ライフサイエンスコーパス: structural

1 Cardiac structural abnormalities, left ventricular hypertrophy,

2 Herein, we report the structural activity relationships (SARs) and analysis of

3 ney of giraffes and how these functional and structural adaptations are related to very high blood pr

4 sing single-cell and bulk TCR sequencing and structural affinity analyses of cytomegalovirus-specific

5 involve multiple chromosomes and additional structural alterations.

6 Whether exposure to BPA or its structural analogs bisphenol S (BPS) and bisphenol F (BP

7 The orthorhombic phase of GeSe, a structural analogue of layered SnSe (space group: Pnma),

8 Structural analyses of DAD2(N242I) and DAD2(D166A) revea

9 ces in susceptibility with multiple in-depth structural analyses to identify key ACE2 amino acid posi

10 of the protein as we show in biochemical and structural analyses.

11 ing, and to facilitate this process, careful structural analysis beyond the antibody binding site is

12 we present a convenient workflow for cryo-EM structural analysis of MPs embedded in liposomes, using

13 We perform the structural analysis of the ComRS system from S. vestibul

14 Structural analysis of the MvcA-UBE2N-Ub complex reveals

15 examples, we perform the first cross-kingdom structural analysis of the OTU fold that highlights comm

16 Structural analysis suggests that in mUHRF1 V1, in contr

17 protein sequences that are more amenable to structural analysis.

18 prehensively analyze all 10 (structural, non-structural and accessory) proteins from SARS-CoV-2 using

19 perception and elucidate protocadherin-15's structural and adhesive properties relevant in disease.

20 Based on structural and affinity analyses, we designed two cyclic

21 rmacokinetic and pharmacodynamic parameters, structural and behavioral interventions that target wome

22 observed in cells, but in a handful of cases structural and biochemical studies have revealed the mec

23 Now, using NMR-based structural and biological approaches, we have characteri

24 binding site into target macromolecules for structural and biophysical characterization.

25 in these materials can be regulated through structural and compositional engineering from the macros

26 However, the structural and electronic interactions between photochro

27 How these structural and functional brain changes may relate to th

28 We performed repeated structural and functional brain MRI in 108 Barcelona par

29 ling after myocardial infarction (MI) causes structural and functional changes in the heart leading t

30 drupled from 36 to 132, covering much of the structural and functional diversity of endonucleases thr

31 ar topology of the UAF complex, describe new structural and functional domains that play roles in UAF

32 re synthetic molecules that aim to mimic the structural and functional features of biological water c

33 Altogether, our studies provide structural and functional insights into an essential pro

34 Structural and functional MRI showed that ZIKV-infected

35 complementary roles in driving formation of structural and functional network connectivity during ea

36 not proteasomal degradation was critical for structural and functional presynaptic CB(1)-iLTD.

37 These findings, along with the structural and functional rationale for epitope conserva

38 bance of metacommunity hub species with core structural and functional roles for their use in restora

39 and CXCL12 have been the subject of numerous structural and functional studies, but the determinants

40 Our structural and functional study establishes the extracel

41 importance of glia-matrix communication for structural and functional support of the nervous system.

42 ulsivity using a behavioral task, as well as structural and functional underpinnings of waiting impul

43 Structural and geometrical fabrication of these material

44 We also show that these structural and higher-order changes induced by the beta3

45 Biochemical, structural and integrated chromatin immunoprecipitation-

46 The structural and mechanistic comparison herein reported be

47 Structural and optical characterization showed that the

48 undaries, where nanoscale domains with local structural and polar heterogeneity are formed, by tuning

49 protein functions requires insight into the structural and reaction dynamics.

50 e 86 patients, 46 had CMD (28 functional, 18 structural), and 40 patients formed the reference group.

51 Taken together, we have provided genetic, structural, and chemical evidence that Gna1 is an antifu

52 llic nanoparticles can merge the functional, structural, and mechanical properties of the two compone

53 An in silico structural approach based on docking simulations, pharma

54 Our study revealed the potential of a structural approach to inform clinical efforts in target

55 An important structural aspect of [Fe(IV)poat(O)](-) is the inclusion

56 creens and cell biological, biochemical, and structural assays to determine that rigosertib, an anti-

57 n cross section (CCS) values that facilitate structural assignment.

