ライフサイエンスコーパス: subcortical

1 ron classes in vertebrate cortical [1-4] and subcortical [5-8] areas and invertebrate peripheral [9-1

2 s significantly associated with cortical and subcortical abnormalities in both mass-univariate and mu

3 target of a multitude of other cortical and subcortical afferents, which likely modulate its functio

4 To better characterize subcortical alterations in 22q11DS, including modulating

5 biological factors such as APOEepsilon4 and subcortical amyloid-beta may identify participants close

6 This study examined whether cortical or subcortical amyloidosis, indicating earlier or later sta

7 ty was highest in APOEepsilon4 carriers with subcortical amyloidosis.

8 nto three regional domains, i.e. a cortical, subcortical and cerebellar domain.

9 ivisions and numerous connections with other subcortical and cortical areas and is directly recipient

10 n is therefore a robust property of both the subcortical and cortical auditory system and accounts fo

11 rom USV-responsive neurons reveals extensive subcortical and cortical inputs into TeA.

12 ampal CA1 field integrates a wide variety of subcortical and cortical inputs, but its synaptic organi

13 constraining the neuronal discrimination in subcortical and cortical levels.SIGNIFICANCE STATEMENT D

14 ied without the 5 kHz carrier frequency both subcortical and cortical motor-evoked potentials were fa

15 se has been reliably associated with smaller subcortical and cortical regional gray matter volumes (G

16 s, volumes were relatively stable, with some subcortical and cortical regions increasing while others

17 rotransmitters nuclei diffusively project to subcortical and cortical regions of RSNs.

18 features beyond ocular dominance, involving subcortical and cortical regions, and connections betwee

19 single-unit spiking from a constellation of subcortical and hippocampal sites to study spatial modul

20 , sex, and site (and intracranial volume for subcortical and surface area measures).

21 connectivity were revealed across cortical, subcortical, and cerebellar regions independent of the s

22 g nuclei, and additional specific brainstem, subcortical, and cortical areas.

23 s, some functional imaging studies find that subcortical anomalies reflect the onset of ADHD and rema

24 orexia nervosa by suggesting disturbances in subcortical appetitive circuits.

25 d shape analysis of local volume deficits in subcortical areas (analysable sample: 57 patients; 35 no

26 RI measures given the putative role of these subcortical areas in modulating widespread cortical func

27 ing at the retina is transmitted to multiple subcortical areas in parallel, before being relayed onto

28 uggests that, in addition to cortical areas, subcortical areas mediating eye movements may be recruit

29 Effective targets are placed in one of four subcortical areas with the goal of capturing prefrontal,

30 eling of FC between association cortical and subcortical areas.

31 wn to induce plastic changes in cortical and subcortical areas.

32 with enhanced activation within cortical and subcortical areas.

33 e effects of temporal lobe epilepsy (TLE) on subcortical arousal structures remain incompletely under

34 lation (tVNS) has been proposed to stimulate subcortical arousal-promoting nuclei, though previous st

35 ed structural connectivity maps of the human subcortical auditory pathway both in vivo (1050 um isotr

36 Studying the human subcortical auditory system non-invasively is challengin

37 tical malformations including pachygyria and subcortical band heterotopia, presumably caused by disru

38 is spectrum includes agyria, pachygyria, and subcortical band heterotopia; each represents anatomical

39 ndings reveal in particular the existence of subcortical body-to-brain neural pathways linking gastro

40 nctional connectivity between perceptual and subcortical brain areas in the enjoyment of music.

41 was associated with atrophy of cortical and subcortical brain areas known for high sensitivity to ox

42 d the SC to a growing number of cortical and subcortical brain areas that form distributed networks s

43 egree of interconnectivity with cortical and subcortical brain areas, mediates cognitive and emotiona

44 highly interconnected with both cortical and subcortical brain areas.

45 eir transcriptional profiles in cortical and subcortical brain regions and brain networks of structur

46 ) is significantly different based on sex in subcortical brain regions associated with the generation

47 te transporter 2 (VGlut2) and are located in subcortical brain regions is sufficient and necessary to

48 ibution of E/I balance to the functioning of subcortical brain regions, such as the lateral septum (L

49 obe the microstructure (cellular density) of subcortical brain regions.

