ライフサイエンスコーパス: structural modification

1 n to be associated with the pressure-induced structural modification.

2 rational design of switching properties via structural modification.

3 ty and selectivity through ligand design and structural modification.

4 ctivity and sensitivity could be improved by structural modification.

5 x2 that are responsible for Pin1 binding and structural modification.

6 zole framework can be achieved with a simple structural modification.

7 arly differing profiles of CarC tolerance to structural modification.

8 mal morphology is extremely sensitive to any structural modification.

9 and biologic impact for postbiosynthetic LPS structural modification.

10 itization properties of Coumarin 343 through structural modification.

11 vity can only be achieved by chemical and/or structural modification.

12 n route in acquisition of resistance via LPS structural modification.

13 owed some limitations in elucidating certain structural modifications.

14 atically addressed and eliminated by concise structural modifications.

15 s with XIAP BIR2 suggested potency-enhancing structural modifications.

16 strate coupling of this redox behaviour with structural modifications.

17 to understand thermoelectric performance by structural modifications.

18 ammalian ceramides distinguished by specific structural modifications.

19 ce, have largely been unexplored for in vivo structural modifications.

20 nfolding of beta-lactoglobulin, resulting in structural modifications.

21 on tag into carboxylic acids with no need of structural modifications.

22 een NPDS and trabeculectomy concerning these structural modifications.

23 e degree of hydrolysis is modulated by minor structural modifications.

24 iciency (LipE) was optimized through two key structural modifications: (1) identification of the pyrr

25 With three distinct sites for structural modification, A affords access to a structura

26 Driven by virus-mediated structural modifications, aberrant immunological respons

27 a function of applied voltage bias indicate structural modifications across multiple length scales v

28 make HA an excellent model of the way subtle structural modifications affect a protein's stability an

29 ow the initial cycloaddition and analyze how structural modifications affect these processes.

30 Structural modifications affecting the efficacy of analo

31 Our study indicates that structural modifications after different heat-treatments

32 ionality to evaluate the contribution of new structural modification against the A3AR.

33 BLG structural modification and LA binding properties were m

34 and delamination are the primary methods for structural modification and pore tailoring.

35 in view of the atomic level understanding of structural modification and the development of high dens

36 31A variant displayed substantial N-terminal structural modifications and a dramatic decrease in acti

37 ity in two cell lines revealed tolerance for structural modifications and agreement in activity trend

38 In the present study, the structural modifications and antigenic response of these

39 cles but also induce particle-size-dependent structural modifications and are likely to promote inter

40 Emphasis is placed on structural modifications and corresponding variations in

41 Focused structural modifications and docking simulations enabled

42 Numerous structural modifications and formulations have been intr

43 KII is necessary for learning and associated structural modifications and learning triggers an FMRP-d

44 ds were designed and synthesized for further structural modifications and led to the identification o

45 ory activity toward TDO and was subjected to structural modifications and molecular docking studies.

46 Using analogous structural modifications and oxidation that results from

47 building-block component change, an overall structural modification, and a functional evolution of a

48 ish that release profiles can be modified by structural modifications, and compare COS/H2S release ra

49 ybin could be significantly enhanced through structural modifications, and identify strong anti-cance

50 es often involve large-amplitude strains and structural modifications, and thus require an understand

51 the development of agents to limit chromatin structural modification as a chemotherapeutic approach i

52 of the parent compound, indicating that the structural modification at least partially decoupled the

53 Synthetic peptides with structural modifications at different amino acid positio

54 Analogues 13h and 13i, with structural modifications at each site, were shown to pos

55 The impact of structural modifications at the C-terminus of 1 upon cyt

56 eneration molecular motors featuring various structural modifications at the central aromatic core ar

57 tely activate integrin signaling and trigger structural modifications at the Drosophila neuromuscular

58 Structural modifications at the indole 3-position of 1-m

59 efficiency (LE) of 0.47, included additional structural modifications binding in the S1 and S3 pocket

60 This subtle structural modification brings about drastic changes in

61 Structural modification by changing the geminal difluoro

62 ptoglobin (Hp), the complex protects Hb from structural modification by preventing alpha-globin cross

