ライフサイエンスコーパス: stun

1 llows brief periods of ischemia ("myocardial stunning").

2 3 d later (late preconditioning [PC] against stunning).

3 urs later (late preconditioning [PC] against stunning).

4 ine-carrying fish where somatic recovery was stunned.

5 x microstructural patterns that are visually stunning.

6 th the protective effects of late PC against stunning.

7 olecular identification, and the results are stunning.

8 ardium but may not play a role in reversible stunning.

9 emic preconditioning (PC) against myocardial stunning.

10 ective effects of late PC against myocardial stunning.

11 SOD2) isoforms to protect against myocardial stunning.

12 xygen species (ROS) contribute to myocardial stunning.

13 annel blockers have been shown to ameliorate stunning.

14 lation to ischemic stress, which induced the stunning.

15 ed for hours or days because of postischemic stunning.

16 s diagnostic scan for any visual evidence of stunning.

17 n in a canine model of repetitive myocardial stunning.

18 oiodine ablation without concern for thyroid stunning.

19 ndicating the development of late PC against stunning.

20 use atherosclerotic disease or microvascular stunning.

21 ny delayed deleterious actions on myocardial stunning.

22 unknown whether it triggers late PC against stunning.

23 his gene therapy protects against myocardial stunning.

24 ate (ISMN, 50 mg once daily) on postexercise stunning.

25 ndicating the development of late PC against stunning.

26 ther, suggesting the induction of myocardial stunning.

27 p IV, n = 6) failed to block late PC against stunning.

28 dicating a late PC effect against myocardial stunning.

29 m overload implicated in the pathogenesis of stunning.

30 amine stress and a reduction in postischemic stunning.

31 the sixth reperfusion, indicating myocardial stunning.

32 nary resuscitation, indicative of myocardial stunning.

33 gineered human-transmissible H5N1 strain are stunning.

34 species, has been associated with myocardial stunning.

35 s showed improved or no effect on myocardial stunning.

36 diagnostic (131)I, the phenomenon was called stunning.

37 -C during reperfusion may prolong myocardial stunning.

38 ion of blood flow, which is called metabolic stunning.

39 or swelling and failed to prevent myocardial stunning.

40 diography to assess intradialytic myocardial stunning.

41 with no stunning, and group S, patients with stunning.

42 ared with postablation scans for evidence of stunning.

43 ion (group 3, n = 6), designed to produce no stunning.

44 t the left atrial appendage is mechanically "stunned."

45 and duration of postconversion left atrial "stunning."

46 associated with decreased Ca(2+) transients (stunned, 0.33+/-0.04 versus normal, 0.49+/-0.05, P<0.01)

47 confer marked protection against myocardial stunning 1-3 d later (late preconditioning [PC] against

48 e from the natural product itself that are a stunning 100-fold more active (IC50 values, 50-75 pM vs.

49 (group V, n = 5), the severity of myocardial stunning 24 h later was not modified.

50 id not exacerbate the severity of myocardial stunning 24 hours later; therefore, the absence of late

51 he heart relatively resistant to myocardial "stunning" 24 hours later (late preconditioning [PC] agai

52 ere labeled as hibernating; 23% (n = 136) as stunned; 30% (n = 177) as remodeled; and 22% (n = 131) a

53 ith decreased L-type Ca(2+)-current density (stunned, -4.8+/-0.4 versus normal, -6.6+/-0.4 pA/pF, P<0

54 low dose dobutamine, was observed in 83% of stunned, 59% of hibernating, 35% of remodeled and 13% of

55 of trehalases in desiccated cell reveals the stunning ability of cells to retain enzymatic activity w

56 In the basic science arena, there have been stunning advancements that illustrate novel biological a

57 ther molecules that mediate taste has led to stunning advances in our understanding of the basic mech

58 Despite stunning advances in our understanding of the genetics a

59 ical concentration and ameliorate myocardial stunning after ischemia-reperfusion.

