ライフサイエンスコーパス: stunning

1 llows brief periods of ischemia ("myocardial stunning").

2 ximately 50%) ("late preconditioning against stunning").

3 3 d later (late preconditioning [PC] against stunning).

4 urs later (late preconditioning [PC] against stunning).

5 ctive response (late preconditioning against stunning).

6 SOD2) isoforms to protect against myocardial stunning.

7 xygen species (ROS) contribute to myocardial stunning.

8 annel blockers have been shown to ameliorate stunning.

9 lation to ischemic stress, which induced the stunning.

10 ed for hours or days because of postischemic stunning.

11 s diagnostic scan for any visual evidence of stunning.

12 n in a canine model of repetitive myocardial stunning.

13 oiodine ablation without concern for thyroid stunning.

14 ndicating the development of late PC against stunning.

15 use atherosclerotic disease or microvascular stunning.

16 ny delayed deleterious actions on myocardial stunning.

17 unknown whether it triggers late PC against stunning.

18 his gene therapy protects against myocardial stunning.

19 ate (ISMN, 50 mg once daily) on postexercise stunning.

20 ndicating the development of late PC against stunning.

21 ther, suggesting the induction of myocardial stunning.

22 p IV, n = 6) failed to block late PC against stunning.

23 dicating a late PC effect against myocardial stunning.

24 m overload implicated in the pathogenesis of stunning.

25 the sixth reperfusion, indicating myocardial stunning.

26 utamine recovery, consistent with myocardial stunning.

27 myofilament proteolysis underlies myocardial stunning.

28 e of late preconditioning against myocardial stunning.

29 mined at baseline, during ischemia and after stunning.

30 of the first sequence, indicating myocardial stunning.

31 amine stress and a reduction in postischemic stunning.

32 red in the etiology of HD-induced myocardial stunning.

33 , resulting in either: no effect, effect, or stunning.

34 dysfunction caused by repetitive myocardial stunning.

35 thways involved in tissue undergoing chronic stunning.

36 nary resuscitation, indicative of myocardial stunning.

37 gineered human-transmissible H5N1 strain are stunning.

38 species, has been associated with myocardial stunning.

39 s showed improved or no effect on myocardial stunning.

40 diagnostic (131)I, the phenomenon was called stunning.

41 -C during reperfusion may prolong myocardial stunning.

42 ion of blood flow, which is called metabolic stunning.

43 or swelling and failed to prevent myocardial stunning.

44 with no stunning, and group S, patients with stunning.

45 diography to assess intradialytic myocardial stunning.

46 ared with postablation scans for evidence of stunning.

47 ion (group 3, n = 6), designed to produce no stunning.

48 th the protective effects of late PC against stunning.

49 olecular identification, and the results are stunning.

50 ardium but may not play a role in reversible stunning.

51 emic preconditioning (PC) against myocardial stunning.

52 x microstructural patterns that are visually stunning.

53 ective effects of late PC against myocardial stunning.

54 and duration of postconversion left atrial "stunning."

55 confer marked protection against myocardial stunning 1-3 d later (late preconditioning [PC] against

56 e from the natural product itself that are a stunning 100-fold more active (IC50 values, 50-75 pM vs.

57 (group V, n = 5), the severity of myocardial stunning 24 h later was not modified.

58 id not exacerbate the severity of myocardial stunning 24 hours later; therefore, the absence of late

59 he heart relatively resistant to myocardial "stunning" 24 hours later (late preconditioning [PC] agai

60 of trehalases in desiccated cell reveals the stunning ability of cells to retain enzymatic activity w

61 h stacks of flat crystals assemble, often in stunning abundance.

62 In the basic science arena, there have been stunning advancements that illustrate novel biological a

63 Stunning advances have been achieved in addressing the p

64 Despite stunning advances in basic science and technology, clini

65 ther molecules that mediate taste has led to stunning advances in our understanding of the basic mech

66 Despite stunning advances in our understanding of the genetics a

67 ical concentration and ameliorate myocardial stunning after ischemia-reperfusion.

