ライフサイエンスコーパス: structural feature

1 g to different compound classes bearing this structural feature.

2 owth, when considered as a tracheophyte-wide structural feature.

3 on dipoles were visualized in the context of structural features.

4 o a test set of substrates possessing varied structural features.

5 active protein kinase with several atypical structural features.

6 rol functions within their compositional and structural features.

7 ous predictors, by including global kmer and structural features.

8 leators that finely control the kinetics and structural features.

9 re of the natural glycans is due to specific structural features.

10 segments, and many have branches that follow structural features.

11 at propagate along the ring to affect distal structural features.

12 ature sensing rely on proteins with specific structural features.

13 of mechanisms of action while sharing common structural features.

14 in part by difficulties establishing global structural features.

15 ng-range contacts and captures more tertiary structural features.

16 cell function as well, exhibits distinctive structural features.

17 fatal tumors, with associations differing by structural features.

18 ged metaphase chromosomes, unravelling their structural features.

19 flexibility, the locus has rigidly conserved structural features.

20 s in some species that might exhibit similar structural features.

21 proteomic studies and to define the critical structural features, a thorough investigation was perfor

22 ath-censored risk of graft failure with each structural feature after adjusting for the predictive cl

23 However, the structural features allowing target RNA-binding-dependen

24 ea lamprey (Petromyzon marinus), with unique structural features, altered kinetics of activation and

25 Differential sequence and structural features among the most and least potent sgRN

26 entation vs. attentional modulation) and one structural feature (anatomically central vs. peripheral)

27 Our findings show how intricate structural features and acetylation patterns of dietary

28 The goal of this study was to evaluate the structural features and anti-inflammatory capacity of Q0

29 ions reveal the effect of the electronic and structural features and confer plausibility to the exist

30 oidetes inhabitants of the gut, have several structural features and conformational transitions that

31 lectronic effects of the substituents on the structural features and electronic properties of the iso

32 Correlation of these structural features and functional observations provide

33 did not show any causal relationship between structural features and functional response to visual se

34 r assays, and animal models, we examined the structural features and functional roles of recombinant

35 ponsible for activation also showed distinct structural features and glycosylation.

36 -1 repeats, member 13), identifying critical structural features and interactions that allosterically

37 and critical insights into their particular structural features and overall performance.

38 sers to download the SQL file, computational structural features and PTM sites' data.

39 Given their modular synthesis, unique structural features and rich functionality, structurally

40 urrently, very little is known about how the structural features and sequences of a given chemokine,

41 This study investigates structural features and substrate binding of YpenMan26A,

42 In this Perspective, the structural features and synthetic principles of 2D CCFs

43 el, we generated 97 different sequential and structural features and used a two-step strategy to sele

44 ot-Sub integrates heterogeneous sequence and structural features and uses a two-step feature selectio

45 vating power of different HFEs with distinct structural features, and considering the shuttle factor

46 thetic enzymes capable of installing unusual structural features are continuously being discovered.

47 We propose that the entry domain's dynamic structural features are critical for function.

48 ty of nitrogen in manganese metal, while its structural features are guided by the complementary inte

49 ehensively analyzed and higher order genomic structural features are largely unknown.

50 actins, suggesting mechanisms for how these structural features are linked to their diverse function

51 It was demonstrated that several structural features are required to retain the anti-glio

52 hase preference of PMP22 derives from global structural features associated with the folded form of t

53 s and multiple smaller groups that differ in structural features, association with distinct effectors

54 s in probing MRI relaxivity of MNPs based on structural features at the molecular and atomic scales i

55 , (c) all while maintaining highly organized structural features at the nanometer length scale that p

56 iltered transmission electron microscopy, of structural features attributable to short-range order in

57 Further, the shared structural feature between unrelated channels suggests t

58 Comparison of structural features between APAQ-Pd complexes and an ace

59 ccessful integration of ligands with similar structural features but with notable chemical distinctio

60 Moreover, we noted that dElys has conserved structural features, but contains a noncanonical AT-hook

61 dral angle than BINOL on the diol part; this structural feature can be an assisting factor for better

62 These unique structural features can serve as potential targets for s

63 s in characterizing these enzymes, including structural features, catalytic mechanisms, regulation, a

64 fungi, protists and algae that contain many structural features characteristic of animal GRLs.

