ライフサイエンスコーパス: structural element

1 AP25 surface, but Rabphilin-3A uses a unique structural element.

2 suggesting later evolution of this critical structural element.

3 nd relative orientation of various secondary structural elements.

4 RNA folding from its secondary and tertiary structural elements.

5 e cleavage sites, and the latency-associated structural elements.

6 red phospholipids with systematically varied structural elements.

7 ishable from holo-CueO in terms of secondary structural elements.

8 its distinct preference for select viral RNA structural elements.

9 th significant differences in some secondary structural elements.

10 ell as subunit interfaces and some secondary structural elements.

11 sequence segments on the scale of secondary-structural elements.

12 (H1-SS-np) confirmed the preservation of key structural elements.

13 in domains lose a significant number of core structural elements.

14 propensity of this protein fold to exchange structural elements.

15 chemical modification or introduction of new structural elements.

16 ion on the regulatory importance of specific structural elements.

17 triad, oxyanion hole, and typical secondary structural elements.

18 8-membered cyclic ether among other distinct structural elements.

19 eveal that NTMT1 contains two characteristic structural elements (a beta hairpin and an N-terminal ex

20 Two types of structural element, a stem-loop and a poly(G) motif, not

21 cture, particularly exceptionally stable RNA structural elements, act as gauges of protein co-transla

22 ted genes due to the coupled formation of 3'-structural elements acting as terminators.

23 er critical insights into how MazF secondary structural elements adapt to recognize diverse RNA subst

24 titration calorimetry, we show how the three structural elements affect the protein's structure, dyna

25 Here, we identify a structural element, alpha-helix-7, in human Argonaute2 (

26 Discovery of common genetic and structural elements among MPER antibodies from different

27 ted in a groove between the alphaB and betaB structural elements and a highly conserved carboxylate-b

28 ns to determine the relative contribution of structural elements and enhancers to the higher order st

29 assignment of (1)H signals belonging to key structural elements and functional groups.

30 resolution, sufficient to identify secondary structural elements and produce an atomic model of the i

31 taining functional groups are valuable polar structural elements and that they deserve to be consider

32 and others have demonstrated that nonduplex structural elements and the conformational flexibility t

33 Based on its distinct structural elements and the genetic distance to other pi

34 show the conservation of the core secondary structural elements and the location of the N-terminal r

35 e the database's function by examining known structural elements and we explore example use cases in

36 ng their entire sequence, i.e. entirely lack structural elements, and IDRs as regions that are at lea

37 o enzymes released ferulic acid from various structural elements, and NMR spectroscopy indicated comp

38 ximities, relative orientations of secondary structural elements, and protein-cofactor interactions i

39 ght affect rates of folding of near-neighbor structural elements, and thus limit the ability to resol

40 sed on similarity in sequence, 2D, and/or 3D structural elements are available, our graph-based searc

41 These structural elements are capable of controlling gating of

42 ifferent conformations and crosstalk between structural elements are essential for the Mediator regul

43 y three-dimensional domain swapping, whereby structural elements are exchanged between adjacent subun

44 These new structural elements are important for growth and mRNA ex

45 conformers having at least some well-defined structural elements are stabilized as temperature is inc

46 ontacts with the receptor, but instead links structural elements associated with binding and activati

47 kinase 1 (TBK1) and have generalized the key structural elements associated with degradation activiti

48 s of azetidinones enabled the recognition of structural elements associated with integrin selectivity

49 A key structural element believed to regulate the degree of pr

50 umerous additions and deletions of secondary structural elements between related domains.

51 Extensive differences in key structural elements between the conformational states gi

52 Here we show how swapping structural elements between two bacteriophytochrome homo

53 nd both activities are highly dependent on a structural element called Loop1.

54 Here, we describe structural elements called interface add-ons that fulfil

55 regions or changes in geometry of secondary structural elements can be identified.