68 0% for 90 minutes, and subsequent myocardial stunning after reperfusion in chronically instrumented c

69 echo contrast and frequently develop atrial stunning after restoration of sinus rhythm.

70 Left atrial appendage stunning also occurs in patients with atrial flutter, al

71 ons in preload after global ischemia-induced stunning also prevented TnI degradation.

72 pite such response dimorphism, we observed a stunning anatomical monomorphism of cortical penis and c

73 ts; p = 0.03) for patients predicted to have stunning and a marked decline in LVEF outside the infarc

74 , clinical exploitation of the powerful anti-stunning and anti-infarct actions of late PC has been el

75 ated TnI proteolysis can be dissociated from stunning and arises from elevations in preload rather th

76 similarly may be associated with myocardial stunning and cell necrosis associated with ischemia/repe

77 ardial infarction (MI) because of myocardial stunning and compensatory hyperkinesia in noninfarct-rel

78 mia in the setting of CD results in enhanced stunning and development of infarct.

79 hat relates to the time course of myocardial stunning and differs transmurally in relation to ischemi

80 This process is known as myocardial stunning and has important clinical ramifications.

81 tanding of the pathophysiology of myocardial stunning and hibernation is important for a more precise

82 t reflecting irreversible injury, myocardial stunning and hibernation result from reversible myocardi

83 ught to prospectively identify patients with stunning and hyperkinesia at hospital discharge on the b

84 AR and VR technologies allow for stunning and immersive experiences, offering untapped op

85 before ischemia would enhance the degree of stunning and induce a sustained decrease in glucose upta

86 ne receptor agonist, in models of myocardial stunning and infarction in chronically instrumented cons

87 tely ablated the late PC effect against both stunning and infarction.

88 e effects of late PC against both myocardial stunning and myocardial infarction, indicating that COX-

89 e effects of late PC against both myocardial stunning and myocardial infarction, indicating that NF-k

90 Closed-chest stunning and SEMI were produced by angioplasty balloon o

91 mibi SPECT and low-dose dobutamine in canine stunning and subendocardial infarction (SEMI).

92 mmalian models of both ischemia/reperfusion (stunning) and chronic pressure overload with hypertrophy

93 powerful protection against both reversible (stunning) and irreversible (infarction) injury during ac

94 tion 24 hours later against both reversible (stunning) and irreversible (infarction) ischemia/reperfu

95 result in reduced postoperative reversible (stunning) and irreversible myocardial injury, as assesse

96 rt failure, ischemia and reperfusion injury, stunning, and familial hypertrophic cardiac myopathies.

97 into two groups: group NS, patients with no stunning, and group S, patients with stunning.

98 ng residual viability, microvascular damage, stunning, and right ventricular infarction.

99 est remains normal, consistent with "chronic stunning," and contrasts with reduced flow and increased

100 lso prevented the contractile dysfunction of stunning; and (3) calpain I could similarly degrade TnI,

101 mia can have a negative effect on the heart: stunning; and on the other hand, they have a protective

102 We hypothesized that stunning arose from the early effects of the therapeutic

103 The plant kingdom contains a stunning array of complex morphologies easily observed a

104 This research line continues to produce stunning arrays of enantioselective technologies either

105 nt cellular processes, leading to myocardial stunning, arrhythmias, and ultimately cell damage and de

106 ce in arthropods and nematodes worldwide and stunning arsenal of parasitic and mutualistic adaptation

107 S and MPT have been implicated in myocardial stunning associated with reperfusion in ischemic hearts,

108 e molecular mechanisms underlying repetitive stunning-associated myocardial dysfunction are not clear

109 ROS contribute to the genesis of myocardial stunning but, at the same time, trigger the development

110 the 6th CS, reflecting persistent myocardial stunning, but baseline CBF was not changed.