58 plementary strategies to overcome social and structural barriers to HIV care will be required to reac

59 These results constitute the first structural basis and a new model not only for the histor

60 Our work provides a structural basis for active single- and double-ring comp

61 Our results provide a structural basis for selective CYP3A5 inhibition, along

62 aims, our results contribute to a systematic structural basis for the emerging field of quantitative

63 Our work thus offers a solid structural basis for the interpretation of a wide range

64 re of M-808 in complex with menin provides a structural basis for their high-affinity, covalent inter

65 Overall, our studies show the structural basis of AAV Rep's structural flexibility req

66 tructure and have facilitated studies of the structural basis of channel gating.

67 To determine the structural basis of neutralization, we generated cryogen

68 cilitated hydrogen-bonding network forms the structural basis of the unusual LH1 redshift.

69 le CA IX mimetic (CA IX-mimic), revealed the structural basis of this particular inhibition profile a

70 This difference in structural behavior follows directly from hydrogen-bondi

71 elationships between cardiotoxicity risk and structural/binding profiles of individual KIs.

72 rass functional trait values (physiological, structural, biochemical, anatomical, phenological, and d

73 Recent structural, biochemical, and biologic work has shown tha

74 rform phylogenetic, population genetics, and structural bioinformatics analyses.

75 Structural biology is entering an exciting time where ma

76 One of the great ambitions of structural biology is to describe structure-function rel

77 merging tools in a variety of fields such as structural biology, cell imaging, and drug discovery.

78 In structural biology, collision cross sections (CCSs) from

79 , an organism that has resisted conventional structural-biology approaches, to obtain atomic models o

80 dic AD and cognitive decline, and changes in structural brain characteristics, suggesting their usefu

81 Structural brain connectivity of the amygdala, fornix, u

82 rovide a more detailed evaluation of altered structural brain development in newborn infants with CHD

83 etic correlation with each other, with other structural brain features and with AD and schizophrenia.

84 To illustrate the approach, we investigated structural brain-behavior associations in an extensively

85 s in all eukaryotic microorganisms that have structural cell wall cellulose, suggesting expansins evo

86 A discontinuous structural change occurred in which low-density liquid d

87 stological examinations did not reveal major structural changes at proximal sciatic nerve branches or

88 The extent of structural changes experienced by genomes of eukaryotic

89 this approach were translated into striking structural changes for parent and affinity-matured antib

90 arison with known structures, we deconvolute structural changes governing the mammalian 'deactive tra

91 Structural changes in both the peripapillary and macular

92 and DTI captured functional, metabolic, and structural changes in key regions of the learning and se

93 powerstroke myosin suggest that dATP induces structural changes in myosin heads that increase the sur

94 dsRNA binding induces allosteric structural changes in OAS1 that reorganize its catalytic

95 Small structural changes in the axial coordinating linkers res

96 Data characterizing structural changes of arrhythmogenic right ventricular (

97 of the outstanding catalytic activities and structural changes of the materials are not clear, in pa

98 tic collisions with background gas can cause structural changes ranging from unfolding to subunit dis

99 ensity functional theory was used to predict structural changes that occur upon spin transition that

100 different times at pH 5.0 and directly image structural changes using single-particle cryo-electron m

101 photoactivation involves a unique series of structural changes which terminate with an opening of th

102 ate and bicarbonate (both chaotropic) caused structural changes.

103 Hence, it is imperative to study the structural characteristics of this molecule, which will

104 However, fundamental understanding into the structural characteristics responsible for efficient C-C

105 Structural characterization by CryoEM reveals a lipid-in

106 IM-MS) has become a powerful tool for glycan structural characterization due to its ability to separa

107 Herein, we report on the detailed structural characterization of atmospherically relevant

108 and defects, which can only be understood by structural characterization with high spatial 3D resolut

109 fficient quality for further biochemical and structural characterization, as well as for use in consu

110 al oxides (P2-Na(x)TmO(2)) often suffer from structural/chemical transformations when contacted with

111 New structural classes of antibiotics are rare, structurally

112 TIP3P water model, leading to an artificial structural collapse, also resulted in unrealistic relaxa

113 Interestingly, angular-independent structural colors, where isotropy in the scattering stru

114 In silico studies and structural comparisons identify essential elements of bo

115 t, identify conserved pathways that regulate structural complexity and reveal the influence of the my

116 The structural complexity of composite biomaterials and biom

117 Phosphatidylinositol (PI) is an essential structural component of eukaryotic membranes that also s

118 tion-to-gel transition of mucin, the primary structural component of mucus.

119 Exopolysaccharides are key structural components of this matrix and are required fo

120 the type and relative contribution of these structural components through empirical correlation with

121 Structural connections were divided into short- (length

122 : 1) a global-adaptation mechanism where the structural connectivity of the network itself changes su

123 revealing that this pilin displays extensive structural conservation.

