ライフサイエンスコーパス: structural basis

1 bacterium thermophilum (EC 1.14.99.50), as a structural basis.

2 ersity across thalamic microcircuits and its structural basis.

3 These results constitute the first structural basis and a new model not only for the histor

4 These results provide insights into the structural basis and dynamics of PTH binding and recepto

5 tively, our studies provide insight into the structural basis and evolution of multiple binding partn

6 sponse against urinary tract infections, the structural basis and mechanism of UMOD polymerization re

7 the most challenging scenario, although the structural basis and physiological implications of this

8 evolving imaging approaches, their molecular structural basis, and the gaps in imaging capabilities t

9 e, we report on the biological activity, the structural basis, and therapeutic effects of the family

10 Here, we describe the functional and structural basis as to how two anti-CHIKV monoclonal ant

11 he past few decades has revealed much of the structural basis driving formation of this complex and s

12 of this process have been characterized, its structural basis, except for the well-known changes in t

13 In summary, we provide the structural basis for a comprehensive description of liga

14 These findings reveal the structural basis for a sequential around-the-ring ATPase

15 Our work provides a structural basis for active single- and double-ring comp

16 ctural features of Uba1 and that the overall structural basis for adenylation and thioester bond form

17 molecular dynamics simulations revealed the structural basis for altered specificity.

18 ribute to our understanding of the molecular structural basis for amyloid formation by FUS and by LC

19 tein to regulate translation, and provides a structural basis for an RNA code that guides global regu

20 ve ATP-binding configuration may provide the structural basis for antimicrobial design against these

21 ransmembrane helix 8, which likely forms the structural basis for CFTR's channel function.

22 for specific tRNA binding is known, but the structural basis for charge sensing and the role of othe

23 assembly of polar microdomains, revealing a structural basis for complex network assembly in Alphapr

24 ght as long-lived radicals, and provides the structural basis for designing photocatalysts with long-

25 Here, we further elucidated the structural basis for differences in replication rates an

26 We elucidate the structural basis for differential binding between NELL a

27 The structural basis for differential potency and selectivit

28 R structure of RD3 presented here provides a structural basis for elucidating RD3-RetGC interactions

29 to directly compare structures to derive the structural basis for enhanced stability.

30 variants that also provide insight into the structural basis for Env antigenicity.

31 be too much to imagine that determining the structural basis for every aspect of catalytic control,

32 n of the ptRNase superfamily, and presents a structural basis for evolutionary tuning of function in

33 ligand exchange on gold clusters evidences a structural basis for exchange of solvated ligands, excha

34 and phenyl groups of nintedanib, providing a structural basis for explaining that the p.L730V mutatio

35 ent studies were undertaken to determine the structural basis for far-red absorption by JSC1_58120g3,

36 Here the authors present the structural basis for formation of the 100S complexes in

37 tinct grey matter areas and may serve as the structural basis for function specialisation within brai

38 ctivation with small molecules and provide a structural basis for further development of Sirt6 activa

39 Importantly, our results will provide a structural basis for further understanding the function

40 However, the structural basis for FUT8 substrate specificity remains

41 ons are vital for drug binding and provide a structural basis for future computational design of GGPP

42 This work provides a structural basis for future rational design of additiona

43 polarized epithelial layers that provide the structural basis for gastrulation or subsequent developm

44 ate and the selectivity filter underlies the structural basis for gating in potassium ion channels.

45 These studies provide the structural basis for gating, ion selectivity, and single

46 y and dissect the genetic, biosynthetic, and structural basis for glycan binding in a natural context

47 In contrast, the structural basis for GPCR-independent G protein activati

48 Our findings provide a structural basis for GPCR-mediated sustained internalize

49 Our results establish a structural basis for GRAS-GRAS and GRAS-BIRD interaction

50 This unique interaction provides a structural basis for grazoprevir's higher potency than s

51 These studies provide a structural basis for Grp94-selective inhibition using si

52 These findings provide the structural basis for harnessing the type I-C Cascade as

53 We aimed to understand the structural basis for HIV Rev-HERV-K RcRE recognition.

54 nterhomolog contacts genome-wide reveals the structural basis for homolog alignment and juxtaposition

55 Here, we present the structural basis for how a mouse-derived neutralizing an

56 These findings provide a structural basis for how cGAS maintains an inhibited sta

57 Our findings provide a structural basis for how ligand binding site alterations

58 Together, this work provides a structural basis for how the Dot/Icm T4CP complex recogn

59 ing visual signaling, as well as providing a structural basis for interpreting how mutations in rod P

60 tagonists and a lack of understanding of the structural basis for ion channel subconductance states f

61 itive S. aureus lacks an RMF homolog and the structural basis for its 100S formation was not known.

