ライフサイエンスコーパス: structural analogue

1 strongly than carboxypropylpyrrole, a close structural analogue.

2 l influence from drug hydrophobicity for two structural analogues.

3 S(2))](2+), in correlation to their peroxide structural analogues.

4 antipsychotics, chemical chaperones, or VPA structural analogues.

5 ing a search without m/z constraints to find structural analogues.

6 fied a triazolopyrimidine hit, with no close structural analogues.

7 that allows it to discriminate choline over structural analogues.

8 ling the incorporation of a broad variety of structural analogues.

9 selectively recognised GA in presence of its structural analogues.

10 her investigated by testing a variety of its structural analogues.

11 ence time compared to their methylene-linked structural analogues.

12 he M1G-2BD duplex was similar to that of the structural analogue 1,N(2)-propanodeoxyguanosine (PdG) i

13 is 10-80-fold more cytotoxic than the close structural analogue 1031U89, which is an equipotent inhi

14 nalysis of HOMePAESe in human urine, using a structural analogue, 4-fluorophenyl 2-aminoethyl selenid

15 5R-5,6-dihydro-5-hydroxythymidine (5R-3) and structural analogue 5,6-dihydro-5-methylthymidine (9) at

16 er exploration of the most potent hit (1), a structural analogue (6) was identified demonstrating 10-

17 is study, the toxic effects of two groups of structural analogues (alcohols and anilines) with predef

18 y of three dichloroacetamide safeners and 12 structural analogues [all neutral compounds of the form

19 Compound 24 and its two structural analogues also inhibited atRA metabolism in H

20 s showed that diacylglycerol and some of its structural analogues also were important, positive effec

21 o-component gelation systems that are direct structural analogues and draws conclusions about the mol

22 ic acid solutions, selectivity studies using structural analogues and food components, and quantifica

23 tures of these compounds and identify active structural analogues and high-confidence target annotati

24 egligible cross reactivity with other tested structural analogues, and the recovery from spiked urine

25 Structural analogues are assumed to elicit toxicity via

26 stins A, B, C, and D as well as a variety of structural analogues are reported.

27 eospecifically by phosphatidylserine and its structural analogues, but not by other anionic phospholi

28 have determined the binding mode of a close structural analogue by X-ray crystallography.

29 be syntheses of trioxacarcin A, DC-45-A1 and structural analogues by late-stage stereoselective glyco

30 veloped approach was further extended to its structural analogues cannabidiorcin and other tail/terpe

31 Prodigiosin and its structural analogue (compound R) induced the expression

32 In contrast, the close structural analogue CP-236,492 inhibited neither process

33 trazepines BN 50727 and BN 50730 and the PAF structural analogues CV 3988 and CV 6209 competitively i

34 sition inhibitor, cyclosporin A, but not the structural analogue, cyclosporin H.

35 mitochondrial uncoupler, and several of its structural analogues decreased ROS levels, normalized mi

36 a synthetically accessible rigid acetylenic structural analogue EL-228 (1), whose structure could be

37 t key oxygen atoms of ring C of COL or C' of structural analogues establish with the protein.

38 indicate that the E2 aptamers bind E2 and a structural analogue, estrone (E1), equally well and are

39 The natural product and its structural analogues exhibited antitumor activities agai

40 uded from the cell/bead interface, whereas a structural analogue, fast DiI, which differs from DiIC16

41 Direct evidence for H-bonding is seen in a structural analogue, [Fe(II)(Cl)(N3Py(amide)SR)](BF4)2 (

42 (2)-Propanodeoxyguanosine (PdG) is a stable structural analogue for the 3-(2'-deoxy-beta- d- erythro

43 h library contained between 10000 and 750000 structural analogues for a total of >6 million compounds

44 The results show that the affinity of the structural analogues for the NIP is controlled mostly by

45 The complexes represent structural analogues for the proposed organonickel inter

46 omain adopts a novel alpha/beta fold with no structural analogues found in the Protein Data Bank (PDB

47 (1)O(2) probe furfuryl alcohol (FFA) and its structural analogue furfuryl amine (FFAm).