63 Our analysis implies that transient structural modification can be an effective tool for man

64 Moreover, the WTW structural modification can be considered as concluded i

65 ids has demonstrated that certain peripheral structural modifications can alter binding affinity and

66 Structural modifications can be foreseen to improve the

67 study provides the first example that simple structural modifications can convert a bona fide PROTAC

68 ractions have held the promise that directed structural modifications can have predictable functional

69 Structural modifications could be used to alter the HOMO

70 Structural modifications designed to address the ADME is

71 Structural modifications detailed herein, including core

72 Understanding how such microscopic structural modifications determine macroscopic diffusion

73 alities and that a broad selection of ligand structural modifications directed to this area can be in

74 sp27 chaperone function, suggesting that the structural modification dissected the dual targeting eff

75 tudy of haloperidol and revealed that subtle structural modifications dramatically change binding kin

76 ations, an unusual phenomenon of interfacial structural modifications, due to the interface chemistry

77 The high precision structural modifications enabled by unnatural amino acid

78 Collectively, our findings suggest that the structural modification enhances efficacy and selectivit

79 core and shell undergo distinct patterns of structural modifications following ethanol exposure and

80 catalytic activity provides new insight into structural modifications for controlling charge separati

81 near the apex of the ovipositor, where other structural modifications for penetrating wood are presen

82 This method involves a purely structural modification free of chemical additives leadi

83 32-Asn oxidase upon introduction of a second structural modification further inside the pathway (Asn-

84 Two types of structural modification have been performed, an introduc

85 ria of free host and guest binding, selected structural modifications have been performed over a fami

86 The noted structural modifications imparted molecular rigidity and

87 I), which contains a deep-seated fundamental structural modification in the CC-1065 and duocarmycin a

88 ed cells showed morphological changes due to structural modifications in actin microfilaments (MFs) a

89 The MD simulations also suggested structural modifications in AQP4 in response to changes

90 Alkali- or acid-induced structural modifications in beta-chitin from squid (Dosi

91 These data highlight how structural modifications in metal complexes can have pro

92 ction method enables accurate measurement of structural modifications in near-surface layers, which m

93 al conditions such as temperature, pressure, structural modifications in proteins, or presence of che

94 is of 63 new thiazole derivatives by further structural modifications in search of more potent fascin

95 Structural modifications in the 5- and 3'-position have

96 harmacological properties were fine-tuned by structural modifications in the arylacetamide and amine

97 Structural modifications in the beta-enamino diketone sy

98 In addition, we detect structural modifications in the Eg5 motor domain during

99 behavior in adulthood via long-term cellular structural modifications in the oPFC.

100 The tailoring of structures via subtle structural modifications in the presented molecular seri

101 as a lead molecule, we were able to engineer structural modifications in the solvent-exposed region o

102 lass of neurosteroid analogues which possess structural modifications in the steroid D-ring region.

103 The structural modifications in these variants reduced, pres

104 Pressure induced structural modifications in vitreous GexSe100-x (where 1

105 Several structural modifications including bringing conformation

106 purine gives several insights into how small structural modifications, including amino substitution a

107 zed a number of derivatives of 4 with subtle structural modifications, including incorporation of car

108 Elucidation of the key structural modifications incorporated into these inhibit

109 in many diseases, in the absence of evident structural modifications, indicating a high sensitivity

110 Finally, the structural modifications induced by oxidation are associ

111 Structural modifications induced by singlet-oxygen produ

112 Thus, AMP activity can be modulated through structural modifications induced by the nature and the p

113 We analyzed the structural modifications induced on human DJ-1 by DAQs i

114 unit are of particular significance as their structural modification inhibits activation by GABA.

115 The structural modifications introduced in the core of the m

116 Activity-induced synaptic structural modification is crucial for neural developmen

117 reasing application in the clinic, extensive structural modification is typically required to prevent

118 timization of peptidic catalysts by rational structural modifications is difficult.

119 th the aid of DFT calculations, finding that structural modifications lead to changes in the frequenc

120 These structural modifications lead to polymers with different

121 This structural modification leads to enhanced electrophilici

122 Extensive structural modifications led to the discovery of a numbe

123 Structural modifications led to the identification of se

124 Vascular occlusions are common structural modifications made by many plant species in r

125 Such structural modifications may account for our observation

126 Both structural modifications may have facilitated the transm

127 Via these structural modifications, more than 50 compounds were pr

128 virus particle, which demonstrated that most structural modification occurred in the putative A prote

129 a remarkable regiochemical switch upon minor structural modification of a diketal is also analyzed.

