ライフサイエンスコーパス: structural analog

1 TIR-199, a natural product-derived syrbactin structural analog.

2 ivity was seen with other anticonvulsants or structural analogs.

3 and successfully predicting the activity of structural analogs.

4 re-activity investigation of suramin and its structural analogs.

5 n of binding in the presence of ChoP but not structural analogs.

6 he fast generation of hundreds of furanolide structural analogs.

7 n slow and struggle to differentiate between structural analogs.

8 n analytes and internal standards were close structural analogs.

9 harmacological properties exhibited by close structural analogs.

10 treatment of water containing 6:2 FTS or its structural analogs.

11 rgeting inhibitor HG-9-91-01 and a series of structural analogs.

12 r total synthesis of RIF-1 stereoisomers and structural analogs.

13 ies systematically improves the detection of structural analogs.

14 ediately accommodating to the preparation of structural analogs.

15 azolylborate) cobalt(II) [Co(Tp)(2)] and two structural analogs.

16 t discriminators between remote homologs and structural analogs.

17 ies of 1 in neurons could be translated into structural analogs.

18 ntic hyaluronan oligosaccharides and related structural analogs.

19 F]FDF revealed greater tumor uptake than did structural analog 1-[(18)F]FDF, whereas 1-[(18)F]FDAM wi

20 tigate the ability of luteolin and its novel structural analog 3',4',5,7-tetramethoxyluteolin (methlu

21 -d]pyrimidine (PP2), but not by the inactive structural analog 4-amino-7-phenylpyrazol[3,4-d]pyrimidi

22 tivity was structurally specific in that the structural analogs 4,5-dihydro-C6-ceramide and dioctanoy

23 Uptake of 5-FTHF was inhibited by the structural analogs 5-methyltetrahydrofolate, methotrexat

24 ned inflammatory properties; conversely, its structural analog acyl-PAF elicits a diminished response

25 The binding modes of ACC and the structural analog alanine specifically labeled with 15N

26 ated alkaloid natural products, and multiple structural analogs, all in <=8 steps longest linear sequ

27 SMZ is a structural analog and competitive antagonist to p-aminob

28 (apparent Km of 1.4 microM), 4) inhibited by structural analogs and anion transport inhibitors, and 5

29 e mechanism of the inactivation by deploying structural analogs and molecular docking, and demonstrat

30 bits specific and selective recognition over structural analogs and non-related carboxyl-containing m

31 construction of other members of the family, structural analogs and provide a practical synthetic rou

32 lective synthesis, we created a series of PB structural analogs and the structurally related compound

33 sents the first database containing pairs of structural analogs and their alignments.

34 the interaction of p17 with heparin, a HSPG structural analog, and CXCR1.

35 the results presented here indicate that LPS structural analog antagonists Rhodobacter sphaeroides di

36 (S/N=3) and a very high selectivity towards structural analogs (aspirin, BPA, and piperazine) even i

37 specifically, they provide a means by which structural analogs, based upon these first-generation My

38 Whether exposure to BPA or its structural analogs bisphenol S (BPS) and bisphenol F (BP

39 letion of the catabolism of ferulate and its structural analogs, caffeate and coumarate, through prot

40 t potent compound discovered by screening of structural analogs, CFTR(inh)-172, reversibly inhibited

41 re we demonstrate that mithramycin A and its structural analog chromomycin A3 are potent inhibitors o

42 ptosis, with the exception of CK-666 and its structural analog CK-636.

43 nh)-02, which was identified by screening 35 structural analogs, competitively inhibited V(2)R-induce

44 ence of four disulfide bridges, but no close structural analogs could be identified.

45 molecular dynamics simulations of THC and 10 structural analogs delineating their spatiotemporal inte

46 Analyses of 5HMT and structural analogs demonstrate a structure-activity rela

47 c for heme; protoporphyrin IX and other heme structural analogs did not activate bhu gene expression.

48 nt include exploiting non-GABAergic targets, structural analogs, enzymatic production of natural ster

49 We identified that R91 and several structural analogs exhibited antimicrobial activity agai

50 We further validated structural analogs for both compound classes as antibact

51 the silicate glasses studies are appropriate structural analogs for understanding the atomic arrangem

52 /ALK activity, cabozantinib (XL-184) and its structural analog foretinib (XL-880) demonstrate a strik

53 leukotriene receptor antagonists-leukotriene structural analogs, FPL 55712 analogs, and random screen

54 Good specificity toward fumonisin B1 and its structural analog, fumonisin B2, was observed, together

55 ibited excellent selectivity for SY over its structural analogs, good stability, and adequate reprodu

56 easured by amperometry, whereas the inactive structural analog had no stimulatory effect on secretion

57 ochemical sequestration of spermidine or its structural analog homospermidine consolidate and expand

58 rlie violent behavior specifically and their structural analogs, however, remain poorly understood.