56 The structural elements computed to contribute to the non-tw

57 h nucleus the embryonic volume arises from a structural element contained within the voxels identifie

58 Computations explain how these structural elements contribute to reversibility and the

59 s studies have investigated the DAT and SERT structural elements contributing to inhibitor and substr

60 We investigate the extent to which structural elements contributing to intermediate conform

61 ptamers against DUX4 with specific secondary structural elements conveying high affinity to DUX4 as a

62 We hypothesize that this structural element could explain their specific bioactiv

63 cardiac glycoside variants, we assessed the structural elements critical for anti-CMV activity by bo

64 hydroxyl radical probing identified aptamer structural elements critical for inhibition and establis

65 In this study, we report a structural element crucial for the biological function a

66 cular structure of TRPV6 and discuss how its structural elements define its unique functional propert

67 an extended alkyl-aryl side chain is the key structural element determining the macrolides' slow diss

68 fied the amino-termini of Rad and Rem as the structural elements dictating the specific modes of inhi

69 To elucidate what structural elements differentiate TTLL glycylases from g

70 ure of an HCN1 channel revealed that a novel structural element, dubbed the HCN domain (HCND), forms

71 c N-terminal helix of MscL acts as a crucial structural element during tension-induced gating, both s

72 d information is required on how the blocker structural elements (e.g., positively charged and aromat

73 nd identified the specific residues in these structural elements employed in these interactions, like

74 These structural elements exhibit flexibility, which may hold

75 -acetyl-muramic acid (NAM), serves as a core structural element for innate immune recognition of PG f

76 A key structural element for inter-head coordination is the ne

77 )A is within loop III of the GFD, a critical structural element for its binding with the beta-PDGF re

78 hlighted the pyrazole moiety as an essential structural element for LsrK inhibition.

79 fic requirement of secondary and/or tertiary structural elements for catalysis by Set7/9.

80 acids (BAs) are building blocks or important structural elements for numerous primary and specialized

81 sess only 24% sequence identity, use similar structural elements for rRNA substrate recognition and p

82 the two enzymes use almost a similar set of structural elements for target recognition, the residues

83 Our method determines essential structural elements for targets of protective antibodies

84 Methyl groups are among the most prevalent structural elements found in bioactive molecules, and so

85 TX, a synthetic synaptic organizer combining structural elements from cerebellin-1 and neuronal pentr

86 Here we combine structural elements from known trypanocidal nucleoside a

87 the kinetics of this interaction, we grafted structural elements from the slowest isoform, syt-7, ont

88 uch an assembly scenario, multiple secondary structural elements from within the RNA, termed "packagi

89 gy is not only the study of the operation of structural elements (functional biology), but also the s

90 protein biology is the understanding of how structural elements give rise to observed function.

91 Cis-acting RNA structural elements govern crucial aspects of viral gene

92 nd to computationally model the sequence and structural elements governing the specificity of TRUB1,

93 s how knowledge of various viral genetic and structural elements has begun to advance the development

94 The structural elements identified are: fibrous, helical, gr

95 mental evidence of a lateral gate in TamA: a structural element implicated in membrane protein assemb

96 The results provide insights into the structural elements important for aminoglycoside inhibit

97 ature of the abeta-PFTs, may be an important structural element in driving efficient pore formation.

98 ese results identify the NTR as an important structural element in myosin force sensing and suggest a

99 Since the dominant repeating structural element in peptides is the locally achiral am

100 Grain boundary triple junctions are a key structural element in polycrystalline materials.

101 phodiester bonds have emerged as a plausible structural element in prebiotic RNAs.

102 a catalytic cofactor in metalloenzymes and a structural element in proteins involved in general metab

103 This structural element in synergy with the HCN cyclic nucleo

104 introducing a pyrazole moiety as the B-ring structural element in the common A-ring-linkage-B-ring n

105 Our work reported here shows that a helix structural element in the MuV nucleocapsid protein becom

106 Instead, a secondary structural element in the peripheral subdomain appears t

107 f tertiary folds combining several secondary structural elements in a single entity are rare.