130 By structural modification of a lead NNMT inhibitor previou

131 Structural modification of a virtual screening hit led t

132 Structural modification of an advanced lead molecule 3 l

133 s after scanning-learning, transmission, and structural modification of an artificial tone system.

134 nstrated by the successful prediction that a structural modification of an aryl group within the cata

135 ty might be predictable-arising via adaptive structural modification of analogous labile regulatory l

136 his methodology has been demonstrated in the structural modification of androsterone.

137 Structural modification of carboxylate-containing lead R

138 g of the biochemical process leading to this structural modification of carotenoids in plants.

139 The structural modification of dendritic spines plays a crit

140 ility to engineer homochiral footedness by a structural modification of enantiopure (S)-proline, whic

141 we have developed potent FCF analogs through structural modification of FCF, coined UR214-1, UR214-7,

142 Herein, we present the first report on structural modification of ivermectin to produce dual-ac

143 Additionally, minor structural modification of J-113,397 can dramatically sh

144 cycles can be improved significantly through structural modification of Mo catalysts.

145 Here we implement a structural modification of multi-walled CNTs (MWCNTs) to

146 The structural modification of nanomaterials at the atomic l

147 Structural modification of peptidoglycan (PG) is one of

148 e rational design of the reaction condition, structural modification of possible quinone methide inte

149 Here, we described the structural modification of previously identified mu opio

150 The Pin1-mediated structural modification of Runx2 is an indispensable ste

151 benzoic acids were extensively explored, and structural modification of the alcoholic and benzoic moi

152 Both approaches require structural modification of the arene, limiting their gen

153 We investigated the structural modification of the bacterial cell wall by Ol

154 ingle-handed helical wrapping and electronic structural modification of the conjugated polymer motif

155 These data demonstrate that structural modification of the HIV-1 envelope immunogen

156 potentially and differentially sensitive to structural modification of the ligand.

157 nd persistence of color vary tremendously on structural modification of the naphthopyran core.

158 nhibitors (NRIs) for multiple indications by structural modification of the previous 3-(arylamino)-3-

159 Structural modification of the submicromolar hit compoun

160 In this article, we describe the structural modification of the tert-butyl phenoxy portio

161 ty and selectivity can be controlled through structural modification of the thiourea substituents.

162 ficacy of delivery might be achieved through structural modification of the viral capsid to avoid pre

163 ng of push-pull dipolar dyes, we introduce a structural modification of the well-known electron-accep

164 ine microorganisms adapt to their habitat by structural modification of their membrane lipids.

165 g debris size, which could be related to the structural modification of this plastic as a consequence

166 Structural modifications of 12a generally weakened bindi

167 /3 receptors, we have explored the effect of structural modifications of 1S,2S,5R,6S-2-aminobicyclo[3

168 Through key structural modifications of a bicyclic lead, stepwise ga

169 Small structural modifications of active compounds were found

170 id-state NMR spectroscopy to investigate the structural modifications of amyloid beta(1-42) (Abeta42)

171 a rare event that can be overcome by subtle structural modifications of an AMP.

172 The emitter presented here contains structural modifications of an existing setup, which inh

173 This paper describes how structural modifications of azobenzenes can influence th

174 Structural modifications of BSA were investigated by 2D

175 ral topics of carbohydrate chemistry embrace structural modifications of carbohydrates and oligosacch

176 In addition, structural modifications of compound 2 were identified t

177 maintenance of LTP as well as LTP-dependent structural modifications of dendritic spines.

178 Structural modifications of DxxG induce rearrangement of

179 These observations provide a platform for structural modifications of efavirenz to modulate CYP46A

180 Our results demonstrate that structural modifications of Env that aim to mimic the CD

181 dulator scaffold has been discovered through structural modifications of hydantoin antiandrogens.