59 ch EF hand in one pair by a duplicate of its structural analog in the other.

60 Experiments with CBI-DA and structural analogs indicated fluorescence was rapidly qu

61 escence characterization of CBI-5-HT and its structural analogs indicated that 5-HT was acting as a q

62 Quercetin or fisetin (a structural analog) inhibited the O-methylation of 2- and

63 MP265, an A22 structural analog, is less toxic than A22 for growth yet

64 ound that acts on Hsp70 but not its inactive structural analog JG-258, enhances the ubiquitination of

65 en the marine toxin domoic acid (DA) and its structural analog kainic acid (KA), which cannot be achi

66 in an appropriate in vivo model with a close structural analog (KDM5-inh1A).

67 ned glycoconjugates containing l-Fuc and its structural analog l-colitose (l-Col), a bacterial dideox

68 and U266 with thalidomide (100 muM) and its structural analog lenalidomide (10 muM) results in stabi

69 nomodulatory drug (IMiD) thalidomide and its structural analogs lenalidomide and pomalidomide are hig

70 ST and its structural analog, linaclotide, an FDA-approved oral sec

71 he uptake process is inhibited by unlabelled structural analogs (lumiflavin, lumichrome) but not by s

72 imately 10 and 100-fold more potent than its structural analogs lycoricidine and lycorine, respective

73 e results suggest that mithramycin A and its structural analogs may be effective agents for the treat

74 )-dependent block of TRPM7, waixenicin A, or structural analogs may have cancer-specific therapeutic

75 diated down-regulation of IP3Rs, whereas the structural analog N-acetyl-Leu-Leu-methioninal was witho

76 The classical cannabinoid agonist HU210, a structural analog of (-)-Delta(9)-tetrahydrocannabinol,

77 In addition, a PPARgamma agonist that is a structural analog of 15d-PGJ2, and lacks the electrophil

78 peridine hydrogen chloride (AC-42), a potent structural analog of AC-42 called 4-[3-(4-butylpiperidin

79 xin pathways; (2) CMA does not function as a structural analog of ACC; (3) COR has a broader range of

80 ML-3H2 is a structural analog of amebicidal drugs, which have porphy

81 A structural analog of celecoxib, SC-236, completely preve

82 A novel structural analog of ceramide was synthesized by N-acyla

83 A structural analog of choline, 3,3-dimethyl-1-butanol (DM

84 Compound 2, a close structural analog of compound 1, was also found to be we

85 yl-cyclopropapyrroloindole (MCPI) residue, a structural analog of cyclopropapyrroloindole (CPI), the

86 ely expressed oleyl-acetyl-glycerol (OAG) (a structural analog of DAG) -sensitive TRPCs, when activat

87 t is noteworthy that trans-stilbene, a close structural analog of DES that lacks hydroxyl and ethyl g

88 ak inhibition was observed with cemadotin, a structural analog of dolastatin 15, and with the depsipe

89 SDX-101 is another structural analog of etodolac that is already used in cl

90 V also catalyzes the amidation of FDM M-3, a structural analog of FDM C, to afford amide FDM M-6 in v

91 Gabapentin is a structural analog of GABA that has anticonvulsant proper

92 hydroglucitol-6-phosphate (1,5AG6P), a close structural analog of glucose-6-phosphate and an inhibito

93 Here, we studied S-sulfocysteine (SSC), a structural analog of glutamate that accumulates in the p

94 We constructed a stable structural analog of H-DNA that cannot flip into B-DNA,

95 s, only the MM-derived ones bind heparin - a structural analog of heparan sulfate proteoglycans known

96 The tracer (18)F-AFETP is a structural analog of histidine and is a lead compound fo

97 A structural analog of HS38, with inhibitory activity towa

98 This study examined whether zileuton (ZL), a structural analog of hydroxyurea, possessed Hb F-inducin

99 id IVa and paclitaxel, which, although not a structural analog of LPS, activates cells expressing mTL

100 to be a potent inhibitor of PI3K activity, a structural analog of LY2, LY303511 (LY3), which did not

101 A structural analog of norepinephrine, (-)-[11C]phenylephr

102 UC-514321, a structural analog of NSC-370284, exhibited a more potent

103 l)methylene)bis(3,5-dimethyl-1H-pyrazole), a structural analog of our originally identified inhibitor

104 s-4alphaH-fluoren-++ +4alpha-amine (NEFA), a structural analog of phencyclidine (PCP).

