ライフサイエンスコーパス: structural requirement

1 imposing any specific sequence or secondary structural requirement.

2 7-position does not appear to be a critical structural requirement.

3 l length requirement, and versatility in the structural requirement.

4 ion of P/rds with Rom-1 has a more stringent structural requirement.

5 as9 CRISPR RNA (crRNA) to probe chemical and structural requirements.

6 m such as binding or phosphorylation and its structural requirements.

7 was also demonstrated and exhibited the same structural requirements.

8 Each of these catenanes has specific structural requirements, allowing control of their forma

9 d molecular dynamics simulations uncover the structural requirement and sequential steps during TRF2-

10 ne tethering assay we have now dissected the structural requirements and concentration ranges for Ca(

11 However, the structural requirements and mechanism of action for NEAT

12 y provides the modeler with insight into the structural requirements and performance capabilities of

13 The present studies addressed the structural requirements and the mechanism for PA regulat

14 y structures of enriched RNAs, their minimal structural requirements and their stabilities in RT-apta

15 the local context, often dictated by protein structural requirements and/or membrane lipid interactio

16 of HOX/TALE superclass interactions, protein structural requirements, and sites of in vivo cooperativ

17 etically separable and suggest that the YidC structural requirements are different for the Sec-indepe

18 We demonstrate that these structural requirements are distinct for each interactio

19 The structural data provide insight into the structural requirements at the catalytic site of RNase H

20 ycin unit C beta-alanine residue, but strict structural requirements at the phenyl group position of

21 p53 modulators were prepared to explore new structural requirements at the thiazolidine domain for t

22 o acid mutagenesis to determine the specific structural requirements at these sites.

23 In order to investigate the structural requirements behind iGb3 triggered iNKT cell

24 ced by copper or CDDP, suggesting a distinct structural requirement between metal transport and oligo

25 Here we studied the detailed C4S structural requirements by assessing the ability of chem

26 the genetic polymorphisms and determined the structural requirements controlling antibody recognition

27 nsitive to aminosulfonates, the well defined structural requirements described here argue strongly fo

28 uted tryptamines was prepared to explore the structural requirements determining TRPM8 modulation.

29 hich initial DNA binding is based on minimal structural requirements followed by a rate-limiting conf

30 Little is known of the structural requirement for atropisomerism in structurall

31 zation, which is consistent with a stringent structural requirement for ion channel modulation by the

32 demonstrate for the first time that the C4S structural requirement for IRBC adherence is parasite st

33 In this study, we defined the structural requirement for its activity to stimulate cas

34 We identify the tile nick position as a structural requirement for lattice formation.

35 ty to form the apoB "lipid pocket" without a structural requirement for microsomal triglyceride trans

36 etent to complete the lipid pocket without a structural requirement for MTP; (ii) a portion, or perha

37 domain of claudin-4 reconstituted the basic structural requirement for optimal binding activity to C

38 Thus, our study reveals an additional structural requirement for pri-miRNA processing and emph

39 tains two types of sterol binding sites; the structural requirement for the ACAT activator site is mo

40 The minimal structural requirement for the activating effect corresp

41 ses from Golgi to lysosomes, but the precise structural requirement for the M6P ligand-receptor recog

42 y leads to the identification of the minimum structural requirement for the macrocyclization and asse

43 revention activity of VCP and identified the structural requirement for this activity.

44 The permissive structural requirement for this to occur is an extremely

45 LR4)-MD-2 dependent and to elucidate the LOS structural requirement for TLR4 activation.

46 Swi1 function and to define the sequence and structural requirements for [SWI(+)] formation and propa

47 ltracentrifugation, which is consistent with structural requirements for a honeycomb.

48 To better understand structural requirements for a mu ligand of the trans-3,4

49 ansion led to the establishment of the basic structural requirements for activity and to the identifi

50 ies of Pam(2)Cys with TLR2 indicate that the structural requirements for activity are, for the most p

51 Progress was also made in understanding the structural requirements for activity by synthesizing a f

52 These models offer insight into the structural requirements for activity of thalidomide anal

53 Critical structural requirements for activity were determined, an

54 subfamilies of the RDR enzyme with distinct structural requirements for activity.