62 0 angstrom has been solved, offering a solid structural basis for its binding validation and further

63 m spinach chloroplasts (cATPase) providing a structural basis for its function as a nanomotor.

64 tal structure of 31 with BRD4 BD2 provides a structural basis for its high binding affinity to BET pr

65 ive, unisolable intermediate, as well as the structural basis for its mechanism of electrochemical fo

66 uman ACE2 receptor binding motif providing a structural basis for its neutralization.

67 hout relinquishing DNA binding, suggesting a structural basis for its processivity.

68 context with related enzymes and reveals the structural basis for its specificity.

69 tal structures of BAR, and further delineate structural basis for its substrate selectivity and catal

70 However, the structural basis for ligand-induced NLR activation has s

71 The crystal structures illuminate the structural basis for LPL-mediated TRL lipolysis as well

72 Our study uncovers the structural basis for LPS recognition, delineates the con

73 e druggability of the FOXO-DBD and provide a structural basis for modulating these important homeosta

74 Na(+)-selective AtTPC1 mutant elucidates the structural basis for Na(+) selectivity in mammalian TPCs

75 ize into membrane-binding filaments, but the structural basis for negative versus positive membrane r

76 th neurofibromin (RasGAP domain) provide the structural basis for neurofibromin-mediated GTP hydrolys

77 years has increased our understanding of the structural basis for normal red cell membrane function a

78 These studies establish the structural basis for NTC engagement by NRARP and provide

79 Therefore, we propose a structural basis for nucleosome recognition by a pioneer

80 lateral than contralateral ORNs, providing a structural basis for odor lateralization behavior.

81 6) f complex from spinach, which reveals the structural basis for operation of the Q cycle and its re

82 In conclusion, we have uncovered the structural basis for PAR4 activation and identified a pr

83 The structural basis for PAR4 activation and the location of

84 we identified its lipid-binding site and the structural basis for phosphatidyl-based substrate bindin

85 The structural basis for Pol II transcription regulation has

86 Despite its biological importance, the structural basis for POR photocatalysis has remained unk

87 DNA polymerase beta (hPolbeta) and provide a structural basis for PPi release.

88 However, the structural basis for prodrug recognition has remained el

89 Our findings further establish a structural basis for PrP(C)'s C-terminal regulation of i

90 molecular dynamics simulations-delineate the structural basis for PTCH1-SMO regulation, and suggest a

91 frequent cause of cancer(4-6); however, the structural basis for RAF regulation is poorly understood

92 ll terminase in GTA production and propose a structural basis for random DNA packaging.IMPORTANCE Ran

93 re and dynamics of Ixolaris and describe the structural basis for recognition of FX.

94 Here, we defined the structural basis for recognition of SSEA-4 by a novel mo

95 with reduced protein stability, suggesting a structural basis for reduced cetuximab efficacy.

96 ects of DksA and its cofactor ppGpp, but the structural basis for regulation by these factors remains

97 Z1 and PDZ3 bound to beta-PIX, we define the structural basis for Scribble's ability to specifically

98 Our results provide a structural basis for selective CYP3A5 inhibition, along

99 residues within Synaptotagmin that suggest a structural basis for several activities required for fus

100 Poz1-Rap1(467-496) complex that provides the structural basis for shelterin bridge assembly.

101 Our results thus provide a structural basis for Sirtuin effects of quercetin-relate

102 The structural basis for specific tRNA binding is known, but

103 Ras WT and K-Ras G12D offer insight into the structural basis for specificity, highlighting differenc

104 Furthermore, we provide the first structural basis for stabilization of triple helical col

105 ted sodium channel and give insight into the structural basis for state-dependent binding of sodium c

106 antiomeric substrate specificity, reveal the structural basis for stereoselectivity and provide insig

107 These findings provide a structural basis for studying retrotransposon capsids, i

108 The structural basis for substrate recognition and transloca

109 Here, we report the structural basis for substrate recognition by MAGE ubiqu

110 with additional conserved proteins, but the structural basis for subunit assembly and the mechanism

111 pensity of S20G, and illustrates a potential structural basis for surface-templated fibril assembly.

112 tatory synaptic inputs, and thus provide the structural basis for synaptic function.