108 (+)-binding reconfigures dynamically coupled structural elements in an allosteric interaction network

109 rived distance measurements between specific structural elements in Bak, here we clarify how the Bak

110 Eight structural elements in biological materials are identifi

111 chers the ability to characterize individual structural elements in controlled synthetic contexts in

112 substitutions can be used to target specific structural elements in EF-Tu to redesign the thermodynam

113 bonds away from the C-N bond) are important structural elements in many pharmaceutical agents and na

114 eric pseudonuclease core of TEFM with mobile structural elements in mtRNAP and the nucleic acid compo

115 al loads; however, little is known about the structural elements in myosin responsible for force sens

116 nduced-fit recognition mechanism adapt local structural elements in response to ligand binding on a r

117 With structural studies, we uncovered 2 key structural elements in SrtA that partake in recognition

118 Given the strong conservation of these structural elements in terminase enzymes, this mechanism

119 priate polypeptide context or other adequate structural elements in the acceptor substrate could faci

120 igh resolution the orientation of individual structural elements in the catalytic domain while myosin

121 e identified multiple previously unannotated structural elements in the HIV-1 genome likely to functi

122 s difference was determined by non-conserved structural elements in the intracellular N terminus.

123 These findings indicate that PKR sequence or structural elements in the kinase domain, present in hPK

124 , both in vitro and in vivo, to sequence and structural elements in the SMN mRNA 3'-untranslated regi

125 antly less adhesive, allowing them to act as structural elements in the web.

126 The identification of conserved structural elements in visual and acoustic communication

127 eatures of the wild-type fold but reveal new structural elements, including a previously unobserved h

128 racterized and put into context discrete RNA structural elements, including the cis-acting Mta respon

129 in assembly in which rhodopsin uses distinct structural elements, including transmembrane helix 7 and

130 onical enzyme for investigating how distinct structural elements influence enzyme catalytic activity.

131 tracellular matrix, bioprinting these simple structural elements into a 3D culture medium made from p

132 as conformation-determining and -restricting structural elements into macrocyclic hot loop-derived pe

133 We demonstrate that insertion of specific structural elements into transcription factor binding ol

134 ies, but pertinent information regarding the structural elements involved in cation translocation and

135 rotein backbone, allowing us to identify the structural elements involved in gating and modulation of

136 yses of 552 Type ISP enzymes showed that the structural elements involved in target recognition of Ll

137 aled unprecedented conformational changes in structural elements involved in the allosteric signal tr

138 To identify the structural elements involved in this signal transduction

139 e centriole distal end, confirming that this structural element is a target of importance for pathoge

140 ormations where the only conserved secondary structural element is one turn of helix that binds the c

141 r-transmembrane GlyR interface and that this structural element is vital for inhibitory GlyR function

142 processivity and the variation of peripheral structural elements is essential for their diverse funct

143 coiled-coil acts as a central regulatory and structural element: it prevents NuMA from binding chromo

144 nknown sites residing within a MAPK-specific structural element known as the MAPK insert: T241 and S2

145 sive and persistent loss of bone mineral and structural elements leading to loss of bone strength and

146 sm, in which the coordinated movement of six structural elements leads to the alternating opening and

147 Our findings indicate that non-coding RNA structural elements may be more broadly targeted by synt

148 nel structures, opening the door for mapping structural elements mediating activation by each stimulu

149 We also identify structural elements modulating viral stability, notably

150 arity to U1 snRNA, we identify RNA secondary structural elements near the alternative 5' splice sites

151 l is supported by our identification of Kip3 structural elements necessary and sufficient for plus-en

152 t 1.2-1.5 A resolution, which reveal several structural elements not detected in recent cryo-EM recon