50 at require interactions between cortical and subcortical brain regions.

51 impacts activity even in deep brain areas: a subcortical brain structure, the amygdala (experiment 1)

52 Subcortical brain structures are integral to motion, con

53 tudies have reported variable alterations in subcortical brain structures in 22q11DS.

54 CNV, and we demonstrate a specific effect on subcortical brain structures, suggesting a neuropatholog

55 the authors found widespread alterations to subcortical brain structures, which were affected by del

56 We tested subcortical brain volume differences between 49 unaffect

57 onset problems were examined in relation to subcortical brain volumes in the first 2 years of life.

58 We compared subcortical brain volumes of 12 16p11.2 distal deletion

59 rials and in the overall task, with enhanced subcortical but suppressed neocortical activity during e

60 Across groups, CBD increased subcortical, but decreased cortical, Glx.

61 The amplitude of subcortical, but not cortical, motor-evoked potentials i

62 parietofrontal signaling is conveyed to the subcortical centers and spinal cord through different pa

63 nt task, there was functional recruitment of subcortical-cerebellar pathways, which were additionally

64 n, indicating the involvement of the frontal-subcortical circuit in the pathogenesis of frontal-subco

65 required for the optimal functioning of this subcortical circuit.

66 eritable traits that are governed by frontal-subcortical circuits and are associated with neuropsychi

67 eritable traits that are governed by frontal-subcortical circuits and are associated with numerous ne

68 A better understanding of cortico-subcortical circuits in individuals will aid in developm

69 or is gradually transferred from cortical to subcortical circuits, while protecting learned behaviors

70 mputations underlying contextual encoding to subcortical circuits.

71 amics driven by self-generated movements and subcortical common modulatory inputs.

72 s to evaluate the maturation of cortical and subcortical components of the visual system in galagos r

73 nvestigation, we quantified the cortical and subcortical connections of S1 in animals that were bilat

74 l connectivity are reported after removal of subcortical connections within the extended hippocampal

75 cal derangements and impaired fronto-cortico-subcortical connectivity in patients and their unaffecte

76 Here, we aimed to first isolate patterns of subcortical connectivity with cortical resting-state net

77 We isolated the patterns of subcortical connectivity with cortical resting-state net

78 of spared inner retinal neurons, recovering subcortical, cortical and behavioural visual responses i

79 dulatory and fast-acting corticocortical and subcortical-cortical neural pathways.

80 for megalencephalic leukoencephalopathy with subcortical cysts 1 (Mlc1), an eight-transmembrane prote

81 d with cannabis-related psychiatric risk and subcortical DAergic dysregulation.

82 l covariance in iRBD, combining cortical and subcortical deformation and subarachnoid/ventricular exp

83 atients, reflecting cortical-dominant AD and subcortical-dominant progressive supranuclear palsy (PSP

84 reclinical evidence on information coding by subcortical dopamine coupled with computational models o

85 ntifies consistent evidence for dysregulated subcortical dopamine function in people at CHR, but also

86 oses that cortical brain disruption leads to subcortical dopaminergic dysfunction, which underlies ps

87 lationship between hippocampal glutamate and subcortical dopaminergic function in people at clinical

88 investigate the large-scale organization of subcortical dynamics.

89 ents with normal cognition (n = 18), frontal-subcortical dysfunction (n = 12) and memory impairment +

90 ion (n = 12) and memory impairment + frontal-subcortical dysfunction (n = 18), we further investigate

91 the underlying pathological basis of frontal-subcortical dysfunction in multiple system atrophy.

92 o examined topographic correlates of frontal-subcortical dysfunction with other clinical symptoms.

93 Twelve of them had pure frontal-subcortical dysfunction, defined as the presence of exec

94 ore commonly when patients developed frontal-subcortical dysfunction, indicating the involvement of t

95 tical circuit in the pathogenesis of frontal-subcortical dysfunction.