48 An inactive structural analogue, GRGESP, did not alter shear stress-

49 c and electrochemical studies on a series of structural analogues have established that the accelerat

50 Butyrate and its structural analogues have recently entered clinical tria

51 ein structures in the Protein Data Bank have structural analogues in the compact model set.

52 had good selectivity for fluorene over close structural analogues including naphthalene, fluoranthene

53 the synthesis of dibenzodiazepines and their structural analogues is reported.

54 Here, JJC8-091 and a structural analogue, JJC8-088, were extensively and comp

55 y, has been explored by the synthesis of its structural analogues, leading to 2-(1-((2-methoxyphenyl)

56 Analysis of a set of structural analogues led us to identify a lead compound

57 ed iron sulfide Li(2)FeS(2) as well as a new structural analogue, LiNaFeS(2), reversibly store >=1.5

58 4) trans-stimulated by unlabelled RF and its structural analogue lumiflavine, (5) cis-inhibited by th

59 gue lumiflavine, (5) cis-inhibited by the RF structural analogues lumiflavine and lumichrome but not

60 well-known PI3K inhibitor LY294002, and its structural analogue LY303511, which does not inhibit PI3

61 hese results, we propose that ShK-Dap22 or a structural analogue may have use as an immunosuppressant

62 relationship studies, MPC-6827 and its close structural analogue, MPI-0441138, were discovered as pro

63 rebiotic substrates for oral health like the structural analogues N-acetyl-D-mannosamine (NADM) and N

64 the industrial substrate gamma-lactam or its structural analogue, norcamphor, result in the displacem

65 spermidine-deficient B. subtilis mutant, the structural analogue norspermidine, but not homospermidin

66 /cm(3) (35 bar and 298 K)) compared with its structural analogue, NOTT-103.

67 A route is developed to a structural analogue of [5]HELOL, a previously reported h

68 r perifusion conditions, whereas an inactive structural analogue of AFC failed to inhibit insulin rel

69 r this binding affinity of darbufelone but a structural analogue of darbufelone competes directly for

70 nd 75% for octreotide, desmopressin, and the structural analogue of desmopressin, respectively.

71 nt, ultralow molecular weight heparin as the structural analogue of fondaparinux that does not contai

72 The rhombohedral phase of GeSe, a structural analogue of GeTe (space group: R3m), previous

73 thyl-4-isoxazole propionic acid), kainate (a structural analogue of glutamate) or NMDA (N-methyl-D-as

74 NMDA (N-methyl-D-aspartate), and kainate, a structural analogue of glutamate.

75 Co(III)bleomycin has often been studied as a structural analogue of HOO-Fe(III)bleomycin, and hence,

76 nhibited by treatment with aminoguanidine, a structural analogue of L-arginine.

77 city of azetidine-2-carboxylic acid (A2C), a structural analogue of L-proline, results from its incor

78 The orthorhombic phase of GeSe, a structural analogue of layered SnSe (space group: Pnma),

79 , herein, we report the first synthesis of a structural analogue of lucidin [N(2)-methyl-(1,3-dimetho

80 gn and de novo total synthesis of (+)-JRT, a structural analogue of lysergic acid diethylamide (LSD)

81 6P-chromogen I is metabolized into a structural analogue of ribose by a promiscuous activity

82 We found that caffeine is a structural analogue of strychnine and a competitive anta

83 The complex is the first structural analogue of the active sites in fully oxidize

84 new palladium macrocycles were discovered: a structural analogue of the existing {Pd84 }(Ac) wheel wi

85 Compound 9 is a structural analogue of the lumazine synthase substrate 5

86 A close structural analogue of the metal-free cytochrome c oxida

87 Similarly, a close structural analogue of the most active inhibitors contai

88 tals of Pb(3)S(2)Cl(2), which proved to be a structural analogue of the recently reported bulk Pb(3)S