105 t to the phytotoxic amino acid m-tyrosine, a structural analog of phenylalanine.

106 An inactive structural analog of PMA, 4alpha-PMA, had no effect on b

107 5-deazariboflavin derivative that is a close structural analog of riboflavin.

108 ble reduction in the selectivity of RY-24 (a structural analog of RY-80) for alpha(5)beta(3)gamma(2)

109 N-linolenoyl-l-glutamine is a structural analog of several other elicitors including v

110 that ceramide phosphoethanolamine (CPE), the structural analog of sphingomyelin, has unique acyl chai

111 nd the therapeutic benefits of fingolimod, a structural analog of sphingosine that is FDA approved fo

112 hthalenetrisulfonic acid hexasodium salt), a structural analog of suramin, has an increased affinity

113 Pomalidomide is a potent structural analog of thalidomide and member of a new cla

114 Escherichia coli Dps, a structural analog of the 12-subunit Listeria innocua fer

115 (trimethylammonio)pentanoate), is a 5-carbon structural analog of the carnitine precursor, gamma-buty

116 Heparin is a functional and structural analog of the Chlamydia trachomatis heparan s

117 SC-58125, a structural analog of the Cox-2-selective inhibitor Celeb

118 Parenterally administered domoic acid, a structural analog of the excitatory amino acids glutamic

119 A recent study showed that SKF92374, a structural analog of the histamine H2 receptor antagonis

120 L-767,827, an inactive structural analog of the insulin mimetic, had no effect

121 We focused on a novel and more potent structural analog of the nonsteroidal anti-inflammatory

122 he-gauche-trans conformer, which serves as a structural analog of the nucleic acid phosphodiester gro

123 Gemcitabine (dFdC), a structural analog of the nucleoside deoxycytidine (dC),

124 BaNi(2)As(2) is a structural analog of the pnictide superconductor BaFe(2)

125 Our research identified 24, a structural analog of the potent GPX4 inhibitor RSL3, tha

126 by ATP in the crystal and represents a close structural analog of the previously proposed CEA-adenyla

127 at an N(2)-furfuryl-dG (N(2)-f-dG) lesion, a structural analog of the principal lesion generated by N

128 2,5-Dimethyl-celecoxib (DMC) is a close structural analog of the selective cyclooxygenase-2 (COX

129 contrast, 50 or 100 microM rosiglitazone, a structural analog of TRO, did not cause apoptosis in the

130 ective HIF-2alpha inhibitor called PT2399 (a structural analog of which was recently FDA-approved) to

131 A structural analog of XA, kynurenic acid (C10H6NO3), also

132 We have synthesized structural analogs of a natural RNA editing substrate an

133 osteric compounds like carbachol, another by structural analogs of AC-42, and a third by structural a

134 Plant oxylipins are structural analogs of animal prostaglandins which are de

135 Finally, we identify structural analogs of APLF in lower eukaryotes with the

136 e similarity to other proteins, a search for structural analogs of BRCT2 returned the second BRCT dom

137 The structural analogs of clozapine, loxapine and amoxapine,

138 Brown algal phlorotannins are structural analogs of condensed tannins in terrestrial p

139 work demonstrates the use of four systematic structural analogs of conductive two-dimensional (2D) me

140 intake suppression and ALDH-2 inhibition by structural analogs of daidzin established a link between

141 vities, we have tested a series of synthetic structural analogs of daidzin.

142 We also observed that structural analogs of DENSPM which differentially induce

143 Further studies with three structural analogs of ditekiren revealed that one analog

144 These effects were mimicked by structural analogs of GABA with relative specificity at

145 f these polymerases to replicate through the structural analogs of gamma-HOPdG that are permanently e

146 by tetradecanol or 2,6 diterbutylphenol, two structural analogs of general anesthetics that are hydro

147 Stable inhibitory structural analogs of hepoxilin A(3) are capable of impe

148 We demonstrate here that structural analogs of individual TMs of GPCRs can serve

149 study mechanism of iNKT cell activation for structural analogs of KRN7000, and our study can aid in

150 We hypothesized that these structural analogs of malondialdehyde would react with D

151 Structural analogs of MDPD did not affect AtFAAH activit

152 structural analogs of AC-42, and a third by structural analogs of N-desmethylclozapine.

153 erences including the 6-biopterin and pterin structural analogs of neopterin as well as glucose and c

154 Two structural analogs of OAC1 also activated Oct4 and Nanog

155 Structural analogs of PCer (1- or 3-deoxy-PCer) were als

156 Flavone and flavanone, two closely related structural analogs of PD98059, inhibited AHR transformat

157 olyl)succinimide, which are chemically inert structural analogs of PDM.