96 pairment: n = 6; memory impairment + frontal-subcortical dysfunction: n = 12) had more neuronal cytop

97 Ds showed increased cortical (e.g., OFC) and subcortical (e.g., NAcc) regional activation compared wi

98 al (e.g., frontal and parietal cortices) and subcortical (e.g., the superior colliculus and the pulvi

99 t that the GP and Th in humans are part of a subcortical executive control network, differentially in

100 Our data support only modest subcortical filtering, with robust, step-like attenuatio

101 Compared with subcortical findings from other neuropsychiatric disorde

102 ume (GMV) involving the cortex and classical subcortical foci, 2) a preponderance of regional GMV sex

103 y to a larger extent regarding curvature and subcortical GM; however, there were also more environmen

104 Cortical and subcortical GMV ROIs were estimated with computational n

105 connectome architecture shapes cortical and subcortical gray matter atrophy across a spectrum of neu

106 orphometry was used to estimate cortical and subcortical gray matter deformation from T1-weighted mag

107 either the presence nor severity of infarct, subcortical gray matter injury, and microhemorrhage was

108 analyses were performed for 12 cortical and subcortical gray matter regions to assess the effect of

109 g 43 isocortical areas and their layers, 329 subcortical gray matter structures, 81 fiber tracts, and

110 t agent (GBCA) exposure has been reported in subcortical gray matter.

111 Basal ganglia are subcortical grey nuclei that play essential roles in con

112 in a novel murine model, tvrm360, displaying subcortical heterotopia, hydrocephalus and disorganizati

113 ent study, Chen et al. showed that divergent subcortical-hippocampal projections are necessary for mn

114 s of cortical (medial prefrontal cortex) and subcortical (hippocampus) brain regions.

115 Finally, non-invasive, subcortical imaging using red XCaMP-R uncovered somatose

116 ted at each visit from both the cortical and subcortical implants.

117 erebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) a

118 erebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) a

119 We also found a notable subcortical innovation: an abundant striatal interneuron

120 lex, convergent topographies of cortical and subcortical input to the EC, combined with short-range i

121 n, we found little evidence for strengthened subcortical input to V5/MT supporting residual visual fu

122 Furthermore, the role of the thalamus for subcortical integration is highlighted as a key mechanis

123 ency, highlighting the importance of cortico-subcortical interactions between regions involved in the

124 fluctuations in ongoing spiking activity in subcortical (lateral geniculate nucleus, LGN) and cortic

125 mbination of fast cortical learning and slow subcortical learning gives rise to a covert learning pro

126 ective value is encoded at both cortical and subcortical levels.

127 Emotions are often assumed to manifest in subcortical limbic and brainstem structures.

128 data suggest an SC-posterior thalamus-BG-SC subcortical loop circuit that encodes the historical val

129 dulated by selective attention, evidencing a subcortical mechanism that contributes to speech-in-nois

130 cted with components of eisosomes, which are subcortical membrane structures with a distinct lipid an

131 Subcortical microvascular disease represented by brain w

132 liculus (SC) is an evolutionarily conserved, subcortical (midbrain) structure that has been implicate

133 t, we show that the inferior colliculus, the subcortical, midbrain center for hearing, receives exten

134 frontal cortex and, in animal models, in the subcortical monoaminergic and cholinergic systems, accom

135 This study investigated subcortical morphometric changes 6 months after switchin

136 These findings show that subcortical motivational circuits are important in guidi

137 RI) results from the ADHD ENIGMA Consortium (subcortical MRI n = 3242; cortical MRI n = 4180) along w

138 pplementary motor area, premotor cortex) and subcortical network (subthalamic nucleus and cerebellum)

139 actions with gamma oscillations in a cortico-subcortical network of interconnected regions and normal

140 ntegration, was calculated for the CON, FPN, subcortical network, and visual network.

141 ocols to target cortico-cortical and cortico-subcortical networks by using different intervals betwee

142 gs demonstrate that many of the core cortico-subcortical networks in humans are also present in marmo

143 pared the functional organization of cortico-subcortical networks in marmosets and humans using ultra

144 teral sensory-motor, auditory, salience, and subcortical networks in participants with SCD compared w

145 used on cortical areas, with connectivity to subcortical networks less extensively explored.

