ライフサイエンスコーパス: sublethal

1 es and field pesticide exposure is typically sublethal.

2 luence pathogen behaviour at levels that are sublethal.

3 er acute (137)Cs whole-body irradiation at a sublethal (4 Gy), a lethal (9 Gy), or a single high-dose

4 with a HIF-1alpha stabilizer before severe, sublethal 9.0-Gy irradiation improved blood recovery and

5 Here we show that sublethal activation of Caspase-3 plays an essential, fa

6 Moreover, this sublethal activation of caspase-3 promoted persistent DN

7 Sublethal amounts of the neurotoxin 5,7-dihydroxytryptam

8 We used sublethal and lethal doses of E. coli to examine the mec

9 mine whether inter-specific variation in the sublethal and lethal effects of parasite exposure exist

10 mics studies of plasma from a mouse model of sublethal and lethal R. conorii identified RC0497 in the

11 mitigating the marrow-suppressive effects of sublethal and lethal TBI in mice.

12 comprehensive, mechanistic understanding of sublethal and lethal thermal tolerances.

13 sponses to host-plant pesticides are largely sublethal and more pronounced in the adult stage, despit

14 genesis when the treatment concentration was sublethal, and those mutants were genetically more stabl

15 lts indicate that zebra in ENP often survive sublethal anthrax infections, encounter most B. anthraci

16 a new study, Schlomann et al. describes how sublethal antibiotics can trigger the purging of bacteri

17 thrax wanes rapidly, subsequent and frequent sublethal B. anthracis infections cause maturation of an

18 ity, providing greater capabilities to clear sublethal bacterial challenges, possibly at the cost of

19 ree silver ion concentration associated with sublethal binding to bacteria.

20 although accumulating evidence suggests that sublethal blood trauma-induced by supraphysiological she

21 to newly synthesized DNA and observed that a sublethal bolus of glycine chloramine, but not H(2)O(2),

22 Sublethal carbon monoxide (CO) exposure is frequently as

23 e spill, caged embryos at oiled sites showed sublethal cardiac toxicity, as expected from exposure to

24 led 2 y later from oiled sites showed modest sublethal cardiotoxicity but no elevated necrosis or mor

25 re measured at 10 points over 19 days in the sublethal case and at 6 points over 7 days in the lethal

26 tested the efficacy of this approach in the sublethal cecal ligation and puncture mouse model, which

27 ic challenge models, and reduces fever after sublethal challenge in cynomolgus monkeys.

28 ected animals, even following clearance of a sublethal challenge.

29 Thus, sublethal cognitive deficits elicited by neonicotinoids

30 earance of the virus from older hosts in the sublethal cohort.

31 Interestingly, sublethal complement membrane attack complex formation,

32 al-time" organism responses, to identify the sublethal concentration at which a toxin impacts an orga

33 Nitric oxide (NO) at sublethal concentration has also been reported to induce

34 to oxidative stress, high temperature and a sublethal concentration of an antibiotic.

35 Using a sublethal concentration of dihydroartemisinin (DHA), we

36 Phaeodactylum tricornutum was treated with a sublethal concentration of trans,trans-2,4-decadienal (D

37 acloprid in the field for several weeks at a sublethal concentration.

38 piration of both plants at a narrow range of sublethal concentrations (e.g., 1 mg/L of 25 nm AgNPs fo

39 effects arising from short-term exposure to sublethal concentrations are unknown.

40 provides clear evidence that imidacloprid at sublethal concentrations has a significant detrimental i

41 evidence that neonicotinoid insecticides at sublethal concentrations have profound effects on social

42 Sublethal concentrations of 7KCh resulted in microglial

43 his, we exposed diverse bacterial species to sublethal concentrations of a cell wall biosynthesis inh

44 Here, we show that in PC12 cells sublethal concentrations of aggregated Abeta(25-35) inhi

45 particular, treatment of P. aeruginosa with sublethal concentrations of antibiotics covering all maj

46 Surprisingly, we find that sublethal concentrations of antibiotics from the most wi

47 d are more sensitive to oxidative stress and sublethal concentrations of antibiotics.

48 Here we show that treating E. coli with sublethal concentrations of antimicrobial peptides cause

49 ch limits the exposure of M. tuberculosis to sublethal concentrations of antimicrobials.