111 thout catalase fails to alleviate myocardial stunning, but extracellular SOD (Ec-SOD) may be more eff

112 implicated in the pathogenesis of myocardial stunning, but the precise mechanism by which OFRs foster

113 fibrillation (AF) is associated with atrial stunning, but the short-term effect of a brief episode o

114 oronary occlusions induces severe myocardial stunning, but when the same sequence is repeated 24 hour

115 st the hypothesis that persistent myocardial stunning can lead to hibernating myocardium, 13 pigs wer

116 Thyroid stunning can occur with 185 MBq of 131I in diagnostic im

117 Biological systems display stunning capacities to self-organize.

118 (PACs) are complex flavan-3-ol polymers with stunning chemical complexity due to oxygenation patterns

119 scope from the Sputnik era, they assembled a stunning collection of micrographs that illustrated how

120 nt plumage of birds creates some of the most stunning color displays known in the natural world.

121 In summary, repetitive myocardial stunning commonly seen in chronic multivessel coronary a

122 Prior structural studies have revealed the stunning complexity of the purified rotor and C-ring ass

123 In phase I (studies of myocardial stunning), conscious rabbits underwent a sequence of six

124 id left ventricular pacing and that regional stunning contributes to persistent global left ventricul

125 schemic LV dysfunction at 1 and 7 days after stunning correlates with the degree of enhanced regional

126 ffectiveness modelling shows that electrical stunning could avert 60-1200 min of moderate to extreme

127 Stunning could potentially reduce the therapeutic effica

128 Stunning decreases contractility at the level of the con

129 The former is often preferred to avoid "stunning"-defined as a reduction in uptake of the therap

130 Percussive stunning demonstrates reliable effectiveness, but still

131 and in situ structural studies have revealed stunning details of the individual components of the fla

132 They also reveal stunning differences between compensatory processes oper

133 om the wider Caribbean, have radiated into a stunning diversity of color patterns but show low diverg

134 their design, have allowed the creation of a stunning diversity of nucleic acid-based nanodevices.

135 Birds present a stunning diversity of plumage colors that have long fasc

136 rimary difficulties exist: Viruses exhibit a stunning diversity of strategies for evading the host im

137 Atrial mechanical stunning due to atrial fibrillation may persist after re

138 ardial wall motion abnormalities (myocardial stunning) due to segmental hypoperfusion.

139 The stunning Early Cretaceous diversity of maniraptorans fro

140 dose of (131)I produces a visually apparent stunning effect 72 h before (131)I ablation therapy.

141 10 mCi) (131)I may be capable of producing a stunning effect on thyroid tissue that may interfere wit

142 APC and IPC exhibit anti-infarct and anti-stunning effects in the ovine heart, but these effects a

143 study, the anti-infarct effects and the anti-stunning effects of APC in contributing to enhanced post

144 ained depressed for 2 hours (ie, endothelial stunning [ES]).

145 These results indicate that persistent stunning, even in the absence of chronic ischemia, can r

146 Collectively, these findings provide a stunning example of chemical mimicry, highlight the comb

147 It is also a stunning example of the power of medical research to sav

148 this symbiosis has produced one of the most stunning examples of rapid adaptive radiation documented

149 l signals in nature provide some of the most stunning examples of rapid phenotypic evolution.

150 One of the more stunning examples of the resourcefulness of human vision

151 obably with immune compromise following cold stunning (extended hypothermia), developed a disseminate

152 The stunning findings disclosed only recently extend wet che

153 an immediate injurious role (as mediators of stunning) followed by a useful function (as mediators of

154 cted to a partial occlusion to produce acute stunning, followed by reperfusion through a critical ste

155 hough doxycycline did not improve myocardial stunning following coronary artery bypass graft surgery

156 The magnitude and time course of myocardial stunning from cardiac arrest is unknown.

157 usion, and the differentiation of myocardial stunning from myocardial necrosis.