89 H-benzimidazole-2-selone, H(sebenzim(Me)), a structural analogue of the selenoamino acid, selenoneine

90 support the hypothesis that tunicamycin is a structural analogue of the UDP-D-HexNAc substrate and is

91 s thus quite different from staurosporine, a structural analogue of UCN-01, which arrests normal cell

92 2-MA is a structural analogue of urea, showing promising competiti

93 Interestingly, alpha-humulene, a structural analogue of zerumbone lacking the carbonyl gr

94 ionic heptamethine cyanine dyes, including a structural analogue of ZW800-1, with greatly enhanced dy

95 100 microM), and a series of closely related structural analogues of (+)-avrainvillamide, the latter

96 -specific responses of several Diabrotica to structural analogues of (E)-cinnamaldehyde, the major at

97 More than 200 structural analogues of 3D-cliff compounds were identifi

98 Novel structural analogues of a HDAC inhibitor FK228 have been

99 The use of two structural analogues of ABA, known to have biological ac

100 in vivo immune response of mice to a set of structural analogues of alpha-GalCer.

101 e a series of 9,10-diaryl compounds that are structural analogues of anthracene derivatives used in t

102 igated using steady-state kinetics employing structural analogues of arginine as both alternative sub

103 available for study by this technique, seven structural analogues of arginine were prepared and used

104 nditions, e.g., in rice paddy soils, and are structural analogues of arsenate.

105 When various synthetic structural analogues of CAPE were examined, it was found

106 The effects of structural analogues of ceramide on rat brain mitochondr

107 Experiments using structural analogues of cholesterol have revealed that s

108 Here, we report the synthesis of structural analogues of CLsuGG and their activities agai

109 Structural analogues of CLsuGG indicate that the conjuga

110 ibitions of tubulin self-assembly by several structural analogues of colchicine (COL) was investigate

111 acterization of a series of morphinans 3a-c, structural analogues of cyclorphan [(-)-3-hydroxy-N-cycl

112 In this study, binding of 31 structural analogues of D-galactose was examined by site

113 aluate this possibility, we synthesized more structural analogues of daidzin and tested and compared

114 bition of 5-HIAA (or DOPAC) formation by six structural analogues of daidzin suggested a potential li

115 ging the symmetric design of Stenhouse salts-structural analogues of DASAs-for direct backbone integr

116 e synthesis of a number of diastereomers and structural analogues of discodermolide, which should ser

117 (DMA), and with three commercially available structural analogues of DMA: EDTA, TmDTA, and CyDTA.

118 Studies with structural analogues of EGCG suggest the importance of D

119 Structural analogues of FPA provide insight on chemical

120 resents the synthesis of various fluorinated structural analogues of FTY720, their in vitro and in vi

121 nalysis of Fe-L(2), we have shown that close structural analogues of heme are required to maintain HO

122 Structural analogues of homocitrate prevent the acetylen

123 A series of bis(phenylalkyl)amines, structural analogues of ifenprodil and nylidrin, were sy

124 ntial to greatly simplify access to epimeric structural analogues of important steroid scaffolds for

125 Several structural analogues of lactic acid affect the efficienc

126 S-mimetic activities are blocked by inactive structural analogues of LPS, indicating that despite the

127 lly simple inorganic materials can behave as structural analogues of otherwise inaccessible 'toy' spi

128 ribution of individual hydroxyls, binding of structural analogues of p-nitrophenyl alpha-D-galactopyr

129 uity of certain pathway enzymes, we produced structural analogues of QS-21 using this biosynthetic pl

130 eactivity and in failing to react with other structural analogues of quinine.

131 We discovered structural analogues of SAMD9/9L in the antibacteriophag

132 Two structural analogues of SB, epiSB and SBimide, were also

133 systematic studies involving four additional structural analogues of TGlu, we unveiled that the accep

134 The quinobenzoxazines, a group of structural analogues of the antibacterial fluoroquinolon

135 xtra A-lattice seams in GMPCPP microtubules, structural analogues of the GTP caps of dynamic microtub

136 gand binding activity of CqsS is probed with structural analogues of the natural signal.