65 These global and local structural features collectively define VA-I as an arche

66 at the nucleotide binding site and exhibits structural features common to myosins of diverse classes

67 de evidence that neuronal TNTs have distinct structural features compared to other cell protrusions.

68 and large variation of their biochemical and structural features complicate classification and annota

69 tudies and ligand-receptor modeling revealed structural features critical to the function of ZmPeps a

70 To determine which structural features define an active JH receptor agonist

71 Statistical modeling of structural features described by intrinsic physical orga

72 The structural features described here serve as a foundation

73 ination of HDAC6 enables an understanding of structural features directing affinity and selectivity i

74 r than as part of a multi-TOG array, and has structural features distinct from previously characteriz

75 al lamination of FA proteins with three main structural features distinct from previously studied foc

76 B mobility) can be explained solely by their structural features (DSB focus size, local chromatin com

77 resolution, and asymmetric synthesis, their structural features, electronic and chiroptical properti

78 The structural features, electronic properties, and surface

79 ion within these experiments to sequence and structural features enabling downstream analyses.

80 including operating algorithms, sequence and structural features, feature selection, model performanc

81 lt, it has become recognized as a privileged structural feature for targeting a wide range of therape

82 From a list of 22 mutations, we uncovered structural features for all, including a crucial role fo

83 sferases to identify conserved and divergent structural features for donor and acceptor recognition a

84 ll-autonomous aspects, as well as the use of structural features for growth.

85 slocation step have been inferred from these structural features for other AAA+ unfoldases, but bioch

86 We reveal key structural features for the activity of this series and

87 Here, we describe critical structural features for the interaction of GpsB with pep

88 laboratories confirms the reproducibility of structural features from side chains down to water and i

89 , we present an analysis of the sequence and structural features governing TNKS interactions with two

90 e-exposed endomannanase whose functional and structural features have been unclear.

91 ely studied, its genome sequence and genomic structural features have never been comprehensively anal

92 nction, can already be identified using only structural features, highlighting the importance of care

93 d to new insights into the nature of genomic structural features identified by sequencing, such as to

94 The structural features identified here may provide opportun

95 To this end, we correlate the membrane structural features imaged by atomic force microscopy (A

96 ugh certain microbial lipids are toxins, the structural features important for cytotoxicity remain un

97 ntly improved along with the addition of new structural features, improved structural moiety assignme

98 A ubiquitous structural feature in biological systems is texture in e

99 Granular protein is an important structural feature in determining starch digestibility.

100 ortant catalytic role has been ascribed to a structural feature in TAPBPR called the scoop loop, but

101 ytosolic soluble domain possesses a distinct structural feature in the form of extended intracellular

102 The cell wall is a crucial structural feature in the vast majority of bacteria and

103 Understanding the degree to which structural features in a compound may affect the biologi

104 ordering temperature in nano- and mesoscale structural features in an iron arsenide.

105 ing the importance of careful integration of structural features in any analysis of inter-individual

106 In summary, our findings unravel the structural features in ArnA and ArnB important for their

107 Subtle structural features in bacterial lipids such as unsatura

108 ys with elemental sensitivity for unraveling structural features in chemically heterogeneous function

109 e information on sequence co-variations with structural features in contact inference.

110 ryo-EM) studies of TRPM8 have shown distinct structural features in its architecture and domain assem

111 bioinformatics sequence analysis unravelled structural features in pUS10 reminiscent of those observ

112 providing a basis for the emulation of these structural features in synthetic molecular complexes.

113 ted because they typically require dedicated structural features in the enzyme, such as a nucleotide

114 We propose that structural features in the narrative that are reflected

115 Structural features in these protrusions vary between ce

116 n crystal structure revealed several unusual structural features, including a three-cysteine active s

117 rning model using functional, mutational and structural features, including new genome essentiality m

118 Overall, specific structural features induced by the intercalation of high

119 tool for testing how symmetric or asymmetric structural features influence HK functions.

120 This work establishes the RNA structural features involved in c-JUN specialized transl

121 The fused spirooxindole structural feature is embedded in many natural products

122 elated P22-like phages, indicating that this structural feature is likely important for stabilizing t

123 Conventional analysis of structural features is extremely time-consuming and subj

124 Varying the key structural features led to the identification of a poten

125 Structural features, like bulges, provide opportunities

126 ds employed to access these compounds, their structural features, magnetic properties, and electronic

127 gh histidine content, suggesting that unique structural features may contribute to coinhibitory mecha

128 This structural feature means that each amino acid spends suf

129 From a close examination of the structural features near the reactive residues, we find

130 Our findings pinpoint active site structural features necessary for the processing of drug

131 als delivered in droplets revealing distinct structural features not previously reported.