124 Our work reveals structural considerations for the nano-bio interfaces in

125 hes has proven to be challenging due to poor structural control at the atomic level.

126 validate that amino acids buried within the structural core are network-central, and those on the su

127 , point to a less segregated organization of structural covariance networks in OCD, and reorganizatio

128 he findings of this study, the largest brain structural covariance study of OCD to date, point to a l

129 retina at earlier stages before irreversible structural damage has occurred.

130 udy is the first that combines the available structural data on villin headpiece with functional assa

131 vances in recombinant expression systems and structural data retrieving, and the pioneer generation o

132 Based on CsMAF1 structural data, we propose a mechanism for how CsMAF1 r

133 isperse and stable in vitro, with sufficient structural definition to support the rapid binding of a

134 These results reveal many structural details that were not visible by cryo-ET alon

135 We observe that INVS is the core structural determinant of a compartment composed of nove

136 (1->6)-N-acetylglucosamine (PNAG) is a major structural determinant of bacterial biofilms responsible

137 However, the structural determinants for tau-HS interaction are not w

138 These results reveal the structural determinants of tip-link-mediated inner-ear s

139 ion of these traits by Q, especially for the structural determination of threshability.

140 ane proteins (IMPs), challenging targets for structural determination.

141 ncodes TTN (titin), a protein that plays key structural, developmental, and regulatory roles in skele

142 r own class of materials due to the specific structural developments that occur during the various st

143 Despite the minimal structural differences between receptor types, selectivi

144 taneous Raman spectroscopy to understand the structural differences in sense and antisense microRNA-2

145 ty in cells and in mice, suggesting that the structural differences may play important roles in disea

146 ular modeling and used for the evaluation of structural differences with a Bgl3 that is inhibited by

147 Subtle structural discrepancies on mechanosensitive channel nan

148 lly pure amino acids, enabling us to explore structural diversity.

149 generation, have been attributed to its main structural domains, the kringles, and have been proposed

150 ique insight into the elusive functional and structural drivers of STM bacteria.

151 to the challenges of monitoring chromophore structural dynamics during the light-induced processes.

152 ; stromal cells produced predominantly core, structural ECM proteins and tumor cells produced a diver

153 their intervening loop, we investigated the structural effects of a patient-derived CF-phenotypic mu

154 s allows us to obtain valuable insights into structural, electronic, and dynamic information from the

155 cular structure of TRPV6 and discuss how its structural elements define its unique functional propert

156 ein, we present our strategic approach using structural elucidation to enable chemistry design/SAR de

157 are sufficient to recover correctly weighted structural ensembles from simulations, even when the rel

158 ng LVAD were estimated in a specific type of structural equation model known as the Actor-Partner Int

159 to genetic and environmental components, and structural equation modeling to test mediation models be

160 Mediation was assessed using structural equation modeling.

161 observe copy number changes, mutations, and structural events in cancer samples.

162 , but also maintains control in function and structural evolution.

163 dues for transporter activity, and provide a structural explanation for varied substrate specificity

164 Further, the shared structural feature between unrelated channels suggests t

165 The interpenetrating structural feature of the as-obtained composites not onl

166 ted because they typically require dedicated structural features in the enzyme, such as a nucleotide

167 use of the inherent challenges of predicting structural features of integral membrane enzymes.

168 tal X-ray analysis was used to elucidate the structural features of the macrocycles.

169 , and enzymological analysis to characterize structural features of the PH domain in its autoinhibite

170 However, it is unclear how distinct structural features of the two PA2G4 isoforms translate

171 ll lines provide insights into the impact of structural features on potency and chemical stability, i

172 species, suggesting involvement of multiple structural features or a nullified function of the chime

173 of heterologous gyrases is in agreement with structural features present: B. subtilis gyrase is a min

174 ince few existing metrics capture high-level structural features such as architectures, folds and con

175 evisiae proteins, we identified sequence and structural features within ALAS that position mtClpX and

176 udies show the structural basis of AAV Rep's structural flexibility required to fulfill its multifunc

177 mp-probe experiments were connected to local structural fluctuations of the free volume elements.

178 adenylate-forming enzymes share a conserved structural fold but act on a wide range of substrates to

179 rtain characteristics of phage biology, with structural fragility under the high temperatures and aci

180 and transgenic mouse models to evaluate the structural, functional and biochemical effects of elimin

181 ter a new genome is sequenced and assembled, structural gene annotation is often the first step in an

182 This process is characterized by structural, gene expression, metabolic, and functional s

183 by transcriptional reprogramming of specific structural genes of the pathway.