113 The structural basis for tarantula-toxin action remains elus

114 Together, we provide a structural basis for TbPRMT1 ENZ activation by PRO heter

115 Here we report the structural basis for the autoinhibition of RIAM by an in

116 However, the structural basis for the binding preference of Chz1 for

117 ges in the size of the D3-D4 cleft provide a structural basis for the conformational selectivity of t

118 These experiments delineate the structural basis for the crosstalk of the TF-FVIIa compl

119 m for ribosome inhibition and can serve as a structural basis for the development of inhibitors again

120 uence influence C99 processing and provide a structural basis for the development of small molecule m

121 These findings provide a structural basis for the development of STING agonists a

122 artial explanation for this conundrum, but a structural basis for the differences is lacking.

123 This work for the first time provides the structural basis for the different remote prior glycosyl

124 aims, our results contribute to a systematic structural basis for the emerging field of quantitative

125 Here, we reveal the structural basis for the exquisite selectivity of CENP-N

126 This work establishes a structural basis for the facile electrochemical oxidatio

127 This work provides a biochemical and structural basis for the function of CtIP at complex DNA

128 This hetero-interaction provides a structural basis for the functional interdependence betw

129 This study provides a structural basis for the functions of TFEalpha and eluci

130 These results provide a structural basis for the further design and optimization

131 The finding reveals the structural basis for the increased HERV-K expression obs

132 immunoglobulin locus and provide a potential structural basis for the interaction of HMCES with long

133 Our work thus offers a solid structural basis for the interpretation of a wide range

134 D160 cross-compete for binding HVEM, but the structural basis for the ligand selectivity by UL144 and

135 Our work reveals the structural basis for the long-standing "barcode" hypothe

136 ding partners MAT1 and Cyclin H, providing a structural basis for the mechanism of CDK7 activation an

137 ther, our structure and analysis provide new structural basis for the molecular events of the GPCR si

138 transition-state analogue to understand the structural basis for the multitude of reactions.

139 However, the structural basis for the mutagenic potential of oxoA, wh

140 The structural basis for the mutagenicity of oxoG, which ind

141 s is the first study to provide the intimate structural basis for the normal and reverse prenylations

142 al models provides physical insight into the structural basis for the observed specificities.

143 This and further understanding of the structural basis for the physical barrier properties wou

144 P-1 as a BMP-2/-4 antagonist and presented a structural basis for the physical interaction between TS

145 A better understanding of the structural basis for the preferences of RNA and DNA poly

146 Modeled structural basis for the recognition of alpha2-3-sialyll

147 However, the structural basis for the regulation of their catalytic a

148 Here we illuminate a structural basis for the retinol-SAA interaction.

149 Molecular modelling provided structural basis for the role of R242 and other critical

150 regulation of LPS biogenesis, presents a new structural basis for the selective recognition of lipids

151 description permits an understanding of the structural basis for the selectivity necessary for corre

152 Our analyses indicate and suggest a structural basis for the sequence specific recognition b

153 The structural basis for the similarities between avian and

154 It provides a structural basis for the specificity of CB-5083 toward t

155 Collectively, these findings elucidate the structural basis for the specificity of the epoxidation

156 ure of CYP2J2 is available, and the proposed structural basis for the substrate recognition and speci

157 re often key virulence determinants, yet the structural basis for their activity remains elusive.

158 pies against trypanosomiases and provide the structural basis for their development.

159 mic thermoregulatory mechanisms, providing a structural basis for their frequently being coordinated

160 res of 16 and 18 complexed with WDR5 provide structural basis for their high affinity binding to WDR5

161 of M-89 in a complex with menin provides the structural basis for their high-affinity interaction.

162 re of M-808 in complex with menin provides a structural basis for their high-affinity, covalent inter

163 tential as anticancer agents, but a detailed structural basis for their mechanism of action is still

164 The structural basis for these activities and how they lead

165 teriophage phi29 ATPase (CTD) that suggest a structural basis for these functional transitions.

166 ight be relevant to these functions, but the structural basis for this activity is poorly understood.

167 To probe the structural basis for this activity, we have prepared rin

168 Here, we elucidate the structural basis for this autoinhibition by determining

169 To elucidate the structural basis for this difference in the inhibitor ef

170 To understand the structural basis for this effect we compared the structu

171 However, the structural basis for this increase is unknown.

172 Here, we report the structural basis for this inhibition.

173 The biochemical and structural basis for this maintenance is poorly understo

174 Understanding the structural basis for this requirement has been elusive b

175 We provided a firm structural basis for this stabilization with an atomic r

176 ne-containing collagen peptide and provide a structural basis for this stabilization with an atomic r

177 To investigate the structural basis for this, we determined crystal structu

178 nd nucleotide (GTP or GDP), and we provide a structural basis for this.