158 echocardiography accurately differentiates 'stunning' from necrosis, delineates transmural extent of

159 duced late PC effect against both myocardial stunning (groups VII through X) and myocardial infarctio

160 Stunning has been observed in several clinical scenarios

161 tic (131)I were measured at 2 d, a time when stunning has been observed, and expressed as ratios of r

162 The mechanism of myocardial stunning has been studied extensively in rodents and is

163 Left atrial appendage stunning has recently been proposed as a key mechanistic

164 This transient "stunning" has potential implications for (3)H-FDG PET, e

165 Patients with stunning have late increases in LVEF; patients with hype

166 hemia-reperfusion-induced LV dysfunction or "stunning" have normal contractile function and normal [C

167 sence of myocardial infarction by repetitive stunning, hibernation or both.

168 lisation microscopy, which have all produced stunning images of cellular structures.

169 with single particle averaging, has produced stunning images of the intact bacterial flagellum, revea

170 viduals synchronize their states, giving the stunning impression that the group behaves as one.

171 nt time after ischemia eliminates myocardial stunning in conscious pigs during augmented carbohydrate

172 the mechanism of late PC against myocardial stunning in conscious rabbits involves a PKC-mediated si

173 he development of late PC against myocardial stunning in conscious rabbits, indicating that NO genera

174 We studied the mechanism of stunning in isolated myocytes from chronically instrumen

175 Thus, mechanisms of stunning in the pig are radically different from the wid

176 olytic ATP in the recovery from postischemic stunning in vivo.

177 ing the genes up-regulated during myocardial stunning, including those not previously described in th

178 development of late preconditioning against stunning, indicating that the production of reactive oxy

179 th chronic animal window models has provided stunning insight into tumor pathophysiology, including g

180 nner organic polymer layers, also results in stunning interference colors.

181 m salvaged by reperfusion." The mechanism of stunning involves generation of oxygen radicals as well

182 f ventricular function in chronic myocardial stunning is associated with restoration of mitochondrial

183 Endothelial stunning is caused by oxidant processes inhibited by asc

184 Myocardial stunning is characterized by decreased myofilament Ca2+

185 ilament proteins in situ during ischemia and stunning is evaluated, and it is concluded that C-termin

186 Recovery from stunning is incompletely understood but may involve adap

187 is repeated 24 hours later, the severity of stunning is markedly reduced (approximately 50%) ("late

188 troponin I (cTnI) proteolysis in myocardial stunning is not fully understood.

189 Myocardial stunning is observed clinically and must be recognized b

190 ecovery of this postresuscitation myocardial stunning is seen by 48 h in this experimental model of v

191 esis that the development of late PC against stunning is triggered by increased generation of NO duri

192 st infarction, their role in late PC against stunning is unknown.

193 h transient contractile dysfunction, termed "stunning." It is not clear whether this phenomenon is pr

194 We find that woody bamboo subgenomes exhibit stunning karyotype stability, with parallel subgenome do

195 After stunning, left ventricular ejection fraction (LVEF) incr

196 solved and a mechanistic explanation for the stunning levels of biodiversity observed in communities

197 lf-assemble into collective communities with stunning macroscopic morphologies.

198 ible DNA alkylation reaction) and define the stunning magnitude of its effect.

199 Myocardial stunning may cause prolonged left ventricular dysfunctio

200 Possible poststress myocardial stunning may have caused gated Tl LVEFs to overestimate

201 eved, reversible myocardial dysfunction, or "stunning," may occur.

202 This stunning mode of action, which is likely shared with Rel

203 allography, NMR, and CryoEM that now produce stunning models of large and complex structures previous

204 dramatic subunit rearrangements, providing a stunning molecular explanation for the allosteric regula

205 ion followed by reperfusion to create either stunning (n=12) or transmural myocardial infarction (n=1

206 hat TOR controls protein synthesis through a stunning number of downstream targets.

