ライフサイエンスコーパス: structure

1 BP lattices due to their spring-shaped space structure.

2 cat-3 expression by affecting its chromatin structure.

3 complexity of LCRs and their connection with structure.

4 on, synaptic plasticity, and dendritic spine structure.

5 s, comparatively little is known about their structure.

6 y correcting inference errors using pedigree structure.

7 oline content, and lacks predicted secondary structure.

8 on of four defects in the resulting hexosome structure.

9 itive information about the underlying motif structure.

10 xhibits an unusual polymethylene-interrupted structure.

11 e, which evolved nearly 200 MYA, is one such structure.

12 d its independence of the detailed molecular structure.

13 imaged zG cells within their native rosette structure.

14 ive and had a milder effect on membrane pore structure.

15 ng processes and consequences for vegetation structure.

16 binding motifs through altered RNA secondary structure.

17 opting higher average secondary and tertiary structure.

18 erved in previously described RSV G-antibody structures.

19 r the scaffold surface with the crypt-shaped structures.

20 uences upon their G-quadruplex and secondary structures.

21 libraries representing a variety of chemical structures.

22 shown to define both deformed and recovered structures.

23 ically precise NCs and determine their total structures.

24 ip-like platforms along with printed 3D-cell structures.

25 ure of both the cell walls and the phytolith structures.

26 ent interactions and maintaining native-like structures.

27 ing was used primarily to visualize anatomic structures.

28 stigation of glycan-binding sites and glycan structures.

29 thod to clean up and reconfigure DNA-origami structures.

30 frameworks composed of hierachical chemical structures.

31 ylazopyrazole derivatives based on four core structures (4pzMe, 3pzH, 4pzH, and 4pzH-F2) and function

32 y efforts on the scaffold revealed a dynamic structure activity relationship and delivered analogues

33 esize large molecular libraries for studying structure-activity profiles.

34 The structure-activity relationship (SAR) trends identified

35 This review is devoted to the synthesis and structure-activity relationships (SAR) of colchicine alk

36 g intrinsic reaction pathways, for affording structure-activity relationships.

37 Results suggest that although soil structure affects local hydrologic response, its implica

38 The structure also revealed the arrangement of multiple form

39 ical shift data is shown to be vital for NMR structure analysis of minor polysaccharide components of

40 Our results on the structure and activity of Lpg2603 reveal a unique mode o

41 to near-atomic resolution and show detailed structure and arrangement of their surface proteins (E a

42 The structure and assembly of SGs and how different componen

43 mprove the representation of tropical forest structure and dynamics in Earth system models (ESMs).

44 orts have been directed towards modeling the structure and dynamics of the underlying networks of fin

45 HIV-1 maturation by BVM involves changes in structure and dynamics that are surprisingly subtle, but

46 catalytic activity suggest nearly invariant structure and function for aluminosilicate zeolite MFI t

47 effects of early ketamine exposure on brain structure and function.

48 inform predictions of specialized metabolite structure and function.

49 annels possess a simpler, fourfold symmetric structure and have facilitated studies of the structural

50 Improved understanding of influenza antigen structure and immunobiology is advancing novel vaccine c

51 metry of VO(2) from 1.86 to 2.44 on the band structure and insulator-metal transitions are presented

52 Analysis of the structure and interactions of the IC from Chaetomium the

53 ained significant correlations between brain structure and markers of heart failure including ejectio

54 ions, and contribute to understanding of the structure and mechanical action of the NER machinery.

55 ations were found to significantly alter the structure and organization of C. elegans sarcomeres.

56 Uncertainty in the structure and parameters of networks is ubiquitous acros

57 latonin can have a strong effect on membrane structure and physical properties, which may provide som

58 stnatal rhIGF-1/BP3 treatment preserved lung structure and prevented RVH in antenatal and postnatal B

59 st century, could thus disrupt the community structure and productivity of a critical functional grou

60 tolerance for major disruptions in chromatin structure and reveal a role for Suv39h2 in depositing su

61 We systematically searched for structure and sequence elements shared by both lineages.

62 F were characterized based on particle size, structure and stability.

63 ging issue for scientists due to the complex structure and various barrier mechanisms surrounding the

64 ough comprehensive digital phenotyping using structured and unstructured data abstraction from the el

65 and fast method for replicating nasal cavity structures and for the experimental testing of nasal fun

66 diffraction-limit information in subcellular structures and organelles that have rotational symmetry.

67 Molecular science entails the study of structures and properties of materials at the level of s

68 ensive, rare and the ability to tailor their structures and properties remains limited.