55 We established the structural requirements for activity: the presence of an

56 ther, our results show that PARP13 lacks the structural requirements for ADP-ribosyltransferase activ

57 and biochemical analyses to investigate the structural requirements for ADP-ribosyltransferase activ

58 In this study, the structural requirements for anionic phospholipid-selecti

59 We define the structural requirements for ankyrin-B/obscurin interacti

60 In this study, the structural requirements for APL-selective binding of nSM

61 ay crystallography), we have established the structural requirements for artificial inhibitors of the

62 We have examined the structural requirements for ASAP1-dependent formation of

63 Acanthamoeba myosin-II tail to delineate the structural requirements for assembly of bipolar mini-fil

64 Here we have investigated the structural requirements for BARD1 in this process by com

65 ni, each of which can be varied to probe the structural requirements for beta-sheet self-assembly pro

66 Structural requirements for binding and isomerization of

67 We investigated the structural requirements for binding of naturally elicite

68 Here we describe the RNA structural requirements for binding to the coat protein

69 We studied the motif and structural requirements for both types of activity using

70 Here, the structural requirements for carbohydrate recognition by

71 hese results contribute to understanding the structural requirements for cargo transport, autoinhibit

72 cluster surfaces to probe the mechanism and structural requirements for CO oxidation catalysis at co

73 To investigate the structural requirements for collagenolysis, varying numb

74 To examine the structural requirements for complement activation, we ha

75 hatases are intrinsically modular and define structural requirements for coupling of enzymatic activi

76 We examined the structural requirements for COX-mediated, AEA oxygenatio

77 urther insight into pancratistatin's minimum structural requirements for cytotoxicity, particularly t

78 In this report we further define the structural requirements for decay-accelerating activity

79 se Delta variants has delineated a number of structural requirements for Delta trafficking, receptor

80 imers within HIV host cells and identify the structural requirements for dimerization in vivo.

81 strates, we have systematically investigated structural requirements for DNA unwinding by DinG.

82 nel internalization partially overlap in the structural requirements for drug binding.

83 The structural requirements for dual emission were explored

84 the hit, it provided a detailed insight into structural requirements for EAAT1 activity of this scaff

85 Nor do we understand the protein structural requirements for each individual function of

86 oid receptor subtypes helps to differentiate structural requirements for each subtype and serves as a

87 The results provided insight into the structural requirements for effective visualization of e

88 athic peptides was designed to elucidate the structural requirements for efficient and nontoxic deliv

89 ions, there do not appear to be any specific structural requirements for either chain collapse or cha

90 re analyzed by crystallography to understand structural requirements for elicitation of human transmi

91 LR4ECD should allow better definition of the structural requirements for endotoxin-induced TLR4 activ

92 vels of constraints on BER, dependent on the structural requirements for enzyme activity.

93 location of a DNA lesion is dependent on the structural requirements for enzyme catalysis.

94 ghlight the unknown complexity of telomerase structural requirements for expression and function in v

95 se findings shed light on the functional and structural requirements for filamentous phage assembly,

96 To probe structural requirements for folate receptor targeting wi

97 gating human centromere organization and the structural requirements for formation of HAC vectors tha

98 of B. subtilis levansucrase (SacB) acceptor structural requirements for fructosylation.

99 Structural requirements for function of the Rho GEF (gua

100 ix of Rev to its nuclear export sequence has structural requirements for function.

101 To define structural requirements for functional interactions of g

102 ons of individual 3Bs to replication and the structural requirements for functionality.

103 ghtly hydrophobic motif to identify possible structural requirements for fusion activity.

104 Here we have analyzed the structural requirements for fusion of domains extracted

105 To determine the structural requirements for gammaKA-PE activity, we test

106 Altogether, these data elucidate crucial structural requirements for glucan hydrolysis on surface

107 To investigate the structural requirements for gp80 independence of vIL-6,

108 We defined interactions and structural requirements for heparin/HS interactions with

109 2.4 nM), allowing us to identify the minimal structural requirements for hERG blocking liability.

110 s of this ion channel have shed light on the structural requirements for hERG interaction but most im

111 action and provide useful information on the structural requirements for high affinity binding of org

112 acyclic nitriles and esters reveals the key structural requirements for high selectivity while provi

113 These results suggest that the structural requirements for high-affinity binding are fu

114 Less is known regarding the structural requirements for highly specific reversible M

115 tablish a new resolution of insight into hTR structural requirements for hTR-TERT interaction and for

116 and revealed a remarkably restrictive set of structural requirements for inducing rosette development

117 and 4-keto group of the C-ring were the main structural requirements for inhibition of adhesion molec

118 While examining the structural requirements for inhibition of PGHS, we disco

119 nd, using mutants, provide evidence that the structural requirements for inhibition of the AP are con