153 affects mobility of the trigger loop (TL), a structural element of Rpb1 that moves in and out of the

154 The cortex of the femoral neck is a key structural element of the human body, yet there is not a

155 The nuclear lamina is a key structural element of the metazoan nucleus.

156 ymerase (RNAP) trigger loop (TL) is a mobile structural element of the RNAP active center that, based

157 s-linking, reveals that Crl interacts with a structural element of the RNAP beta'-subunit that we cal

158 tator of membrane interactions but also as a structural element of the StII(1-30) pore that is recrui

159 regions of ACKR3 that elucidate fundamental structural elements of agonism in this atypical receptor

160 The main structural elements of biological smell systems are the

161 Centrioles are core structural elements of both centrosomes and cilia.

162 human A3B-CD1 variant and delineate several structural elements of CD1 involved in molecular assembl

163 Our study has uncovered the mechanism and structural elements of convallatoxin, which are importan

164 bis-THF) derivative, which is one of the key structural elements of darunavir, an FDA-approved drug f

165 we deconvoluted three key morphological and structural elements of FeN(4) sites, including particle

166 stablish conformational coupling between key structural elements of Galphas.

167 equence analysis and structure-based design, structural elements of glucagon were engineered into the

168 N- and O-linked glycans express structural elements of HMOs, and thus, the reported synt

169 veals how GTP, fMet-tRNA(fMet), and specific structural elements of IF2 drive and regulate this confo

170 undergoes a concerted reorganization of the structural elements of its central channel during intera

171 selectivity obtained by merging distinctive structural elements of known agonists and antagonists of

172 Whereas some structural elements of lipids are readily derived from h

173 ophore hybridization strategy to combine key structural elements of merbarone and etoposide and gener

174 of the nanoparticles efficiently "glued" the structural elements of microfibrils together, producing

175 -13 amino acids is sufficient to build major structural elements of modern proteins.

176 Besides being important structural elements of plant membranes, their particular

177 Here, we hierarchically review the structural elements of RNA and how they contribute to RN

178 no concomitant denaturation of the secondary structural elements of Rsn-2 with the large-scale transf

179 ver, unlike in an NNRTI-bound state in which structural elements of RT restrict the movement of the p

180 e components that are dependent on different structural elements of RyR1.

181 o encourage findability, and how to leverage structural elements of software to make it easier to fin

182 ually mediated by direct interaction(s) with structural elements of the actin cytoskeleton.

183 n c-di-GMP content and altered expression of structural elements of the biofilm extracellular matrix.

184 - to atomic-resolution structures reveal the structural elements of the enzyme involved in utilizatio

185 pose and consider two limiting cases for the structural elements of the glycocalyx: stiff beams and f

186 olecular simulations to show that individual structural elements of the group I ribozyme from the bac

187 hese distributions, when correlated with the structural elements of the kinase core, allow for a deta

188 t of GRK5 in a partially closed state, where structural elements of the kinase domain C-tail are alig

189 This vaccine candidate preserved structural elements of the native PvMSP119 and elicited

190 ction-oriented synthesis to identify the key structural elements of the potential therapeutic pharmac

191 DCs must be designed to address the specific structural elements of the protein scaffold, linker, and

192 its dynamic interactions with tRNA and other structural elements of the ribosome.

193 nvolving a fine-tuned interplay of important structural elements of the sensor, as well as the sensor

194 ne a digital rock model exemplifying the key structural elements of these carbonate grainstones.

195 ia and E. coli, with distinctively different structural elements of TopoI-CTD utilized for this prote

196 Caged (or bridged) bicyclic structural elements offer a variety of diverse features,

197 Of all predicted secondary structural elements, only a single 15-nt stem-loop showe

198 ses to actuate hydrogels containing DNA as a structural element or as an anchor for pendant groups.