60 0% for 90 minutes, and subsequent myocardial stunning after reperfusion in chronically instrumented c

61 echo contrast and frequently develop atrial stunning after restoration of sinus rhythm.

62 Left atrial appendage stunning also occurs in patients with atrial flutter, al

63 ons in preload after global ischemia-induced stunning also prevented TnI degradation.

64 pite such response dimorphism, we observed a stunning anatomical monomorphism of cortical penis and c

65 accurate foot strikes that are sufficient to stun and kill prey requires precision targeting, demandi

66 ilon(sys)) was significantly reduced in both stunned and infarcted walls compared with their remote w

67 be used to differentiate between viable but stunned and nonviable myocardium within the postischemic

68 ate (A(SR)) diastole were comparable between stunned and remote walls (epsilon(A): 7.3+/-1.6% versus

69 , clinical exploitation of the powerful anti-stunning and anti-infarct actions of late PC has been el

70 ated TnI proteolysis can be dissociated from stunning and arises from elevations in preload rather th

71 similarly may be associated with myocardial stunning and cell necrosis associated with ischemia/repe

72 ardial infarction (MI) because of myocardial stunning and compensatory hyperkinesia in noninfarct-rel

73 mia in the setting of CD results in enhanced stunning and development of infarct.

74 hat relates to the time course of myocardial stunning and differs transmurally in relation to ischemi

75 This process is known as myocardial stunning and has important clinical ramifications.

76 ught to prospectively identify patients with stunning and hyperkinesia at hospital discharge on the b

77 AR and VR technologies allow for stunning and immersive experiences, offering untapped op

78 before ischemia would enhance the degree of stunning and induce a sustained decrease in glucose upta

79 tely ablated the late PC effect against both stunning and infarction.

80 e effects of late PC against both myocardial stunning and myocardial infarction, indicating that COX-

81 e effects of late PC against both myocardial stunning and myocardial infarction, indicating that NF-k

82 Closed-chest stunning and SEMI were produced by angioplasty balloon o

83 mibi SPECT and low-dose dobutamine in canine stunning and subendocardial infarction (SEMI).

84 Myocytes were isolated from the ischemic (stunned) and nonischemic (normal) regions after 90-minut

85 mmalian models of both ischemia/reperfusion (stunning) and chronic pressure overload with hypertrophy

86 tion 24 hours later against both reversible (stunning) and irreversible (infarction) ischemia/reperfu

87 result in reduced postoperative reversible (stunning) and irreversible myocardial injury, as assesse

88 dL, use of inotropes, presence of myocardial stun, and requirement of cardiopulmonary resuscitation d

89 dogs were included in the study: 7 normal, 7 stunned, and 4 with SEMI.

90 d simultaneous differentiation of infarcted, stunned, and normal myocardial regions on the basis of g

91 ft ventricular wall thickening in infarcted, stunned, and remote myocardial regions were 2% +/- 4 (SD

92 rt failure, ischemia and reperfusion injury, stunning, and familial hypertrophic cardiac myopathies.

93 into two groups: group NS, patients with no stunning, and group S, patients with stunning.

94 ng residual viability, microvascular damage, stunning, and right ventricular infarction.

95 est remains normal, consistent with "chronic stunning," and contrasts with reduced flow and increased

96 mia can have a negative effect on the heart: stunning; and on the other hand, they have a protective

97 We hypothesized that stunning arose from the early effects of the therapeutic

98 This research line continues to produce stunning arrays of enantioselective technologies either

99 es were decreased in infants with myocardial stun, arrhythmia, and cardiac arrest.

100 nt cellular processes, leading to myocardial stunning, arrhythmias, and ultimately cell damage and de

101 S and MPT have been implicated in myocardial stunning associated with reperfusion in ischemic hearts,

102 the 6th CS, reflecting persistent myocardial stunning, but baseline CBF was not changed.