69 This stabilizes the PbI(6) structures and weakens the electron-LO phonon (Frohlich)

70 of "structronics" (a neologism derived from "structure" and "electronics").

71 termost carbon covering, a nonfilling porous structure, and a graphite core.

72 volumetric parameters, pituitary morphologic structure, and aqueductal cerebrospinal fluid (CSF) hydr

73 otide polymorphisms can affect RNA secondary structure, and here we show that single nucleotide polym

74 inheritance patterns, time scales, chromatin structures, and environmental exposures, all of which im

75 atabase is regularly self-updating, once new structures are deposited in the PDB.

76 G-Quadruplex (G4) structures are four-stranded noncanonical DNA structures

77 ECs between PVs and other adjacent structures are frequent in patient with atrial fibrillat

78 While their structures are normally determined under solvent-free co

79 5' Cap structures are ubiquitous on eukaryotic mRNAs, essential

80 processes to model changes in the community structure as a smooth function of time.

81 ighlight the importance of considering these structures, as regions of interest, in clarifying the ne

82 cycles open to the corresponding heterodiene structure at elevated temperature, which was used to gen

83 of silent chromatin, a heterochromatin-like structure at HML and HMR in Saccharomyces cerevisiae, de

84 Structure-based bioinformatic analysis identified 10 sub

85 bifunctional inhibitors was achieved through structure-based inhibitor design.

86 Computationally efficient all-atom structure-based simulations, calibrated against explicit

87 oreover, by using priors informed by dataset structures, bayNorm improves accuracy and sensitivity of

88 eir evolutionary adaptations to these highly structured but heterogeneous environments.

89 ble not only direct observation of molecular structures but also local probe reactions, in which unst

90 n Prph2 protein levels and rod outer segment structure, but not functional rescue in rods or cones.

91 Nutrient depleted compost retained its structure, but plants grown in this medium were severely

92 essfully applied to a large number of target structures, but requires excess quantities of suitably p

93 ly intermediates, and indeed we observe such structures by negative stain EM of in vitro assembly rea

94 pathways to integrate organic and inorganic structures by templating strategies and electrodepositio

95 Using grand-canonical electronic-structure calculations, we directly infer the coupled el

96 The dynamics of theorized network structures called ring attractors elegantly account for

97 lations that rely on knowledge of the native structure can provide critical, detailed information on

98 scussed next, focusing on the role of sulfur structure, carbon host chemistry and porosity, and elect

99 Plant cellulose is synthesized by rosette-structured cellulose synthase (CESA) complexes (CSCs).

100 hness was unaffected by fertilisers, network structure changed significantly as the replacement of fo

101 The DEC-205 monomer forms a compact structure comprising two intercalated rings of C-type le

102 le and nuclear electric quadrupole hyperfine structure constants and level isotope shifts of the [For

103 nd particle size increased and alpha helical structure decreased, reducing the stability of skim or f

104 ions and suggests that the protein secondary structure defines not only tertiary geometry, but also m

105 This structure-dependent mechanism therefore enables cells to

106 strate that this method is suited to both 3D structure determination and correlative light/electron m

107 Structure determination by X-ray crystallography and cry

108 The highly structured differential cross sections directly reflect

109 e developed a new strategy using proteins as structure-directed agents to direct the formation of new

110 Photoexciting these structures drives spin-triplet exciton transfer from sil

111 genetic risk for MS is associated with brain structure during early neurodevelopment remains unclear.

112 t ecosystem productivity and plant community structure during the growing season.

113 lpha/beta proteins exhibit more conventional structure-dynamics relationships.

114 racts were used for isolation and subsequent structure elucidation of chloroxanthic acid A as the fou

115 ding of ion transport behavior in wood-based structures enhances the capability to design high-perfor

116 tructures are four-stranded noncanonical DNA structures enriched at telomeres and oncogenes' promoter

117 The structure exhibits similarity to eIF3 recognizing motifs

118 d effect of germline variants that alter the structure, expression, or function of protein-coding reg

119 nduction polarity and their identifying band structure fingerprints.

120 ave emerged as fascinating materials and key structures for electrocatalysis.

121 r mouth and cumulative height of trans-river structures from the river mouth to each site.

122 ing high-throughput discovery and subsequent structure-function characterization, we present simple p

123 onoclonal antibodies as tools to interrogate structure-function relationships of assembly line PKSs.

124 orts provides a further understanding of the structure-function relationships of large viruses and sh

125 plays a significant role in maintaining the structure, functions and integrity of the aquatic ecosys

126 al neural network to segment six major renal structures: glomerular tuft, glomerulus including Bowman

127 arbene-ligated 3-benzoborepin with a bridged structure has been synthesized by double radical trans-h

128 However, the glycan's structure has not been described so far.

129 energy-resolution X-ray absorption near edge structure (HR-XANES) spectroscopy, under conditions of h

130 Dose metrics for several structures (i.e., optic disc, macula, retina, globe, len

131 d tandem multistage MS (MS(n)) were used for structure identification of vaping products.