184 d be better suited to measure progression of structural glaucomatous loss.

185 application areas of FHE in wearable health, structural health, industrial, environmental, and agricu

186 different molecular targets, consistent with structural heterogeneity.

187 (MANF), an ER-resident protein with no known structural homologs and unclear ER function.

188 function with low sequence homology but high structural homology to both yeast Get2 and mammalian CAM

189 lavivirus with a high degree of sequence and structural homology to Dengue virus (DENV), the role of

190 To dissect the activation mechanism, structural homology was used to identify an unstructured

191 Here we access structural information encoded in this underexploited re

192 While structural information exists for several A3 proteins, t

193 se of machine learning to extract meaningful structural information from complex physical systems whe

194 XPA is bound within the NER bubble, provide structural insights into the molecular basis for malfunc

195 lial growth factor D (VEGFD) is required for structural integrity of dendrites and cognitive abilitie

196 to reduced production of collagens, loss of structural integrity of the cuticle, and impaired barrie

197 Sac1(ts)), we show that Sac1 is required for structural integrity of the Drosophila retinal floor.

198 ch detail the mechanism while confirming the structural integrity of the polyolefin-polar blocks.

199 stability of this RNA genome relative to the structural landscape of other well-known viral RNAs.

200 gional activity, functional connections, and structural linkages together support integrative process

201 ent in the evolution of SARS-CoV-2 with this structural loop affecting virus stability and transmissi

202 Structural magnetic resonance imaging data were availabl

203 Structural maintenance of chromosomes flexible hinge dom

204 s and being fabricated into high-performance structural materials that are both strong and tough.

205 thelial tubules form by cell coalescence and structural maturation.

206 an be viewed as a generalization of marginal structural mean models to enable effect decomposition.

207 By revealing the structural mechanisms of SA perception by NPR proteins,

208 The resulting selenomelanin is a structural mimic of pheomelanin.

209 o any peptide-MHC complex of interest with a structural model as input, representing an important ste

210 bines the proteome allocation theory and the structural model of cell division.

211 ganize compartment assembly to develop a new structural model.

212 iers for estimating the quality of a protein structural model.

213 Previous biophysical experiments and structural modeling have suggested that the N-terminal m

214 Structural modeling predicts that SY242CS confers a conf

215 propensity score (PS) matching and marginal structural models (MSMs) to account for confounding by i

216 nking mass spectrometry to build integrative structural models of protein complexes.

217 ons, propensity-matched models, and marginal structural models were used to assess the association be

218 eneration molecular motors featuring various structural modifications at the central aromatic core ar

219 Here, we establish a structural-molecular basis for these observations.

220 nds that contain the pyrrolodiketopiperazine structural motif.

221 blishes the extracellular loops as important structural motifs for ion selectivity and channel inhibi

222 ins to be designed by using only examples of structural motifs from unrelated proteins.

223 anding of their function and elucidating key structural motifs that can be targeted for therapeutic r

224 itectures, folds and conformity to conserved structural motifs.

225 pitope-focused immunogens displaying complex structural motifs.

226 ), and control (CN, n = 322) groups, we used structural MRI data and neuropsychological assessments t

227 nalysis and interpretation in functional and structural MRI research.

228 PK11195 PET) and brain atrophy (derived from structural MRI) predicted longitudinal cognitive changes

229 e the existing literature on neurocognitive, structural neuroimaging, and functional neuroimaging out

230 rst study to comprehensively analyze all 10 (structural, non-structural and accessory) proteins from

231 We found that some of the calculated structural observables, such as the relative accessible

232 tified DBeQ as a promising lead compound for structural optimization aimed at selective targeting of

233 eneration fouling-resistant RO membranes via structural optimization: first, a smooth selective layer

234 orcement learning (RL) problems differing in structural or sensory properties.

235 The increased structural order of the crystalline state contributes to

236 Here, we investigated the function and structural organization of the protein corona using an i

237 as shown that FR PBM improves functional and structural outcomes in animal models of retinal injury a

238 Recent case series suggested that negative structural outcomes including accelerated OA progression

239 cribe re-treatment rates rather than retinal structural outcomes predictive of long-term vision.

240 ices, we show that transparency results from structural partial order inhibiting light scattering, wh

241 B has an ABC exporter fold, but also reveals structural peculiarities at the transmembrane region of

242 In addition to providing new structural perspectives for specific therapeutic aims, o

243 fine-tunes the fracture strain by providing structural plasticity at the network and fiber level.