120 nalling provided succinct information on the structural requirements for inhibition, and demonstrated

121 To dissect the structural requirements for inhibition, RT-catalyzed DNA

122 es with alanine substitution to evaluate the structural requirements for interactions with the APJ re

123 These results elucidate some of the structural requirements for isoform-selective inhibition

124 bacteria, its activation mechanism, and the structural requirements for its function as a molecular

125 To analyze structural requirements for ligand binding we made a mut

126 n efficiency in vitro, provided that optimal structural requirements for ligation were met by both li

127 bed here can be useful for understanding the structural requirements for LPC recognition by G2A and t

128 rbazole natural product (+)K-252a identified structural requirements for MLK activity and a novel ser

129 These data suggest separable structural requirements for modulation of TRPA1 by coval

130 Here we investigate the structural requirements for mono- and poly-ubiquitinatio

131 The strict structural requirements for mPGES-1 and 5-LO inhibition

132 studies might help to understand the general structural requirements for natural endogenous ligands r

133 ylic acid have been synthesized to probe the structural requirements for NR2C/NR2D selectivity.

134 sigma(1) receptors were performed to examine structural requirements for optimal binding at these two

135 and the acceptor sides of FDDNP to learn the structural requirements for optimal binding to Abeta agg

136 Opposing stereoselectivity and divergent structural requirements for optimal DAT binding suggest

137 Here we examined the minimal DNA structural requirements for optimal hRad54 ATPase and br

138 nstrated different trends in substituent and structural requirements for optimal photochromism.

139 d there is relatively little known about the structural requirements for phosphorylating internal 2'O

140 Structural requirements for potency were systematically

141 ogy, and computational chemistry merging the structural requirements for potency with the requirement

142 In this work, we investigate the structural requirements for potent HDAC inhibition by ma

143 We explored the structural requirements for potentiation of glutamate-in

144 Here, we have examined the structural requirements for pre-microRNA binding by Exp5

145 ectionality and to explore poorly understood structural requirements for processive stepping.

146 emical natures are known to possess specific structural requirements for producing functional effects

147 ing to MART-1.HLA-A2, probably due to either structural requirements for proper Valpha/Vbeta associat

148 ogenesis in vitro and were used to probe the structural requirements for PSTPIP2 suppression of osteo

149 In this study, we set out to test the structural requirements for PTEN complex assembly and id

150 s were synthesized to gain insights into the structural requirements for quorum sensing inhibition in

151 The DNA structural requirements for reaction with alpha,beta-uns

152 Further insights into the structural requirements for retinoid isomerization by RP

153 le Michael acceptors have been reported, the structural requirements for reversibility are poorly und

154 ding that significant latitude exists in the structural requirements for ring closure may facilitate

155 The structural requirements for RNAP interaction and promote

156 ed in order to further ascertain the optimal structural requirements for S-adenosylmethionine decarbo

157 The structural requirements for scission are even more strin

158 (Sfh1), which seemingly conserves all of the structural requirements for Sec14 function.

159 this study provides valuable clues about the structural requirements for selective A-site recognition

160 s on the study of the three-dimensional (3D) structural requirements for selective antagonist activit

161 re synthesized in an effort to delineate the structural requirements for selectively inhibiting human

162 We define here the structural requirements for small peptides to competitiv

163 idea that single domains do not possess the structural requirements for specific CSA binding.

164 re, we established Sre2 as a model to define structural requirements for SREBP cleavage.

165 sults yield an improved understanding of the structural requirements for stabilizing the DFG-out form

166 ion of the STAT signaling pathway and on the structural requirements for STAT activation.

167 The descriptors reflect the structural requirements for strong inhibition: good ster

168 studies provide additional insight into the structural requirements for substrate metabolism and ina

169 The structural requirements for such an effector mechanism,

170 yields (42-77%) with a Z geometry due to the structural requirements for syn-beta-hydride elimination

171 We then examined the structural requirements for synaptobrevin to function in

172 inactive against HIV-2 virus, suggesting the structural requirements for targeting these two retrovir

173 this study also suggests differences in the structural requirements for the activation of homomeric

174 Prp22 highlights common as well as distinct structural requirements for the ATP-dependent steps in p

175 The structural requirements for the binding of AMDA at 5-HT(

176 ticle, I suggest an explanation based on the structural requirements for the binding of transcription

177 The structural requirements for the chemokines CXCL8 and CCL

178 We determined structural requirements for the dumbbell templates used

179 To understand the structural requirements for the electrogenicity of NBCe1

180 full-length and functional BAX(O), revealing structural requirements for the elusive execution phase

181 To evaluate the structural requirements for the formation and allosteric

182 these data define in vitro the sequence and structural requirements for the function of bacterial N-

183 Here, we explored the structural requirements for the functional interaction b

184 of compound 1 has provided insight into the structural requirements for the inhibition of Tdp1.