132 llows for beam focusing and steering and for structured illumination via beam shaping.

133 on to MB learning by representing relational structure in a cognitive map.

134 mentation and a higher genetic diversity and structure in ground-level populations could be driving t

135 Brain structure in later life reflects both influences of intr

136 vestigated the role of in vivo RNA secondary structure in miRNA cleavage by developing the new CAP-ST

137 The cristae structure in the Opa1 (+/-) photoreceptors was not great

138 udies have highlighted fine-scale population structure in the UK on a North-West to South-East cline,

139 X-ray structures in complex with HIV-1 RT/dsDNA showed binding

140 an in vitro model for the induction of these structures in mouse macrophages undergoing IL-4-mediated

141 , and identify proteins belonging to 1-2 mum structures in primary human foreskin fibroblasts or mous

142 more significant surface trends and spatial structures in SOC and TN in both croplands, and the fert

143 Cryo-EM structures in the open and closed states reveal a dynami

144 evidence for the participation of cerebellar structures in the persistent storage of visual informati

145 ex genomic landscape of internal chromosomal structures in vertebrate cells(3-7), but the identical s

146 culminating in defects to anterior embryonic structures, including the pharyngeal arches, heart, and

147 These structures indicate movements of the LBDs that might be

148 osphorylation of CpxA despite its asymmetric structures, indicating that these asymmetric domain arra

149 es revealed alterations in protein secondary structure induced by plasma, particularly contents of be

150 To determine if structure informs function, we generated mice with zG-sp

151 As in embryogenesis, the development of structure inside a cell can be broken down into a number

152 tal questionnaire, clinical visits including structured interviews and skin prick tests (SPT).

153 ive X-ray crystallographic study (12 crystal structures), involving both CA II and a soluble CA IX mi

154 The structure is intrinsically disordered and therefore rema

155 ated in the growing polymer where the opened structure is stabilized, similar to a surfactant molecul

156 corporation of molecular switches in organic structures is of great interest in the chemical design o

157 N-terminal region of RNF4 bears no secondary structure, it maintains a compact global architecture pr

158 heir triboelectric charge densities and band structures, it is found that the triboelectric output is

159 ts in interactions appear to reshape network structure, leading to dramatic community changes, includ

160 ibility and stage distribution using a stage-structured Lefkovitch matrix model.

161 tals in a controlled (tier, composition, and structure) manner by exploiting underlying stochastic fr

162 ts a potential role of vertical transport in structuring mesopelagic NCLDV communities.

163 The fields of Electronic Structure Methods, Non-Adiabatic Molecular Dynamics, and

164 ghlighting the potential of protein tertiary structure mimetics as an emerging class of PPI modulator

165 , our results show no evidence of population structure (non-significant F(ST) < 0.001) for M. alfredi

166 d is achieved using pressure to modulate the structure of a recently developed 2D perovskite (HA)(2)

167 s together with the chemical composition and structure of both the cell walls and the phytolith struc

168 eins, resulting in a subnanometer resolution structure of capsid proteins within the virus particle.

169 -quadruplex (G4) is a noncanonical secondary structure of DNA or RNA which can enhance or repress gen

170 The structure of fungal oxyluciferin (light emitter) was pro

171 tic data, we evaluate the population genetic structure of historical A. varius and A. zeteki populati

172 We further report the cryoEM structure of human CMG bound to the replisome hub AND-1

173 Here, we report the structure of human SOAT1 (hSOAT1) determined by cryo-EM.

174 o further support this model, we altered the structure of osteoblast HS genetically to make it incapa

175 e report a cryo-electron microscopy (cryoEM) structure of PDE6 complexed to GTP-bound Galpha(T).

176 g between endogenous TruB1 and the stem-loop structure of pri-let-7, which also binds Lin28A/B.

177 spatial scale-interact to shape the spatial structure of range edges along climate gradients, and we

178 may in turn feedback to change the incentive structure of strategic interactions.

179 ind modified bases due to differences in the structure of the active site compared with other zinc-de

180 XS data provided constraints on the solution structure of the aptamer and enable computational modeli

181 P through a 2.5- angstrom-resolution crystal structure of the BRAF(KD)-14-3-3 complex, in which dimer

182 mall peptidic inhibitors based on the atomic structure of the core of alpha-syn fibrils.

