ライフサイエンスコーパス: structural model

1 ta to build a practically complete human PIC structural model.

2 (1.08, 1.57), respectively, in the marginal structural model.

3 iers for estimating the quality of a protein structural model.

4 ng further support for the well-corroborated structural model.

5 ehavior/intentions were inspected in another structural model.

6 s a time-dependent exposure using a marginal structural model.

7 ganize compartment assembly to develop a new structural model.

8 time-effective way to derive low-resolution structural models.

9 terpret without the assistance of additional structural models.

10 game Foldit to generate high-quality de novo structural models.

11 stic sampling of any set of models, not just structural models.

12 evere hypoxemia) at day 30, we used marginal structural models.

13 others, using the correct metal improved the structural models.

14 obability of treatment weighting of marginal structural models.

15 AR and PAF were derived using marginal structural models.

16 e utility of fork classifications to improve structural models.

17 tals had been misidentified in the deposited structural models.

18 emain enigmatic due to lack of pre-catalytic structural models.

19 distance constraints and combined this with structural modeling.

20 other biophysical methods for more accurate structural modeling.

21 ethod, NetMHCpan 4.0, with three-dimensional structural modeling.

22 sidue contact prediction with template-based structural modelling.

23 of restraints that would result in the best structural model?

24 In the structural model, a resilience pathway showed less pover

25 Recent structural models additionally suggest TNT1 may restrain

26 Site-directed mutagenesis and structural modeling analyses directly implicated N-glyca

27 e support the functional significance of the structural model and indicate that the same interaction

28 describe opportunities and challenges in RNA structural modeling and design, as recently discussed du

29 Here, we used Rosetta structural modeling and docking as well as molecular dyn

30 In this paper, we use structural modeling and functional data of these mutatio

31 RP1), CAPN5, and TYK2 were characterized via structural modeling and in silico calculations to predic

32 Structural modeling and molecular docking show that a re

33 Structural modeling and molecular simulations reveal uni

34 Computational structural modeling and simulations were also performed

35 We performed whole-genome sequencing, structural modelling and cytogenetic analyses of 17 diff

36 s to map the correspondence between specific structural models and available experimental observation

37 Both origami structural models and electronic band structures are com

38 Furthermore, analysis of the structural models and molecular simulations suggested th

39 Our structural models and simulations of the ternary protoch

40 nt approach for FRET-assisted coarse-grained structural modeling, and all-atom molecular dynamics sim

41 variants were analyzed using bioinformatics, structural modeling, and epidemiological methods.RESULTS

42 A phenotype-driven analysis, protein structural modeling, and in silico calculations were the

43 emical genetic analyses, biochemical assays, structural modeling, and molecular docking, we demonstra

44 rative analysis of chemokine NMR structures, structural modeling, and molecular dynamic simulations t

45 e, using biochemistry, immunohistochemistry, structural modeling, and mouse genetics, we demonstrate

46 ar basis of BBS, here we used an integrative structural modeling approach consisting of EM and chemic

47 ken together, our results suggest that these structural models are representative of the closed and o

48 o any peptide-MHC complex of interest with a structural model as input, representing an important ste

49 ool for assessing the adequacy of a proposed structural model as well as for future model development

50 Structural modeling, as supported by experimental probin

51 tructural optimizations do not give accurate structural models, as assessed by the experimental chemi

52 these new methodical approaches and provides structural models based on recent findings about the pla

53 ased modeling (TBM), which aims to construct structural models by copying and refining the structural

54 The predictions of the Structural Model can be applied to the human cortex, in

55 We used a structural model causal inference approach to investigat

56 on for arbitrary protein families leading to structural models complementary to often-difficult exper

57 Structural modeling, confirmed by mutational analysis, i

58 d straightness of newly polymerized MTs, and structural modeling data suggest a conformational change

59 Structural modeling demonstrates a TB19/TB38 biparatopic

60 on and specificity in CYP2J2 varies with the structural models developed using different computationa

61 we argue that primary sequence analysis and structural modelling do not readily explain why NasA, Na

62 Here, the constructed structural models, docking and scoring schemes were vali

63 Many structural models employ mean values of vessel microstru

64 The structural model enabled design of XPA mutations that in

65 Biochemical analysis and structural modeling establish that UFMylated RPL26 and t

66 core sulfocarbide unit {C-S}(4-) serves as a structural model for a proposed intermediate in the radi