103 thout catalase fails to alleviate myocardial stunning, but extracellular SOD (Ec-SOD) may be more eff

104 fibrillation (AF) is associated with atrial stunning, but the short-term effect of a brief episode o

105 st the hypothesis that persistent myocardial stunning can lead to hibernating myocardium, 13 pigs wer

106 Thyroid stunning can occur with 185 MBq of 131I in diagnostic im

107 Biological systems display stunning capacities to self-organize.

108 scope from the Sputnik era, they assembled a stunning collection of micrographs that illustrated how

109 Prior structural studies have revealed the stunning complexity of the purified rotor and C-ring ass

110 In phase I (studies of myocardial stunning), conscious rabbits underwent a sequence of six

111 Stunning could potentially reduce the therapeutic effica

112 Stunning decreases contractility at the level of the con

113 The former is often preferred to avoid "stunning"-defined as a reduction in uptake of the therap

114 They also reveal stunning differences between compensatory processes oper

115 their design, have allowed the creation of a stunning diversity of nucleic acid-based nanodevices.

116 Birds present a stunning diversity of plumage colors that have long fasc

117 rimary difficulties exist: Viruses exhibit a stunning diversity of strategies for evading the host im

118 Atrial mechanical stunning due to atrial fibrillation may persist after re

119 The stunning Early Cretaceous diversity of maniraptorans fro

120 dose of (131)I produces a visually apparent stunning effect 72 h before (131)I ablation therapy.

121 10 mCi) (131)I may be capable of producing a stunning effect on thyroid tissue that may interfere wit

122 APC and IPC exhibit anti-infarct and anti-stunning effects in the ovine heart, but these effects a

123 study, the anti-infarct effects and the anti-stunning effects of APC in contributing to enhanced post

124 ained depressed for 2 hours (ie, endothelial stunning [ES]).

125 These results indicate that persistent stunning, even in the absence of chronic ischemia, can r

126 this symbiosis has produced one of the most stunning examples of rapid adaptive radiation documented

127 One of the more stunning examples of the resourcefulness of human vision

128 obably with immune compromise following cold stunning (extended hypothermia), developed a disseminate

129 cted to a partial occlusion to produce acute stunning, followed by reperfusion through a critical ste

130 hough doxycycline did not improve myocardial stunning following coronary artery bypass graft surgery

131 usion, and the differentiation of myocardial stunning from myocardial necrosis.

132 echocardiography accurately differentiates 'stunning' from necrosis, delineates transmural extent of

133 sed significantly compared with rest for the stunned group (29.1 +/- 10.4 vs. 10.1 +/- 9.0; P = 0.000

134 n the antioxidant group relative to both the stunned group and to nonischemic controls.

135 pletely in the antioxidant group, but in the stunned group it recovered by only 57%.

136 during low-dose dobutamine infusion for the stunned group was comparable to that for the normal grou

137 mia and reperfusion in the absence of drugs (stunned group) or to the same protocol in the presence o

138 e global ischemia and 20-minute reperfusion (stunned group), or for 20-minute ischemia without reflow

139 ed depression of myofilament function in the stunned group, with no change in Ca2+ transients relativ

140 as significantly higher in the normal versus stunned groups (21.1 +/- 3.1 vs. 10.1 +/- 9.0; P = 0.000

141 duced late PC effect against both myocardial stunning (groups VII through X) and myocardial infarctio

142 eform of a commercially available electrical stun gun (Taser X-26, Taser International, Scottsdale, A

143 The interaction of cocaine and the stun gun on VF induction is unknown.

144 Stun guns are increasingly used by law enforcement offic

145 Stunning has been observed in several clinical scenarios

146 tic (131)I were measured at 2 d, a time when stunning has been observed, and expressed as ratios of r

147 The mechanism of myocardial stunning has been studied extensively in rodents and is

148 Left atrial appendage stunning has recently been proposed as a key mechanistic

149 This transient "stunning" has potential implications for (3)H-FDG PET, e

150 Patients with stunning have late increases in LVEF; patients with hype

151 hemia-reperfusion-induced LV dysfunction or "stunning" have normal contractile function and normal [C

152 enesis of cardiac contractile failure in the stunned heart.