183 rm before or concurrently with the secondary structure of the disordered protein)-an observation supp

184 Here, we report a crystal structure of the DNA-binding domain of a model ASO-bindi

185 of the biological system by the mathematical structure of the DNN.

186 is model-based learning, which considers the structure of the environment.

187 A 2.1 angstrom X-ray crystal structure of the FigC N-citrylornithine decarboxylase re

188 CV-infected individuals, we solved a crystal structure of the HCV E2 ectodomain in complex with AR3X,

189 Cardiac pumping depends on the morphological structure of the heart, but also on its subcellular (ult

190 together, our data shed light on the genetic structure of the HHV-6A and HHV-6B integration locus, de

191 ust histones, we have determined the crystal structure of the LSD1/CoREST complex bound to a 191-bp n

192 Structure of the multi-dimensional dataset was explored

193 Here we present the first high-resolution structure of the receptor type found in muscle-endplate

194 Although the structure of the TSWV G(N) is different from other bunya

195 We used the well known hierarchical structure of the visual motion pathway to demonstrate di

196 a 'black box' approach in which the internal structure of themodel used is set purely by machine lear

197 X-ray scattering (SAXS) to characterize the structure of this carotenoprotein in two distinct oligom

198 Moreover, we also present a structure of this domain bound to the substrate diC8-PI(

199 The structure of this network impacts not only the socioecon

200 We examined the structure of two of the novel orbitides by NMR, finding

201 The structure of VCBC-Cullin5 has recently been solved by X-

202 On the basis of X-ray structures of a CNS-penetrating reactivator, monoxime RS

203 The structures of A11 and B12A TCR are nearly identical to t

204 The crystal structures of AaTPS and FgGS provide insights into the c

205 er, Ciudad et al. elucidate the first atomic structures of Abeta oligomers, which reveal how they for

206 e facilitated the elucidation of solid-state structures of all five compounds with <1.1 angstrom reso

207 rphic assemblies, we have determined cryo-EM structures of apo-CA hexamers and in complex with cyclop

208 Crystal structures of arsenic-bound p53 mutants reveal a cryptic

209 ty and allows us to solve 3D single particle structures of clustered protocadherin, an elongated part

210 Although the crystal structures of dark- and light-adapted states have been d

211 small molecule drugs through the layers and structures of ex vivo nude mouse ear skin and extracted

212 Structures of flavivirus (dengue virus and Zika virus) p

213 Lung granulomas are organized structures of host immune cells that function to contain

214 Here we present two cryo-electron microscopy structures of human PAC in a high-pH resting closed stat

215 exciting time where many new high-resolution structures of large complexes and membrane proteins are

216 Here we present structures of PIPS from Mycobacterium kansasii with and

217 idence of membrane association, and probable structures of prefusion intermediates.

218 Cryo-electron microscopy structures of Saccharomyces cerevisiae Spf1 revealed a l

219 d change to adapt while supporting essential structures of society.

220 etermined under solvent-free conditions, the structures of solvated 2D COFs are largely unexplored.

221 Here, we present the near-atomic structures of the BBSome by itself and in complex with A

222 raphy (SFX), we have determined the pristine structures of the Fe(III) and Fe(IV) =O redox states of

223 Here, we report two cryo-EM structures of the intact V-ATPase from bovine brain with

224 with electrophysiological characterization, structures of TRPV3 in a lipid membrane environment prov

225 We define the structures of two unique species-specific components (Ca

226 X-ray crystal structures of variously modified ASL(Arg1)(ICG) and ASL(

227 to this debate is whether wings are a novel structure on the body wall resulting from gene co-option

228 ate the impact of STR sequence and secondary structure on their genomic representation and mutability

229 n frosting process on surfaces with serrated structures on the millimeter scale, which is distinct fr

230 sion (TOCI) method to introduce fractal-like structures on the surface of these metals in a controlle

231 Lead structure optimization is needed to minimize the percent

232 of the human heart, and abnormalities in its structure or function cause sick sinus syndrome, the mos

233 sing ChIP, we show that the occurrence of G4 structures peaks at the late S phase, thus correlating w

234 A variety of structure-permeability trends were observed including a

235 Early structured physiotherapy involved mobilisation technique

236 nary innovations in cold acclimation ability structuring plant distributions across biomes.

237 We launch a webserver for RNA structure prediction and design corresponding to tools d

238 The accuracy of chemical structure prediction enables the development of machine-

239 ing algorithms drive the progress in protein structure prediction, a lot remains to be studied at thi

240 ng superhighway of deep learning and protein structure prediction.