207 Stunning occurred more often with ISMN than amlodipine (

208 Although stunning occurs after brief total occlusions and prolong

209 If thyroid remnant stunning occurs due to 74 MBq (131)I used as a diagnosti

210 t to determine whether left atrial appendage stunning occurs in patients with atrial flutter and to c

211 ffects of Clo-Lip treatment, indicating that stunning of PMN rather than depletion of MoPh accounts f

212 sed NGF protects against postischemic neural stunning of sympathetic cardiac innervation.

213 Coronary occlusion produced stunning of the anterolateral left ventricle that resolv

214 PFA resulted in no or transient stunning of the phrenic nerve (<5 minutes) without histo

215 This "mechanical stunning" of left atrial systolic function appears to be

216 These results support the hypothesis that "stunning" of thyroid tissues, often observable by 2 d, i

217 d by XO + P, mimic the effects of myocardial stunning on cardiac excitation-contraction coupling.

218 ecessary not only to trigger late PC against stunning on day 1 but also to mediate the protection on

219 idant therapy markedly attenuates myocardial stunning on day 1, indicating that ROS play an important

220 ntioxidant therapy in attenuating myocardial stunning on day 1, it has no effect on late precondition

221 a (group VI, n = 11) induced late PC against stunning on day 2 and the magnitude of this effect was e

222 r; therefore, the absence of late PC against stunning on day 2 in group II cannot be ascribed to a de

223 rmed on day 1 failed to precondition against stunning on day 2, but the same sequence performed on da

224 pletely prevented the late PC effect against stunning on day 2.

225 performed on day 2 did precondition against stunning on day 3.

226 However, data did not show any effect of stunning on the efficacy of 131I therapy for differentia

227 y compared the effects of porcine myocardial stunning on the uptake of [18F]-fluorodeoxyglucose (FDG)

228 the 10th reperfusion, indicating myocardial "stunning." On days 2 and 3, however, the recovery of WTh

229 Many organisms produce stunning optical displays based on structural color inst

230 ic myocardium in the presence of infarction, stunning or hibernation, alone or in combination.

231 nt the development of late PC against either stunning or infarction on day 2.

232 fter acute MI may be secondary to myocardial stunning or necrosis.

233 o limitation of infarct size, alleviation of stunning, or both.

234 tion in myocardial infarct size, severity of stunning, or incidence of cardiac arrhythmias.

235 d to produce different degrees of myocardial stunning; or (c) a single episode of 2 minutes of occlus

236 read and rewrite it at will has ushered in a stunning period in the history of science.

237 In the early postischemic stunning phase of reperfusion, the inotropic response to

238 The future challenge is how to minimize the stunning phenomenon and maximize the preconditioning phe

239 e molecular genetic variation underlying the stunning phenotypic diversity in crops and domesticated

240 Parrots produce stunning plumage colors through unique pigments called p

241 y flow velocity was unchanged, indicating LV stunning post balloon occlusion.

242 formed in this way, may be used for hunting/stunning prey and communication.

243 Despite the stunning progress in all disciplines of auxin research,

244 he role of the erbB2 gene in cancers and the stunning progress in developing targeted therapies for e

245 arch, we explore the gap between 25 years of stunning progress in fundamental neuroscience and the pe

246 phrenic nerve function including reversible stunning (R(2)=0.965, P<0.001).

247 In phase I (studies of myocardial stunning), rabbits were subjected to six 4-minute corona

248 he perfusion findings suggested that chronic stunning rather than hibernation is the principal cause

249 reduced L-type Ca2+ current contribute to a stunning reduction of intracellular Na+ concentration fo

250 felt to be sufficient to allow recovery from stunning, regional function was disproportionately low f

251 t the precise mechanism by which OFRs foster stunning remains unclear.