199 orly structured regions connecting secondary structural elements, or linkers that connect entire prot

200 We analyzed the secondary structural elements, or motifs, present in all human miR

201 The dynamic motions of protein structural elements, particularly flexible loops, are in

202 Paradoxically, neither structural element performs its implied function.

203 Additionally, the variation in structural elements peripheral to catalytic motor domain

204 hin the R2 surface region, whereas divergent structural elements pinpoint regions mediating virus-spe

205 Our goal was to determine the structural elements present in this peptide and evaluate

206 to changes of accessibility and dynamics of structural elements previously implicated in the transpo

207 d chemical cross-linking, we show that three structural elements protruding from the motor domain-the

208 hifts in the dynamic properties of adjoining structural elements rather than through a few discrete c

209 hroughs led to the identification of the key structural elements regulating gating, transport, select

210 Our understanding of the structural elements regulating this signaling cascade is

211 xisting immune effectors yet retain the core structural elements required for localization and functi

212 nstruct (mini-hSIRT1) containing the minimal structural elements required for lysine deacetylation an

213 ngaged, these precursors contain many of the structural elements required for neutralization, and can

214 ehydratases, wherein insertions of secondary structural elements result in the formation of a distinc

215 h nucleic acids, proteins, or lipids and of "structural elements" (SEs) directing their wiring within

216 tant receptors have proportions of secondary structural elements similar to wild-type receptors.

217 rate throughput, could be used to screen for structural elements, small molecules, and host factors t

218 le topologies formed by up to five secondary structural elements (SSEs), searched for their occurrenc

219 ain a variety of conserved, nonproteinogenic structural elements such as d-amino acids and amide N-me

220 The inter-subunit interfaces show unique structural elements such as inter-subunit parallel-stack

221 ble linker that harbors additional secondary structural elements, such as Stem III.

222 is a transportable domain that contains the structural elements sufficient for activation by noxious

223 lity of the AHR PAS-A and its loosely packed structural elements, suggest a dynamic structural hierar

224 Bax clusters contain structural elements suggesting a higher order organizati

225 revealed six residues that provide essential structural elements supporting the fold of the loop and

226 Structural elements surrounding the triplex regulate the

227 Moreover, we identify a novel structural element, termed the homo-oligomer assembly (H

228 known to bind the kink-turn (K-turn), an RNA structural element that causes axial bending.

229 that the overhang of a pre-miRNA is the key structural element that is recognized by TUT7 and its pa

230 he beta gate loop, a conserved and essential structural element that lies across the DNA channel from

231 The structure also reveals two structural elements that appear to mediate the coupling

232 esent study, we investigated the genetic and structural elements that are important for ampC inductio

233 AR) studies provided insights into conserved structural elements that are important for inhibition po

234 ns as well as loop diminutions affecting RNA structural elements that are otherwise conserved from ba

235 Collectively, our data identify key structural elements that are required for PCO activity a

236 These nucleotide pockets have structural elements that are well-conserved in two human

237 from E2 to lysine residues by: (1) harboring structural elements that block E2 Ub from adopting a 'cl

238 107 analogs will allow us to define critical structural elements that can be mapped onto the receptor

239 Transib possesses unique structural elements that compensate for the absence of a

240 The composite of secondary structural elements that comprise miRNAs could aid the d

241 Identifying the structural elements that constitute red sites can expand

242 In this work, we analyzed sequence and structural elements that contribute to efficient ligand-

243 genesis was also used to further dissect the structural elements that contribute to the interactions

244 Determining the structural elements that define substrates and inhibitor

245 wever, little is known about the residues or structural elements that define this activity.

246 y is unique to the SARM1 TIR domain, yet the structural elements that enable this activity are unknow

247 We propose that the native state contains structural elements that frustrate one another's folding

248 the aquatic environment feature stereogenic structural elements that give rise to enantiomerism.