50 We found that embryonic exposure to sublethal concentrations of carbaryl induced higher tole

51 during the cell cycle, we treated cells with sublethal concentrations of carbenicillin (Cb) to assess

52 P53-null hESC in the presence and absence of sublethal concentrations of cisplatin and identified 137

53 al passage of influenza virus populations in sublethal concentrations of drug.

54 we demonstrate that exposure of S. aureus to sublethal concentrations of H2O2 leads to a specific, do

55 biotransformation and effects of exposure to sublethal concentrations of hexaethylene glycol monodode

56 een antibiotics were tested with and without sublethal concentrations of manuka honey against each of

57 Sublethal concentrations of mixtures of TCDD and endosul

58 ffs in a population of microalgae exposed to sublethal concentrations of organic micropollutants over

59 We investigated the effects of exposure to sublethal concentrations of the water accommodated fract

60 ane like the addition of SDS or challenge to sublethal concentrations of Zn(2+).

61 At sublethal concentrations, the heat stress response is cr

62 changes in the intestinal microbiome even at sublethal concentrations, through mechanisms that remain

63 s to investigate cellular responses at these sublethal concentrations.

64 ons but cause bacterial endoreduplication at sublethal concentrations.

65 isruption among aquatic organisms even under sublethal conditions.

66 Our analysis reveals that sublethal costs of chronic heat exposure are likely to d

67 osure to conditions associated with chronic, sublethal costs related to progressive body mass loss, r

68 Long-term sublethal CXL146 exposure also led to reduction in GRP78

69 Interestingly, HL60/MX2 upon long-term sublethal CXL146 exposure regained sensitivity to mitoxa

70 tophagy, a process of cellular adaptation to sublethal damage.

71 od mononuclear cell conditioned media causes sublethal degeneration of neurons in culture.

72 2) showed significant feeding inhibition and sublethal developmental disruption in the cabbage looper

73 Sublethal dosage of salubrinal, an eIF2alpha phosphatase

74 e of these that could clear the bacterium at sublethal dosages in all replicate populations, even tho

75 eir larval development or early adulthood to sublethal dosages of flupyradifurone (0.025 mug for larv

76 Mice challenged with a sublethal dose (<2.0 x 10(6) CFU) rapidly lost weight, h

77 Within 1 h of consuming a single sublethal dose (1.34 ng/bee), foragers showed excitation

78 nd MCRR (microcystin-arginine-arginine) at a sublethal dose (10 mug L(-1)) for a period of 30 days.

79 Infection with a sublethal dose of a less virulent influenza virus strain

80 A sublethal dose of a representative derivative, 3a, signi

81 Macrophages pre-exposed to a sublethal dose of anthrax lethal toxin (LeTx) are refrac

82 ive, active-site mutant or pre-exposure to a sublethal dose of antibiotic.

83 Whereas the wild-type mice infected with a sublethal dose of bacteria could resolve the infection w

84 in response to myogenic differentiation and sublethal dose of cisplatin.

85 +CpG DNA, compared with mice infected with a sublethal dose of DENV2 and mice immunized with OVA (neg

86 With a sublethal dose of E. coli, GRK5 knockout (KO) mice exhib

87 Mice were challenged a first time with a sublethal dose of H1N1 2009 pandemic virus and, four wee

88 sic sites in DNA from E. coli treated with a sublethal dose of hydrogen peroxide.

89 encephalomyelitis (EAE) were administered a sublethal dose of influenza.

90 bone marrow-derived macrophages exposed to a sublethal dose of LeTx were resistant to LeTx in an HDAC

91 ts in dampened proinflammatory response to a sublethal dose of LPS in vivo, which is dependent on inc

92 cancer cell lines by exposure of cells to a sublethal dose of radiation and screened for lines that

93 These findings demonstrate that a sublethal dose of radiation can enhance the metastatic p

94 Finally, a sublethal dose of several ceramide analogs significantly

95 dividuals challenged with either a lethal or sublethal dose of virus increased the P : C ratio of the

96 antigens, than mice immunized with the same sublethal dose of WT CO92.

97 ed five novel ceramide analogs that act at a sublethal dose to enhance the efficacy of tumor-specific

98 Naja sputatrix venom sublethal dose was injected subcutaneously for 3 consecu

99 bacterial loads in GRK5 KO mice following a sublethal dose, at a lethal dose of E. coli, the bacteri

100 ast, SFX displayed no effect at a comparable sublethal dose.