185 tants and UCNII fragments, we determined the structural requirements for the interaction between the

186 Structural requirements for the interaction of these age

187 suit of a more detailed understanding of the structural requirements for the key side chain cannabino

188 To understand the structural requirements for the kinase-CPD domain, we pe

189 tion with careful analysis of electronic and structural requirements for the PDE2a enzyme.

190 he results from the NaChBac channel point to structural requirements for the S3-S4 loop to generate a

191 SAR studies in the CCK region examined the structural requirements for the side chain groups at pos

192 To better understand the structural requirements for the switch to nanomolar cyto

193 These results demonstrated the structural requirements for the transformation of daidze

194 s (GABA(A)Rs), but little is known about the structural requirements for their actions.

195 ngiogenic activities to probe more fully the structural requirements for these anticancer properties.

196 Here, we studied the structural requirements for these penetrating ODNs to el

197 To further investigate structural requirements for this divergent binding mode,

198 To investigate the structural requirements for this function of SV2, we use

199 The structural requirements for this inhibition were explore

200 bacterial membranes and the possible peptide structural requirements for this phenomenon.

201 To understand the structural requirements for this transformation and obta

202 To unveil the structural requirements for TLR4.MD-2-specific ligands,

203 h was developed by rationally dissecting the structural requirements for TLR7-targeted activity for a

204 Therefore, the template structural requirements for transcription in vivo by RNA

205 Because the structural requirements for transport activity are not k

206 em, and the results provide insight into the structural requirements for transport by AtSUC2.

207 duced a series of mutations to determine the structural requirements for tropomyosin binding (using n

208 To delineate the structural requirements for VWF-mediated conformational

209 led to a number of conclusions regarding the structural requirements for woody odor, including absolu

210 These results may give new insights into the structural requirements for zinc finger and polyamide bi

211 ither the function of these clusters nor the structural requirements governing their persistence have

212 The essential active-site structural requirements have been identified for the pos

213 though its precise biochemical activities or structural requirements have not been elucidated.

214 f siRNA, meeting different compositional and structural requirements, have been reported to trigger I

215 To determine the structural requirements in HIV-1 Vif HCCH motif for Cul5

216 N-linked carbohydrate chain suggesting that structural requirements in this region favored O-glycosy

217 vity enhancement and highlight the divergent structural requirements inherent to supporting C-H amina

218 2, and fragment U-II(4-11) (3) shed light on structural requirements involved in their functional sel

219 This mechanism does not have the typical structural requirements, making it easier to overlook in

220 In an effort to understand the structural requirements necessary for auxotroph rescue,

221 We also discuss the structural requirements necessary for the formation of a

222 protein-protein interactions, establish the structural requirements needed for efficient CD40-CD40L

223 These synthetic systems meet the structural requirements needed to support Darwinian evol

224 Functional and structural requirement of CL for mitochondrial membrane

225 pted to distinguish between a functional and structural requirement of cytochrome c in COX assembly.

226 lts provide additional indications about the structural requirement of pharmacophores for further inc

227 ividual ion channels, is constrained by this structural requirement of sustaining several functional

228 In this study the structural requirement of transmembrane segment 1 (TM1)

229 herein can be utilized to further elucidate structural requirements of alpha-syn fibril growth and t

230 Together, these studies have defined structural requirements of an anchor residue within the

231 The elucidation of structural requirements of apelin-13 in its interaction

232 ode of action of bistramide A and identifies structural requirements of bistramide-based compounds th

233 -containing drug structures that satisfy the structural requirements of blood-brain barrier diffusion

234 We also deduced the structural requirements of BPA analogues that activate h

235 straightforward adaptation to the different structural requirements of dedicated nuclear or hybrid i

236 The structural requirements of flavaglines for cardio- and n

237 The identification of the structural requirements of Gli1/DNA interaction highligh

238 was undertaken to resolve the mechanism and structural requirements of heparin inhibition of human n

239 We assessed the structural requirements of HP activity and excluded that

240 and primary SMG epithelia to investigate the structural requirements of HS for FGF10-mediated epithel