67 These results support a structural model for Ca(2+) and CaNAbeta compartmentatio

68 CD20 into circular assemblies and lead to a structural model for complement recruitment.

69 inary point exposure, we describe a marginal structural model for estimation of risk (or prevalence)

70 We report a high-resolution molecular structural model for fibrils formed by the C-terminal ha

71 Murray et al. report an atomic-level structural model for FUS LCD fibrils that answers some q

72 The most probable structural model for hDAT dimer suggested by computation

73 These data allow us to present a structural model for how acidification during endocytic

74 e us to propose an experimentally consistent structural model for how CXCL12 binds CXCR4 and initiate

75 We present a functionally validated structural model for how human telomerase engages TPP1 a

76 electron microscopy enabled me to propose a structural model for its quaternary structure.

77 rements to derive a novel, to our knowledge, structural model for myosin-II in complex with actin and

78 To explain these observations, we present a structural model for organo-mineral associations based o

79 4G peptide and propose the first eIF4E-eIF4G structural model for plants.

80 ycobacterium tuberculosis has been used as a structural model for rationalizing functional observatio

81 These results provide the first structural model for the activated state of the transduc

82 In addition to being a high fidelity structural model for the biological cofactor, the comple

83 raction within eIF2alpha; and (ii) the first structural model for the complex of eIF2B with its subst

84 electron microscopic imaging, to arrive at a structural model for the dodecameric complex of CaMKII w

85 The functional studies led us to a new structural model for the ErmC or ErmE-rRNA complex.

86 he ExoY structure to construct a dimer-based structural model for the ExoY-F-actin complex.

87 Here, we have tried to determine the structural model for the protein and predicted the assoc

88 Walther and co-workers have proposed a structural model for the TatA oligomer in which TatA mon

89 aggregation, and we present an atomic-level structural model for the TDP-43 dimer based on NMR data.

90 Our findings provide a structural model for the trehalose synthase:maltokinase

91 olecular modeling protocols, have provided a structural model for the TTR-Abeta interaction, as well

92 try of ChiLS, we derive a highly constrained structural model for this complex, which adopts a rotati

93 al sub-states, which provide a comprehensive structural model for this widely studied bacterial molec

94 has been implicated in disease etiology, but structural models for amyloid/nucleic acid co-assemblies

95 So far, efforts to generate accurate structural models for heteromeric GABA(A) receptors have

96 Structural models for kinases relevant to MTC were gener

97 power of our approach to generate predictive structural models for other experimentally challenging i

98 ster ions is reported, which are employed as structural models for the catalytically active site of P

99 putative closed state has been reported, and structural models for the channel open state have been p

100 Based on our experimental data, we suggest structural models for the oligomeric pinhole (right-hand

101 e now many published applications of causal (structural) models for estimating effects of time-varyin

102 Structural modeling further demonstrates that the bindin

103 n channelrhodopsin crystal structure, and by structural model-guided redesign of channelrhodopsins fo

104 Previous biophysical experiments and structural modeling have suggested that the N-terminal m

105 Four distinct structural models have been obtained experimentally for

106 The structural model identified the top novel ligands, 426 (

107 Structural modeling identified likely mechanisms for los

108 The structural model illustrates the effects of using social

109 We used structural modeling, immunoblotting, live cell imaging,

110 Structural modeling implied that the pai-pai interaction

111 ed clinical information, and statistical and structural modeling improve the prognostication and trea

112 ther with biochemical analysis, we propose a structural model in which CSN9 binding triggers CSN to a

113 These results enabled us to propose a structural model in which Ecm29 intrudes on the interact

114 talysis and substrate binding, and support a structural model in which rearrangement of a flexible lo

115 Functional-structural modeling in SimRoot indicates that, in common

116 These results and our structural modeling indicate that a more complex binding

117 Structural modeling indicated that all substitutions aff

118 Structural modeling indicated that the binding of compou

119 Structural models indicated that external Na(+) binding

120 RP3 PYD abrogate inflammasome activation and structural modeling indicates that phosphorylation of th

121 The depolarized structural model is also consistent with the formation o

122 formation can be obtained even when only one structural model is available.