101 n was altered within the lethal, but not the sublethal, dose range.

102 hological changes in RAW 264.7 cells, and at sublethal doses (i.e., 10 mg/L) it induced the early exp

103 to honey bees, but little is known about how sublethal doses affect honey bees or whether they will c

104 The interaction between sublethal doses of a neurotoxin, clothianidin, and the e

105 Moreover, we show that sublethal doses of Abeta(1-42) oligomers enter the nucle

106 on in adult human cortical slices exposed to sublethal doses of AbetaOs.

107 of B. burgdorferi, the results suggest that sublethal doses of antibiotics could negatively impact s

108 ring tumor cells hypersensitive to otherwise sublethal doses of clinically relevant chemotherapeutic

109 xoid or genetically derived CNF1 toxoid plus sublethal doses of CNF1.

110 Finally, sublethal doses of CSE reduced cell motility and gel con

111 Our findings indicate that sublethal doses of doxorubicin and melphalan initiate a

112 In this work, we show that sublethal doses of doxorubicin and vorinostat still incr

113 Upon exposure to sublethal doses of gamma-irradiation, Parp-2-/- mice exh

114 We studied the effects of sublethal doses of imidacloprid on olfactory learning in

115 ow that codelivery of insulin with otherwise sublethal doses of LPS induced hypoglycemic shock in mic

116 of Dab2 (Dab2fl/fl Lysm-Cre), treatment with sublethal doses of LPS resulted in increased proinflamma

117 Hence, sublethal doses of neonicotinoids might compromise the f

118 represented in Daphnia magna (DM) exposed to sublethal doses of presumed narcotic chemicals with log

119 ination of microbial dynamics, we found that sublethal doses of the common antibiotic ciprofloxacin c

120 present in the spleens of mice infected with sublethal doses of the Francisella tularensis live vacci

121 Here we show that sublethal doses of the neonicotinoid imidacloprid impair

122 The occurrence at sublethal doses of this insecticide-induced viral prolif

123 known to induce chromosomal fragmentation in sublethal doses, and yet UV irradiation causes genetic i

124 At sublethal doses, AZT has no significant effect on frame

125 that UV irradiation induces fragmentation in sublethal doses, but the broken chromosomes are repaired

126 abolite when applied to Bacillus subtilis at sublethal doses.

127 nd are unable to control bacterial growth at sublethal doses.

128 However, the sublethal effect of neonicotinoids on S. invicta has nev

129 Pericardial edema was the most sensitive sublethal effect that often preceded embryo mortality, a

130 vincingly shown in a handful of lab studies, sublethal effects at environmentally relevant concentrat

131 pesticide concentrations can have subtle or sublethal effects at the individual level, it is not kno

132 e analysis and metabolome analysis indicated sublethal effects consistent with perturbations of calci

133 osure, we need tools to extrapolate from the sublethal effects observed in the laboratory under const

134 owed the predicted direction indicating that sublethal effects of contaminant exposure can lead to ov

135 For relatively oxidized sediments, sublethal effects of copper to the epibenthic deposit-fe

136 Exploring the sublethal effects of disease outbreaks among natural pop

137 application of molecular profiling to assess sublethal effects of environmental stressors in field-co

138 serve as a quantitative basis for assessing sublethal effects of global change.

139 We investigated the sublethal effects of ingested plastic in Flesh-footed Sh

140 on is one of the few examples to date of the sublethal effects of marine debris and highlights that s

141 entage of northern Ontario waterbodies where sublethal effects of mercury on fish can occur may incre

142 We hypothesize that any sublethal effects of neonicotinoid seed dressings on Bom

143 However, the sublethal effects of pesticides on locomotion and moveme

144 ppropriate guidelines for testing chronic or sublethal effects of pesticides used in agriculture.

145 odels and presents a novel approach to study sublethal effects of pollutants on fish larvae in situ.

