(2+) signaling governed by stromal interaction molecule 1 (STIM1) plays a central r

48 Stromal interaction molecule 1 (STIM1) regulates store-o

49 protein ORAI1 or the Ca(2+) sensing protein stromal interaction molecule 1 (STIM1) result in severe

50 ut strict Ca(2+) selectivity or based on the stromal interaction molecule 1 (STIM1) that might crosst

51 the endoplasmic reticulum (ER) Ca(2+) sensor stromal interaction molecule 1 (STIM1) to ER-plasma memb

52 e photoreceptors into modular domains of the stromal interaction molecule 1 (STIM1) to manipulate pro

53 ntration triggers its Ca(2+) ssensor protein stromal interaction molecule 1 (STIM1) to oligomerize an

54 The Ca2+ sensor stromal interaction molecule 1 (STIM1) triggers SOCE by

55 endoplasmic reticulum-resident Ca(2+) sensor stromal interaction molecule 1 (STIM1) with the PMCA4b s

56 re fully reconstituted via two proteins, the stromal interaction molecule 1 (STIM1), a Ca(2+) sensor

57 7)-mediated complex between calreticulin and stromal interaction molecule 1 (STIM1), a protein of the

58 Here, we demonstrate that stromal interaction molecule 1 (STIM1), a sensor of Ca(2

59 amines this issue by focusing on the role of stromal interaction molecule 1 (STIM1), an endo/sarcopla

60 ular myocytes, the physiological function of stromal interaction molecule 1 (STIM1), an endo/sarcopla

61 rexpression of fluorescently tagged RyR2 and stromal interaction molecule 1 (STIM1), an ER Ca(2+) sen

62 Stromal interaction molecule 1 (STIM1), an ER transmembr

63 n, TRPC1 interaction with the SOCE modulator stromal interaction molecule 1 (STIM1), and Ca(2)(+) ent

64 When we knocked out the SOCE gene, stromal interaction molecule 1 (STIM1), it eliminated SO

65 tion of store operated Ca(2+) entry involves stromal interaction molecule 1 (STIM1), localized to the

66 The single-pass transmembrane protein Stromal Interaction Molecule 1 (STIM1), located in the e

67 hannel gating by the CRAC channel activator, stromal interaction molecule 1 (STIM1), remains unknown.

68 found that PMP22 co-immunoprecipitated with stromal interaction molecule 1 (STIM1), the Ca(2+) senso

69 vel truncating mutation in the gene encoding stromal interaction molecule 1 (STIM1), the endoplasmic

70 calcium stores results in the aggregation of stromal interaction molecule 1 (STIM1), the endoplasmic

71 We addressed the requirement for stromal interaction molecule 1 (STIM1), the endoplasmic

72 Oxidant stress triggers relocation of stromal interaction molecule 1 (STIM1), the endoplasmic

73 ticulum (ER) triggers the oligomerization of stromal interaction molecule 1 (STIM1), the ER Ca(2+) se

74 the redistribution of the ER Ca(2+) sensor, stromal interaction molecule 1 (STIM1), to peripheral si

75 of the transmembrane Ca(2+) sensor protein, stromal interaction molecule 1 (STIM1), to the junctions

76 An ER calcium sensor, stromal interaction molecule 1 (STIM1), translocates wit

77 asmic reticulum (ER) calcium-sensing protein stromal interaction molecule 1 (STIM1), which interacts

78 depletion, which redistributes and clusters stromal interaction molecule 1 (STIM1), which then coclu

79 (CRAC)-mediated capacitive Ca(2+) entry, and stromal interaction molecule 1 (STIM1)- and Orai1-defici

80 Stromal interaction molecule 1 (STIM1)-mediated SOCE is

81 via channels composed primarily of Orai1 and stromal interaction molecule 1 (STIM1).

82 culum (ER) Ca(2+) stores, which is sensed by stromal interaction molecule 1 (STIM1).

83 through activation of the ER calcium sensor stromal interaction molecule 1 (STIM1).

84 of secretory pathway Ca(2+)-ATPase (SPCA2), stromal interaction molecule 1 (STIM1)/calcium release-a

85 rated Ca(2+) entry (SOCE) channels formed by stromal interaction molecule 1 (STIM1)/Orai complexes, a

86 We observe that KSR2 deficiency affects stromal interaction molecule 1 (STIM1)/ORAI1 puncta form

87 we examined the role of two Ca(2+) sensors, stromal interaction molecule 1 and 2 (STIM1 and STIM2),

88 y (SOCE) accompanied by the up-regulation of stromal interaction molecule 1 and calcium release-activ

89 I(SkCRAC) was reduced by siRNA knockdown of stromal interaction molecule 1 and expression of dominan

90 -activated Ca(2+) (CRAC) channels encoded by stromal interaction molecule 1 and Orai1 are a major rou

91 from control of the expression level of the stromal interaction molecule 1 and Orai1 proteins.

92 ression of the Ca(2+) sensor protein STIM1L (stromal interaction molecule 1 long isoform) in CTEPH my

93 rotein levels of Orai1, TRPC1, -C4, -C5, and stromal interaction molecule 1 through MR activation.