241 rgy conversion and storage, but the chemical structures present in this heterogeneous pigment remain

242 Kirigami structures provide a promising approach to transform fla

243 The structure provides a framework for understanding mechani

244 in vitro as well as in diverse intracellular structures ranging from contractile bundles to the mitot

245 nitial set of trials, they selected a reward structure (ratio of points for target hits and misses) f

246 A comprehensive understanding of structure-reactivity relationships is critical to the de

247 further made the annotated data and protein structures readily downloadable from MISCAST to foster a

248 The small and transient actin structures regulating organelle dynamics are challenging

249 However, predicting a conserved RNA structure remains unreliable, even when using a combinat

250 lgorithms, the fundamental predictability of structures remains unclear, as networks' complex underly

251 tein that binds to SMCR8 such that the whole structure resembles an eye slip hook.

252 of a high-resolution X-ray crystallographic structure resolving the site of catalysis, a protein-bou

253 The structure reveals a composite binding site bridging over

254 The structure reveals that FlhB/SctU extends the helical exp

255 This structure reveals that two Rab33B molecules bind to the

256 e charge carriers and is affected by crystal structure, scattering from boundaries and defects, and s

257 in miRNA cleavage by developing the new CAP-STRUCTURE-seq method to capture the intact mRNA structur

258 These structures show how the donor and acceptor substrates bi

259 They also support the view that global RNA structure significantly modulates protein-RNA interactio

260 LUCS greatly expands the designable structure space and offers a new paradigm for designing

261 infrared and extended X-ray absorption fine structure spectra.

262 cal lipid environment is known to affect the structure, stability and intercellular channel activity

263 ed as a cycad, but new evidence from cuticle structure suggests that it is an angiosperm.

264 e studies demonstrate a strategy to tune RNA structure-targeting compounds to the cellular localizati

265 The kinetochore is a macromolecular structure that assembles on the centromeres of chromosom

266 We find that the mitotic centrosome, a structure that assembles the mitotic spindle [1], is not

267 They fold up into a hairpin structure that is cleaved at its base by an enzyme compl

268 oach to transform flat films into 3D complex structures that are difficult to achieve by conventional

269 and cryo-electron microscopy, we determined structures that capture RAG engaged with transposon ends

270 cs simulations to examine specific secondary structures that resist mechanical unfolding while minimi

271 gal pathogen affected the assembly processes structuring the amphibian skin microbiome.

272 aterials featuring an unprecedented backbone structure, the polyallophanates (PAs).

273 inesis, FtsZ protofilaments form a ring-like structure, the Z-ring, in most bacterial species.

274 Together with recently solved structures, these provide coverage of the major class B

275 Guided by chromatin structure, through the use of Chromosome Conformation Ca

276 image sequences containing internal temporal structure to humans of either sex and male macaque monke

277 ally based and proportionate risk governance structure to support innovation, including a robust fram

278 photons that can be integrated into photonic structures to amplify, direct, and tune their emission o

279 Recent experiments reveal that micro-structured tungsten can exhibit significant deviation fr

280 The structure uncovers an unexpected, eukaryotic specific an

281 ing operator resolves the true compartmental structure up to the theoretical detectability threshold,

282 volumetric architectures containing desired structures using programmed automation processes.

283 peroxidation) on mitochondrial function and structure was assessed in HL1 murine cardiomyocytes and

284 portance of this macromolecule, its tertiary structure was never determined.

285 ntacts at a certain position in sequence and structure, we introduced a new metric designated 'contac

286 with different environmental and taxonomical structure, we show that large scale patterns in the EMP

287 The complexes were crystallized, and their structures were determined by X-ray diffraction.

288 Anatomic structures were segmented, and median R2* values were ca

289 rbitides by NMR, finding one had a definable structure, whereas the other did not.

290 good results when combined with high-quality structures, whereas it can even be detrimental otherwise

291 -blocked" [(PDT)Mo(V)O(S(Cys))(thiolate)](-) structure, which is supported by new EXAFS data.

292 ular network (LCN) is a fluid-filled network structure, which pervades our bones and accommodates a c

293 -understood electronic transport within such structures will potentially lead to accessible device fa

294 nthesized MOF Azole-Th-1 shows a UiO-66-type structure with fcu topology built on a Th(6) secondary b

295 HsZnT8 forms a dimeric structure with four Zn(2+) binding sites within each sub

296 Throughout, we correlate structure with function whenever possible.

297 le multiple subwavelength elements to create structures with extraordinary physical properties (1-4).

298 heterogeneous aggregates ('organoids') or 3D structures with less physiological relevance ('spheroids

299 CNTs) in particular, the inability to access structures with specific diameters or chiralities severe

300 APOE structures with various glycan residues were predicted.