153 to characterize dysfunctional myocardium as stunned, hibernating, remodeled and nonviable.

154 y of CAD and the presence of ischemia and/or stunned/hibernating myocardium should be assessed for op

155 lisation microscopy, which have all produced stunning images of cellular structures.

156 with single particle averaging, has produced stunning images of the intact bacterial flagellum, revea

157 viduals synchronize their states, giving the stunning impression that the group behaves as one.

158 nt time after ischemia eliminates myocardial stunning in conscious pigs during augmented carbohydrate

159 the mechanism of late PC against myocardial stunning in conscious rabbits involves a PKC-mediated si

160 We studied the mechanism of stunning in isolated myocytes from chronically instrumen

161 Thus, mechanisms of stunning in the pig are radically different from the wid

162 olytic ATP in the recovery from postischemic stunning in vivo.

163 ing the genes up-regulated during myocardial stunning, including those not previously described in th

164 th chronic animal window models has provided stunning insight into tumor pathophysiology, including g

165 m salvaged by reperfusion." The mechanism of stunning involves generation of oxygen radicals as well

166 Endothelial stunning is caused by oxidant processes inhibited by asc

167 Myocardial stunning is characterized by decreased myofilament Ca2+

168 ilament proteins in situ during ischemia and stunning is evaluated, and it is concluded that C-termin

169 Recovery from stunning is incompletely understood but may involve adap

170 troponin I (cTnI) proteolysis in myocardial stunning is not fully understood.

171 st infarction, their role in late PC against stunning is unknown.

172 h transient contractile dysfunction, termed "stunning." It is not clear whether this phenomenon is pr

173 ysfunctioning kidney after decompression, or stunned kidney.

174 ication of recent obstruction and 22.5% with stunned kidneys after spontaneous decompression).

175 s such that beetles alighting onto them were stunned, killed, and collected.

176 ible DNA alkylation reaction) and define the stunning magnitude of its effect.

177 Myocardial stunning may cause prolonged left ventricular dysfunctio

178 dramatic subunit rearrangements, providing a stunning molecular explanation for the allosteric regula

179 cardium as brighter than both the normal and stunned myocardial regions but darker than the blood poo

180 d with 32 kD for the full-length protein) in stunned myocardial samples only.

181 ged MRI can differentiate between viable but stunned myocardium and nonviable myocardium.

182 Defect severity for stunned myocardium and SEMI was mild and was not signifi

183 ctile reserve was significantly different in stunned myocardium and SEMI.

184 Stunned myocardium demonstrated no change in the 31- or

185 sent in hibernating myocardium but absent in stunned myocardium evaluated after 24 hours.

186 he increase of end-systolic fiber lengths in stunned myocardium had no significant transmural gradien

187 ase inhibition with dichloroacetate (DCA) of stunned myocardium in conscious pigs.

188 ckers have been shown to enhance function of stunned myocardium in experimental studies, and in a few

189 Stunned myocardium is a syndrome of reversible contracti

190 Regional function in stunned myocardium is usually thought to be more depress

191 Thus, stunned myocardium occurs without TnI degradation or alt

192 ed SR gene expression and TnI degradation in stunned myocardium produced by 10-minute total left ante

193 at the time course of functional recovery of stunned myocardium reflects the resynthesis of reversibl

194 Stunned myocardium was delineated with MnCl2-enhanced MR

195 epicardium, reflecting that this response in stunned myocardium was proportional to the severity of t

196 version power Doppler techniques, identifies stunned myocardium, and accurately predicts recovery of

197 a central role in ischemic preconditioning, stunned myocardium, and in anesthetic-induced protection

198 To investigate the molecular basis of stunned myocardium, we performed PAGE and Western immuno

199 One of these monuments is stunned myocardium, which represents "prolonged postisch

200 that Ca2+ channel activity is diminished in stunned myocardium.

201 rdium, which is distinct from hibernating or stunned myocardium.

202 rylated phospholamban monomer was reduced in stunned myocardium.