123 tal diffraction data deposited alongside the structural model it enables validation and potential rem

124 acy and coverage of three-dimensional genome structural models, it is important to integrate all avai

125 Thus, our revised structural models may provide a useful tool for interpre

126 ding modes for TRPA1-PIPC interactions using structural modeling, molecular docking, and mutational a

127 Here, structural modeling, molecular dynamics simulations, and

128 Marginal structural models (MSM)-derived statistical weighting cr

129 ding by bisphosphonate use using 1) marginal structural models (MSMs) and 2) G-estimation of structur

130 propensity score (PS) matching and marginal structural models (MSMs) to account for confounding by i

131 al activity on current asthma using marginal structural models (MSMs).

132 in silico and in vitro techniques involving structural modeling, mutagenesis, and functional charact

133 Based on structural models, NMR titrations, DNA-binding studies,

134 lar dynamics simulations provided a detailed structural model of a 2:1 POT1:DNA complex that is fully

135 We report the first structural model of a eukaryotic membrane-bound O-acyltr

136 A structural model of an anti-terminated glyQS T-box in co

137 Our structural model of AZ11645373 binding is consistent wit

138 ed and validated sites of modifications on a structural model of C9, as present in the MAC, hints at

139 bines the proteome allocation theory and the structural model of cell division.

140 A consensus structural model of conformational shifts occurring betw

141 Using a structural model of cooperating miRISCs, we identified a

142 In this study, we developed a new structural model of CYP2J2, and explored its sensitivity

143 Using a structural model of DnaB complexed with the C-terminal d

144 e upon nucleosome engagement and compare the structural model of endogenous BAF to those of related S

145 An electron microscopy structural model of full-length ERdj3 shows that these t

146 ng these sequence variations, we developed a structural model of Hsp21 based on homology modeling, cr

147 m powder X-ray diffraction data an idealized structural model of K-PHI has been derived.

148 For the first time, the structural model of LnFe2O4.5 was fully understood by hi

149 erformed computational docking to generate a structural model of m102.4-NiV interaction.

150 Using a predictive structural model of MmpL3 from M. tuberculosis, docking

151 The Co4O4 cubane is a representative structural model of oxidic cobalt oxygen-evolving cataly

152 We generated a structural model of Rabex5, using chemical cross-linking

153 Herein, we provide a structural model of RF-sputtered LiPON.

154 ation system informs revision of the current structural model of rhamnogalacturonan-II and highlights

155 e used computational approaches to develop a structural model of SERCA-PLB interactions to gain a mec

156 this work, we present the first full-length structural model of tetrameric SinR using a hybrid appro

157 tural, and biophysical methods, we present a structural model of the 400-kDa Cas14-Cas2-32 complex fr

158 s simulations, we generated the first atomic structural model of the binding interface between the tr

159 This extensive data set informs the first structural model of the CAF and provides insights into h

160 Our structural model of the CaM-K-Ras4B HVR association prov

161 ss-linking mass spectrometry, an integrative structural model of the complex of interest can be gener

162 A structural model of the complex was built via partial ho

163 We built a structural model of the designed Cu binding site from ex

164 Here, we present a structural model of the endogenously purified human cano

165 In summary, we show a highly compact, 3D structural model of the human holo-MSC.

166 e simulations were based on a very tentative structural model of the interaction between subunit a an

167 Finally, we propose a structural model of the Kv1.3-KCNE4 complex.

168 Sequence analysis of the structural model of the L142 N-terminal domain indicated

169 uterium exchange (HDX-MS) mapped onto a full structural model of the ligase revealed long-range allos

170 In the liver, a structural model of the lobule was pioneered by Elias in

171 ption and Raman spectroscopies to assemble a structural model of the potent methane-activating interm

172 A structural model of the productive dimer/tetramer was ob

173 tor and the perovskite lattice and propose a structural model of the stabilized three-dimensional str

174 computational approaches are used to test a structural model of the Vif/PPP2R5 complex.

175 We report a complete 3D structural model of typical epithelial primary cilia bas

176 We derived a structural model of WDR26 and note that missense variant

177 Here a NMR structural model of WhiB1 reveals that Wbl proteins are

178 formed comparative evolutionary analysis and structural modeling of ABHD5 and ABHD4, a functionally d

179 Structural modeling of missense variants suggests delete

180 Structural modeling of RTY elucidated the relationships

181 Structural modeling of TbGPR89 predicts unexpected simil

182 utics would benefit from improved, in-silico structural modeling of the kinase's solution ensemble.