94 and the endoplasmic reticulum Ca(2+) sensor stromal interaction molecule 1 with CD20 and CD95 into a

95 rophil Cracr2a rapidly interacts with Stim1 (stromal interaction molecule 1) after agonist stimulatio

96 stores, and a second phase involving STIM 1 (stromal interaction molecule 1) clustering and CRAC (cal

97 or activated protein kinase C-1), and STIM1 (stromal interaction molecule 1) interact with Orai1 upon

98 STIM1 (stromal interaction molecule 1) is a calcium (Ca(2+)) se

99 STIM1 (stromal interaction molecule 1) regulates Ca(2+) signali

100 ctly with the coiled-coil 2 domain of Stim1 (stromal interaction molecule 1) via its joining region.

101 In many cells, STIM1 (stromal interaction molecule 1), a single-transmembrane-

102 We found that STIM1 (stromal interaction molecule 1), the main activator of s

103 sion levels of some SOCE components, such as stromal interaction molecule 1, calcium release-activate

104 ce-site mutation in STIM1, the gene encoding stromal interaction molecule 1, which regulates store-op

105 To determine whether stromal interaction molecule 1-dependent (STIM1-dependen

106 766 reduces its binding to the Ca(2+) sensor stromal interaction molecule 1.

107 Many proteins, including stromal interaction molecule 1/2 (STIM1/2), Orai1/2/3, a

108 The endoplasmic reticulum calcium sensors stromal interaction molecules 1 and 2 (STIM1 and STIM2)

109 Stromal-interaction molecule 1 (STIM1) is an endoplasmic

110 Stromal-interaction molecule 1 (STIM1), upon sensing the

111 ore-operated Ca(2+) entry pathway, involving stromal interaction molecule-1 (STIM1) and Orai1, but al

112 n the molecular machinery that mediate SOCE: stromal interaction molecule-1 (STIM1), which functions

113 at the stimulation-induced redistribution of stromal interaction molecule-1, a critical event for the

114 , including the transmembrane proteins Stim (stromal interaction molecule) and Orai.

115 t that mice with T-cell-targeted deletion of Stromal Interaction Molecule (STIM) 1 and STIM2 [double-

116 , ORAI2, and ORAI3 proteins and activated by stromal interaction molecule (STIM) 1 and STIM2.

117 Ca(2+) (CRAC) channels that are activated by stromal interaction molecule (STIM) 1 and STIM2.

118 In line with these observations, the stromal interaction molecule (STIM) 1 and the calcium re

119 dered upon binding, the EF-SAM domain in the stromal interaction molecule (STIM) 1 is distinct in tha

120 a(2+) channel ORAI1 and the ER Ca(2+) sensor stromal interaction molecule (STIM) 1.

121 d by the endoplasmic reticulum Ca(2+) sensor stromal interaction molecule (STIM) 1.

122 Stromal interaction molecule (STIM) 2, but not STIM1, wa

123 In T cells, stromal interaction molecule (STIM) and Orai are dispens

124 AC channel function is the identification of stromal interaction molecule (STIM) and ORAI, two essent

125 The Ca(2+)-sensing stromal interaction molecule (STIM) proteins are crucial

126 + entry signals triggered by the Ca2+ sensor Stromal Interaction Molecule (STIM) proteins of the endo

127 e endoplasmic reticulum (ER) and mediated by stromal interaction molecule (STIM) proteins.

128 has revealed that a calcium-binding protein, stromal interaction molecule (STIM), plays an essential

129 of the store-operated Ca(2+) influx mediator stromal interaction molecule (STIM), the plasma membrane

130 ling mechanism in myogenesis, is mediated by stromal interaction molecule (STIM), which senses the de

131 The stromal interaction molecule (STIM)-ORAI calcium release

132 eins in the plasma membrane and activated by stromal interaction molecule (STIM)1 and STIM2 in the en

133 Orai1 and stromal interaction molecule (STIM)1 are critical compon

134 genetic approaches, we demonstrate that the stromal interaction molecule (STIM)2, a calcium sensor,

135 They are activated by stromal interaction molecules (STIM) 1 and 2 in response

136 in the plasma membrane and are activated by stromal interaction molecules (STIM) located in the endo

137 ontroversy concerning externalization of the stromal interaction molecule STIM1 upon depletion of Ca(

138 The Orai1 channel is regulated by stromal interaction molecules STIM1 and STIM2 within end

139 the endoplasmic reticulum (ER) Ca2+ sensors, stromal interaction molecules STIM1 and STIM2, are key r

140 Stromal interaction molecules (STIM1 and STIM2) are sing

141 Stromal interaction molecules (STIM1, 2) are acting as s

142 identify endoplasmic reticulum (ER)-resident stromal interaction molecules (STIM1/2), which are Ca(2+

143 Stromal interaction molecules, STIM1 and STIM2, sense de

144 Orai channels and the endoplasmic reticulum stromal interaction molecules (STIMs), is a major Ca(2+)