146 roposed alongside CTLs, to better assess the sublethal effects of rising temperatures on species pers

147 We propose that differences in the sublethal effects of SFX reflect a different mode of act

148 m of this study was to assess the lethal and sublethal effects of the disazo dye Disperse Yellow 7 (D

149 exposure to field-realistic levels can have sublethal effects on bees, affecting their foraging beha

150 To evaluate potential sublethal effects on dolphins, health assessments were c

151 he lethal effects of TFM are well-known, the sublethal effects on fishes are virtually unknown.

152 End points included LC50 values, and sublethal effects on growth, yolk utilization, and pancr

153 Here we report on the sublethal effects Pb exposure has on the breeding perfor

154 t high concentrations, but their chronic and sublethal effects should not be overlooked.

155 erns, given their acknowledged potential for sublethal effects to sensitive species and lifecycle sta

156 the sediment-water interface and lethal and sublethal effects to the amphipod Melita plumulosa were

157 of subcellular partitioning of copper on the sublethal effects to two deposit-feeding organisms (41-d

158 DOPO showed only sublethal effects with an EC50 value of 48 mg L(-1) for

159 result in less visible and poorly documented sublethal effects, and as a consequence, the true impact

160 xposure also revealed significant lethal and sublethal effects, at concentrations 3-5 orders of magni

161 Sublethal effects, including delayed development and red

162 Contrary to models without sublethal effects, our model suggests that modest increa

163 arative species sensitivity, consequences of sublethal effects, potential hazards of greater AR resid

164 s of magnitude, we expect acute mortality or sublethal effects, respectively.

165 drocarbons (PAHs), which can have lethal and sublethal effects.

166 te lethality, slow responses may not prevent sublethal effects.

167 may cause mass mortality or result in other sublethal effects.

168 materials requires studies that address both sublethal end points and multigenerational effects.

169 This study is the first to report on sublethal end points for azo dyes in amphibians, a growi

170 o acute toxicity test was modified by adding sublethal endpoints.

171 aromyces cerevisiae to show that exposure to sublethal ethanol concentrations causes DNA replication

172 ith increasing evidence suggesting that this sublethal exposure has implications for pollinator decli

173 e is extreme but also cytoprotective in that sublethal exposure leads to the synthesis of heat shock

174 We assessed adverse effects of external sublethal exposure of Deepwater Horizon, Mississippi Can

175 eutrophilic infiltration.Sublytic EC injury: Sublethal exposure to DSA with EC activation predominate

176 in organisms, and would be induced following sublethal exposure to natural and anthropogenic stressor

177 sic level of phenotypic expression caused by sublethal exposure to oil can have effects that would be

178 Sublethal exposure to QDs stimulated the expression of g

179 aFG pathway was selective, with induction by sublethal exposure to the CAPs, RP-1 (platelets), and po

180 top to test the effects of acute and chronic sublethal exposures to TMX.

181 lower dose of 0.066 microg/adult bee/day) at sublethal, field-realistic doses given over 3 days.

182 is well documented, but the consequences of sublethal fitness costs associated with chronic exposure

183 d exposure to acute lethal risks and chronic sublethal fitness costs under past, present, and future

184 inflammatory capacity at early times towards sublethal Ft.

185 age in human cells in response to a panel of sublethal genotoxic treatments, using other topoisomeras

186 were highly enriched in cells survived after sublethal H(2)O(2) challenge.

187 of early-stationary-phase cells exposed to a sublethal H(2)O(2) concentration detected significant (P

188 polA1 double mutant following adaptation at sublethal H(2)O(2) levels was decreased 9-fold relative

189 severely attenuated even after adaptation at sublethal H(2)O(2) levels, whereas wild-type bacteria co

190 Sublethal heat treatment skews HCC cells toward EMT and

191 At moderate sublethal histone doses (30 mg/kg), left ventricular con

192 We examined impacts of constant and variable sublethal hypoxia exposures on multiple biological proce

193 e translational regulation under control and sublethal hypoxia stress conditions in seedlings of Arab

194 r variable, and 6-hour variable exposures to sublethal hypoxia, and compared responses for each hypox

195 y can differentially modulate the impacts of sublethal hypoxia, and may impact sea urchin populations

196 However, this overlooks important sublethal impacts of temperature that could affect speci

197 The sublethal impacts of variable hypoxia differed among bio

198 Oxygen limitation affected both lethal and sublethal impacts of warming in each species.

199 eratorPAH50) from the DWH event, significant sublethal impacts were observed ranging from impaired ne

200 a lethal disease, anthrax often occurs as a sublethal infection in some susceptible hosts.