249 We explore the structural elements that govern Oct4 recognition by thes

250 rovide novel molecular information about the structural elements that govern the interaction between

251 mining region 3 (HCDR3) and possesses unique structural elements that interact with protein and glyca

252 Kink turns (k-turns) are widespread structural elements that introduce an axial bend into du

253 To examine the structural elements that lead to differences in force se

254 necessary step to unravel the electronic and structural elements that lead to ultrafast and near-unit

255 -associated hyperactivating mutations map to structural elements that maintain the inactive state, an

256 suggest that RAM contains sequence-specific structural elements that may be important for activation

257 e JEV at near-atomic resolution and identify structural elements that modulate stability and virulenc

258 nslocation, focusing on rate-limiting steps, structural elements that modulate them, and accessory pr

259 ly, these regions also contain the secondary structural elements that nucleate subsequently in the se

260 esence of a bulge between the G-quartets are structural elements that potentially can be targeted by

261 mbrane permeability by producing lipids with structural elements that putatively improve membrane int

262 of self-stress--tensions and compressions of structural elements that result in zero net forces--play

263 es of the viral cycle, of a highly conserved structural element, the major homology region (MHR), wit

264 e virion architecture that lacks several key structural elements thought to stabilize a single-shelle

265 HX MS determines the response of each Hsp104 structural element to the different bound adenosine nucl

266 ring proteins vary the precise geometries of structural elements to create distinct shapes optimal fo

267 g cell cycle progression and requires unique structural elements to function.

268 Large RNAs often utilize GNRA tetraloops as structural elements to stabilize the overall tertiary fo

269 is circuitry subserve that link these unique structural elements to their function?

270 by exploiting the ability of flavivirus RNA structural elements to trap XRN1 decay intermediates in

271 ore, the contributions of several peripheral structural elements to triplex formation and protective

272 c rings are postulated to serve as important structural elements toward tuning the chemical and elect

273 The location of these structural elements ultimately determines the dependency

274 d2 fold in crystal and in solution, its core structural elements undergo discernible rigid-body movem

275 The actin cytoskeleton is a structural element underlying the proper morphology of d

276 Structural elements underlying the theft occurred early

277 ends on the conformation of the E3 insert, a structural element unique to SMAD2 and previously though

278 uence element also turns into a well-defined structural element upon fibril formation.

279 d for measuring the rate of formation of two structural elements using a single triple-labeled mutant

280 addition, the residue positions within these structural elements were under strong evolutionary const

281 responded to half of the total population of structural elements, whereas the remaining half were equ

282 ctions contain hot-spot regions on secondary structural elements, which contribute disproportionately

283 It shares core structural elements with clan CD cysteine peptidases but

284 hitectured materials is enhanced by aligning structural elements with expected loading; our findings

285 PON-2 shares key structural elements with MEC-6, an endoplasmic reticulum

286 tric superfold protein composed of repeating structural elements with multivalent carbohydrate-bindin

287 In conclusion, P4H-TM shares key structural elements with other P4Hs while having a uniqu

288 wo SMYD proteins, Set5 and Set6, which share structural elements with the mammalian SMYD enzymes.

289 iant CENP-A, hence, serving as a reinforcing structural element within the histone core.

290 nt genus, suggesting a conserved stabilizing structural element within the paramyxovirus family.

291 We also define a novel structural element within the second insertion that is h

292 red regions that connect protein domains and structural elements within domains and which facilitate

293 cting initiation factors as well as sequence/structural elements within messenger RNAs and that non-A

294 single metal centers that typically serve as structural elements within such cages.

295 ough a 'molecular corset' mechanism, whereby structural elements within the epithelium become circumf

296 highlights the presence of varyingly stable structural elements within the IDRs.

297 ting the physiological relevance of specific structural elements within the IRES for virus infection.

298 PRF is typically stimulated by structural elements within the mRNA that generate mechan

299 ton relay network and other highly conserved structural elements within this class of enzymes.

300 e in good agreement with the known secondary structural elements within ubiquitin.