146 Understanding the similarity of cortico-subcortical networks topologies between humans and nonhu

147 patients with psychosis in both cortical and subcortical networks, notably affecting the orbitofronta

148 itate such interactions between cortical and subcortical neural populations.

149 e used as a tool for studying how endogenous subcortical neuromodulatory signaling affects human cogn

150 anges require precise homeostatic control by subcortical neuromodulatory structures(2).

151 In each acoustic condition, subcortical neurons better discriminated target vocaliza

152 structural neuroimaging research into small subcortical nuclei and help to chart terra incognita.

153 The basal ganglia are a group of subcortical nuclei that contribute to action selection a

154 ing the volume of thalamus, corpus callosum, subcortical nuclei, hippocampus) as parameters that corr

155 es projections from visuotopically organized subcortical nuclei, in addition to inputs from the retin

156 rincipal targets of visuotopically organized subcortical nuclei.

157 , no signatures of criticality were found in subcortical or peripheral nerve activity.

158 directional, revealing prominent cortical-to-subcortical or subcortical-to-cortical pathways.

159 subjects and SCI participants, suggesting a subcortical origin for these effects.

160 Preserving this cortico-subcortical pathway may be critical for behavioral flexi

161 diffusion-weighted images, reconstructing a subcortical pathway to the amygdala from the superior co

162 ormed to explain spontaneous activity in the subcortical pathway, rather than ignoring it as noise.

163 tory midbrain, and support a hypothesis that subcortical pathways can mediate highly trained auditory

164 Two main subcortical pathways serving conscious visual perception

165 These subcortical pathways, many of which we share with other

166 , medial prefrontal-posterior cingulate, and subcortical-posterior insular cortices, with hubs in med

167 ltures exhibit active neuronal networks, and subcortical projecting tracts can innervate mouse spinal

168 For inhibitory and subcortical projection neurons (SCPNs), there is a stron

169 dvancing age) in frontal regions and related subcortical projections and synaptic pruning (decreasing

170 Here, we study subcortical projections to the geniculate from the super

171 1451 components' loadings were found in both subcortical (R = 0.769, p < 0.0001) and cortical regions

172 Similar results were obtained with all subcortical reference regions and for all cortical regio

173 anchored in the frontoparietal cortices and subcortical regions (including the thalamus and striatum

174 whole brain areas including the cortical and subcortical regions and hippocampal subfields in particu

175 amyloid-beta deposition in both cortical and subcortical regions as a promising approach to the study

176 orrelated with pupil dilation, activation in subcortical regions associated with dopamine, game enjoy

177 ecovered mGluR5 availability in cortical and subcortical regions compared with the baseline, up to th

178 ctivity between the orbitofrontal cortex and subcortical regions correlated with symptom improvement.

179 between pairs of 330 cortical regions and 16 subcortical regions in 298 healthy adolescents scanned 5

180 ization primarily involving frontal lobe and subcortical regions in nonpsychotic relatives may be rel

181 nterconnected with prefrontal, parietal, and subcortical regions involved in valuation and action sel

182 mography (PET) signal across 41 cortical and subcortical regions of interest (ROIs).

183 Cortical and subcortical regions of interest were defined and differe

184 thalamus and nucleus accumbens (NAcc)-three subcortical regions selected for their associations with

185 t (meta-ROI), entorhinal cortex and cortical/subcortical regions selected to match the tau lesion ana

186 Subcortical regions show similar temporal regulation exc

187 lex behavior, it requires communication with subcortical regions to do so.

188 ithin the local hippocampal circuits or with subcortical regions was not significantly affected.

189 18F-flortaucipir SUVRs in subcortical regions were higher in autopsy-confirmed pro

190 16 consolidated cortical and subcortical regions were selected as regions of interest

191 n the striatum and in dozens of cortical and subcortical regions with known striatal afferents.

192 trality metrics in the prefrontal cortex and subcortical regions, and higher nodal centrality metrics

193 ibrillar amyloid-beta burden in cortical and subcortical regions, and measurement of anxiety using th

194 re positioned to exert top-down control over subcortical regions, such as the nucleus accumbens shell

195 initial processing circuits can incorporate subcortical regions, such as the thalamus and brainstem

196 was characteristic of association cortex and subcortical regions, where connectivity was remodeled: c

197 parietal, temporal, occipital, cingular and subcortical regions.