183 Here, we perform structural modeling of the SARS-CoV-2 spike glycoprotein

184 ed version of our integrated web service for structural modeling of three-dimensional genome (3D-GNOM

185 present TCRpMHCmodels, a method for accurate structural modelling of the TCR-peptide-MHC (TCR-pMHC) c

186 Here, we combined structural modelling of ZAR1, with molecular and functio

187 brane region, we generated and validated new structural models of alpha7.

188 mple and select" method to generate relevant structural models of alternative conformations of the C-

189 Accurate structural models of biological systems can be obtained

190 nd bioinformatics may be integrated to build structural models of entire cells with molecular detail.

191 In this work, structural models of full-length BLV Gag and Gag lacking

192 ctive drugs is boosted by recent advances in structural models of human telomerase.

193 From an earlier study, we had structural models of M.tb at a proteome scale from which

194 resents the first, to our knowledge, dimeric structural models of OAS2 that enhance our understanding

195 al protein of interest, HMI-PRED will return structural models of potential host-microbe interaction

196 nking mass spectrometry to build integrative structural models of protein complexes.

197 producing, entirely by computational means, structural models of proteins that rival in quality thos

198 ue, based on the LC-MS/MS data and available structural models of SrtB-substrate complexes.

199 We built structural models of TARP-AMPA receptor complexes for TA

200 Structural models of the complex that regulates the dire

201 ilies proves sufficient to assemble accurate structural models of the diverse protein-oligomers.

202 We describe structural models of the Escherichia coli chromosome in

203 We were able to construct the structural models of the fibrinogen alpha-chain (excludi

204 omputational ligand docking of the NAMs into structural models of the homomeric GluA2 receptor and op

205 We report structural models of the Hv1 voltage-sensing domain (VSD

206 h electrophysiological studies, we developed structural models of the KCNQ1-KCNE1 complex that sugges

207 Our results can be rationalized with de novo structural models of the N-terminal tails of the synthet

208 ints that can assist validation of candidate structural models of the native HIV-1 Env trimer.IMPORTA

209 To this end, we used structural models of the open-channel conformation of th

210 In two structural models of the perfluoroarylated product, dist

211 The first structural models of the proposed cis-Fe(III)(OH)(halide

212 We generated structural models of the RSV N(0)-P with biophysical app

213 rce microscopy to deliver, in atomic detail, structural models of three key PANS: the hexasome (H2A.H

214 Although published structural models of viral capsids generally exhibit a h

215 elaxation dispersion can be used to generate structural models of weakly populated alternative confor

216 Here we present detailed structural models of Y(D) and its environment using larg

217 Structural modeling placed ABHD5 R299/G328 and R303/G332

218 Structural modelling points towards two plausible and di

219 Three-dimensional structural modeling predicted that all five ABCB4 varian

220 Structural modeling predicted that the variants, located

221 Structural modeling predicts that SY242CS confers a conf

222 classification performance, and analysis of structural models provides physical insight into the str

223 nd time-varying confounders using a marginal structural model, RBV/rIFN was not associated with chang

224 d) conformation of the insulin receptor, the structural models reconstructed at different pH values r

225 Whole-genome three-dimensional structural models reveal a radial architecture of chromo

226 NMR-based structural models reveal diverse binding geometries and

227 Structural modeling revealed a higher binding energy of

228 interface between 2 distinct subdomains, and structural modeling revealed conservation in zebrafish a

229 Cellular and biochemical analyses as well as structural modelling revealed that two mutations disrupt

230 Comparison of the two structural models revealed that the largest differences

231 Adding covariates into a structural model showed significant paths from country t

232 Structural modeling showed that the stretch surrounding

233 The combined structural model shows how Ragulator functions as a plat

234 Structural modeling shows that this amino acid residue 1

235 We used the functional-structural model SimRoot to evaluate the functional impl

236 e cerebral cortex: architectonic similarity (structural model), spatial proximity (distance model) an

237 Although structural models (stoichiometry matrices) and pathway d

238 Bioinformatics and structural modelling studies indicate that the accumulat

239 nt of the B'-helix, DEER-constrained Rosetta structural models suggest that channel activation involv