244 Furthermore, H1 provides a structural platform alternative to the native fold for R

245 rodegenerative disorders, are orphans from a structural point of view, and new I(2)-IR ligands are ur

246 In vitro DNA-binding experiments and structural prediction show that CTM provides an importan

247 TFBSshape content has increased to 2428 structural profiles for 1900 TFs from 39 different speci

248 ce of liquid droplets and ignore the complex structural properties of spheroids.

249 Structural protein-encoding genes constitute a large fra

250 ther heterogeneity in phosphorylation of key structural proteins alters tissue integrity and organ fu

251 is, glycogen accumulation, and alteration of structural proteins.

252 unt for coupled residue pairs being in close structural proximity, both domain-swapped and nondomain-

253 rprise must directly confront the reality of structural racism in scientific funding and the widespre

254 d biochemical analyses, we have explored the structural rearrangements of the respiratory chain in hu

255 ationally designed to stabilize Sn through a structural reconstruction mechanism.

256 ets compounds for which neither spectral nor structural reference data are available and predicts cla

257 dentify 59 features indicative of proteomic, structural, regulatory or evolutionary relevance and int

258 o acids and ligands) and the edges represent structural relationships (e.g. distances ligand - amino

259 ary efficacy end point), quality of life, LV structural remodeling ( EF >5% and ESV 10%) and heart fa

260 verload, contributing to both electrical and structural remodeling.

261 observed were temporary and did not lead to structural reorganisation of the transportation network

262 akoid membranes to be able to understand its structural responses to diverse environmental fluctuatio

263 ammonium for the organic cations to tune the structural rigidity and octahedral distortion yields a r

264 ally, edges with different DD play different structural roles and the DD distribution is an important

265 Structural rules underlying functional properties of cor

266 atrix proteins (EMPs) play a key role as the structural scaffolds for regulating mineral morphology d

267 We demonstrate that this configuration is a structural signature for a ubiquitous class of receptors

268 Despite high sequence conservation and structural similarity in the NES-binding cleft region, (

269 ror, the peak signal-to-noise ratio, and the structural similarity index, in addition to a joint hist

270 s the highest peak signal-to-noise ratio and structural similarity index.

271 Cryo-EM of the NTD dimer revealed a structural similarity to the scaffold domain of TBK1, su

272 Despite the structural simplicity, the probe turned out to be unprec

273 lectrostatic charge patterns, on the complex structural space of the intrinsically disordered protein

274 rsatile tool for expanding the boundaries of structural space.

275 ivity (C140S, C163, C241, and C253), and (3) structural stability (C253) and (4) those with no known

276 n the P2-type cathode easily induces the bad structural stability at deep desodiation states and limi

277 into the impact of SEI homogeneities on the structural stability of Si-based lithium-ion batteries.

278 s chosen as the model protein because of its structural stability which allows the protein charge in

279 There is increasing interest in extending structural studies by cryo-EM into the cell, where biolo

280 Previous structural studies showed that Rad4, when tethered to DN

281 igomers in the gas phase where mass-selected structural studies using ion-mobility spectrometry mass

282 dding of gp120, known to severely complicate structural studies, can be prevented by using the unclea

283 Guided by previous structural studies, we hypothesized that Asn-169, a cons

284 iallelic variants in EXOSC5, which encodes a structural subunit of the RNA exosome.

285 Using the NTF2-like structural superfamily as a model system, we developed a

286 We thus demonstrate that structural systems biology enables a proteome-wide, comp

287 ned angles of the ligands and the mismatched structural tensions created from the multi-layered geome

288 However, very few show a reversible structural transformation at room-temperature.

289 rface modification to suppress this unwanted structural transformation.

290 cancer is provided, along with a summary of structural trends that contribute to this type of biolog

291 aterials, featuring high surface areas, rich structural tunability, and functional pore surfaces, whi

292 ides insights into the genomic properties of structural variant classes and short tandem repeats that

293 For structural variants, we present two methods of driver di

294 ere enriched in motif-rewiring mutations and structural variants.

295 38 tumor types, we analyzed 288,457 somatic structural variations (SVs) to understand the distributi

296 We initially screened a library with a large structural variety of lipidoids ex vivo and identified i

297 n, with substitution rates comparable across structural versus nonstructural genes.

298 ion is displayed, and links are provided for structural visualization and redirection to other module

299 We find that the interplay between structural water and strain-specific amino acid groups i

300 Each vector was defined by structural (x-axis) and functional (y-axis) components.