198 in ventral occipitotemporal, and distributed subcortical regions.

199 l targeting during surgical implantations in subcortical regions.

200 ties in a widespread network of cortical and subcortical regions.

201 white matter alterations in the frontal and subcortical regions.

202 d 'core aggression circuit' composed of four subcortical regions.

203 ed brain networks in widespread cortical and subcortical regions.

204 Despite robust subcortical responses to visual stimulation, we found li

205 l-being, recruit the ventral visual pathway, subcortical reward circuitry, and parts of the medial pr

206 l involvement of the interaction between the subcortical reward system and higher-order cortical area

207 gs demonstrate that many of the core cortico-subcortical RSNs in humans are also present in marmosets

208 edial frontal) and in reward responsiveness (subcortical, salience, motor/sensory).

209 biguous evidence of abstract processing in a subcortical sensory pathway.

210 The subcortical sensory pathways are the fundamental channel

211 evidence suggest an atypical functioning of subcortical sensory structures.

212 ggest that altered sensory processing within subcortical sensory-emotional circuitry after TBI result

213 ng harmonized protocols for gross volume and subcortical shape morphometry in 533 individuals with 22

214 Here, we identify a subcortical signature of back pain.

215 puts in three frequency ranges which reflect subcortical/spinal (0-5 and 6-15 Hz) and corticospinal i

216 uring Stroop test performance and concurrent subcortical stimulation clustered in a region of white m

217 ials in arm muscles elicited by cortical and subcortical stimulation of corticospinal axons before an

218 s, investigating whether derived measures of subcortical structural asymmetries predict interhemisphe

219 0.17 ug . g(-1) +/- 0.04 in hippocampus) and subcortical structures (0.47 ug . g(-1) +/- 0.10 in faci

220 methods, and can easily be extended to other subcortical structures and applied to any quantitative M

221 ual-specific functional connectivity between subcortical structures and cortical functional networks.

222 ew algorithm has been tested on 17 prominent subcortical structures based on a large quantitative MRI

223 may affect hemisphere volume at the level of subcortical structures connected to the surgical target.

224 were found with volume trajectories of other subcortical structures examined (the amygdala, caudate,

225 hey investigated volume asymmetries of eight subcortical structures in 2,540 individuals with major d

226 Local atrophy of subcortical structures in 48 patients with MDD (24 with

227 tex within medial frontal cortex, a group of subcortical structures including striatum, substantia ni

228 Thus, these subcortical structures likely provide visual information

229 carriers have reduced volume in some of the subcortical structures previously shown to be reduced in

230 While electrical stimulation of cortical and subcortical structures provides unique means to deliver

231 e mechanistic research on anxiety focuses on subcortical structures such as the amygdala; however, le

232 Whereas subcortical structures such as the basal ganglia have be

233 at least in part, in response to inputs from subcortical structures that release neuromodulators such

234 Moreover, co-transmission allows subcortical structures to bi-directionally control posts

235 y between stimulation sites and cortical and subcortical structures to identify connections for effec

236 d new light on the specific contributions of subcortical structures to robust sound encoding, and sug

237 ghly bidirectional, the IC connectivity with subcortical structures was often unidirectional, reveali

238 Subcortical structures were measured using harmonized pr

239 volumetric analysis of whole hemisphere and subcortical structures, we observed whether implantation

240 ssible functional relationship between these subcortical structures, we recorded CDh neuronal activit

241 until now OBBBO has been achieved safely in subcortical structures, which prevented direct insight i

242 /g) in the cortex and 17.09 +/- 7.22%ID/g in subcortical structures.

243 ith frontal cortical areas, and with several subcortical structures.

244 tracerebral depth electrodes in cortical and subcortical structures.

245 exist between multiple cortical domains and subcortical structures.

246 anatomic vulnerabilities in the cortical and subcortical structures.

247 ore, the effects of space-clamping errors on subcortical synaptic currents were evaluated in vivo, by

248 This computation may arise within an unknown subcortical system that integrates cortical commands to

249 fault mode systems, and integration with the subcortical system.