240 Finally, structural modeling suggested a plausible model for the

241 Structural modeling suggested that C-terminal processing

242 Structural modeling suggested that SCR-2, SCR-3 and SCR-

243 Structural modeling suggested that the missense mutation

244 Structural modeling suggested that this mutation may fac

245 Based on structural modeling suggesting that Pro-205 in green con

246 A structural model suggests that RDV, when serving as the

247 Structural modelling suggests that K265 interacts with D

248 complementary approaches resulted in a novel structural model that rationalizes previous experimental

249 Here, we establish through structural modeling that this footprint overlaps in part

250 CFAP45 binds AMP in vitro, consistent with structural modelling that identifies an AMP-binding inte

251 These forms can be integrated into structural models that add predictive power or process m

252 Furthermore, we present structural models that explain known properties of this

253 anning up to 56 nucleotides in length yields structural models that recapitulate experimentally deter

254 tionally used a weighted Cox model (marginal structural model) that accounts for time-dynamic imbalan

255 When these links do not match to previous structural models, they may indicate changes in protein

256 These measurements are coupled to DFT structural models through an analytical point-dipole Ham

257 By structurally threading low-resolution structural models through the BioLiP library, the COFACT

258 Our coarse-grained structural model thus suggests that the high efficiency

259 ructed mammalian AncFMO1 serves as the first structural model to corroborate and rationalize the cata

260 f CLC-2 gating and provide a high-resolution structural model to guide future investigations.

261 irus (MERS-CoV) RNA clearance using marginal structural modeling to account for baseline and time-var

262 oscopy, cross-linking mass spectrometry, and structural modeling to build a complete model of human R

263 re, we used novel statistical algorithms and structural modeling to identify EE mutation hotspots in

264 e site of the 2005 outbreak, and use protein structural modeling to propose a mechanism for how strai

265 olecular genetics, protein biochemistry, and structural modeling to understand the topological framew

266 We then used marginal structural models to decompose total effect of knee SxOA

267 GA), a duplex-forming sequence, and use both structural models to provide insight into the motif-spec

268 Fitting structural models to three of these maps shows that thei

269 were well modelled using the refined average structural models: trigonal R[Formula: see text], orthor

270 ng of the identified mutations onto the SHMT structural model uncovered key residues for structural s

271 st methods to create and refine atomic-level structural models using low-resolution EM density maps.

272 The structural model, validated by EPR distance measurements

273 Structural modeling was used to elucidate the mechanisti

274 An inverse probability weighting of marginal structural models was used to estimate the controlled di

275 Here, building on our latest structural model, we used a systematic mutagenesis strat

276 Through natural evolution and structural modeling, we identified host-range-determinin

277 Based on in silico structural modeling, we show that 5-methylcytosine indee

278 Based on a combination of mutagenesis and structural modeling, we suggest that all benzothiazole/o

279 ording, immunoblotting, confocal imaging and structural modelling, we characterized the effects of th

280 Using marginal structural models, we calculated model-adjusted prevalen

281 Using marginal structural models, we calculated model-adjusted prevalen

282 f treatment- and censoring-weighted marginal structural model were attenuated in low BMI categories a

283 Clear structure-activity relationships and a structural model were developed in the studies which pro

284 Marginal structural models were used to assess impacts of the pro

285 ons, propensity-matched models, and marginal structural models were used to assess the association be

286 Our analysis provides an MKK4-JNK1 structural model, which has thus far been crystallograph

287 t is the resilience pathway suggested by the structural model, which is highly amenable to interventi

288 tical connections is better predicted by the Structural Model, which relates cytoarchitectonic differ

289 lose was also explained on the basis of a 3D structural model, which was compared to the 3D structure

290 omain-ligand interaction was explained by 3D structural models, which showed a hormone-regulated mech

291 ake predictions based on individual, perfect structural models, while experimentalists work with more

292 nd SPINDOC protein complex, culminating in a structural model with two SPINDOC molecules docked on on

293 Here, we combine structural modeling with phylogenetic analysis to shed l

294 of 285 non-homologous proteins and generated structural models with correct folds for 260 proteins, w

295 Structural models with different geometric constraints w

296 We analyzed the data using marginal structural models with inverse-probability-of-treatment

297 ssential for unbiased estimation in marginal structural models with inverse-probability-of-treatment

298 ent- and censoring-weighted Poisson marginal structural models with results from an unweighted adjust

299 two different starting models results in one structural model, with one Ca position and the caged O o

300 We study Alp14 mutants designed based on structural models, with defects in either tubulin recrui