201 We analyzed the outcome of sublethal infection of C3H/HeJ mice older than age 10 we

202 Here, we show that sublethal infection of mice with Streptococcus pneumonia

203 nimals fed upon by infected nymphs developed sublethal infection with 27% lethality.

204 C57BL/6 and BALB/c mice induces a lethal or sublethal infection with high bacterial burdens in perit

205 is, contrasting their protective role during sublethal infection.

206 iggering host immune responses, these common sublethal infections may act as immunomodulators and aff

207 signaling networks distinguished lethal from sublethal infections.

208 n in vitro, protects mice against lethal and sublethal influenza challenge after oral administration,

209 t in resistance to S. aureus pneumonia after sublethal influenza infection.

210 Sepsis was triggered in vivo using a sublethal injection of lipopolysaccharide (O55B5, 10 mg/

211 Sublethal injurious stimuli in neurons induce transient

212 rent energy devices create variable zones of sublethal injury that may promote tumor recurrence.

213 Sublethal injury triggers long-lasting sensitization of

214 Following sublethal inocula (1 x 10(7) CFU), the intra-abscess bur

215 onal antibody (mAb), by immunizing mice with sublethal inocula of a hypervirulent XDR clinical isolat

216 Sublethal inocula of BG2 (1 x 10(8) or 1 x 10(7) CFU) ca

217 When sublethal inocula were used, however, the Deltaplb1-2 mu

218 ngs, liver, and spleen of mice that received sublethal inocula.

219 In contrast, a sublethal inoculum (1 x 10(7) CFU) of BG2 caused less ne

220 well as decreased survival in response to a sublethal inoculum of H. capsulatum The absence of myelo

221 d cultured differentiating oligodendrocytes, sublethal intermittent hypoxic (IH) stress activated cyc

222 njury in wild-type and Nlrc4(-/-) mice using sublethal intranasal inocula of P. aeruginosa strain CHA

223 one marrow with allogeneic donor cells after sublethal irradiation by a ~2-fold increase.

224 icate that survival of a few neoblasts after sublethal irradiation results in the clonal expansion of

225 long-term suppression of thymopoiesis after sublethal irradiation was primarily due to fewer progeni

226 We previously determined that sublethal irradiation, unlike bleeding or hemolysis, dep

227 d BMT following conditioning with lethal and sublethal irradiation.

228 We observe that a sublethal ischaemic preconditioning insult also leads to

229 Sublethal ischemia in neurons induces calcineurin-depend

230 g is the phenomenon whereby brief periods of sublethal ischemia protect against a subsequent, more pr

231 ing in vivo and in vitro models that, during sublethal ischemia, local neurons rapidly produce interl

232 We showed previously that sublethal ischemia, which renders neurons transiently re

233 A mouse model for sublethal Leptospira infection allows understanding of t

234 We found that at sublethal levels a representative NCR peptide specifical

235 We then exposed bumblebee colonies to sublethal levels of a neonicotinoid pesticide.

236 ons and stress responses that are induced by sublethal levels of NCR peptides and other antimicrobial

237 Although sublethal levels of neonicotinoids are known to disrupt

238 Our analysis reveals that exposure to sublethal levels of NMDA does not alter phosphorylation

239 Sublethal levels of oxidative stress are commonly associ

240 R to induce preconditioning, suggesting that sublethal levels of ROS are indeed an important mediator

241 communities that had previously experienced sublethal levels of stress and had been connected by dis

242 ns in vivo are always lethal or can occur at sublethal levels that increase HIV-1 diversification and

243 sticides adversely affect bee health even at sublethal levels.

244 ALPI also affected sublethal life cycle parameters, with an EC50 of 2.8 mg

245 We exposed male fish to sublethal low-dose ionizing radiation, a genotoxic stres

246 inflammatory response elicited in mice by a sublethal LPS dose, and protected mice against a lethal

247 o showed enhanced bacterial clearance during sublethal lung infection.

248 A sublethal model of anaphylaxis was used, in which BALB/c

249 In this study, a sublethal mouse MRSA pneumonia model was employed to inv

250 f co-encapsidation with APOBEC3G can promote sublethal mutagenesis of HIV-1 proviral DNA.