132 Our collective results reveal a structural feature of an ICE TA toxin that influences su

133 TANCE The immature Gag lattice is a critical structural feature of assembling HIV-1 particles, which

134 vered, (+)-aristolactam GI displays a unique structural feature of having the aristolactam scaffold l

135 The interpenetrating structural feature of the as-obtained composites not onl

136 acted by the amide group, which is a crucial structural feature of the radical precursor, with the as

137 predict that each variant affects a distinct structural feature of this DNA-binding domain, and funct

138 different dentin-conditioning methods on the structural features of AAMP-coated dentin.

139 -relevant mutations localize to these unique structural features of AFG3L2 and distinctly influence i

140 Our results provide insight into the structural features of alphaM4 that are important.

141 pectroscopy enabled the determination of the structural features of amyloids, such as the HET-s prion

142 ce methods to connect catalyst and substrate structural features of an array of reported enantioselec

143 cs of LTA(4)H, a series of analogues bearing structural features of ARM1 and 4MDM were synthesized us

144 selectivity of 1,3-dipolar cycloaddition and structural features of beta-proline tripeptides.

145 how how systematic inclusion of salient soil structural features of biophysical origin affect local a

146 f a multiciliated cell, a hybrid cilium with structural features of both primary and motile cilia is

147 major driver of genome architecture and that structural features of chromatin act as modulators, rath

148 The structural features of CR binding were unknown for years

149 roup to a cytosine base locally modifies the structural features of DNA in multiple ways, which may c

150 ) and larger A/B compartments as two salient structural features of eukaryotic chromosomes.

151 mance through the modulation of chemical and structural features of framework materials with atomic p

152 GOxploreR are (I) easy and direct access to structural features of GO, (II) structure-based ranking

153 Overall, our study not only reveals unique structural features of GPBAR that are involved in bile a

154 ological relevance, reported modulators, and structural features of GPR18.

155 furan as a nucleophilic terminator, the key structural features of hatJ were rapidly constructed.

156 Solution NMR analysis reveals structural features of IL-36alpha and its complex with h

157 use of the inherent challenges of predicting structural features of integral membrane enzymes.

158 geting lipid A biosynthesis, while revealing structural features of interest for future investigation

159 In the present work, we sought to analyze structural features of IRR by comparing them with those

160 ctivation methods allow elucidation of basic structural features of lipids but fail to reveal the pre

161 ment of new synthetic methods to control key structural features of low-dimensional TMD crystals (e.g

162 iting the binding of KTN1 and identifies the structural features of MAP65-1 that are important for th

163 This study confirms that the composition and structural features of microcalcifications correlate wit

164 This review initially overviews the complex structural features of mucosal tissues, including the st

165 The intriguing solar-thermal properties and structural features of multilayer PPy nanosheets can be

166 Distinctive structural features of mycobacterial Pol1 POL include a

167 resent evidence that previously unrecognized structural features of NEAT1 serve an important role in

168 In this review, we first highlight structural features of NF-kappaB:DNA complexes and how d

169 can sequencing approach can highlight shared structural features of nonisomeric glycans in a high-thr

170 Here we report structural features of postsynaptic mitochondria in the

171 buffer exchange (OBE) nMS to directly screen structural features of pre-purified proteins, protein co

172 rovides a direct measure of the chemical and structural features of proteins with the potential for r

173 Here we report how key structural features of prothrombin can be monitored by l

174 onal bias, the proposed model reproduces key structural features of real-world diffusion trees across

175 Understanding the structural features of Rieske oxygenases responsible for

176 roles for fork-loop 2 and switch 2-universal structural features of RNAP-in restricting access of DNA

177 These structural features of SARS-CoV-2 RBD increase its ACE2-

178 inct pharmacological profile and interesting structural features of teixobactin with nonstandard amin

179 rototypes that replicate the three principal structural features of the baleen plate (hollow medulla,

180 , and our reconstructions reveal identifying structural features of the BB, TZ, and axoneme.