241 the G2-G3-C1 regions underlies the different structural requirements of IF2 during the initiation pro

242 Here, we reveal key structural requirements of indole-2-carboxamides for all

243 A better understanding of the structural requirements of inhibitors for these transpor

244 rts have been made to further understand the structural requirements of its mechanism of action throu

245 ses lead to an improved understanding of the structural requirements of kinase binding that will be u

246 trix biosynthesis, little is known about the structural requirements of LOXL2 that enable collagen IV

247 Here, we examined the structural requirements of NBD1 for sterol transport.

248 Here we examined the structural requirements of NS3.4A and the therapeutic po

249 To define the relative and unified structural requirements of nucleoside analogs for intera

250 ses lead to an improved understanding of the structural requirements of PDE binding that will be usef

251 To establish the structural requirements of PGN recognition and the enzym

252 sults contribute to our understanding of the structural requirements of potent AHR antagonists and th

253 ghts the importance of specific sequence and structural requirements of pre-miRNA for editing along w

254 Here we dissected the minimal structural requirements of PTIP and its different protei

255 icity k(cat)/K(m) provided insights into the structural requirements of quinone substrates.

256 Here, we have dissected the structural requirements of RCA proteins that are crucial

257 cell receptor (TCR) signaling; however, the structural requirements of SLP-76 for mediating thymopoi

258 To test the structural requirements of SLP-76 in mast cell signaling

259 To better understand the structural requirements of specific residues for convers

260 To define the structural requirements of subglutinols for immunomodula

261 To determine the sequence and structural requirements of the 5'-proximal stem-loop RNA

262 modifications enabled an exploration of the structural requirements of the anticodon for aminoacylat

263 We examined the structural requirements of the AT1 receptor for transact

264 These analogues were designed to study the structural requirements of the corresponding GABAA recep

265 To understand the molecular and structural requirements of the enzymes that favor the bi

266 Here, we test the minimal structural requirements of the Escherichia coli DinJ ant

267 , each defined by antibody specificities and structural requirements of the HIV envelope monomer.

268 the CR7 domain, identified the sequence and structural requirements of the hTR processing and CB loc

269 m to further analyze the Ca2+ dependence and structural requirements of the IP3R proteasomal degradat

270 In this study, sequence and structural requirements of the M1H were further assayed

271 Here we have defined 1) the structural requirements of the N terminus of tropomyosin

272 To identify the structural requirements of the NTP, we determined the ef

273 Here, we clarify the structural requirements of the pathway effector Gli1 for

274 Here, we have investigated structural requirements of the PT alpha/beta-subunit pre

275 Exploration of the structural requirements of the substituents by probing t

276 To study the structural requirements of the substrate for this cataly

277 ave used Xenopus oocytes to characterize the structural requirements of the U3 snoRNA 3'-hinge intera

278 ese derivatives have been used to define the structural requirements of the VMAT substrate and inhibi

279 data provide the first insight into the RNA structural requirements of the yeast translational machi

280 , this study is the first to demonstrate the structural requirements of these thiosemicarbazones nece

281 recombinant human NK(2) receptor support the structural requirements of this new designed molecular t

282 We define the minimal structural requirements on ankyrin-B for direct Na/Ca ex

283 We define the structural requirements on ankyrin-G for Na(v)1.5 intera

284 egrees vertex) in a 3:2 ratio to explore the structural requirements on the building blocks for the s

285 the latter cells was characterized by strict structural requirements, PTX sensitivity, and dependence

286 The structural requirements rendering certain AQPs permeable

287 4 have hampered investigation of the precise structural requirements rendering inhibition by this dru

288 The key structural requirement responsible for optimal V(1b) sel

289 We discover the unanticipated structural requirement that TFP motors need to have a mi

290 The structural requirements that appear necessary to provide

291 erging mephedrone analogs, and give clues to structural requirements that govern drug selectivity at

292 standing of carbohydrate specificity and the structural requirements that lead to high-affinity inter

293 eling studies were conducted to define those structural requirements that were responsible for the di

294 etails of the consequential significance and structural requirements to form the dimerization interfa

295 each of which have different minimum ligand structural requirements to induce structural changes.

296 ite of the kynurenine pathway that meets the structural requirements to interact with glutamate recep

297 with the aim of revealing the most relevant structural requirements underlying the binding affinity

298 ncover the reason for these isoform-specific structural requirements, we analyzed a series of Orai mu

299 Distinct structural requirements were identified for activation o

300 The structural requirements within E3/19K necessary to seque