179 molecular dynamic simulations discovered the structural basis for turning nonselective or promiscuous

180 Our results provide insights into a structural basis for uncompetitive lithium inhibition an

181 oidogenic cytochrome P450 enzymes, provide a structural basis for understanding human steroidogenesis

182 These studies offer a structural basis for understanding LC domain self-assemb

183 Our results provide a structural basis for understanding nucleotide sugar reco

184 Collectively, our results provide the structural basis for understanding peptide repertoire se

185 Our work provides a structural basis for understanding RPo formation and its

186 Our results provide a structural basis for understanding selective proton perm

187 Collectively, our work provides a structural basis for understanding the biochemical funct

188 ure of ER-luminal GT-C enzymes and provide a structural basis for understanding their catalytic mecha

189 c are evolutionarily conserved and provide a structural basis for understanding their function in int

190 n has been extensively studied, the detailed structural basis for voltage-dependent gating mechanisms

191 ane proteins differently, thus revealing the structural basis for why peptidiscs can stabilize such a

192 Our analyses indicate, and suggest a structural basis for, the preferential recognition of 5c

193 ognitive deficits in T2DM patients has brain structural basis in the condition.

194 Overall, our studies show the structural basis of AAV Rep's structural flexibility req

195 l event in Alzheimer's disease (AD), but the structural basis of Abeta-elicited neurotoxicity is unkn

196 Although the structural basis of actin and Myosin interaction is reve

197 ional changes also provide insights into the structural basis of agonism versus antagonism in steroid

198 sertib, providing critical insights into the structural basis of AKT1 inhibition by this unique class

199 Uncovering the structural basis of allergenicity would allow improved d

200 ed chemical shift predictions to explore the structural basis of allosteric product release.

201 of GH110 enzymes while also illuminating the structural basis of alpha-1,3-galactoside processing by

202 o-EM, but also pave the way to elucidate the structural basis of amyloid strains and toxicity, and po

203 ther, our study identifies the molecular and structural basis of an DISC1-ATF4 interaction underlying

204 We report here the structural basis of Ang1-induced Tie2 dimerization in ci

205 Our study thus reveals the structural basis of anion conduction in a TMEM16 channel

206 is of protein-drug interactions revealed the structural basis of avanafil's superior isoform selectiv

207 th brain microstructure at birth will reveal structural basis of behavioral emergence in typical deve

208 ge will require further understanding of the structural basis of broadly neutralizing HA and NA antib

209 ter understand the prevalence, function, and structural basis of catalytic activity in antibodies.

210 However, the structural basis of CB-cycle regulation by CP12 is unkno

211 erse activation and signaling mechanism, the structural basis of CB2-selective agonists design, and t

212 To further understand the structural basis of CD-I control of Kir channel gating,

213 Here, we used cryo-EM to elucidate structural basis of channel assembly and gating.

214 tructure and have facilitated studies of the structural basis of channel gating.

215 In an effort to better understand the structural basis of coupling specificity, we used time-r

216 To understand the physiological role and structural basis of Dh, we carried out a comparative stu

217 sh Wee1 and Wee2 from Myt1 and establish the structural basis of differential inhibition by the widel

218 However, the structural basis of EMC assembly and its functions are p

219 gnetic-resonance (NMR) analysis provides the structural basis of F29 specificity for Fyn over homolog

220 Structural basis of fibril polymorphism is thus importan

221 To investigate the structural basis of flagellar supercoiling, which is cri

222 ular mechanism of DSPs, with emphasis on the structural basis of function.

223 To better define the structural basis of genome packaging and organization in

224 odeling chromatin dynamics and assessing the structural basis of genome-wide observations.

225 results not only experimentally confirm the structural basis of glucose tolerance in GH1 beta-glucos

226 We characterize the structural basis of histone and DNA binding and determin

227 To better understand the structural basis of HLA-DQ2.5's unusual CLIP association

228 However, the structural basis of homo-oligomerization and the fractio

229 lts not only fill a gap in understanding the structural basis of IEP-assisted group II intron splicin

230 ity in IGF1 binding to IGF1R and reveals the structural basis of IGF1R activation.

231 Understanding the structural basis of immune recognition of capsular polys

232 Here, we report the structural basis of inhibition for one target, Gsk, the

233 P-9 are also disclosed and indicate that the structural basis of inhibition is a consequence of the a

234 o- and heterodimers, and unveiled the likely structural basis of interallelic complementation.

235 catalytic module of human CAK, revealing the structural basis of its assembly and providing insight i

236 e spike glycoprotein trimer to elucidate the structural basis of its cross-reactivity.

237 rallel beta-helix fold of the enzyme and the structural basis of its inverting catalytic mechanism.