181 broad specificity of bGalE was explained by structural features of the binding pocket for the N-acet

182 mulatory and inhibitory signaling and reveal structural features of the channel subunits that determi

183 to peptide segments, correlates closely with structural features of the crystal structure of the Hb t

184 We identify key structural features of the cyclooxygenases, break down t

185 We reveal structural features of the human enzyme that explain its

186 CHEDDA-related variants alter the particular structural features of the HX repeat motif, suggesting t

187 The structural features of the individual stereoisomers were

188 establishing a correlation between these two structural features of the lattice.

189 etrosynthetic ring dissection and the unique structural features of the linear precursor sequences th

190 ferent parenchymal liver cell types and have structural features of the liver, using human pluripoten

191 aches now provide an opportunity to quantify structural features of the locus coeruleus in vivo durin

192 tal X-ray analysis was used to elucidate the structural features of the macrocycles.

193 properties, and this is based on the unusual structural features of the major lipid species-triacylgl

194 sis of sequence alignments, we show that the structural features of the MOR:CI complex are likely con

195 y sequence, binds to alpha-Cbtx by mimicking structural features of the nAChR binding pocket.

196 ncludes a symmetry mismatch between distinct structural features of the outer membrane cap (OMC) and

197 Together this study sheds light on the structural features of the PCBP2/SLIV complex vital for

198 , and enzymological analysis to characterize structural features of the PH domain in its autoinhibite

199 rize pore formation, and to identify the key structural features of the pore.

200 The structural features of the probes including azido groups

201 n of 3.8 angstrom by cryo-EM, where specific structural features of the protein are visible.

202 nd functional analyses, we identify variable structural features of the substrate-binding pocket that

203 In accordance with the observed structural features of the substrate-binding pocket, kin

204 We validated key structural features of the SurA*uOMP ensemble using inde

205 hemical nature of the inhibitor, but also on structural features of the target.

206 ed to 2.5- angstrom resolution and shows the structural features of the three conserved domains C2A,

207 However, it is unclear how distinct structural features of the two PA2G4 isoforms translate

208 Explaining how structural features of these polymers change their bindi

209 s and microorganisms revealed several unique structural features of this plant hydroxyl pyruvate redu

210 walls are preparation artefacts rather than structural features of transporting sieve elements.

211 erved elbow of tRNA and recognized conserved structural features of tRNAs using mechanisms that are d

212 t biofilm assembly resembles certain spatial-structural features of urbanization, where population gr

213 Certain structural features of ZP proteins suggest that they may

214 al materials suffers from needing to capture structural features on many length scales.

215 ll lines provide insights into the impact of structural features on potency and chemical stability, i

216 species, suggesting involvement of multiple structural features or a nullified function of the chime

217 se performance is strongly correlated to the structural features over a wide range of length scales,

218 However, whether these structural features predict kidney transplant recipient

219 e been rationalized in terms of chemical and structural features present in the binding pockets of me

220 of heterologous gyrases is in agreement with structural features present: B. subtilis gyrase is a min

221 DAXX's structural features provide a framework for deciphering

222 nalyses of these complexes, coupled to their structural features, provide support for the conclusion

223 ows for useful insights into the distinctive structural features reflected by the target data.

224 -Cpf1 gRNAs data and found many sequence and structural features related to their target efficiency.

225 The structural features relevant for protease binding and in

226 izations of these channels and highlight the structural features relevant to the mechanotransduction

227 most complex viral genomes, and yet its RNA structural features remain relatively unexplored.

228 The new structural features reported here for protein C have gen

229 ot always guided by hypotheses regarding the structural features required for bioactivity.

230 reaction are disclosed that identify the key structural features required for participation in the re

231 that enabled the dissection of the essential structural features required for the observed anticancer

232 Our work clarifies the structural features responsible for heterogeneous huntin

233 echanisms are often well understood, but the structural features setting their rates are mostly unkno

234 ased approach was applied to find the common structural features shared by the new compounds and alre

235 This structure exhibits unique structural features such as an adenine bulge and a G.G.T

236 ince few existing metrics capture high-level structural features such as architectures, folds and con

237 Sequence features such as kmer words, structural features such as Q(MFE), and sequence/structu

238 Domains are demarcated by structural features such as the axoneme and its connecti

239 PORE-cupine also captures global structural features, such as RNA-binding-protein binding

240 ground states, arising from its atomic-scale structural features, such as rotational disorders and ed

241 lations provided insight into other required structural features, such as steric fit and H-bonding wi

242 ry); however, the ability to tune macroscale structural features, such as the relative positions of c

243 The unraveling of electronic structural features suggests that a synergistic effect b

244 that PHD homologues have evolved kinetic and structural features suited to their specific sensing rol

245 ocars all possess unexplored combinations of structural features: tert-butyl wheels, short alkyne cha

246 , we show that aggrecan glycosylation is the structural feature that causes HA stiffening.