203 protein troponin I has been correlated with stunned myocardium.

204 ponsiveness, recapitulating the phenotype of stunned myocardium.

205 rinol+MPG antioxidant cocktail in a model of stunned myocardium.

206 radation pattern similar to that observed in stunned myocardium.

207 e more compliant walls containing viable but stunned myocardium.

208 ocardial infarction and five had evidence of stunned myocardium.

209 that arising from viable (hibernating and/or stunned) myocardium has important implications for the m

210 for 70% relaxation was prolonged, P<0.01, in stunned myocytes (131+/-8 ms) compared with normal myocy

211 myocyte contraction was reduced, P<0.01, in stunned myocytes (6.3+/-0.4%) compared with normal myocy

212 Action potential measurements in stunned myocytes demonstrated a decrease in plateau pote

213 In rats, stunned myocytes demonstrated reduced systolic contracti

214 ion followed by reperfusion to create either stunning (n=12) or transmural myocardial infarction (n=1

215 hat TOR controls protein synthesis through a stunning number of downstream targets.

216 Stunning occurred more often with ISMN than amlodipine (

217 Although stunning occurs after brief total occlusions and prolong

218 If thyroid remnant stunning occurs due to 74 MBq (131)I used as a diagnosti

219 sed NGF protects against postischemic neural stunning of sympathetic cardiac innervation.

220 Coronary occlusion produced stunning of the anterolateral left ventricle that resolv

221 PFA resulted in no or transient stunning of the phrenic nerve (<5 minutes) without histo

222 This "mechanical stunning" of left atrial systolic function appears to be

223 These results support the hypothesis that "stunning" of thyroid tissues, often observable by 2 d, i

224 ecessary not only to trigger late PC against stunning on day 1 but also to mediate the protection on

225 a (group VI, n = 11) induced late PC against stunning on day 2 and the magnitude of this effect was e

226 r; therefore, the absence of late PC against stunning on day 2 in group II cannot be ascribed to a de

227 rmed on day 1 failed to precondition against stunning on day 2, but the same sequence performed on da

228 pletely prevented the late PC effect against stunning on day 2.

229 performed on day 2 did precondition against stunning on day 3.

230 However, data did not show any effect of stunning on the efficacy of 131I therapy for differentia

231 Areas of nonfunctional but viable (stunned or hibernating) myocardium can also contribute t

232 ic myocardium in the presence of infarction, stunning or hibernation, alone or in combination.

233 nt the development of late PC against either stunning or infarction on day 2.

234 fter acute MI may be secondary to myocardial stunning or necrosis.

235 o limitation of infarct size, alleviation of stunning, or both.

236 tion in myocardial infarct size, severity of stunning, or incidence of cardiac arrhythmias.

237 d to produce different degrees of myocardial stunning; or (c) a single episode of 2 minutes of occlus

238 read and rewrite it at will has ushered in a stunning period in the history of science.

239 In the early postischemic stunning phase of reperfusion, the inotropic response to

240 The future challenge is how to minimize the stunning phenomenon and maximize the preconditioning phe

241 y flow velocity was unchanged, indicating LV stunning post balloon occlusion.

242 y snails in the marine gastropod genus Conus stun prey by injecting a complex mixture of peptide neur

243 formed in this way, may be used for hunting/stunning prey and communication.

244 Despite the stunning progress in all disciplines of auxin research,

245 he role of the erbB2 gene in cancers and the stunning progress in developing targeted therapies for e

246 arch, we explore the gap between 25 years of stunning progress in fundamental neuroscience and the pe

247 In phase I (studies of myocardial stunning), rabbits were subjected to six 4-minute corona

248 he perfusion findings suggested that chronic stunning rather than hibernation is the principal cause

249 reduced L-type Ca2+ current contribute to a stunning reduction of intracellular Na+ concentration fo

250 t it improved to nearly normal levels in the stunned region 1 week after induced occlusion (mean, 40%

251 felt to be sufficient to allow recovery from stunning, regional function was disproportionately low f

252 During reflow, blood flow in stunned regions was restored to near-normal levels (0.89

253 However, glucose uptake in stunned regions was significantly decreased at 4 h (73%

254 Similarly, oxidative metabolism in stunned regions was significantly decreased at 4 h (84%

255 ardial segments were defined as hibernating, stunned, remodeled or scarred.