137 p to 4 mol of nitric oxide (NO) and that are structural analogues of the NO prodrug and anticancer le

138 basic molecules in a biomimetic approach to structural analogues of the oxidized sites in the xanthi

139 ical characterization and provides access to structural analogues of the siderophore.

140 In this work, a series of structural analogues of the substrate SRH and a 2-ketone

141 er nonimprinted (NIP), of compounds that are structural analogues of the template were acquired by fr

142 has been then applied to the preparation of structural analogues of the trisaccharide repeating unit

143 These molecular cages are close structural analogues of the two well-known cryptophane-A

144 analysis shows that the nucleodyes are sound structural analogues of their native nucleoside counterp

145 First, close structural analogues of thiazolidenediones, whereas devo

146 activity relationship study with a series of structural analogues of thioxolone yielded similar estim

147 Effects of daidzin and its structural analogues on the activities of monoamine oxid

148 e can be used to prioritize the synthesis of structural analogues on the basis of their potentials of

149 ecision, and is free from interferences from structural analogues, qualifies as a candidate reference

150 cationic and preferred their templates over structural analogues regardless of their ionic character

151 tuents from a crude extract containing close structural analogues remains a significant challenge.

152 Several BTEA structural analogues reversibly inhibited Na,K-pump curr

153 ec is computationally more scalable allowing structural analogue searches in large databases within s

154 The antioxidant activity of curcumin and its structural analogues such as hispolon, halfcurcumin and

155 170 samples in order to identify a series of structural analogues suitable for future optimization to

156 e MIP affinity toward the enantiomers of the structural analogues that have a stereochemistry differe

157 s of the MIP toward the enantiomers of these structural analogues that have the same stereochemistry

158 g 38% of viral proteins, many have non-viral structural analogues that revealed surprising similariti

159 Close structural analogues that showed only weak binding to th

160 ined full selectivity for SAH over its close structural analogue, the highly abundant methylation cof

161 ells may respond to endogenous PGs and their structural analogues through interaction with these rece

162 %) of dichloronitrolysine, a halonitroalkane structural analogue to chloropicrin.

163 ,6-trifluorophenol, acts as a highly soluble structural analogue to the native substrate 2,4,6-tribro

164 rmidine, and spermine) and a series of their structural analogues to stabilize DNA.RNA and RNA.RNA du

165 rmidine, and spermine, and a series of their structural analogues to stabilize RNA-DNA hybrids using

166 eceptor protein; stimulation with CRF, or it structural analogue urocortin (Ucn) showed that the rece

167 tide and two amino acids with deuterated and structural analogues used as internal standards.

168 xicants and facilitate the identification of structural analogues using computational tools.

169 Notably, the accuracy of exact deuterated structural analogues was found to vary based upon the nu

170 es of overlapping H2B synthetic peptides and structural analogues, we have mapped the different epito

171 targeting activity and cytotoxicity of these structural analogues were assessed in RPMI8402 and P388

172 Values of K(i) for 1 and a series of 31 structural analogues were determined from radioligand bi

173 Ansamycin natural products and selected structural analogues were evaluated in a competitive bin

174 Using a flexible synthesis, families of TLM structural analogues were obtained that possess selectiv

175 -12-ol ring (designated ring C), a series of structural analogues were prepared and evaluated using a

176 Structural analogues were prepared for biological evalua

177 n addition, calphostins A, B, D, and several structural analogues were prepared to evaluate biologica

178 The substituted triazolopyrimidine and its structural analogues were produced by an inexpensive thr

179 r 100 naturally occurring small molecules or structural analogues were screened for ligand binding us

180 zoic acid, as lead compound, five classes of structural analogues were synthesized and evaluated for

181 ese initial analogues proved to be excellent structural analogues with good cross-linking capability,

182 be characteristic of many hundreds of their structural analogues XM(YCH(2)CH(2))(3)N (M = Si, Ge, Sn

183 ogical properties of this BR subunit and its structural analogue, (Z)-vinylneoxanthobilirubic acid me