247 ficity for CO(2) This paper identifies a key structural feature that enabled the enzyme to evolve imp

248 The cannabinoid alkyl group is a critical structural feature that governs therapeutic activity.

249 of organo-iridium drug candidates bearing a structural feature that results in a leap in anticancer

250 hyperoxidation varies greatly and depends on structural features that affect the lifetime of the C(P)

251 with regional centromeres contain additional structural features that aid in dimerization.

252 the dopamine D(1) receptor (D(1) R) contains structural features that allow it to reside in lipid raf

253 modulation of the AgcS family and reveal key structural features that allow this transporter to accom

254 el approaches have been developed to resolve structural features that are not discernible by traditio

255 exhibit distinct temperature-dependent local structural features that are related to macroscopic prop

256 i) visually inspect the protein sequence and structural features that are responsible for a particula

257 UDA has predicted structural features that are similar to certain nonclass

258 tivity by identifying and characterizing the structural features that constitute an active surface, u

259 -binding site with allosteric properties and structural features that contribute to bias properties.

260 binding partners possess unique sequence and structural features that control binding and PARylation.

261 ic structure that arises is sensitive to the structural features that could be in turn used as a knob

262 lar modeling techniques to elucidate the key structural features that define how SurA solubilizes uOM

263 We infer that the structural features that develop below 240 K determine t

264 While the structural features that distinguish between the active

265 ticle provides a framework for understanding structural features that enable function of canonical re

266 tational modeling are also included with the structural features that facilitate TLR2 activation.

267 The structural features that govern broad-spectrum activity

268 The crystal structure reveals key structural features that have enabled the integration of

269 mined to provide additional insight into the structural features that influence the stability of silo

270 is structure identifies multiple specialized structural features that integrate with conserved motifs

271 g attractor while also revealing unpredicted structural features that might enhance the network's com

272 nalization and highlights the key design and structural features that permit the discovery of new hyb

273 ng microcomputed tomography, we examined key structural features that pertain to bone quality in the

274 to be functional, yet knowledge of secondary structural features that regulate the exposure of exonic

275 This Review examines common structural features that render most cyclic peptides mem

276 olymers comprised of hexameric rosettes with structural features that resemble nucleic acids are form

277 tionship study enabled us to identify unique structural features that result in high selectivity agai

278 This review summarizes structural features that underlie response regulator fun

279 PdCu/HCS), respectively, while keeping other structural features the same.

280 With these structural features, the electrocatalytic framework exhi

281 ing as indicated by the stabilization of key structural features: the nonprime binding cleft and the

282 Each receptor uses specific ligand structural features to achieve optimal binding, which wi

283 a starting point to exploit HIPK2's distinct structural features to develop selective small-molecule

284 These structural features, together with atoms in molecules (Q

285 Notably, network connectance, a structural feature typically thought to increase robustn

286 To uncover the structural features underlying SSBP1 mutations, we deter

287 n the Ebolavirus genus, recognized a similar structural feature upstream of the ebolavirus NP C-termi

288 th exquisite control on their electronic and structural features via ligand design.

289 t of the cobalamin riboswitch with predicted structural features was identified in Bacillus subtilis

290 Using these structural features, we identified homologs of this enzy

291 ree energy and commonly studied sequence and structural features, we propose a new feature, Sequence

292 To connect these results to structural features, we used the structure of CelE from

293 operly interact with their viral target, the structural features were determined by NMR spectroscopy

294 he most commonly used, and a wide variety of structural features were observed within the derived dru

295 ion of optical fields displaying a wealth of structural features, which include three-dimensional top

296 f a unique inactive conformation that shares structural features with both the ligand-free, inactive

297 e Drosophila nephrocytes share molecular and structural features with mammalian podocytes, they provi

298 LOS+) showed that the Shaker-VSD shares many structural features with the homologous Kv1.2/2.1 chimer

299 AimR presents intrinsic plasticity, sharing structural features with the RRNPP quorum-sensing family

300 evisiae proteins, we identified sequence and structural features within ALAS that position mtClpX and