256 Finally, evidence of both stunning (rest asynergy with normal flow) and hibernatio

257 the same time we reveal for driven systems a stunning result - the distribution of temperatures in gr

258 resuscitation and is mediated by myocardial stunning resulting from mitochondrial electron transport

259 ernation may represent persistent myocardial stunning resulting from repeated episodes of ischemia an

260 dase-4 inhibition mitigated the postischemic stunning seen in the control scan.

261 Myocardium subjected to repetitive stunning showed a prolonged yet reversible reduction in

262 Recent discoveries have uncovered stunning similarities among the molecular circuitries of

263 o decades of network science have discovered stunning similarities in the topological characteristics

264 The stunning simplicity of the motif and its surprisingly st

265 Although crystal structures provide stunning snap shots, biochemical approaches addressing t

266 future and pursue a path that builds on the stunning successes of the past.

267 ays and protects against both infarction and stunning, suggesting that it may have greater clinical r

268 Stunning technical advances in the ability to image the

269 a unique metabolic adaptation in repetitive stunning that is different from that typically seen in c

270 urrent segmental ischemic injury (myocardial stunning) that drives cumulative cardiac damage.

271 Myocardial stun, the near-total absence of systolic function during

272 protects against infarction but not against stunning, the late phase of PC lasts 3 to 4 days and pro

273 the kilowatt pulses with which electric fish stun their prey-to the quotidian-the acidification of en

274 datory strains use karlotoxins as a means of stunning their prey, before ingesting it.

275 Relative to baseline, radial segments in stunned tissue were significantly thinner at the endocar

276 transition from a physiological phenotype of stunning to hibernation.

277 The ability to distinguish between stunned versus necrotic myocardium early after reperfusi

278 and was not statistically different for the stunned versus SEMI groups (P = not significant).

279 as higher for infarcted (P<0.05) but not for stunned walls (P=NS) compared with their remote walls.

280 Late PC against stunning was also abrogated when LD-A was given before t

281 In contrast, in DCA pigs, myocardial stunning was ameliorated (P<0.05).

282 n and metabolism, suggesting that myocardial stunning was common.

283 Stunning was defined when the diagnostic scan showed act

284 Stunning was induced in 14 anesthetized swine by partial

285 Myocardial stunning was induced in conscious pigs by coronary steno

286 ere chronically instrumented, and persistent stunning was induced regionally by 6 repetitive episodes

287 egional cardiac denervation (CD), myocardial stunning was intensified, ie, at 12 hours reperfusion wa

288 The severity of myocardial stunning was measured as the total deficit of LV wall th

289 In the absence of DCA, myocardial stunning was observed; ie, wall thickening was reduced b

290 mental stress echocardiography parameters of stunning were attenuated in patients while taking amlodi

291 The protective effects of IB-MECA against stunning were completely blocked by pretreatment with th

292 No cases of visually apparent thyroid stunning were observed on any of the postablation scans

293 le levels of ischemia, amlodipine attenuated stunning when compared with ISMN.

294 denosine blocker 8-PT enhanced the degree of stunning when given before ischemia but did not induce a

295 n = 10) abrogated the late PC effect against stunning, whereas a 10-fold lower dose (0.5 mg/kg; group

296 rfusion followed by ventricular dysfunction (stunning), which more closely resembles clinical conditi

297 ized that hibernation is preceded by chronic stunning with normal resting perfusion.

298 eatment to assess the degree of postexercise stunning with simultaneous sestamibi single-photon emiss

299 Significant myocardial stunning with subsequent improvement of ventricular func

300 th substantial protection against myocardial stunning without the need for concomitant administration