182 Raman measurements, provides information on structural modifications of hydrogen as a function of de

183 Structural modifications of identified hit VA240 in synt

184 likely, it occurs in the following sequence: Structural modifications of individual nucleobases (G >

185 Surprisingly, we found that simple structural modifications of MD-222, a bona fide MDM2 PRO

186 properties on immunogenicity in relation to structural modifications of MPER/liposome vaccines.

187 c gamma receptors, but it is unclear how the structural modifications of N-glycan termini, which are

188 Structural modifications of nonsteroidal anti-inflammato

189 ur program to explore the influence of small structural modifications of our drug candidate 3beta-(hy

190 is work focuses on elucidating dynamical and structural modifications of porcine aortic elastin expos

191 Structural modifications of psymberin uncoupled inhibiti

192 Structural modifications of Q121 generated analogs that

193 e organization of actin filaments leading to structural modifications of synapses.

194 Sequential structural modifications of the aryloxypropanamine templ

195 stry, and chemical analyses, we propose that structural modifications of the cell wall matrix in the

196 se behavioral deficits possibly occur due to structural modifications of the cerebral cortex secondar

197 the kinetic product could be achieved by key structural modifications of the different reaction partn

198 e concentrations can be realized with simple structural modifications of the familiar kinetic proofre

199 ty arising from the flexibility and possible structural modifications of the host material.

200 How the chromatin structural modifications of the inner centromere are int

201 Structural modifications of the known autotaxin inhibito

202 en discovered and synthesized as a result of structural modifications of the lead compound 2-arylthia

203 asing k(ET) and/or decreasing k(CdS) through structural modifications of the nanocrystals.

204 increase in sensitivity is achieved through structural modifications of the peptide and the expressi

205 objective of investigating the influence of structural modifications of the polyketide chain of the

206 Structural modifications of the pyridine moiety, side ch

207 cardioprotection, high levels of ROS induce structural modifications of the sarcomere that impact on

208 Structural modifications of the scaffold led to compound

209 ent of intersystem crossing) responds to the structural modifications of the series as a whole.

210 We also reveal unexpected structural modifications of the spindle pole bodies (SPB

211 Based on structural modifications of the switching unit the photo

212 iaminals has been developed using late-stage structural modifications of the tert-leucinol-derived ch

213 Structural modifications of these molecules can regulate

214 Herein, we explored three structural modifications of these prodrugs in an attempt

215 In the present study, a series of structural modifications of UA was achieved, which resul

216 examine directly the influence of nanoscale structural modifications on electronic carrier dynamics,

217 Further structural modifications on myricetin might improve its

218 ure to drugs of abuse can result in profound structural modifications on neurons in circuits involved

219 To test the effect of such structural modifications on the hormonal activities of t

220 These structural modifications on the rudimentary I-domain fol

221 Further structural modifications on the trisubstituted piperidin

222 The structural modifications optimized polymers' spectral co

223 Leaves have undergone structural modifications over evolutionary time, and pre

224 Despite their versatility and ease of structural modification, peptidomimetic oligomers have n

225 Structural modification performed on a 4-methyl-4-(4-hyd

226 In general, all structural modifications performed on HOCPCA led to redu

227 ity profile was found to be dependent on the structural modifications performed on the dietary antiox

228 Structural modifications, pre-organisation and different

229 l to these pathways and is often achieved by structural modification, principally the introduction of

230 istered at moderate doses, but fairly simple structural modifications profoundly impact its pharmacol

231 The structural modifications result in significant shifts of

232 arrangements combined with a knowledge-based structural modification resulted in a protein unable to

233 Our structural modifications resulted in analogues with incr

234 sed to create polyladderane allowed specific structural modification, resulting in the formation of t

235 Structural modifications showed that both the carboxylic

236 These structural modifications, some of which likely predate e

237 terations in behavior are thought to involve structural modifications, specifically alterations in pa

238 Further, through structural modifications such as oxidation, the function

239 potencies among homologues of chrysene with structural modifications such as the numbers of constitu

240 uning of their electronic properties through structural modifications, such as heteroatom doping or t

241 bitor (K(i) = 21 muM) more than 200-fold via structural modifications targeting two binding hot spots

242 -metal regions are highly sensitive to local structural modifications, thanks to (17)O wide chemical

243 Here we describe a simple structural modification that improves the brightness and

244 pping of the DENV RNA genome is an essential structural modification that protects the RNA from degra