252 hus, late preconditioning against myocardial stunning requires > 6 hours to develop, lasts for at lea

253 Finally, evidence of both stunning (rest asynergy with normal flow) and hibernatio

254 the same time we reveal for driven systems a stunning result - the distribution of temperatures in gr

255 resuscitation and is mediated by myocardial stunning resulting from mitochondrial electron transport

256 ernation may represent persistent myocardial stunning resulting from repeated episodes of ischemia an

257 hanges associated with repetitive myocardial stunning seen in chronic multivessel coronary artery dis

258 dase-4 inhibition mitigated the postischemic stunning seen in the control scan.

259 Myocardium subjected to repetitive stunning showed a prolonged yet reversible reduction in

260 Recent discoveries have uncovered stunning similarities among the molecular circuitries of

261 o decades of network science have discovered stunning similarities in the topological characteristics

262 The stunning simplicity of the motif and its surprisingly st

263 Although crystal structures provide stunning snap shots, biochemical approaches addressing t

264 Specifically, we present a stunning study system to investigate the relationship of

265 future and pursue a path that builds on the stunning successes of the past.

266 ays and protects against both infarction and stunning, suggesting that it may have greater clinical r

267 development of late preconditioning against stunning supports a complex pathophysiological paradigm,

268 Stunning technical advances in the ability to image the

269 a unique metabolic adaptation in repetitive stunning that is different from that typically seen in c

270 urrent segmental ischemic injury (myocardial stunning) that drives cumulative cardiac damage.

271 protects against infarction but not against stunning, the late phase of PC lasts 3 to 4 days and pro

272 datory strains use karlotoxins as a means of stunning their prey, before ingesting it.

273 transition from a physiological phenotype of stunning to hibernation.

274 Phytoplankton come in a stunning variety of shapes but elongated morphologies do

275 Late PC against stunning was also abrogated when LD-A was given before t

276 In contrast, in DCA pigs, myocardial stunning was ameliorated (P<0.05).

277 n and metabolism, suggesting that myocardial stunning was common.

278 Stunning was defined when the diagnostic scan showed act

279 Stunning was induced in 14 anesthetized swine by partial

280 Myocardial stunning was induced in conscious pigs by coronary steno

281 Stunning was induced in eight swine by partially occludi

282 ere chronically instrumented, and persistent stunning was induced regionally by 6 repetitive episodes

283 egional cardiac denervation (CD), myocardial stunning was intensified, ie, at 12 hours reperfusion wa

284 The severity of myocardial stunning was measured as the total deficit of LV wall th

285 rts subjected to 20-minute ischemia in which stunning was mitigated by 10-minute reperfusion with low

286 during dobutamine stress, and (3) myocardial stunning was observed during postdobutamine recovery.

287 In the absence of DCA, myocardial stunning was observed; ie, wall thickening was reduced b

288 easure of the overall severity of myocardial stunning) was reduced by 68% (control, 129 +/- 16 arbitr

289 In a canine model of repetitive myocardial stunning, we showed that carvedilol, a non-selective bet

290 mental stress echocardiography parameters of stunning were attenuated in patients while taking amlodi

291 The protective effects of IB-MECA against stunning were completely blocked by pretreatment with th

292 No cases of visually apparent thyroid stunning were observed on any of the postablation scans

293 le levels of ischemia, amlodipine attenuated stunning when compared with ISMN.

294 denosine blocker 8-PT enhanced the degree of stunning when given before ischemia but did not induce a

295 n = 10) abrogated the late PC effect against stunning, whereas a 10-fold lower dose (0.5 mg/kg; group

296 rfusion followed by ventricular dysfunction (stunning), which more closely resembles clinical conditi

297 ized that hibernation is preceded by chronic stunning with normal resting perfusion.

298 eatment to assess the degree of postexercise stunning with simultaneous sestamibi single-photon emiss

299 Significant myocardial stunning with subsequent improvement of ventricular func

300 th substantial protection against myocardial stunning without the need for concomitant administration