250 bral cortex with inputs from sensory organs, subcortical systems and the cortex itself.

251 Our findings help to localize cortical and subcortical systems that represent candidate biological

252 pment of the cortex and its connections with subcortical targets has been argued to permit more oppor

253 eurons establish glutamatergic synapses with subcortical targets, including the serotonin (5-HT) and

254 al outputs affect not only cortical but also subcortical targets, we examined the impact of SPW-Rs on

255 responses and recruited proximal and distal subcortical targets.

256 relations between clinical severity and both subcortical tau pathology (R = 0.667, p = 0.003) and neu

257 e in PSP, and that individual differences in subcortical tau pathology and neuroinflammation are link

258 for the axonal part of neurons, cortical and subcortical tissues, and specific cell types, including

259 vealing prominent cortical-to-subcortical or subcortical-to-cortical pathways.

260 Another subcortical visual relay center is the inferior pulvinar

261 cortical thickness (r = 0.37, p = 0.98) and subcortical volume (r = 0.56, p = 0.15).

262 Subcortical volume and cortical thickness in regions def

263 rtical thickness, cortical surface area, and subcortical volume between individuals with major depres

264 -resistant schizophrenia display progressive subcortical volume deficits after switching to clozapine

265 ct size estimates for cortical thickness and subcortical volume differences between healthy control s

266 Whereas no significant subcortical volume differences were found between patien

267 could be predicted by cortical thickness or subcortical volume in regions previously reported.

268 Cortical thickness and subcortical volume were obtained using the software Free

269 main effects for diagnostic group in FA, MD, subcortical volume, and cortical thickness.

270 al inflammatory markers, cortical thickness, subcortical volume, cognition, and symptoms.

271 The authors examined subcortical volume, cortical thickness, and cortical sur

272 effects were present for cortical thickness, subcortical volume, or NODDI indices.

273 ing was applied to assess the differences in subcortical volume, surface area and cortical thickness

274 was applied to integrate cortical thickness, subcortical volume, white matter fractional anisotropy (

275 Subcortical volumes (pallidum, nucleus accumbens, thalam

276 MD), and from T1-weighted imaging (n = 333), subcortical volumes and cortical thickness in frontal-ex

277 ortical thickness, cortical surface area and subcortical volumes confirmed that each imaging phenotyp

278 COVA was used to assess group differences in subcortical volumes over time and partial correlations t

279 Subcortical volumes were segmented using the Freesurfer

280 (regional cortical thickness, surface area, subcortical volumes) from 853 BD and 2167 control partic

281 areas, 33 cortical thickness values, and six subcortical volumes), in which edge weights were proport

282 cting chronological age (18-75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surfac

283 peer problems have indirect effects through subcortical volumetric alteration (i.e., increased NAcc

284 We aimed to examine the role of subcortical volumetric alteration in the association bet

285 er problems on adolescent depression through subcortical volumetric alteration.

286 ffusion in bilateral supratentorial deep and subcortical white matter (in 10 of 11 patients) and (b)

287 ized uptake value ratios were generated with subcortical white matter as a reference region.

288 y matter, cerebellar white matter, pons, and subcortical white matter as reference regions.

289 Although subcortical white matter changes were common, signs of w

290 as associated with a reduction in accrual of subcortical white matter disease.

291 rstitial cells (WMICs), are found within the subcortical white matter of the mammalian telencephalon.

292 limited recovery of individual axons in this subcortical white matter tract over time.

293 the left primary motor cortex and the right subcortical white matter, and one animal remained as uni

294 those affecting the microcirculation of the subcortical white matter, are key contributors to the cl

295 Results: Of the reference regions used, subcortical white matter, cerebellar white matter, and t

296 to the striatal lesion such as white matter (subcortical white matter, corpus callosum, internal caps

297 convolutions, and extraordinarily voluminous subcortical white matter.

298 These included subcortical, white matter, and cortical regions and nonv

299 Individually variable subcortical zones correspond to DBS sites with less cons

300 This approach revealed distinct subcortical zones of network specificity and multi-netwo