251 OBEC3F and/or other deaminases may result in sublethal mutations that might facilitate viral diversif

252 opulations to determine how treatment with a sublethal NCR peptide affects the cell cycle and physiol

253 tantial transcriptional response elicited by sublethal NCR treatment that affected approximately 15%

254 emicals affecting cardiovascular function at sublethal, nonteratogenic concentrations.

255 or necrotic cells we exposed fibroblasts to sublethal oxidative stress.

256 ock protein 70 (hsp70) were characterized at sublethal particle concentrations (25-50 mg/L).

257 We studied the effects of sublethal Pb exposure on immunity, carotenoid-based colo

258 sperm from oxidative stress in the event of sublethal Pb exposure.

259 tages, but we found simultaneous exposure to sublethal pesticide concentrations and Bd had no such ef

260 may affect aquatic ecosystems, we tested how sublethal pesticide concentrations modify body stoichiom

261 Previous studies reported effects of early sublethal pesticide exposure on amphibian Bd sensitivity

262 We conclude that short episodes of sublethal pesticide exposures during development are suf

263 This study investigated the effect of sublethal physiological stressors on OMV production by P

264 We used an experimental model of sublethal polymicrobial sepsis induced by cecal ligation

265 nt cortical dronc activity is initiated by a sublethal pulse of the inhibitor of apoptosis protein (I

266 We conclude that sublethal radiation is a unique model of endogenous stre

267 ructure, and the inflammatory response after sublethal renal ischemia-reperfusion injury.

268 ature and hydrostatic pressure on lethal and sublethal (respiration rate, antioxidant enzyme activity

269 calanoid copepod, monitoring for lethal and sublethal responses.

270 mice were treated with Dbait alone (n = 20), sublethal RFA (n = 21), three different Dbait schemes an

271 (n = 21), three different Dbait schemes and sublethal RFA (n = 52), or a sham treatment (n = 18).

272 Sublethal RFA or Dbait treatment alone moderately improv

273 oropharyngeal aspiration model of lethal and sublethal S. marcescens pneumonia in BALB/c mice and ext

274 otics must be carefully deployed and not all sublethal sequential treatments succeed.

275 amming into pluripotent cells by exposure to sublethal stimuli, which we call stimulus-triggered acqu

276 investigate how these results can be due to sublethal stress impairing colony function.

277 failures, highlighting an important role for sublethal stress in colony declines.

278 activity remained low; however, exposure to sublethal stress resulted in hyperactive p53 and p53-dep

279 cell cycle arrest that occurs in response to sublethal stress.

280 c to multiple competitors, typically causing sublethal suppression of growth.

281 Conversely, a sublethal surface infection of worms with Verde1 conferr

282 We investigated the effects of sublethal TBI on T cell memory responses to gain insight

283 regulate stress-response systems to tolerate sublethal temperature exposures with climate change, whe

284 ylcholinesterase (AChE) during adaptation to sublethal temperatures by acclimating the fish to 37 deg

285 Despite the use of sublethal temperatures, all bacteria types were subseque

286 area, by extending the focus from lethal to sublethal thiamine deficiency, and by linking biochemica

287 ciated with growth repression and hence need sublethal to lethal NP doses, which besides stopping fun

288 TLI/ATS/CTX compared with TLI/ATS, lethal or sublethal total body irradiation/ATS/CTX, or CTX/ATS con

289 ctivity may be a useful complement to screen sublethal toxicity effects of chemicals.

290 method to remove PAHs and reduce lethal and sublethal toxicity in both species.

291 applied to investigate imidacloprid-induced sublethal toxicity in the central nervous system of the

292 Significant sublethal toxicity was observed with the charged particl

293 cal devices in which RBCs are susceptible to sublethal trauma.

294 obust repair of DNA double-strand breaks and sublethal-type damage induced by gamma-rays, but not by

295 In response to sublethal ultraviolet B (UVB) irradiation, human keratin

296 These data indicate that a sublethal WAF exposure directly modifies detection and a

297 In both cases, recurrent sublethal warming decreased embryonic survival and hatch

298 whether oxygen shortages might also underlie sublethal warming effects.

299 Here, we examine impacts of recurrent sublethal warming on development and survival in ecologi

300 compared to models that did not incorporate sublethal warming.