245 However, structural modifications that affected MPER membrane ori

246 An improved understanding of specific structural modifications that are likely to alter the fu

247 systematically examines the various types of structural modifications that can be made to cyclic pept

248 Our results add to the types of structural modifications that can be used in the gap-reg

249 nhancing the affinity of lead molecules with structural modifications that displace water molecules f

250 HLB-infected citrus phloem cells undergo structural modifications that include cell wall thickeni

251 tary motors and their modes of function, the structural modifications that led to newer motor designs

252 MDR1-MDCKII cells, we were able to identify structural modifications that markedly reduce recognitio

253 and was found to be amenable to predictable structural modifications that modulate intrinsic reactiv

254 Herein, we report selected structural modifications that resulted in the identifica

255 is of 80 piperlongumine analogs has revealed structural modifications that retain, enhance, and ablat

256 s 3b and 3c were used as vehicles to explore structural modifications that retained antiviral potency

257 onamide 1 as a starting point, we engineered structural modifications that significantly improved hum

258 In addition to identifying structural modifications that were critical to the emerg

259 nability of unnatural polyketides to further structural modifications, the chemical probes constitute

260 as deleterious may not result in significant structural modifications, they can plausibly modify the

261 Structural modification to affect clearance, and to a le

262 r potent antitubercular properties was their structural modification to evade the Rv1258c efflux pump

263 selectivity with metabolic stability through structural modification to the metabolized site on the q

264 ology model of the GR ligand binding domain, structural modifications to 2 were carried out that were

265 Making relatively small structural modifications to a macrocycle can result in l

266 The agonist, THI0019, was generated via two structural modifications to a previously identified alph

267 We report structural modifications to achieve compounds with an im

268 Hypothesis driven structural modifications to endogenous FFAs, focused on

269 ing natural draft (ND) stoves, which feature structural modifications to enhance air flow, and forced

270 inhibitors with the active site that suggest structural modifications to further enhance potency.

271 Neither structural modifications to GM volume nor modifications

272 There are many reported examples of small structural modifications to GPCR-targeted ligands leadin

273 We aimed to use structural modifications to increase the tumor-to-kidney

274 This review discusses examples where small structural modifications to macrocyclic scaffolds change

275 n renal clearance and can aid the chemist in structural modifications to optimize drug disposition.

276 ent evaluation of AG treatment paradigms and structural modifications to reduce hair cell damage.

277 ily accessible precursors and is amenable to structural modifications to tailor color and lifetime of

278 We carried out a series of systematic structural modifications to the (8-cyano-7-hydroxyquinol

279 ive Hsp90 inhibitor was accomplished through structural modifications to the amide side chain, coumar

280 nblastine analogues that contain deep-seated structural modifications to the core ring system of the

281 biased agonism can be finely tuned by minor structural modifications to the head group containing th

282 Herein, structural modifications to the N, 4, 5, and 4' position

283 tigate the B atom positions, properties, and structural modifications to the palladium lattice of an

284 ompounds have the potential, with additional structural modifications, to yield clinical agents that

285 re, the great versatility of NHC ligands for structural modifications, together with the use of other

286 ecular hybridization approach is an emerging structural modification tool to design new molecules wit

287 ly grown gold nanowires undergo irremediable structural modification under external stimuli.

288 e important insight about the lesion-induced structural modifications upon dehydration in the cancer

289 a new insight into the atomic-scale surface structural modification using ALD and post-treatment, wh

290 First, a series of structural modifications was conducted which included re

291 mportant insights into the interplay between structural modifications, water exchange rate, and kinet

292 Through molecular modeling and structural modification, we identified a compound PHT-7.

293 Structural modifications were confirmed by mass spectrom

294 xicity-required improvement for translation, structural modifications were made by introducing nitrog

295 ivo with positron emission tomography (PET), structural modifications were made to the high-affinity

296 Herein, more impactful structural modifications were performed via alteration o

297 ulk rutile structure, but as an orthorhombic structural modification, which previously has only been

298 hat the Fe4S4-to-Fe2S2 change requires large structural modifications, which are most likely responsi

299 This occurrence of slow structural modification with changes in trap state occup

300 Thus, N-cadherin couples persistent spine structural modifications with long-lasting synaptic func