158 Structural analogs of phthalimide, such as phthalic anhy

159 or this hypothesis was obtained by examining structural analogs of PM in which its known bidentate me

160 For structural analogs of RH-4032 and various N-phenylcarbam

161 n were explored by studies of the effects of structural analogs of taurine on the activity of Cx26-co

162 Photoproducts can also react to produce structural analogs of TBA metabolites.

163 K inhibitors achieved by covalent linking of structural analogs of the ATP-competitive PI3K inhibitor

164 The structural analogs of the BBB are occlusive (pleated-she

165 (S)- and (R)-enantiomers of (+/-)-ABS01-113, structural analogs of the D(3)R partial agonist, (+/-)-V

166 rther investigated by solution studies using structural analogs of the drugs and the T306A CYP46A1 mu

167 Therefore, structural analogs of the drugs that bind to the target

168 pounds, including 2-oxypyrimidine containing structural analogs of the marketed endothelin receptor A

169 and S1.ADP.AlF(4)(-), i.e., the established structural analogs of the myosin weakly bound states.

170 we establish that the biological activity of structural analogs of the natural inducer displays a mar

171 ationally designed and assembled a series of structural analogs of the natural product, including a f

172 Functional assessment of structural analogs of the prototype CCK-2R antagonist, L

173 A series of structural analogs of the Pseudomonas aeruginosa autoind

174 l transferases that can recognize and couple structural analogs of their natural substrates and the i

175 However, close structural analogs of these PAMs are negative allosteric

176 the resting state channel, we have employed structural analogs of TID.

177 Depolarization enhanced responses of several structural analogs of U46619 with modifications to a sim

178 nd the polyphenols resveratrol (RES) and its structural analog (RESAn1), using the real-time analysis

179 nd the polyphenols resveratrol (RES) and its structural analog (RESAn1), using the real-time analysis

180 CB002 and structural-analogs restore p53 signaling in tumors with

181 Further screening of >1000 structural analogs revealed tetrahydrobenzothiophenes th

182 RKI-18, but not the inactive closely related structural analog RKI-11 is effective at suppressing mal

183 selected a pair of RKIs, the closely related structural analogs RKI-18 (potent; IC50 values of 397 nM

184 Recent studies suggest its structural analog, scytonemin imine, may serve as a bios

185 Kinetic studies using cysteine structural analogs show that most are inhibitors and tha

186 We found that C-5 alkylcytosines and related structural analogs specifically enhance the reactivity o

187 NO synthesis, in that a number of "inactive" structural analogs still bind to iNOS and affect its hem

188 Analysis of structural analogs suggested that the molecular interact

189 als 15 steps and is immediately amenable for structural analog synthesis.

190 ecific antagonists of p38 MAPK, but not by a structural analog that does not inhibit p38.

191 However, unlike its herbicide structural analogs, the mode of action of cyperin is not

192 As evidenced by the binding of structural analogs, the primary arylamine group is indis

193 replacing choline in the growth medium with structural analogs, the quantity of capsular polysacchar

194 s binding affinity for carbamazepine and its structural analogs, thereby mediating the immune respons

195 However, even though compounds are not structural analogs, they may achieve the desired respons

196 Using structural analogs to 1, 25-(OH)2D3, we found that analo

197 were applied to CBI-DA, CBI-5-HT, and select structural analogs to determine structural correlations

198 We deployed structural analogs to investigate the molecular interact

199 1, 25-dihydroxyvitamin D3 (1,25(OH)2D3) and structural analogs to modulate expression of voltage-sen

200 he binding of chemically diverse PGF(2alpha) structural analogs to the FP receptor and compared these

201 de (Pca) and hydralazine (Hyd) with those of structural analogs, to determine if the degree of LFA-1

202 B was leucine-specific because isoleucine, a structural analog, was ineffective in these regards.

203 Thirty-three structural analogs were examined to develop a stronger S

204 and A77636), as well as six less efficacious structural analogs, were obtained from D1 dopamine radio

205 sembly pathways, unlike the beta-carboxysome structural analog which only involves the "Cargo first"

206 oyl-2-arachidonyl-PC, and four corresponding structural analogs with CD36 binding activity were ident

207 a promising starting point for the design of structural analogs with improved activity.

208 nal will facilitate the preparation of novel structural analogs with potential biological activity.

209 e introduce "promiscuity cliffs" as pairs of structural analogs with single-site substitutions that l

210 odels, TM-align can almost always find close structural analogs, with an average root mean square dev

211 entration-dependent manner but not by B17, a structural analog without effects on Golgi function.