238 rules governing RGS-Galpha recognition, the structural basis of its selectivity, and provide princip

239 With these results, we analyze the structural basis of KLK7 inhibition by the covalent atta

240 Recent insights into the structural basis of labile fibrils and potential mechani

241 However, the structural basis of LBP-8 action remains unclear.

242 nal evolution of ABHD family members and the structural basis of lipase regulation.

243 These results establish the structural basis of metal ion binding, transport and inh

244 The structural basis of minor groove recognition of a DNA du

245 h the N-terminal domain of CI, revealing the structural basis of MOR inhibition of CI binding to the

246 Until recently, the structural basis of MraY inhibition was poorly understoo

247 c" conditions, including a discussion of the structural basis of mutations that cause distinctive cha

248 To determine the structural basis of neutralization, we generated cryogen

249 these co-structures provide a comprehensive structural basis of NK(1)R antagonism and will facilitat

250 ding to the W-box of gene promoters, but the structural basis of OsWRKY45/W-box DNA recognition is un

251 Understanding the structural basis of P-gp, substrate polyspecificity has

252 To investigate the structural basis of partial agonism, we performed compar

253 This work sheds light on the structural basis of Pol delta's activity in replicating

254 ome initiation, reveals the architecture and structural basis of potential pre-inflammasome, and sugg

255 cture of authentic infectious prions and the structural basis of prion strain diversity remain unknow

256 tudies provide a framework to understand the structural basis of proposed hyperosmolality sensing in

257 sed in two main directions, the sequence and structural basis of protein thermostability and the mech

258 e models provide a platform to elucidate the structural basis of RAF activation by RAS and to develop

259 Our results help illuminate the structural basis of resistance to apoptosis, immune evas

260 The model provides insight into the structural basis of selective permeability of the carbox

261 type of genome organization may provide the structural basis of the 'one-neuron, one-receptor' rule

262 ico docking, which provide insights into the structural basis of the activity of the two series of co

263 Our study establishes the structural basis of the AtERF96 transcription factor in

264 rived amyloid fibrils when investigating the structural basis of the disease.

265 Our results thus provide insights into the structural basis of the distinct functions of the angiot

266 wders (genomic crowders), we demonstrate the structural basis of the enhanced facilitated diffusion o

267 However, little is known about the structural basis of the interactions of PS nucleic acids

268 However, the structural basis of the mechanism underlying fusion inhi

269 Our findings uncover the structural basis of the progression of Arctic mutant Abe

270 ch has enabled detailed understanding of the structural basis of the remarkable substrate promiscuity

271 conformation of kinesins, which provides the structural basis of the stable 2HB state and offers a te

272 domain of FBXL2 and PTAR1, which unmasks the structural basis of the substrate-enzyme specificity.

273 The structural basis of the switch and many of the pathways

274 cilitated hydrogen-bonding network forms the structural basis of the unusual LH1 redshift.

275 ate orders using information relating to the structural basis of their various functions.

276 dels of depressed systolic function, but the structural basis of these effects has remained unresolve

277 glycan maturation in the Golgi; however, the structural basis of these substrate preferences and the

278 ved in numerous allergens, understanding the structural basis of this interaction could yield insight

279 le CA IX mimetic (CA IX-mimic), revealed the structural basis of this particular inhibition profile a

280 s a first step toward the elucidation of the structural basis of this phenomenon, we solved the struc

281 The structural basis of this process has remained obscure du

282 To determine the structural basis of this selectivity, we determined crys

283 e at 1.39 angstrom resolution, revealing the structural basis of this strict selectivity.

284 Recently, our understanding of the structural basis of troponin-tropomyosin's Ca(2+)-trigge

285 e provides a framework for investigating the structural basis of TRP channel gating mechanisms and ph

286 This work provides a structural basis of ubiquitination by transglutamination

287 s, yet there is limited understanding of the structural basis of visual functional losses.

288 The structural basis of voltage gating is uncertain because

289 Despite recent advances, the structural basis of voltage sensing, electromechanical c

290 ial regulators of stem cell biology, yet the structural basis of Wnt signaling through Fzd remains po

291 n of RAF kinases, however, the mechanism and structural basis remain elusive.

292 on to nucleosome sliding, but the underlying structural basis remains unknown.

293 This work provides a structural basis to explain biochemical and genetic data

294 This study provides a structural basis to further investigate the starch degra

295 ical architecture of the mouse IC and thus a structural basis to guide investigations into its comple

296 in human cells; thus, our results provide a structural basis to understand their potential regulator

297 Our data shed new light on the structural basis underlying the interaction between PRL

298 However, structural basis underlying these base pairs remains poo

299 The structural basis underlying these distinctive transport

300 d alpha cell secretory activity, however the structural basis underlying this regulation has yet to b